G13 - ADGRV1 complex model

GPCR CLASS (FAMILY)

B2 (Adhesion)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 71.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.4
PAE mean: 23.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar C-term L 6306 - H.HB T 127 H.HB.14
Hydrophobic C-term L 6306 - H.HB T 127 H.HB.14
Van-der-waals C-term L 6306 - H.HB T 127 H.HB.14
Hydrophobic C-term F 6263 - G.s2s3 N 215 G.s2s3.02
Van-der-waals C-term F 6263 - G.s2s3 N 215 G.s2s3.02
Aromatic H8 Y 6167 8x58 G.H5 H 368 G.H5.17
Hydrophobic H8 Y 6167 8x58 G.H5 H 368 G.H5.17
Van-der-waals H8 Y 6167 8x58 G.H5 H 368 G.H5.17
Hydrophobic TM3 F 5995 3x54 G.H5 L 374 G.H5.23
Van-der-waals TM3 F 5995 3x54 G.H5 L 374 G.H5.23
Polar C-term H 6305 - H.hbhc A 133 H.hbhc.06
Hydrophobic C-term H 6305 - H.hbhc A 133 H.hbhc.06
Van-der-waals C-term H 6305 - H.hbhc A 133 H.hbhc.06
Hydrophobic TM3 V 5998 3x57 G.H5 Q 373 G.H5.22
Ionic C-term D 6303 - G.hfs2 K 204 G.hfs2.06
Polar C-term D 6303 - G.hfs2 K 204 G.hfs2.06
Van-der-waals C-term D 6303 - G.hfs2 K 204 G.hfs2.06
Hydrophobic C-term I 6203 - G.H3 T 274 G.H3.11
Hydrophobic C-term A 6205 - G.H2 K 231 G.H2.05
Van-der-waals ICL3 F 6096 - G.S6 Y 343 G.S6.02
Polar TM5 Y 6092 5x66 G.H5 N 370 G.H5.19
Hydrophobic TM5 Y 6092 5x66 G.H5 N 370 G.H5.19
Hydrophobic C-term L 6265 - G.S3 V 216 G.S3.01
Van-der-waals C-term L 6265 - G.S3 V 216 G.S3.01
Ionic ICL2 D 6003 - G.hns1 K 46 G.hns1.02
Polar ICL2 D 6003 - G.hns1 K 46 G.hns1.02
Hydrophobic ICL2 D 6003 - G.hns1 K 46 G.hns1.02
Van-der-waals ICL2 D 6003 - G.hns1 K 46 G.hns1.02
Hydrophobic C-term F 6258 - G.H5 I 355 G.H5.04
Aromatic C-term F 6258 - G.H5 F 359 G.H5.08
Hydrophobic C-term F 6258 - G.H5 F 359 G.H5.08
Van-der-waals C-term F 6258 - G.H5 F 359 G.H5.08
Hydrophobic H8 M 6171 8x62 G.S6 L 342 G.S6.01
Van-der-waals H8 M 6171 8x62 G.S6 L 342 G.S6.01
Hydrophobic ICL3 V 6095 - G.H5 D 364 G.H5.13
Van-der-waals ICL3 V 6095 - G.H5 D 364 G.H5.13
Ionic C-term K 6266 - G.S2 E 212 G.S2.07
Polar C-term K 6266 - G.S2 E 212 G.S2.07
Hydrophobic C-term K 6266 - G.S2 E 212 G.S2.07
Van-der-waals C-term K 6266 - G.S2 E 212 G.S2.07
Hydrophobic TM6 N 6101 6x35 G.H5 L 374 G.H5.23
Van-der-waals TM6 N 6101 6x35 G.H5 L 374 G.H5.23
Polar C-term T 6267 - G.s2s3 N 215 G.s2s3.02
Hydrophobic TM5 D 6093 5x67 G.H5 L 371 G.H5.20
Van-der-waals TM5 D 6093 5x67 G.H5 L 371 G.H5.20
Hydrophobic H8 A 6165 8x56 G.H5 M 375 G.H5.24
Hydrophobic TM2 A 5937 2x46 G.H5 L 374 G.H5.23
Van-der-waals TM2 A 5937 2x46 G.H5 L 374 G.H5.23
Polar H8 N 6172 8x63 G.S6 H 344 G.S6.03
Hydrophobic H8 N 6172 8x63 G.S6 H 344 G.S6.03
Van-der-waals H8 N 6172 8x63 G.S6 H 344 G.S6.03
Hydrophobic C-term L 6261 - G.H5 K 363 G.H5.12
Van-der-waals C-term L 6261 - G.H5 K 363 G.H5.12
Polar C-term L 6265 - G.hns1 R 47 G.hns1.03
Hydrophobic C-term L 6265 - G.hns1 R 47 G.hns1.03
Van-der-waals C-term L 6265 - G.hns1 R 47 G.hns1.03
Hydrophobic H8 M 6171 8x62 G.S6 H 344 G.S6.03
Van-der-waals H8 M 6171 8x62 G.S6 H 344 G.S6.03
Hydrophobic H8 Y 6167 8x58 G.H5 M 375 G.H5.24
Van-der-waals H8 Y 6167 8x58 G.H5 M 375 G.H5.24
Hydrophobic C-term K 6266 - G.S3 V 216 G.S3.01
Van-der-waals C-term K 6266 - G.S3 V 216 G.S3.01
Hydrophobic C-term L 6265 - G.H5 I 366 G.H5.15
Hydrophobic TM2 M 5935 2x44 G.H5 Q 373 G.H5.22
Polar C-term T 6199 - G.H3 N 270 G.H3.07
Hydrophobic TM6 N 6101 6x35 G.H5 L 371 G.H5.20
Van-der-waals TM6 N 6101 6x35 G.H5 L 371 G.H5.20
Hydrophobic C-term I 6262 - G.s2s3 N 215 G.s2s3.02
Van-der-waals C-term I 6262 - G.s2s3 N 215 G.s2s3.02
Polar C-term A 6302 - G.hfs2 K 204 G.hfs2.06
Van-der-waals C-term A 6302 - G.hfs2 K 204 G.hfs2.06
Polar H8 Q 6158 8x49 G.H5 Q 377 G.H5.26
Hydrophobic H8 Q 6158 8x49 G.H5 Q 377 G.H5.26
Van-der-waals H8 Q 6158 8x49 G.H5 Q 377 G.H5.26
Polar C-term I 6299 - G.H2 R 232 G.H2.06
Hydrophobic C-term I 6299 - G.H2 R 232 G.H2.06
Van-der-waals C-term I 6299 - G.H2 R 232 G.H2.06
Polar C-term E 6254 - G.H5 R 356 G.H5.05
Hydrophobic H8 M 6171 8x62 G.H4 R 331 G.H4.16
Van-der-waals H8 M 6171 8x62 G.H4 R 331 G.H4.16
Hydrophobic TM2 L 5941 2x50 G.H5 L 376 G.H5.25
Hydrophobic C-term I 6301 - G.H2 R 232 G.H2.06
Van-der-waals C-term I 6301 - G.H2 R 232 G.H2.06
Hydrophobic TM2 M 5935 2x44 G.H5 K 372 G.H5.21
Van-der-waals TM2 M 5935 2x44 G.H5 K 372 G.H5.21
Aromatic C-term F 6258 - G.H5 R 356 G.H5.05
Hydrophobic C-term F 6258 - G.H5 R 356 G.H5.05
Polar TM2 F 5936 2x45 G.H5 Q 373 G.H5.22
Hydrophobic TM5 Y 6092 5x66 G.H5 K 363 G.H5.12
Van-der-waals TM5 Y 6092 5x66 G.H5 K 363 G.H5.12
Hydrophobic ICL3 F 6096 - G.H5 L 371 G.H5.20
Van-der-waals ICL3 F 6096 - G.H5 L 371 G.H5.20
Hydrophobic ICL2 E 6004 - G.H5 I 366 G.H5.15
Van-der-waals ICL2 E 6004 - G.H5 I 366 G.H5.15
Hydrophobic ICL2 E 6004 - G.H5 D 369 G.H5.18
Polar ICL2 H 6005 - G.hns1 K 46 G.hns1.02
Hydrophobic ICL2 H 6005 - G.hns1 K 46 G.hns1.02
Van-der-waals ICL2 H 6005 - G.hns1 K 46 G.hns1.02
Hydrophobic ICL3 F 6096 - G.H5 L 367 G.H5.16
Polar C-term R 6298 - H.hbhc Q 134 H.hbhc.07
Polar C-term N 6201 - G.H2 R 227 G.H2.01
Van-der-waals C-term N 6201 - G.H2 R 227 G.H2.01
Hydrophobic C-term I 6262 - G.S2 I 213 G.S2.08
Van-der-waals C-term I 6262 - G.S2 I 213 G.S2.08
Polar TM3 M 6001 3x60 G.hns1 R 47 G.hns1.03
Hydrophobic TM3 M 6001 3x60 G.hns1 R 47 G.hns1.03
Van-der-waals TM3 M 6001 3x60 G.hns1 R 47 G.hns1.03
Hydrophobic C-term I 6262 - G.H5 F 359 G.H5.08
Van-der-waals C-term I 6262 - G.H5 F 359 G.H5.08
Polar C-term T 6199 - G.H3 T 274 G.H3.11
Hydrophobic C-term T 6199 - G.H3 T 274 G.H3.11
Hydrophobic ICL3 F 6096 - G.H5 D 364 G.H5.13
Van-der-waals ICL3 F 6096 - G.H5 D 364 G.H5.13
Van-der-waals C-term S 6198 - G.H2 R 230 G.H2.04
Polar C-term W 6213 - G.H3 R 279 G.H3.16
Aromatic C-term W 6213 - G.H3 R 279 G.H3.16
Hydrophobic C-term W 6213 - G.H3 R 279 G.H3.16
Van-der-waals C-term W 6213 - G.H3 R 279 G.H3.16
Hydrophobic C-term F 6258 - G.H1 H 72 G.H1.12
Hydrophobic C-term I 6262 - G.s2s3 K 214 G.s2s3.01
Van-der-waals C-term I 6262 - G.s2s3 K 214 G.s2s3.01
Hydrophobic H8 H 6156 8x47 G.H5 L 376 G.H5.25
Van-der-waals H8 H 6156 8x47 G.H5 L 376 G.H5.25
Hydrophobic TM5 A 6091 5x65 G.H5 K 363 G.H5.12
Van-der-waals TM5 A 6091 5x65 G.H5 K 363 G.H5.12
Polar TM5 Y 6092 5x66 G.H5 I 366 G.H5.15
Hydrophobic TM5 Y 6092 5x66 G.H5 I 366 G.H5.15
Van-der-waals TM5 Y 6092 5x66 G.H5 I 366 G.H5.15
Aromatic C-term F 6181 - G.H4 K 324 G.H4.09
Hydrophobic C-term F 6181 - G.H4 K 324 G.H4.09
Van-der-waals C-term F 6181 - G.H4 K 324 G.H4.09
Hydrophobic C-term K 6266 - G.S3 P 217 G.S3.02
Van-der-waals C-term K 6266 - G.S3 P 217 G.S3.02
Polar TM3 V 5998 3x57 G.H5 N 370 G.H5.19
Hydrophobic TM3 V 5998 3x57 G.H5 N 370 G.H5.19
Van-der-waals TM3 V 5998 3x57 G.H5 N 370 G.H5.19
Polar C-term P 6300 - G.H2 R 232 G.H2.06
Van-der-waals C-term P 6300 - G.H2 R 232 G.H2.06
Hydrophobic TM4 R 6009 4x42 G.hns1 K 46 G.hns1.02
Polar C-term K 6266 - G.s2s3 N 215 G.s2s3.02
Hydrophobic C-term K 6266 - G.s2s3 N 215 G.s2s3.02
Van-der-waals C-term K 6266 - G.s2s3 N 215 G.s2s3.02
Hydrophobic ICL1 S 5934 - G.H5 Q 377 G.H5.26
Van-der-waals ICL1 S 5934 - G.H5 Q 377 G.H5.26
Hydrophobic C-term K 6266 - G.HN Y 44 G.HN.53
Hydrophobic C-term L 6202 - G.H3 T 274 G.H3.11
Polar ICL2 E 6004 - G.H5 N 370 G.H5.19
Hydrophobic ICL2 E 6004 - G.H5 N 370 G.H5.19
Van-der-waals ICL2 E 6004 - G.H5 N 370 G.H5.19
Polar TM2 A 5938 2x47 G.H5 M 375 G.H5.24
Hydrophobic TM7 Y 6152 7x57 G.H5 L 376 G.H5.25
Van-der-waals TM7 Y 6152 7x57 G.H5 L 376 G.H5.25
Polar C-term S 6198 - G.H2 R 227 G.H2.01
Hydrophobic C-term S 6198 - G.H2 R 227 G.H2.01
Van-der-waals C-term S 6198 - G.H2 R 227 G.H2.01
Hydrophobic TM6 I 6108 6x42 G.H5 L 376 G.H5.25
Van-der-waals TM6 I 6108 6x42 G.H5 L 376 G.H5.25
Polar TM2 M 5935 2x44 G.H5 Q 377 G.H5.26
Van-der-waals TM2 M 5935 2x44 G.H5 Q 377 G.H5.26
Hydrophobic TM6 T 6100 6x34 G.H5 M 375 G.H5.24
Hydrophobic H8 M 6163 8x54 G.H5 Q 377 G.H5.26
Van-der-waals H8 M 6163 8x54 G.H5 Q 377 G.H5.26
Hydrophobic TM2 M 5935 2x44 G.H5 M 375 G.H5.24
Van-der-waals TM2 M 5935 2x44 G.H5 M 375 G.H5.24
Ionic C-term D 6259 - G.s2s3 K 214 G.s2s3.01
Hydrophobic C-term D 6259 - G.s2s3 K 214 G.s2s3.01
Van-der-waals C-term D 6259 - G.s2s3 K 214 G.s2s3.01
Polar TM2 A 5937 2x46 G.H5 Q 373 G.H5.22
Hydrophobic TM2 A 5937 2x46 G.H5 Q 373 G.H5.22
Van-der-waals TM2 A 5937 2x46 G.H5 Q 373 G.H5.22
Hydrophobic TM5 Q 6088 5x62 G.H5 L 367 G.H5.16
Van-der-waals TM5 Q 6088 5x62 G.H5 L 367 G.H5.16
Polar C-term F 6263 - G.s2s3 K 214 G.s2s3.01
Van-der-waals C-term F 6263 - G.s2s3 K 214 G.s2s3.01
Aromatic ICL3 F 6096 - G.H5 H 368 G.H5.17
Hydrophobic ICL3 F 6096 - G.H5 H 368 G.H5.17
Van-der-waals ICL3 F 6096 - G.H5 H 368 G.H5.17
Hydrophobic TM6 E 6104 6x38 G.H5 L 376 G.H5.25
Van-der-waals TM6 E 6104 6x38 G.H5 L 376 G.H5.25
Polar ICL2 T 6006 - G.H5 Q 373 G.H5.22
Van-der-waals ICL2 T 6006 - G.H5 Q 373 G.H5.22
Hydrophobic TM2 A 5937 2x46 G.H5 L 376 G.H5.25
Hydrophobic TM5 Y 6092 5x66 G.H5 L 371 G.H5.20
Hydrophobic TM3 L 5999 3x58 G.H5 L 374 G.H5.23
Van-der-waals TM3 L 5999 3x58 G.H5 L 374 G.H5.23
Polar C-term I 6301 - G.hfs2 K 204 G.hfs2.06
Hydrophobic C-term I 6301 - G.hfs2 K 204 G.hfs2.06
Van-der-waals C-term I 6301 - G.hfs2 K 204 G.hfs2.06
Hydrophobic C-term I 6301 - G.H2 E 229 G.H2.03
Van-der-waals C-term I 6301 - G.H2 E 229 G.H2.03
Polar C-term S 6198 - G.H3 E 267 G.H3.04
Hydrophobic C-term S 6198 - G.H3 E 267 G.H3.04
Van-der-waals C-term S 6198 - G.H3 E 267 G.H3.04
Hydrophobic TM5 W 6089 5x63 G.H5 L 367 G.H5.16
Hydrophobic C-term L 6202 - G.H2 R 230 G.H2.04
Hydrophobic H8 V 6169 8x60 G.h4s6 P 341 G.h4s6.20
Hydrophobic H8 M 6171 8x62 G.S6 Y 343 G.S6.02
Van-der-waals H8 M 6171 8x62 G.S6 Y 343 G.S6.02
Hydrophobic TM2 A 5938 2x47 G.H5 Q 377 G.H5.26
Van-der-waals TM2 A 5938 2x47 G.H5 Q 377 G.H5.26
Hydrophobic C-term A 6205 - G.H2 F 234 G.H2.08
Polar TM5 Y 6092 5x66 G.H5 L 367 G.H5.16
Hydrophobic TM5 Y 6092 5x66 G.H5 L 367 G.H5.16
Van-der-waals TM5 Y 6092 5x66 G.H5 L 367 G.H5.16
Polar C-term K 6266 - G.hns1 R 47 G.hns1.03
Hydrophobic C-term K 6266 - G.hns1 R 47 G.hns1.03
Van-der-waals C-term K 6266 - G.hns1 R 47 G.hns1.03
Hydrophobic TM3 V 5998 3x57 G.H5 L 374 G.H5.23
Van-der-waals TM3 V 5998 3x57 G.H5 L 374 G.H5.23
Hydrophobic TM2 A 5938 2x47 G.H5 L 376 G.H5.25
Van-der-waals TM2 A 5938 2x47 G.H5 L 376 G.H5.25
Polar C-term I 6262 - G.S3 V 216 G.S3.01
Hydrophobic C-term I 6262 - G.S3 V 216 G.S3.01
Van-der-waals C-term I 6262 - G.S3 V 216 G.S3.01
Hydrophobic TM6 T 6100 6x34 G.H5 L 371 G.H5.20
Van-der-waals TM6 T 6100 6x34 G.H5 L 371 G.H5.20
Polar C-term L 6306 - H.hbhc R 128 H.hbhc.01
Hydrophobic C-term L 6306 - H.hbhc R 128 H.hbhc.01
Hydrophobic C-term M 6206 - G.H3 N 278 G.H3.15
Van-der-waals C-term M 6206 - G.H3 N 278 G.H3.15
Polar ICL2 E 6004 - G.H5 Q 373 G.H5.22
Hydrophobic ICL2 E 6004 - G.H5 Q 373 G.H5.22
Van-der-waals ICL2 E 6004 - G.H5 Q 373 G.H5.22
Polar C-term N 6201 - G.H2 K 231 G.H2.05
Hydrophobic C-term N 6201 - G.H2 K 231 G.H2.05
Van-der-waals C-term N 6201 - G.H2 K 231 G.H2.05
Polar C-term S 6217 - G.H3 R 279 G.H3.16
Polar C-term F 6258 - G.s2s3 K 214 G.s2s3.01
Aromatic C-term F 6258 - G.s2s3 K 214 G.s2s3.01
Hydrophobic C-term F 6258 - G.s2s3 K 214 G.s2s3.01
Van-der-waals C-term F 6258 - G.s2s3 K 214 G.s2s3.01
Hydrophobic H8 H 6156 8x47 G.H5 Q 377 G.H5.26
Hydrophobic C-term I 6301 - G.hfs2 G 205 G.hfs2.07
Van-der-waals C-term I 6301 - G.hfs2 G 205 G.hfs2.07
Hydrophobic C-term L 6202 - G.H2 W 233 G.H2.07