G12 - FPR2/ALX complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 83.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 15.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 N 135 34x55 G.S3 I 221 G.S3.01
Hydrophobic TM2 T 60 2x39 G.H5 I 378 G.H5.23
Polar TM2 Y 64 2x43 G.H5 I 378 G.H5.23
Van-der-waals TM2 Y 64 2x43 G.H5 I 378 G.H5.23
Hydrophobic TM5 G 209 5x461 G.HN M 1 G.HN.01
Van-der-waals TM5 G 209 5x461 G.HN M 1 G.HN.01
Polar ECL2 T 166 - G.HN S 9 G.HN.09
Hydrophobic ECL2 T 166 - G.HN S 9 G.HN.09
Van-der-waals ECL2 T 166 - G.HN S 9 G.HN.09
Van-der-waals TM3 W 95 3x22 G.HN C 11 G.HN.11
Hydrophobic H8 G 306 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 G 306 8x47 G.H5 L 380 G.H5.25
Hydrophobic ICL2 P 130 34x50 G.H5 I 370 G.H5.15
Hydrophobic TM3 V 127 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 V 127 3x54 G.H5 L 375 G.H5.20
Hydrophobic ECL2 T 177 45x51 G.HN R 6 G.HN.06
Van-der-waals ECL2 T 177 45x51 G.HN R 6 G.HN.06
Polar TM3 W 95 3x22 G.HN R 10 G.HN.10
Hydrophobic TM3 W 95 3x22 G.HN R 10 G.HN.10
Van-der-waals TM3 W 95 3x22 G.HN R 10 G.HN.10
Hydrophobic TM4 L 164 4x65 G.HN L 8 G.HN.08
Hydrophobic TM6 R 238 6x32 G.H5 Q 381 G.H5.26
Van-der-waals TM6 R 238 6x32 G.H5 Q 381 G.H5.26
Polar TM5 R 205 5x43 G.HN M 1 G.HN.01
Hydrophobic TM5 R 205 5x43 G.HN M 1 G.HN.01
Van-der-waals TM5 R 205 5x43 G.HN M 1 G.HN.01
Polar ICL3 K 235 - G.h4s6 S 343 G.h4s6.12
Hydrophobic ICL3 K 235 - G.h4s6 S 343 G.h4s6.12
Van-der-waals ICL3 K 235 - G.h4s6 S 343 G.h4s6.12
Polar ICL2 P 130 34x50 G.H5 N 374 G.H5.19
Hydrophobic ICL2 P 130 34x50 G.H5 N 374 G.H5.19
Van-der-waals ICL2 P 130 34x50 G.H5 N 374 G.H5.19
Polar TM3 C 126 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 C 126 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 C 126 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM4 S 140 4x40 G.HN R 52 G.HN.52
Van-der-waals TM4 S 140 4x40 G.HN R 52 G.HN.52
Polar ECL2 F 178 45x52 G.HN V 5 G.HN.05
Hydrophobic ECL2 F 178 45x52 G.HN V 5 G.HN.05
Van-der-waals ECL2 F 178 45x52 G.HN V 5 G.HN.05
Van-der-waals TM6 Q 258 6x52 G.HN M 1 G.HN.01
Hydrophobic ICL2 V 131 34x51 G.H5 F 363 G.H5.08
Hydrophobic TM4 F 163 4x64 G.HN L 8 G.HN.08
Van-der-waals TM4 F 163 4x64 G.HN L 8 G.HN.08
Hydrophobic N-term F 5 - G.HN V 5 G.HN.05
Van-der-waals N-term F 5 - G.HN V 5 G.HN.05
Hydrophobic ICL2 Q 134 34x54 G.H5 I 370 G.H5.15
Van-der-waals ICL2 Q 134 34x54 G.H5 I 370 G.H5.15
Hydrophobic ICL3 M 233 - G.H5 L 375 G.H5.20
Hydrophobic H8 F 309 8x50 G.H5 L 380 G.H5.25
Hydrophobic TM4 L 164 4x65 G.HN V 4 G.HN.04
Van-der-waals TM4 L 164 4x65 G.HN V 4 G.HN.04
Hydrophobic TM6 P 239 6x33 G.H5 M 379 G.H5.24
Polar ICL2 N 135 34x55 G.s2s3 K 220 G.s2s3.02
Van-der-waals ICL2 N 135 34x55 G.s2s3 K 220 G.s2s3.02
Hydrophobic TM5 I 228 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 I 228 5x65 G.H5 L 375 G.H5.20
Hydrophobic TM3 V 127 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 127 3x54 G.H5 L 371 G.H5.16
Polar TM3 D 106 3x33 G.HN M 1 G.HN.01
Hydrophobic TM3 D 106 3x33 G.HN M 1 G.HN.01
Van-der-waals TM3 D 106 3x33 G.HN M 1 G.HN.01
Polar ICL2 N 135 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 N 135 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 N 135 34x55 G.hns1 R 56 G.hns1.03
Polar H8 G 306 8x47 G.H5 M 379 G.H5.24
Hydrophobic H8 G 306 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 G 306 8x47 G.H5 M 379 G.H5.24
Polar ICL2 Q 134 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 Q 134 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 Q 134 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 P 130 34x50 G.H5 L 371 G.H5.16
Polar ECL2 V 167 - G.HN T 7 G.HN.07
Hydrophobic ECL2 V 167 - G.HN T 7 G.HN.07
Van-der-waals ECL2 V 167 - G.HN T 7 G.HN.07
Hydrophobic TM1 M 55 1x61 G.H5 L 380 G.H5.25
Hydrophobic N-term P 8 - G.HN R 6 G.HN.06
Van-der-waals N-term P 8 - G.HN R 6 G.HN.06
Polar ECL2 T 168 - G.HN R 10 G.HN.10
Hydrophobic ECL2 T 168 - G.HN R 10 G.HN.10
Van-der-waals ECL2 T 168 - G.HN R 10 G.HN.10
Hydrophobic TM5 L 198 5x36 G.HN V 5 G.HN.05
Hydrophobic ECL2 F 178 45x52 G.HN R 6 G.HN.06
Van-der-waals ECL2 F 178 45x52 G.HN R 6 G.HN.06
Polar ECL2 N 179 - G.HN L 8 G.HN.08
Hydrophobic ECL2 N 179 - G.HN L 8 G.HN.08
Van-der-waals ECL2 N 179 - G.HN L 8 G.HN.08
Polar TM3 V 105 3x32 G.HN M 1 G.HN.01
Hydrophobic TM6 V 242 6x36 G.H5 M 379 G.H5.24
Hydrophobic TM5 K 231 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 K 231 5x68 G.H5 L 371 G.H5.16
Polar TM3 R 123 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 123 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 123 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL3 K 235 - G.h4s6 K 344 G.h4s6.19
Van-der-waals ICL3 K 235 - G.h4s6 K 344 G.h4s6.19
Hydrophobic ICL2 Q 134 34x54 G.S1 V 58 G.S1.02
Hydrophobic TM3 H 102 3x29 G.HN V 4 G.HN.04
Van-der-waals TM3 H 102 3x29 G.HN V 4 G.HN.04
Hydrophobic H8 D 308 8x49 G.H5 Q 381 G.H5.26
Polar TM3 W 95 3x22 G.HN S 9 G.HN.09
Hydrophobic TM3 W 95 3x22 G.HN S 9 G.HN.09
Van-der-waals TM3 W 95 3x22 G.HN S 9 G.HN.09
Hydrophobic TM7 V 303 7x54 G.H5 L 380 G.H5.25
Hydrophobic ECL2 V 167 - G.HN L 8 G.HN.08
Van-der-waals ECL2 V 167 - G.HN L 8 G.HN.08
Polar TM5 R 201 5x39 G.HN S 2 G.HN.02
Aromatic ICL2 H 136 34x56 G.hns1 R 56 G.hns1.03
Polar H8 Q 307 8x48 G.H5 L 380 G.H5.25
Van-der-waals H8 Q 307 8x48 G.H5 L 380 G.H5.25
Polar N-term S 6 - G.HN R 6 G.HN.06
Hydrophobic N-term S 6 - G.HN R 6 G.HN.06
Van-der-waals N-term S 6 - G.HN R 6 G.HN.06
Polar ECL2 T 177 45x51 G.HN T 7 G.HN.07
Hydrophobic ECL2 T 177 45x51 G.HN T 7 G.HN.07
Van-der-waals ECL2 T 177 45x51 G.HN T 7 G.HN.07
Hydrophobic TM7 V 305 7x56 G.H5 M 379 G.H5.24
Hydrophobic ICL2 V 131 34x51 G.H5 K 367 G.H5.12
Hydrophobic ECL2 T 165 - G.HN L 8 G.HN.08
Van-der-waals ECL2 T 165 - G.HN L 8 G.HN.08
Polar ECL2 T 166 - G.HN R 10 G.HN.10
Van-der-waals ECL2 T 166 - G.HN R 10 G.HN.10
Hydrophobic ECL2 F 178 45x52 G.HN V 4 G.HN.04
Van-der-waals ECL2 F 178 45x52 G.HN V 4 G.HN.04
Hydrophobic ICL3 M 233 - G.H5 L 371 G.H5.16
Van-der-waals ICL3 M 233 - G.H5 L 371 G.H5.16
Hydrophobic TM3 V 113 3x40 G.HN M 1 G.HN.01
Ionic ECL1 E 89 - G.HN R 6 G.HN.06
Polar ECL1 E 89 - G.HN R 6 G.HN.06
Hydrophobic ECL1 E 89 - G.HN R 6 G.HN.06
Van-der-waals ECL1 E 89 - G.HN R 6 G.HN.06
Ionic TM5 K 231 5x68 G.H5 D 368 G.H5.13
Polar TM5 K 231 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 K 231 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 K 231 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM3 C 126 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 C 126 3x53 G.H5 I 378 G.H5.23
Ionic ICL2 R 137 34x57 G.H5 D 377 G.H5.22
Polar ICL2 R 137 34x57 G.H5 D 377 G.H5.22
Van-der-waals ICL2 R 137 34x57 G.H5 D 377 G.H5.22
Hydrophobic TM3 L 109 3x36 G.HN M 1 G.HN.01
Van-der-waals TM3 L 109 3x36 G.HN M 1 G.HN.01
Hydrophobic ICL2 V 131 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 V 131 34x51 G.S3 I 221 G.S3.01
Hydrophobic TM3 V 127 3x54 G.H5 I 378 G.H5.23
Hydrophobic ECL2 N 179 - G.HN T 7 G.HN.07
Van-der-waals ECL2 N 179 - G.HN T 7 G.HN.07
Polar TM2 T 60 2x39 G.H5 D 377 G.H5.22
Hydrophobic TM2 T 60 2x39 G.H5 D 377 G.H5.22
Van-der-waals TM2 T 60 2x39 G.H5 D 377 G.H5.22
Van-der-waals ECL2 F 178 45x52 G.HN L 8 G.HN.08
Hydrophobic ECL2 V 167 - G.HN S 9 G.HN.09
Hydrophobic TM4 T 138 4x38 G.HN R 52 G.HN.52
Hydrophobic ICL2 P 130 34x50 G.H5 K 367 G.H5.12
Hydrophobic TM3 V 105 3x32 G.HN S 2 G.HN.02
Van-der-waals TM3 V 105 3x32 G.HN S 2 G.HN.02
Polar ECL2 T 165 - G.HN R 10 G.HN.10
Van-der-waals ECL2 T 165 - G.HN R 10 G.HN.10
Polar TM5 R 201 5x39 G.HN V 4 G.HN.04
Hydrophobic TM5 R 201 5x39 G.HN V 4 G.HN.04
Van-der-waals TM5 R 201 5x39 G.HN V 4 G.HN.04
Polar ECL2 T 165 - G.HN S 9 G.HN.09
Hydrophobic ECL2 T 165 - G.HN S 9 G.HN.09
Van-der-waals ECL2 T 165 - G.HN S 9 G.HN.09
Polar ECL2 T 177 45x51 G.HN L 8 G.HN.08
Hydrophobic ECL2 T 177 45x51 G.HN L 8 G.HN.08
Van-der-waals ECL2 T 177 45x51 G.HN L 8 G.HN.08
Hydrophobic ICL3 M 233 - G.H5 Q 372 G.H5.17
Van-der-waals ICL3 M 233 - G.H5 Q 372 G.H5.17
Hydrophobic ECL2 T 166 - G.HN L 8 G.HN.08
Hydrophobic TM2 Y 64 2x43 G.H5 L 380 G.H5.25
Van-der-waals TM2 Y 64 2x43 G.H5 L 380 G.H5.25
Hydrophobic TM7 F 292 7x42 G.HN S 2 G.HN.02
Hydrophobic TM3 F 110 3x37 G.HN M 1 G.HN.01
Van-der-waals TM3 F 110 3x37 G.HN M 1 G.HN.01
Polar ICL2 Q 134 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 Q 134 34x54 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 Q 134 34x54 G.hns1 R 56 G.hns1.03
Polar ECL2 F 178 45x52 G.HN T 7 G.HN.07
Hydrophobic ECL2 F 178 45x52 G.HN T 7 G.HN.07
Van-der-waals ECL2 F 178 45x52 G.HN T 7 G.HN.07
Polar TM5 R 205 5x43 G.HN S 2 G.HN.02
Hydrophobic TM6 W 254 6x48 G.HN M 1 G.HN.01
Polar H8 D 308 8x49 G.H5 L 380 G.H5.25
Hydrophobic H8 D 308 8x49 G.H5 L 380 G.H5.25
Van-der-waals H8 D 308 8x49 G.H5 L 380 G.H5.25
Polar TM3 D 106 3x33 G.HN S 2 G.HN.02
Van-der-waals TM3 D 106 3x33 G.HN S 2 G.HN.02
Hydrophobic TM2 T 60 2x39 G.H5 L 380 G.H5.25
Polar N-term S 6 - G.HN T 7 G.HN.07
Hydrophobic N-term S 6 - G.HN T 7 G.HN.07
Van-der-waals N-term S 6 - G.HN T 7 G.HN.07