G12 - ADGRG5 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 82.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 15.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 L 343 3x58 G.H5 N 374 G.H5.19
Polar TM6 H 454 6x37 G.H5 Q 381 G.H5.26
Hydrophobic TM6 H 454 6x37 G.H5 Q 381 G.H5.26
Van-der-waals TM6 H 454 6x37 G.H5 Q 381 G.H5.26
Hydrophobic H8 R 509 8x49 G.H5 Q 381 G.H5.26
Van-der-waals H8 R 509 8x49 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 Y 347 - G.H5 V 366 G.H5.11
Van-der-waals ICL2 Y 347 - G.H5 V 366 G.H5.11
Hydrophobic TM5 L 441 5x64 G.H5 Q 372 G.H5.17
Polar H8 S 510 8x50 G.H5 L 380 G.H5.25
Polar H8 A 520 8x60 G.H3 K 284 G.H3.16
Hydrophobic H8 A 520 8x60 G.H3 K 284 G.H3.16
Van-der-waals H8 A 520 8x60 G.H3 K 284 G.H3.16
Hydrophobic ICL2 N 348 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 N 348 - G.S3 I 221 G.S3.01
Hydrophobic TM3 L 342 3x57 G.H5 I 378 G.H5.23
Van-der-waals TM3 L 342 3x57 G.H5 I 378 G.H5.23
Hydrophobic TM7 Q 506 7x60 G.H5 M 379 G.H5.24
Ionic H8 E 513 8x53 G.H5 K 376 G.H5.21
Polar H8 E 513 8x53 G.H5 K 376 G.H5.21
Van-der-waals H8 E 513 8x53 G.H5 K 376 G.H5.21
Hydrophobic TM6 L 462 6x45 G.H5 I 378 G.H5.23
Hydrophobic H8 E 513 8x53 G.H5 Q 381 G.H5.26
Van-der-waals H8 E 513 8x53 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 V 346 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 V 346 - G.H5 I 370 G.H5.15
Hydrophobic ICL3 R 444 - G.S6 F 347 G.S6.02
Hydrophobic TM5 T 437 5x60 G.H5 L 371 G.H5.16
Van-der-waals TM5 T 437 5x60 G.H5 L 371 G.H5.16
Hydrophobic TM5 L 441 5x64 G.H5 L 375 G.H5.20
Van-der-waals TM5 L 441 5x64 G.H5 L 375 G.H5.20
Ionic TM2 D 278 2x44 G.hns1 R 55 G.hns1.02
Polar TM2 D 278 2x44 G.hns1 R 55 G.hns1.02
Van-der-waals TM2 D 278 2x44 G.hns1 R 55 G.hns1.02
Polar TM7 Q 506 7x60 G.H5 I 378 G.H5.23
Van-der-waals TM7 Q 506 7x60 G.H5 I 378 G.H5.23
Hydrophobic TM6 T 458 6x41 G.H5 L 375 G.H5.20
Hydrophobic TM5 L 441 5x64 G.H5 L 371 G.H5.16
Polar H8 S 523 8x63 G.H3 K 284 G.H3.16
Van-der-waals H8 S 523 8x63 G.H3 K 284 G.H3.16
Hydrophobic ICL2 Y 347 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 Y 347 - G.S3 I 221 G.S3.01
Van-der-waals H8 Q 517 8x57 G.h3s5 N 288 G.h3s5.02
Hydrophobic ICL3 A 445 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 A 445 - G.h4s6 P 345 G.h4s6.20
Ionic ICL3 R 444 - G.H5 D 368 G.H5.13
Polar ICL3 R 444 - G.H5 D 368 G.H5.13
Van-der-waals ICL3 R 444 - G.H5 D 368 G.H5.13
Hydrophobic ICL2 Y 350 - G.HN R 52 G.HN.52
Van-der-waals ICL2 Y 350 - G.HN R 52 G.HN.52
Hydrophobic H8 R 509 8x49 G.H5 L 380 G.H5.25
Van-der-waals H8 R 509 8x49 G.H5 L 380 G.H5.25
Hydrophobic TM3 L 343 3x58 G.H5 I 378 G.H5.23
Hydrophobic TM3 L 343 3x58 G.H5 L 371 G.H5.16
Van-der-waals TM3 L 343 3x58 G.H5 L 371 G.H5.16
Hydrophobic TM7 W 502 7x56 G.H5 M 379 G.H5.24
Hydrophobic ICL2 Y 347 - G.S3 F 223 G.S3.03
Hydrophobic ICL2 V 346 - G.H5 L 371 G.H5.16
Van-der-waals ICL2 V 346 - G.H5 L 371 G.H5.16
Hydrophobic TM7 Q 506 7x60 G.H5 L 380 G.H5.25
Van-der-waals TM7 Q 506 7x60 G.H5 L 380 G.H5.25
Hydrophobic TM3 L 343 3x58 G.H5 L 375 G.H5.20
Polar ICL2 Y 350 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 Y 350 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 Y 350 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 Y 347 - G.S1 V 58 G.S1.02
Hydrophobic TM2 L 280 2x46 G.H5 D 377 G.H5.22
Van-der-waals TM2 L 280 2x46 G.H5 D 377 G.H5.22
Hydrophobic TM6 H 454 6x37 G.H5 M 379 G.H5.24
Van-der-waals TM6 H 454 6x37 G.H5 M 379 G.H5.24
Hydrophobic TM2 L 280 2x46 G.H5 I 378 G.H5.23
Van-der-waals TM2 L 280 2x46 G.H5 I 378 G.H5.23
Polar TM6 R 451 6x34 G.h4s6 S 343 G.h4s6.12
Hydrophobic TM6 R 451 6x34 G.h4s6 S 343 G.h4s6.12
Van-der-waals TM6 R 451 6x34 G.h4s6 S 343 G.h4s6.12
Polar ICL1 Q 276 - G.HN R 51 G.HN.51
Hydrophobic TM6 T 458 6x41 G.H5 M 379 G.H5.24
Van-der-waals TM6 T 458 6x41 G.H5 M 379 G.H5.24
Hydrophobic TM5 L 441 5x64 G.H5 D 368 G.H5.13
Polar ICL2 Y 347 - G.H5 F 363 G.H5.08
Aromatic ICL2 Y 347 - G.H5 F 363 G.H5.08
Hydrophobic ICL2 Y 347 - G.H5 F 363 G.H5.08
Van-der-waals ICL2 Y 347 - G.H5 F 363 G.H5.08
Polar TM3 L 342 3x57 G.H5 N 374 G.H5.19
Hydrophobic TM3 L 342 3x57 G.H5 N 374 G.H5.19
Van-der-waals TM3 L 342 3x57 G.H5 N 374 G.H5.19
Hydrophobic ICL2 Y 347 - G.H5 I 370 G.H5.15
Van-der-waals ICL2 Y 347 - G.H5 I 370 G.H5.15
Hydrophobic ICL2 V 346 - G.H5 K 367 G.H5.12
Van-der-waals ICL2 V 346 - G.H5 K 367 G.H5.12
Hydrophobic TM7 W 502 7x56 G.H5 I 378 G.H5.23
Van-der-waals TM7 W 502 7x56 G.H5 I 378 G.H5.23
Hydrophobic C-term S 524 - G.H3 K 284 G.H3.16
Polar TM3 G 344 3x59 G.H5 K 367 G.H5.12
Van-der-waals TM3 G 344 3x59 G.H5 K 367 G.H5.12
Polar ICL2 Y 347 - G.H5 K 367 G.H5.12
Hydrophobic ICL2 Y 347 - G.H5 K 367 G.H5.12
Van-der-waals ICL2 Y 347 - G.H5 K 367 G.H5.12
Hydrophobic TM3 L 339 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 L 339 3x54 G.H5 I 378 G.H5.23
Polar ICL2 N 348 - G.s2s3 K 220 G.s2s3.02
Hydrophobic ICL2 N 348 - G.s2s3 K 220 G.s2s3.02
Van-der-waals ICL2 N 348 - G.s2s3 K 220 G.s2s3.02
Hydrophobic TM5 L 438 5x61 G.H5 L 375 G.H5.20
Van-der-waals TM5 L 438 5x61 G.H5 L 375 G.H5.20