Gs - B2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 12.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar H8 R 338 8x49 G.H5 E 392 G.H5.24
Hydrophobic H8 R 338 8x49 G.H5 E 392 G.H5.24
Van-der-waals H8 R 338 8x49 G.H5 E 392 G.H5.24
Polar TM3 D 154 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 D 154 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 D 154 3x49 G.H5 Y 391 G.H5.23
Polar TM3 L 159 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 159 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 159 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 M 168 34x56 G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 T 162 34x50 G.H5 R 380 G.H5.12
Hydrophobic TM3 L 159 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 L 159 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM5 M 256 5x70 G.H5 D 381 G.H5.13
Van-der-waals TM5 M 256 5x70 G.H5 D 381 G.H5.13
Hydrophobic TM5 V 250 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 V 250 5x64 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 M 168 34x56 G.HN Q 35 G.HN.52
Van-der-waals ICL2 M 168 34x56 G.HN Q 35 G.HN.52
Hydrophobic H8 R 338 8x49 G.H5 R 389 G.H5.21
Van-der-waals H8 R 338 8x49 G.H5 R 389 G.H5.21
Hydrophobic TM3 A 158 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM2 A 92 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 A 92 2x39 G.H5 Y 391 G.H5.23
Polar ICL2 R 169 34x57 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 R 169 34x57 G.H5 Y 391 G.H5.23
Van-der-waals ICL2 R 169 34x57 G.H5 Y 391 G.H5.23
Ionic TM6 E 265 6x30 G.H5 R 385 G.H5.17
Polar TM6 E 265 6x30 G.H5 R 385 G.H5.17
Van-der-waals TM6 E 265 6x30 G.H5 R 385 G.H5.17
Polar ICL2 R 167 34x55 G.S1 H 41 G.S1.02
Aromatic ICL2 R 167 34x55 G.S1 H 41 G.S1.02
Hydrophobic ICL2 R 167 34x55 G.S1 H 41 G.S1.02
Van-der-waals ICL2 R 167 34x55 G.S1 H 41 G.S1.02
Hydrophobic ICL2 T 162 34x50 G.H5 H 387 G.H5.19
Hydrophobic TM2 A 92 2x39 G.H5 Q 390 G.H5.22
Van-der-waals TM2 A 92 2x39 G.H5 Q 390 G.H5.22
Polar TM6 A 268 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 A 268 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 A 268 6x33 G.H5 L 388 G.H5.20
Ionic ICL3 K 260 - G.H5 D 381 G.H5.13
Polar ICL3 K 260 - G.H5 D 381 G.H5.13
Hydrophobic ICL3 K 260 - G.H5 D 381 G.H5.13
Van-der-waals ICL3 K 260 - G.H5 D 381 G.H5.13
Hydrophobic ICL2 M 163 34x51 G.H5 C 379 G.H5.11
Hydrophobic TM6 V 272 6x37 G.H5 L 393 G.H5.25
Hydrophobic ICL2 R 167 34x55 G.H5 I 383 G.H5.15
Hydrophobic H8 K 337 8x48 G.H5 L 394 G.H5.26
Van-der-waals H8 K 337 8x48 G.H5 L 394 G.H5.26
Hydrophobic ICL2 M 163 34x51 G.H5 I 383 G.H5.15
Polar H8 K 337 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 K 337 8x48 G.H5 E 392 G.H5.24
Polar ICL2 R 167 34x55 G.S1 T 40 G.S1.01
Hydrophobic ICL2 R 167 34x55 G.S1 T 40 G.S1.01
Van-der-waals ICL2 R 167 34x55 G.S1 T 40 G.S1.01
Hydrophobic TM5 M 256 5x70 G.H5 N 377 G.H5.09
Polar TM6 R 267 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM6 R 267 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 R 267 6x32 G.H5 L 394 G.H5.26
Polar ICL2 T 162 34x50 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 T 162 34x50 G.H5 Q 384 G.H5.16
Van-der-waals ICL2 T 162 34x50 G.H5 Q 384 G.H5.16
Hydrophobic TM5 M 256 5x70 G.S6 H 362 G.S6.04
Hydrophobic ICL3 K 260 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 K 260 - G.H5 R 385 G.H5.17
Hydrophobic TM5 L 251 5x65 G.H5 L 388 G.H5.20
Hydrophobic H8 G 336 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 G 336 8x47 G.H5 E 392 G.H5.24
Polar ICL2 R 169 34x57 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 R 169 34x57 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 T 162 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 T 162 34x50 G.H5 I 383 G.H5.15
Hydrophobic ICL3 F 259 - G.S6 Y 360 G.S6.02
Hydrophobic ICL2 M 163 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 M 163 34x51 G.S1 H 41 G.S1.02
Hydrophobic TM6 L 271 6x36 G.H5 L 393 G.H5.25
Hydrophobic ICL2 M 163 34x51 G.H5 R 380 G.H5.12
Van-der-waals ICL2 M 163 34x51 G.H5 R 380 G.H5.12
Polar ICL2 R 167 34x55 G.h2s4 T 242 G.h2s4.05
Van-der-waals ICL2 R 167 34x55 G.h2s4 T 242 G.h2s4.05
Hydrophobic TM3 L 159 3x54 G.H5 H 387 G.H5.19
Hydrophobic TM6 T 264 6x29 G.H5 L 394 G.H5.26
Van-der-waals TM6 T 264 6x29 G.H5 L 394 G.H5.26
Polar TM5 N 254 5x68 G.H5 D 381 G.H5.13
Van-der-waals TM5 N 254 5x68 G.H5 D 381 G.H5.13
Polar H8 F 339 8x50 G.H5 E 392 G.H5.24
Hydrophobic H8 F 339 8x50 G.H5 E 392 G.H5.24
Van-der-waals H8 F 339 8x50 G.H5 E 392 G.H5.24
Hydrophobic C-term T 369 - G.H3 R 280 G.H3.16
Van-der-waals C-term T 369 - G.H3 R 280 G.H3.16
Van-der-waals TM5 M 256 5x70 G.H5 D 378 G.H5.10
Hydrophobic ICL2 M 163 34x51 G.S3 V 217 G.S3.01
Hydrophobic TM3 V 151 3x46 G.H5 Y 391 G.H5.23
Hydrophobic TM6 E 265 6x30 G.H5 L 388 G.H5.20
Polar TM3 R 155 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 155 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 155 3x50 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 M 163 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL3 K 260 - G.S6 Y 360 G.S6.02
Van-der-waals ICL3 K 260 - G.S6 Y 360 G.S6.02
Hydrophobic ICL3 F 259 - G.S6 P 361 G.S6.03
Van-der-waals ICL3 F 259 - G.S6 P 361 G.S6.03
Hydrophobic TM3 A 158 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 158 3x53 G.H5 H 387 G.H5.19
Aromatic ICL3 F 259 - G.S6 H 362 G.S6.04
Hydrophobic ICL3 F 259 - G.S6 H 362 G.S6.04
Van-der-waals ICL3 F 259 - G.S6 H 362 G.S6.04
Polar TM6 T 264 6x29 G.H5 R 385 G.H5.17
Hydrophobic TM3 L 159 3x54 G.H5 L 393 G.H5.25
Polar ICL2 R 169 34x57 G.H5 H 387 G.H5.19
Aromatic ICL2 R 169 34x57 G.H5 H 387 G.H5.19
Hydrophobic ICL2 R 169 34x57 G.H5 H 387 G.H5.19
Van-der-waals ICL2 R 169 34x57 G.H5 H 387 G.H5.19
Polar ICL2 R 167 34x55 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 R 167 34x55 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 R 167 34x55 G.hns1 R 38 G.hns1.02
Hydrophobic TM3 R 155 3x50 G.H5 L 393 G.H5.25
Hydrophobic ICL2 R 167 34x55 G.hns1 A 39 G.hns1.03
Hydrophobic ICL2 M 163 34x51 G.S3 F 219 G.S3.03
Van-der-waals ICL2 M 163 34x51 G.S3 F 219 G.S3.03