Gs - CB1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM6 Q 334 6x26 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 Q 334 6x26 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM6 Q 334 6x26 G.h4s6 Y 358 G.h4s6.20
Ionic C-term D 423 - G.h4s6 R 356 G.h4s6.12
Polar C-term D 423 - G.h4s6 R 356 G.h4s6.12
Hydrophobic C-term D 423 - G.h4s6 R 356 G.h4s6.12
Van-der-waals C-term D 423 - G.h4s6 R 356 G.h4s6.12
Hydrophobic ICL2 L 222 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 222 34x51 G.H5 F 376 G.H5.08
Polar TM3 D 213 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 D 213 3x49 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 221 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 221 34x50 G.H5 R 380 G.H5.12
Hydrophobic TM5 M 308 5x72 G.S6 Y 360 G.S6.02
Ionic C-term D 430 - G.H3 R 280 G.H3.16
Polar C-term D 430 - G.H3 R 280 G.H3.16
Hydrophobic C-term D 430 - G.H3 R 280 G.H3.16
Van-der-waals C-term D 430 - G.H3 R 280 G.H3.16
Polar C-term K 455 - G.s4h3 Q 262 G.s4h3.13
Van-der-waals C-term K 455 - G.s4h3 Q 262 G.s4h3.13
Hydrophobic ICL2 L 222 34x51 G.H5 C 379 G.H5.11
Hydrophobic ICL3 Q 314 - G.h4s6 Y 358 G.h4s6.20
Polar TM3 S 217 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 S 217 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 S 217 3x53 G.H5 H 387 G.H5.19
Polar ICL3 I 317 - G.H4 R 347 G.H4.17
Hydrophobic ICL2 L 222 34x51 G.H5 R 380 G.H5.12
Hydrophobic ICL3 T 313 - G.S6 C 359 G.S6.01
Van-der-waals ICL3 T 313 - G.S6 C 359 G.S6.01
Polar H8 S 401 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 S 401 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 S 401 8x47 G.H5 E 392 G.H5.24
Polar ICL2 L 222 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 222 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 222 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL3 I 317 - G.H4 D 343 G.H4.13
Van-der-waals ICL3 I 317 - G.H4 D 343 G.H4.13
Hydrophobic TM6 T 344 6x36 G.H5 L 393 G.H5.25
Van-der-waals TM6 T 344 6x36 G.H5 L 393 G.H5.25
Hydrophobic TM5 I 297 5x61 G.H5 L 388 G.H5.20
Hydrophobic TM6 M 337 6x29 G.H5 L 394 G.H5.26
Van-der-waals TM6 M 337 6x29 G.H5 L 394 G.H5.26
Hydrophobic TM3 S 217 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 S 217 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM5 H 304 5x68 G.H5 R 385 G.H5.17
Van-der-waals TM5 H 304 5x68 G.H5 R 385 G.H5.17
Hydrophobic TM5 I 297 5x61 G.H5 L 393 G.H5.25
Ionic H8 K 402 8x48 G.H5 E 392 G.H5.24
Polar H8 K 402 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 K 402 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 K 402 8x48 G.H5 E 392 G.H5.24
Hydrophobic TM5 R 311 5x75 G.S6 Y 360 G.S6.02
Van-der-waals TM5 R 311 5x75 G.S6 Y 360 G.S6.02
Polar H8 D 403 8x49 G.H5 Q 390 G.H5.22
Polar C-term K 455 - G.s4h3 D 260 G.s4h3.11
Hydrophobic C-term K 455 - G.s4h3 D 260 G.s4h3.11
Van-der-waals C-term K 455 - G.s4h3 D 260 G.s4h3.11
Hydrophobic ICL2 P 221 34x50 G.H5 I 383 G.H5.15
Van-der-waals ICL2 P 221 34x50 G.H5 I 383 G.H5.15
Ionic C-term D 428 - G.h3s5 R 283 G.h3s5.01
Polar C-term D 428 - G.h3s5 R 283 G.h3s5.01
Van-der-waals C-term D 428 - G.h3s5 R 283 G.h3s5.01
Van-der-waals TM2 R 150 2x37 G.H5 Q 390 G.H5.22
Polar TM6 L 341 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 L 341 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 341 6x33 G.H5 L 393 G.H5.25
Polar TM5 R 311 5x75 G.S6 H 362 G.S6.04
Van-der-waals TM5 R 311 5x75 G.S6 H 362 G.S6.04
Polar ICL1 C 149 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 K 225 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 K 225 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic C-term G 427 - G.H3 R 280 G.H3.16
Ionic ICL3 K 315 - G.hgh4 D 323 G.hgh4.13
Polar ICL3 K 315 - G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL3 K 315 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 K 315 - G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL2 R 226 34x55 G.hns1 A 39 G.hns1.03
Hydrophobic ICL3 Q 314 - G.h4s6 T 350 G.h4s6.03
Hydrophobic TM5 A 301 5x65 G.H5 L 388 G.H5.20
Ionic H8 R 405 8x51 G.H5 E 392 G.H5.24
Polar H8 R 405 8x51 G.H5 E 392 G.H5.24
Hydrophobic H8 R 405 8x51 G.H5 E 392 G.H5.24
Van-der-waals H8 R 405 8x51 G.H5 E 392 G.H5.24
Polar H8 K 402 8x48 G.H5 L 394 G.H5.26
Van-der-waals H8 K 402 8x48 G.H5 L 394 G.H5.26
Hydrophobic ICL3 T 313 - G.h4s6 T 350 G.h4s6.03
Polar ICL3 R 331 - G.h4s6 A 351 G.h4s6.04
Hydrophobic TM3 I 218 3x54 G.H5 H 387 G.H5.19
Hydrophobic ICL2 L 222 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 222 34x51 G.H5 I 383 G.H5.15
Polar ICL2 R 226 34x55 G.s2s3 K 216 G.s2s3.02
Van-der-waals ICL2 R 226 34x55 G.s2s3 K 216 G.s2s3.02
Hydrophobic TM6 L 345 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 345 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM6 L 341 6x33 G.H5 L 394 G.H5.26
Hydrophobic TM2 S 152 2x39 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 221 34x50 G.H5 H 387 G.H5.19
Hydrophobic ICL2 P 221 34x50 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 222 34x51 G.S3 V 217 G.S3.01
Ionic TM5 R 307 5x71 G.H5 D 381 G.H5.13
Polar TM5 R 307 5x71 G.H5 D 381 G.H5.13
Van-der-waals TM5 R 307 5x71 G.H5 D 381 G.H5.13
Polar H8 K 402 8x48 G.H5 R 389 G.H5.21
Van-der-waals H8 K 402 8x48 G.H5 R 389 G.H5.21
Van-der-waals C-term S 429 - G.H3 R 280 G.H3.16
Hydrophobic ICL3 T 313 - G.H4 L 346 G.H4.16
Polar C-term D 428 - G.H3 R 280 G.H3.16
Hydrophobic C-term D 428 - G.H3 R 280 G.H3.16
Van-der-waals C-term D 428 - G.H3 R 280 G.H3.16
Hydrophobic ICL3 K 315 - G.h4s6 T 350 G.h4s6.03
Aromatic ICL2 Y 224 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 Y 224 34x53 G.H5 H 387 G.H5.19
Van-der-waals ICL2 Y 224 34x53 G.H5 H 387 G.H5.19
Ionic TM5 H 304 5x68 G.H5 D 381 G.H5.13
Polar TM5 H 304 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 H 304 5x68 G.H5 D 381 G.H5.13
Van-der-waals TM5 H 304 5x68 G.H5 D 381 G.H5.13
Hydrophobic ICL2 L 222 34x51 G.S3 F 219 G.S3.03
Aromatic TM3 R 214 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 214 3x50 G.H5 Y 391 G.H5.23
Polar ICL3 R 331 - G.h4s6 G 353 G.h4s6.09
Van-der-waals ICL3 R 331 - G.h4s6 G 353 G.h4s6.09
Hydrophobic TM7 R 400 7x56 G.H5 E 392 G.H5.24
Van-der-waals TM7 R 400 7x56 G.H5 E 392 G.H5.24
Hydrophobic ICL3 I 317 - G.H4 L 346 G.H4.16
Polar ICL3 R 331 - G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL3 R 331 - G.h4s6 T 350 G.h4s6.03
Van-der-waals ICL3 R 331 - G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL3 T 313 - G.S6 P 361 G.S6.03
Hydrophobic TM3 I 218 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 218 3x54 G.H5 L 388 G.H5.20
Hydrophobic TM5 M 308 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 M 308 5x72 G.H5 R 385 G.H5.17
Polar TM6 T 344 6x36 G.H5 E 392 G.H5.24
Van-der-waals TM6 T 344 6x36 G.H5 E 392 G.H5.24
Ionic TM5 R 311 5x75 G.H5 D 378 G.H5.10
Polar TM5 R 311 5x75 G.H5 D 378 G.H5.10
Hydrophobic TM5 R 311 5x75 G.H5 D 378 G.H5.10
Van-der-waals TM5 R 311 5x75 G.H5 D 378 G.H5.10
Hydrophobic TM6 L 341 6x33 G.H5 L 388 G.H5.20
Polar ICL2 Y 224 34x53 G.H5 Y 391 G.H5.23
Polar TM3 I 218 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 I 218 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 I 218 3x54 G.H5 Q 384 G.H5.16
Polar TM6 Q 334 6x26 G.H5 R 385 G.H5.17
Hydrophobic TM6 Q 334 6x26 G.H5 R 385 G.H5.17
Van-der-waals TM6 Q 334 6x26 G.H5 R 385 G.H5.17