Gi3 - D4 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 89.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.9
iPTM Score: 0.8
PAE mean: 10.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Aromatic ICL3 R 233 - G.H5 F 334 G.H5.06
Hydrophobic ICL3 R 233 - G.H5 F 334 G.H5.06
Van-der-waals ICL3 R 233 - G.H5 F 334 G.H5.06
Polar TM5 K 229 5x75 G.H5 D 337 G.H5.09
Hydrophobic TM5 K 229 5x75 G.H5 D 337 G.H5.09
Van-der-waals TM5 K 229 5x75 G.H5 D 337 G.H5.09
Hydrophobic ICL3 P 235 - G.H4 A 301 G.H4.08
Van-der-waals ICL3 P 235 - G.H4 A 301 G.H4.08
Hydrophobic TM3 V 137 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 140 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 140 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM3 A 136 3x53 G.H5 C 351 G.H5.23
Polar TM5 W 222 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 W 222 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 W 222 5x68 G.H5 D 341 G.H5.13
Ionic TM5 K 229 5x75 G.H5 D 341 G.H5.13
Polar TM5 K 229 5x75 G.H5 D 341 G.H5.13
Hydrophobic TM5 K 229 5x75 G.H5 D 341 G.H5.13
Van-der-waals TM5 K 229 5x75 G.H5 D 341 G.H5.13
Ionic TM7 L 381 7x33 G.H4 E 308 G.H4.16
Polar TM7 L 381 7x33 G.H4 E 308 G.H4.16
Ionic ICL2 R 145 34x55 G.s2s3 D 193 G.s2s3.02
Polar ICL2 R 145 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 R 145 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 R 145 34x55 G.s2s3 D 193 G.s2s3.02
Ionic TM7 L 381 7x33 G.H4 D 309 G.H4.17
Polar TM7 L 381 7x33 G.H4 D 309 G.H4.17
Hydrophobic TM7 L 381 7x33 G.H4 D 309 G.H4.17
Van-der-waals TM7 L 381 7x33 G.H4 D 309 G.H4.17
Hydrophobic TM7 L 388 7x40 G.H5 Y 354 G.H5.26
Van-der-waals TM7 L 388 7x40 G.H5 Y 354 G.H5.26
Hydrophobic ICL3 L 230 - G.S6 Y 320 G.S6.02
Hydrophobic TM7 T 386 7x38 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM7 T 386 7x38 G.h4s6 D 315 G.h4s6.09
Hydrophobic ICL2 L 141 34x51 G.H5 T 340 G.H5.12
Polar ICL3 A 234 - G.H4 Q 304 G.H4.12
Hydrophobic ICL3 A 234 - G.H4 Q 304 G.H4.12
Polar TM7 V 391 7x43 G.H5 Y 354 G.H5.26
Hydrophobic TM7 V 391 7x43 G.H5 Y 354 G.H5.26
Van-der-waals TM7 V 391 7x43 G.H5 Y 354 G.H5.26
Hydrophobic TM5 L 219 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 219 5x65 G.H5 L 348 G.H5.20
Polar TM3 A 136 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 136 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 Y 143 34x53 G.H5 N 347 G.H5.19
Hydrophobic TM5 W 222 5x68 G.H5 L 348 G.H5.20
Hydrophobic TM7 L 388 7x40 G.h4s6 T 316 G.h4s6.10
Hydrophobic ICL2 L 141 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 L 141 34x51 G.H5 F 336 G.H5.08
Polar ICL2 N 144 34x54 G.H5 N 347 G.H5.19
Hydrophobic ICL2 N 144 34x54 G.H5 N 347 G.H5.19
Van-der-waals ICL2 N 144 34x54 G.H5 N 347 G.H5.19
Hydrophobic ICL3 L 230 - G.S6 I 319 G.S6.01
Van-der-waals ICL3 L 230 - G.S6 I 319 G.S6.01
Polar ICL2 R 145 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 R 145 34x55 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 R 145 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 P 140 34x50 G.H5 I 343 G.H5.15
Polar TM3 R 133 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 133 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 133 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 L 141 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 141 34x51 G.H5 I 343 G.H5.15
Hydrophobic ICL3 L 230 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM7 L 395 7x48 G.H5 L 353 G.H5.25
Hydrophobic TM7 N 396 7x49 G.H5 L 353 G.H5.25
Van-der-waals TM7 N 396 7x49 G.H5 L 353 G.H5.25
Polar TM7 N 392 7x45 G.H5 L 353 G.H5.25
Hydrophobic TM7 N 392 7x45 G.H5 L 353 G.H5.25
Van-der-waals TM7 N 392 7x45 G.H5 L 353 G.H5.25
Hydrophobic TM5 W 222 5x68 G.H5 K 345 G.H5.17
Hydrophobic TM5 R 226 5x72 G.H5 D 341 G.H5.13
Polar ICL2 P 140 34x50 G.H5 N 347 G.H5.19
Hydrophobic ICL2 L 141 34x51 G.S3 L 194 G.S3.01
Ionic TM7 L 388 7x40 G.h3s5 E 261 G.h3s5.02
Polar TM7 L 388 7x40 G.h3s5 E 261 G.h3s5.02
Van-der-waals TM7 L 388 7x40 G.h3s5 E 261 G.h3s5.02
Hydrophobic TM5 K 229 5x75 G.S6 Y 320 G.S6.02
Hydrophobic TM5 W 222 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 W 222 5x68 G.H5 I 344 G.H5.16
Hydrophobic ICL2 N 144 34x54 G.H5 I 343 G.H5.15
Van-der-waals ICL2 N 144 34x54 G.H5 I 343 G.H5.15
Hydrophobic ICL3 R 233 - G.H4 Q 304 G.H4.12
Ionic TM5 R 226 5x72 G.h4s6 E 318 G.h4s6.12
Polar TM5 R 226 5x72 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 R 226 5x72 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM5 R 226 5x72 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM3 R 133 3x50 G.H5 L 353 G.H5.25
Polar ICL3 R 233 - G.S6 H 322 G.S6.04
Hydrophobic ICL3 R 233 - G.S6 H 322 G.S6.04
Van-der-waals ICL3 R 233 - G.S6 H 322 G.S6.04
Hydrophobic ICL2 N 144 34x54 G.hns1 K 32 G.hns1.03