Gi2 - C3a receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 74.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.8
PAE mean: 17.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM6 T 375 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM6 T 375 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 T 375 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM6 V 378 6x36 G.H5 L 354 G.H5.25
Van-der-waals TM6 V 378 6x36 G.H5 L 354 G.H5.25
Hydrophobic ICL2 P 127 34x50 G.H5 I 344 G.H5.15
Hydrophobic TM3 R 120 3x50 G.H5 L 354 G.H5.25
Hydrophobic H8 G 439 8x47 G.H5 D 351 G.H5.22
Van-der-waals H8 G 439 8x47 G.H5 D 351 G.H5.22
Polar TM2 N 57 2x39 G.H5 D 351 G.H5.22
Ionic TM5 R 362 5x64 G.H5 D 342 G.H5.13
Polar TM5 R 362 5x64 G.H5 D 342 G.H5.13
Van-der-waals TM5 R 362 5x64 G.H5 D 342 G.H5.13
Hydrophobic ICL2 I 128 34x51 G.s2s3 D 194 G.s2s3.02
Polar ICL2 Q 131 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 Q 131 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 Q 131 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic H8 G 439 8x47 G.H5 G 353 G.H5.24
Polar TM3 V 123 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 V 123 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 V 123 3x53 G.H5 N 348 G.H5.19
Polar TM6 K 374 6x32 G.H5 F 355 G.H5.26
Hydrophobic TM6 K 374 6x32 G.H5 F 355 G.H5.26
Van-der-waals TM6 K 374 6x32 G.H5 F 355 G.H5.26
Hydrophobic ICL3 F 368 - G.H5 K 346 G.H5.17
Hydrophobic ICL3 K 370 - G.h4s6 D 316 G.h4s6.09
Hydrophobic ICL2 Q 131 34x54 G.S1 V 34 G.S1.02
Van-der-waals ICL2 Q 131 34x54 G.S1 V 34 G.S1.02
Polar TM3 R 120 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM3 R 120 3x50 G.H5 C 352 G.H5.23
Van-der-waals TM3 R 120 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM6 K 374 6x32 G.H5 L 354 G.H5.25
Polar ICL3 K 370 - G.h4s6 K 315 G.h4s6.08
Hydrophobic ICL3 K 370 - G.h4s6 K 315 G.h4s6.08
Van-der-waals ICL3 K 370 - G.h4s6 K 315 G.h4s6.08
Ionic ICL3 R 367 - G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL3 R 367 - G.h4s6 E 319 G.h4s6.12
Van-der-waals ICL3 R 367 - G.h4s6 E 319 G.h4s6.12
Hydrophobic TM3 V 124 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 V 124 3x54 G.H5 L 349 G.H5.20
Hydrophobic ICL3 F 368 - G.H5 F 355 G.H5.26
Hydrophobic ICL2 Q 131 34x54 G.S3 L 195 G.S3.01
Van-der-waals ICL2 Q 131 34x54 G.S3 L 195 G.S3.01
Hydrophobic TM5 Y 356 5x58 G.H5 L 354 G.H5.25
Hydrophobic H8 G 439 8x47 G.H5 C 352 G.H5.23
Hydrophobic ICL3 S 371 - G.H5 F 355 G.H5.26
Van-der-waals ICL3 S 371 - G.H5 F 355 G.H5.26
Ionic H8 K 440 8x48 G.h3s5 D 262 G.h3s5.02
Polar H8 K 440 8x48 G.h3s5 D 262 G.h3s5.02
Hydrophobic H8 K 440 8x48 G.h3s5 D 262 G.h3s5.02
Van-der-waals H8 K 440 8x48 G.h3s5 D 262 G.h3s5.02
Polar H8 K 440 8x48 G.H5 K 350 G.H5.21
Hydrophobic H8 K 440 8x48 G.H5 K 350 G.H5.21
Van-der-waals H8 K 440 8x48 G.H5 K 350 G.H5.21
Hydrophobic ICL3 F 368 - G.H5 I 345 G.H5.16
Polar ICL3 R 367 - G.S6 I 320 G.S6.01
Hydrophobic ICL2 P 127 34x50 G.H5 I 345 G.H5.16
Hydrophobic ICL3 F 368 - G.H5 D 342 G.H5.13
Van-der-waals ICL3 F 368 - G.H5 D 342 G.H5.13
Hydrophobic ICL3 R 367 - G.S6 Y 321 G.S6.02
Hydrophobic ICL2 I 128 34x51 G.S3 L 195 G.S3.01
Hydrophobic ICL2 Q 131 34x54 G.H5 I 344 G.H5.15
Van-der-waals ICL2 Q 131 34x54 G.H5 I 344 G.H5.15
Hydrophobic ICL2 P 127 34x50 G.H5 T 341 G.H5.12
Van-der-waals ICL2 P 127 34x50 G.H5 T 341 G.H5.12
Hydrophobic TM5 I 359 5x61 G.H5 L 349 G.H5.20
Hydrophobic TM5 M 363 5x65 G.H5 I 345 G.H5.16
Van-der-waals TM5 M 363 5x65 G.H5 I 345 G.H5.16
Polar ICL2 N 132 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 N 132 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 N 132 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 I 128 34x51 G.H5 F 337 G.H5.08
Van-der-waals ICL2 I 128 34x51 G.H5 F 337 G.H5.08
Hydrophobic TM7 L 438 7x56 G.H5 G 353 G.H5.24
Van-der-waals TM7 L 438 7x56 G.H5 G 353 G.H5.24
Hydrophobic TM5 R 362 5x64 G.H5 I 345 G.H5.16
Van-der-waals TM5 R 362 5x64 G.H5 I 345 G.H5.16
Polar ICL2 N 132 34x55 G.s2s3 D 194 G.s2s3.02
Van-der-waals ICL2 N 132 34x55 G.s2s3 D 194 G.s2s3.02
Hydrophobic TM5 M 363 5x65 G.H5 L 349 G.H5.20
Van-der-waals TM5 M 363 5x65 G.H5 L 349 G.H5.20
Hydrophobic TM3 V 124 3x54 G.H5 I 345 G.H5.16