G12 - FFA1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 85.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 15.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 Q 115 34x54 G.H5 I 370 G.H5.15
Van-der-waals ICL2 Q 115 34x54 G.H5 I 370 G.H5.15
Hydrophobic TM5 L 209 5x65 G.H5 L 375 G.H5.20
Hydrophobic TM4 R 119 4x38 G.HN R 52 G.HN.52
Van-der-waals TM4 R 119 4x38 G.HN R 52 G.HN.52
Polar ICL2 A 116 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 A 116 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 A 116 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 L 112 34x51 G.H5 K 367 G.H5.12
Hydrophobic TM6 V 225 6x37 G.H5 M 379 G.H5.24
Ionic ICL2 R 118 34x57 G.H5 E 373 G.H5.18
Hydrophobic ICL2 P 111 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 111 34x50 G.H5 K 367 G.H5.12
Polar TM3 G 107 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 G 107 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 G 107 3x53 G.H5 N 374 G.H5.19
Ionic ICL2 R 118 34x57 G.H5 D 377 G.H5.22
Polar ICL2 R 118 34x57 G.H5 D 377 G.H5.22
Van-der-waals ICL2 R 118 34x57 G.H5 D 377 G.H5.22
Hydrophobic ICL3 L 214 - G.H5 L 375 G.H5.20
Van-der-waals ICL3 L 214 - G.H5 L 375 G.H5.20
Hydrophobic ICL2 P 111 34x50 G.H5 L 371 G.H5.16
Polar TM3 A 109 3x55 G.H5 K 367 G.H5.12
Polar ICL2 P 111 34x50 G.H5 N 374 G.H5.19
Van-der-waals ICL2 P 111 34x50 G.H5 N 374 G.H5.19
Polar TM2 S 41 2x39 G.H5 D 377 G.H5.22
Hydrophobic TM2 S 41 2x39 G.H5 D 377 G.H5.22
Polar ICL2 Q 115 34x54 G.H5 E 373 G.H5.18
Van-der-waals ICL2 Q 115 34x54 G.H5 E 373 G.H5.18
Hydrophobic ICL2 P 111 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 111 34x50 G.H5 I 370 G.H5.15
Hydrophobic ICL3 L 214 - G.H5 L 371 G.H5.16
Hydrophobic H8 G 280 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 G 280 8x47 G.H5 M 379 G.H5.24
Hydrophobic TM3 A 108 3x54 G.H5 I 378 G.H5.23
Hydrophobic ICL2 L 112 34x51 G.S1 V 58 G.S1.02
Van-der-waals ICL2 L 112 34x51 G.S1 V 58 G.S1.02
Hydrophobic TM3 A 108 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 A 108 3x54 G.H5 L 371 G.H5.16
Hydrophobic ICL3 L 214 - G.H5 Q 372 G.H5.17
Van-der-waals ICL3 L 214 - G.H5 Q 372 G.H5.17
Polar ICL2 A 116 34x55 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 A 116 34x55 G.hns1 R 55 G.hns1.02
Hydrophobic TM6 V 225 6x37 G.H5 I 378 G.H5.23
Polar ICL2 R 118 34x57 G.H5 N 374 G.H5.19
Van-der-waals ICL2 R 118 34x57 G.H5 N 374 G.H5.19
Hydrophobic TM2 S 41 2x39 G.H5 L 380 G.H5.25
Hydrophobic ICL2 L 112 34x51 G.H5 V 366 G.H5.11
Hydrophobic TM7 T 276 7x53 G.H5 L 380 G.H5.25
Van-der-waals TM7 T 276 7x53 G.H5 L 380 G.H5.25
Hydrophobic ICL2 L 112 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 112 34x51 G.H5 I 370 G.H5.15
Hydrophobic TM6 A 222 6x34 G.H5 L 375 G.H5.20
Van-der-waals TM6 A 222 6x34 G.H5 L 375 G.H5.20
Hydrophobic ICL3 S 212 - G.H5 L 371 G.H5.16
Van-der-waals ICL3 S 212 - G.H5 L 371 G.H5.16
Polar TM2 T 39 2x37 G.H5 D 377 G.H5.22
Hydrophobic TM2 T 39 2x37 G.H5 D 377 G.H5.22
Van-der-waals TM2 T 39 2x37 G.H5 D 377 G.H5.22
Hydrophobic TM6 R 221 6x33 G.H5 M 379 G.H5.24
Polar TM6 R 218 6x30 G.H5 Q 372 G.H5.17
Van-der-waals TM6 R 218 6x30 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 L 112 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 112 34x51 G.S3 I 221 G.S3.01
Polar TM3 R 104 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 104 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 104 3x50 G.H5 I 378 G.H5.23
Polar H8 G 280 8x47 G.H5 Q 381 G.H5.26
Hydrophobic H8 G 280 8x47 G.H5 Q 381 G.H5.26
Van-der-waals H8 G 280 8x47 G.H5 Q 381 G.H5.26
Hydrophobic TM2 A 45 2x43 G.H5 L 380 G.H5.25
Polar ICL3 G 213 - G.H5 D 368 G.H5.13
Hydrophobic ICL3 G 213 - G.H5 D 368 G.H5.13
Van-der-waals ICL3 G 213 - G.H5 D 368 G.H5.13
Hydrophobic H8 R 281 8x48 G.H5 Q 381 G.H5.26
Hydrophobic ICL3 S 212 - G.H5 D 368 G.H5.13
Ionic TM1 R 37 1x64 G.H5 E 373 G.H5.18
Polar TM1 R 37 1x64 G.H5 E 373 G.H5.18
Hydrophobic TM1 R 37 1x64 G.H5 E 373 G.H5.18
Van-der-waals TM1 R 37 1x64 G.H5 E 373 G.H5.18
Polar TM6 R 218 6x30 G.h4s6 S 343 G.h4s6.12
Van-der-waals TM6 R 218 6x30 G.h4s6 S 343 G.h4s6.12
Hydrophobic ICL2 L 112 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 112 34x51 G.H5 F 363 G.H5.08
Polar TM1 H 33 1x60 G.H5 Q 381 G.H5.26
Hydrophobic TM1 H 33 1x60 G.H5 Q 381 G.H5.26
Van-der-waals TM1 H 33 1x60 G.H5 Q 381 G.H5.26
Hydrophobic TM2 L 42 2x40 G.H5 L 380 G.H5.25
Van-der-waals TM2 L 42 2x40 G.H5 L 380 G.H5.25