Ggust - FFA1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 87.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic ICL2 R 118 34x57 G.H5 D 350 G.H5.22
Polar ICL2 R 118 34x57 G.H5 D 350 G.H5.22
Hydrophobic ICL2 R 118 34x57 G.H5 D 350 G.H5.22
Van-der-waals ICL2 R 118 34x57 G.H5 D 350 G.H5.22
Hydrophobic ICL3 L 214 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 L 214 - G.h4s6 E 318 G.h4s6.12
Polar TM2 S 41 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 S 41 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 S 41 2x39 G.H5 C 351 G.H5.23
Hydrophobic H8 G 280 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 G 280 8x47 G.H5 G 352 G.H5.24
Hydrophobic ICL2 Y 114 34x53 G.H5 N 347 G.H5.19
Hydrophobic ICL3 S 212 - G.H5 I 344 G.H5.16
Ionic TM1 R 37 1x64 G.H5 E 346 G.H5.18
Polar TM1 R 37 1x64 G.H5 E 346 G.H5.18
Van-der-waals TM1 R 37 1x64 G.H5 E 346 G.H5.18
Hydrophobic ICL2 L 112 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 112 34x51 G.H5 I 343 G.H5.15
Polar TM4 R 119 4x38 G.HN Q 24 G.HN.48
Hydrophobic TM4 R 119 4x38 G.HN Q 24 G.HN.48
Van-der-waals TM4 R 119 4x38 G.HN Q 24 G.HN.48
Polar TM3 R 104 3x50 G.H5 G 352 G.H5.24
Van-der-waals TM3 R 104 3x50 G.H5 G 352 G.H5.24
Hydrophobic TM5 L 209 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 209 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 111 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 111 34x50 G.H5 I 344 G.H5.16
Hydrophobic ICL3 G 213 - G.S6 Y 320 G.S6.02
Polar ICL2 P 111 34x50 G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 111 34x50 G.H5 N 347 G.H5.19
Hydrophobic ICL2 Q 115 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 A 116 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 A 116 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL3 L 214 - G.H5 K 345 G.H5.17
Polar ICL2 R 118 34x57 G.H5 N 347 G.H5.19
Van-der-waals ICL2 R 118 34x57 G.H5 N 347 G.H5.19
Hydrophobic ICL2 Q 115 34x54 G.H5 I 343 G.H5.15
Van-der-waals ICL2 Q 115 34x54 G.H5 I 343 G.H5.15
Ionic TM1 R 37 1x64 G.H5 D 350 G.H5.22
Polar TM1 R 37 1x64 G.H5 D 350 G.H5.22
Hydrophobic TM1 R 37 1x64 G.H5 D 350 G.H5.22
Van-der-waals TM1 R 37 1x64 G.H5 D 350 G.H5.22
Hydrophobic TM6 R 218 6x30 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 218 6x30 G.H5 F 354 G.H5.26
Hydrophobic TM5 C 205 5x61 G.H5 L 348 G.H5.20
Hydrophobic ICL3 S 212 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 S 212 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 P 111 34x50 G.H5 T 340 G.H5.12
Van-der-waals ICL2 P 111 34x50 G.H5 T 340 G.H5.12
Polar TM3 R 104 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 104 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 104 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL3 L 214 - G.H5 I 344 G.H5.16
Polar ICL2 Q 115 34x54 G.H5 E 346 G.H5.18
Hydrophobic TM3 R 104 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 104 3x50 G.H5 L 353 G.H5.25
Ionic TM6 R 217 6x29 G.h4s6 E 315 G.h4s6.09
Polar TM6 R 217 6x29 G.h4s6 E 315 G.h4s6.09
Hydrophobic TM6 R 217 6x29 G.h4s6 E 315 G.h4s6.09
Van-der-waals TM6 R 217 6x29 G.h4s6 E 315 G.h4s6.09
Polar TM3 G 103 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM3 G 103 3x49 G.H5 C 351 G.H5.23
Polar TM3 G 107 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 G 107 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 G 107 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL3 L 214 - G.H5 F 354 G.H5.26
Polar ICL3 T 215 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 T 215 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 T 215 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 V 225 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 225 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM3 A 108 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 L 112 34x51 G.H5 F 336 G.H5.08
Ionic ICL2 R 118 34x57 G.H5 E 346 G.H5.18
Hydrophobic TM5 C 205 5x61 G.H5 L 353 G.H5.25
Ionic TM6 R 218 6x30 G.h4s6 E 318 G.h4s6.12
Polar TM6 R 218 6x30 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 R 218 6x30 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 R 218 6x30 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 P 111 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 111 34x50 G.H5 I 343 G.H5.15
Polar TM2 S 41 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM2 S 41 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 S 41 2x39 G.H5 D 350 G.H5.22
Polar ICL3 L 214 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 L 214 - G.H5 D 341 G.H5.13
Hydrophobic TM5 L 209 5x65 G.H5 I 344 G.H5.16
Polar ICL3 G 213 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 G 213 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 G 213 - G.H5 D 341 G.H5.13
Hydrophobic ICL2 L 112 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 112 34x51 G.S3 L 194 G.S3.01
Polar TM6 R 218 6x30 G.h4s6 D 316 G.h4s6.10
Hydrophobic TM6 R 218 6x30 G.h4s6 D 316 G.h4s6.10
Van-der-waals TM6 R 218 6x30 G.h4s6 D 316 G.h4s6.10
Polar H8 G 282 8x49 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 218 6x30 G.H5 K 345 G.H5.17
Van-der-waals TM6 R 218 6x30 G.H5 K 345 G.H5.17
Hydrophobic TM6 A 222 6x34 G.H5 L 353 G.H5.25
Ionic TM4 R 119 4x38 G.HN E 28 G.HN.52
Polar TM4 R 119 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 R 119 4x38 G.HN E 28 G.HN.52
Hydrophobic TM3 A 108 3x54 G.H5 I 344 G.H5.16
Polar TM6 R 218 6x30 G.h4s6 E 315 G.h4s6.09
Van-der-waals TM6 R 218 6x30 G.h4s6 E 315 G.h4s6.09
Van-der-waals H8 G 280 8x47 G.H5 F 354 G.H5.26
Polar TM2 T 39 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 T 39 2x37 G.H5 D 350 G.H5.22
Hydrophobic ICL3 L 214 - G.H5 L 348 G.H5.20
Polar TM6 R 221 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 221 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 221 6x33 G.H5 F 354 G.H5.26