Golf - apelin receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 77.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 25.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 D 126 3x49 G.H5 L 380 G.H5.25
Van-der-waals TM3 D 126 3x49 G.H5 L 380 G.H5.25
Polar ICL2 V 135 34x51 G.H5 Q 371 G.H5.16
Hydrophobic ICL2 V 135 34x51 G.H5 Q 371 G.H5.16
Van-der-waals ICL2 V 135 34x51 G.H5 Q 371 G.H5.16
Polar TM3 R 127 3x50 G.H5 L 380 G.H5.25
Hydrophobic TM3 R 127 3x50 G.H5 L 380 G.H5.25
Van-der-waals TM3 R 127 3x50 G.H5 L 380 G.H5.25
Polar ICL1 E 59 12x50 G.hns1 K 40 G.hns1.02
Van-der-waals ICL1 E 59 12x50 G.hns1 K 40 G.hns1.02
Hydrophobic C-term L 377 - G.h1ha V 67 G.h1ha.01
Polar TM6 K 242 6x29 G.h4s6 Y 345 G.h4s6.20
Hydrophobic TM6 K 242 6x29 G.h4s6 Y 345 G.h4s6.20
Van-der-waals TM6 K 242 6x29 G.h4s6 Y 345 G.h4s6.20
Hydrophobic TM4 R 143 4x39 G.HN L 37 G.HN.52
Van-der-waals TM4 R 143 4x39 G.HN L 37 G.HN.52
Polar ICL1 R 61 12x52 G.hns1 K 40 G.hns1.02
Hydrophobic ICL2 V 135 34x51 G.S3 V 204 G.S3.01
Van-der-waals ICL2 V 135 34x51 G.S3 V 204 G.S3.01
Hydrophobic ICL2 R 141 34x57 G.H5 L 375 G.H5.20
Van-der-waals ICL2 R 141 34x57 G.H5 L 375 G.H5.20
Hydrophobic ICL2 V 135 34x51 G.H5 R 367 G.H5.12
Van-der-waals ICL2 V 135 34x51 G.H5 R 367 G.H5.12
Polar TM6 E 238 6x25 G.h4s6 Y 345 G.h4s6.20
Hydrophobic TM6 E 238 6x25 G.h4s6 Y 345 G.h4s6.20
Van-der-waals TM6 E 238 6x25 G.h4s6 Y 345 G.h4s6.20
Hydrophobic ICL2 V 135 34x51 G.s2s3 D 202 G.s2s3.01
Van-der-waals ICL2 V 135 34x51 G.s2s3 D 202 G.s2s3.01
Polar ICL1 R 58 12x49 G.hns1 K 40 G.hns1.02
Hydrophobic TM6 K 242 6x29 G.h4s6 K 343 G.h4s6.12
Van-der-waals TM6 K 242 6x29 G.h4s6 K 343 G.h4s6.12
Hydrophobic TM6 R 243 6x30 G.H5 R 372 G.H5.17
Van-der-waals TM6 R 243 6x30 G.H5 R 372 G.H5.17
Ionic ICL1 E 59 12x50 G.HN R 36 G.HN.51
Hydrophobic ICL1 E 59 12x50 G.HN R 36 G.HN.51
Van-der-waals ICL1 E 59 12x50 G.HN R 36 G.HN.51
Hydrophobic TM2 R 62 2x37 G.H5 Y 378 G.H5.23
Van-der-waals TM2 R 62 2x37 G.H5 Y 378 G.H5.23
Hydrophobic TM4 L 142 4x38 G.hns1 A 41 G.hns1.03
Hydrophobic ICL3 E 235 - G.S6 Y 347 G.S6.02
Van-der-waals ICL3 E 235 - G.S6 Y 347 G.S6.02
Polar ICL2 R 139 34x55 G.S2 Q 200 G.S2.07
Polar TM6 G 239 6x26 G.h4s6 Y 345 G.h4s6.20
Hydrophobic TM6 G 239 6x26 G.h4s6 Y 345 G.h4s6.20
Van-der-waals TM6 G 239 6x26 G.h4s6 Y 345 G.h4s6.20
Ionic TM2 R 62 2x37 G.H5 E 379 G.H5.24
Polar TM2 R 62 2x37 G.H5 E 379 G.H5.24
Hydrophobic TM2 R 62 2x37 G.H5 E 379 G.H5.24
Van-der-waals TM2 R 62 2x37 G.H5 E 379 G.H5.24
Hydrophobic TM3 A 130 3x53 G.H5 L 375 G.H5.20
Van-der-waals TM3 A 130 3x53 G.H5 L 375 G.H5.20
Hydrophobic TM4 R 143 4x39 G.hns1 K 40 G.hns1.02
Van-der-waals TM4 R 143 4x39 G.hns1 K 40 G.hns1.02
Polar ICL1 R 58 12x49 G.HN R 36 G.HN.51
Hydrophobic ICL1 R 58 12x49 G.HN R 36 G.HN.51
Van-der-waals ICL1 R 58 12x49 G.HN R 36 G.HN.51
Polar TM5 T 227 5x64 G.H5 R 372 G.H5.17
Hydrophobic TM5 T 227 5x64 G.H5 R 372 G.H5.17
Van-der-waals TM5 T 227 5x64 G.H5 R 372 G.H5.17
Hydrophobic TM4 L 142 4x38 G.HN L 37 G.HN.52
Hydrophobic ICL2 R 139 34x55 G.s2s3 K 203 G.s2s3.02
Van-der-waals ICL2 R 139 34x55 G.s2s3 K 203 G.s2s3.02
Ionic TM5 H 231 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 H 231 5x68 G.H5 I 369 G.H5.14
Van-der-waals TM5 H 231 5x68 G.H5 I 369 G.H5.14
Hydrophobic TM2 S 63 2x38 G.H5 L 380 G.H5.25
Van-der-waals TM2 S 63 2x38 G.H5 L 380 G.H5.25
Hydrophobic TM2 A 64 2x39 G.H5 L 380 G.H5.25
Van-der-waals TM2 A 64 2x39 G.H5 L 380 G.H5.25
Polar TM5 H 231 5x68 G.H5 R 372 G.H5.17
Aromatic TM5 H 231 5x68 G.H5 R 372 G.H5.17
Hydrophobic TM5 H 231 5x68 G.H5 R 372 G.H5.17
Van-der-waals TM5 H 231 5x68 G.H5 R 372 G.H5.17
Polar TM6 K 242 6x29 G.h4s6 D 341 G.h4s6.10
Hydrophobic TM6 K 242 6x29 G.h4s6 D 341 G.h4s6.10
Van-der-waals TM6 K 242 6x29 G.h4s6 D 341 G.h4s6.10
Polar H8 R 315 8x49 G.H5 Q 377 G.H5.22
Hydrophobic TM3 R 127 3x50 G.H5 L 381 G.H5.26
Van-der-waals TM3 R 127 3x50 G.H5 L 381 G.H5.26
Hydrophobic ICL2 A 138 34x54 G.S3 V 204 G.S3.01
Van-der-waals ICL2 A 138 34x54 G.S3 V 204 G.S3.01
Hydrophobic TM4 V 144 4x40 G.HN L 37 G.HN.52
Van-der-waals TM4 V 144 4x40 G.HN L 37 G.HN.52
Polar TM3 I 131 3x54 G.H5 R 372 G.H5.17
Hydrophobic TM3 I 131 3x54 G.H5 R 372 G.H5.17
Polar TM6 K 242 6x29 G.h4s6 G 342 G.h4s6.11
Hydrophobic TM6 K 242 6x29 G.h4s6 G 342 G.h4s6.11
Van-der-waals TM6 K 242 6x29 G.h4s6 G 342 G.h4s6.11
Hydrophobic ICL2 P 134 34x50 G.H5 D 368 G.H5.13
Van-der-waals ICL2 P 134 34x50 G.H5 D 368 G.H5.13
Hydrophobic ICL2 P 134 34x50 G.H5 L 375 G.H5.20
Hydrophobic TM6 L 246 6x33 G.H5 L 381 G.H5.26
Van-der-waals TM6 L 246 6x33 G.H5 L 381 G.H5.26
Ionic H8 R 315 8x49 G.H5 E 379 G.H5.24
Polar H8 R 315 8x49 G.H5 E 379 G.H5.24
Hydrophobic H8 R 315 8x49 G.H5 E 379 G.H5.24
Van-der-waals H8 R 315 8x49 G.H5 E 379 G.H5.24
Hydrophobic TM3 I 131 3x54 G.H5 L 381 G.H5.26
Van-der-waals TM3 I 131 3x54 G.H5 L 381 G.H5.26
Hydrophobic TM6 L 246 6x33 G.H5 K 376 G.H5.21
Van-der-waals TM6 L 246 6x33 G.H5 K 376 G.H5.21
Ionic TM5 H 231 5x68 G.H5 D 365 G.H5.10
Polar ICL3 K 234 - G.hgh4 T 312 G.hgh4.15
Hydrophobic ICL3 K 234 - G.hgh4 T 312 G.hgh4.15
Van-der-waals ICL3 K 234 - G.hgh4 T 312 G.hgh4.15
Polar ICL2 P 134 34x50 G.H5 Q 371 G.H5.16
Hydrophobic ICL2 P 134 34x50 G.H5 Q 371 G.H5.16
Van-der-waals ICL2 P 134 34x50 G.H5 Q 371 G.H5.16
Hydrophobic TM3 A 130 3x53 G.H5 L 381 G.H5.26