G12 - GAL2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 78.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 A 126 3x53 G.H5 I 378 G.H5.23
Hydrophobic TM6 M 237 6x36 G.H5 I 378 G.H5.23
Van-der-waals TM6 M 237 6x36 G.H5 I 378 G.H5.23
Hydrophobic TM2 T 60 2x39 G.H5 I 378 G.H5.23
Polar TM5 Y 213 5x64 G.H5 K 367 G.H5.12
Van-der-waals TM5 Y 213 5x64 G.H5 K 367 G.H5.12
Hydrophobic ICL2 L 131 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 131 34x51 G.S3 I 221 G.S3.01
Hydrophobic TM3 I 127 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 I 127 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM3 I 127 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 127 3x54 G.H5 L 371 G.H5.16
Hydrophobic TM2 T 60 2x39 G.H5 D 377 G.H5.22
Hydrophobic ICL2 P 130 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 130 34x50 G.H5 I 370 G.H5.15
Polar ICL2 H 132 34x52 G.s2s3 K 219 G.s2s3.01
Van-der-waals ICL2 H 132 34x52 G.s2s3 K 219 G.s2s3.01
Hydrophobic TM3 I 127 3x54 G.H5 L 375 G.H5.20
Ionic ICL2 E 135 34x55 G.hns1 R 56 G.hns1.03
Polar ICL2 E 135 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 E 135 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 E 135 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic TM4 T 138 4x38 G.hns1 R 55 G.hns1.02
Hydrophobic TM5 L 214 5x65 G.H5 L 375 G.H5.20
Hydrophobic TM7 Y 292 7x53 G.H5 L 380 G.H5.25
Hydrophobic H8 F 299 8x50 G.H5 L 380 G.H5.25
Hydrophobic TM6 M 237 6x36 G.H5 M 379 G.H5.24
Polar ICL2 R 134 34x54 G.S1 L 57 G.S1.01
Van-der-waals ICL2 R 134 34x54 G.S1 L 57 G.S1.01
Polar ICL2 R 134 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 R 134 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 R 134 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 P 130 34x50 G.H5 K 367 G.H5.12
Hydrophobic TM6 A 230 6x29 G.H5 M 379 G.H5.24
Polar ICL2 R 134 34x54 G.hns1 V 54 G.hns1.01
Polar ICL2 P 130 34x50 G.H5 N 374 G.H5.19
Van-der-waals ICL2 P 130 34x50 G.H5 N 374 G.H5.19
Hydrophobic H8 K 297 8x48 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 P 130 34x50 G.H5 L 371 G.H5.16
Polar TM3 A 126 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 126 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 126 3x53 G.H5 N 374 G.H5.19
Polar TM4 N 141 4x41 G.HN R 52 G.HN.52
Van-der-waals TM4 N 141 4x41 G.HN R 52 G.HN.52
Hydrophobic TM6 V 234 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 V 234 6x33 G.H5 M 379 G.H5.24
Hydrophobic TM6 V 234 6x33 G.H5 L 375 G.H5.20
Polar H8 S 296 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 S 296 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 S 296 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 H 298 8x49 G.H5 Q 381 G.H5.26
Hydrophobic TM5 V 218 5x69 G.H5 L 371 G.H5.16
Van-der-waals TM5 V 218 5x69 G.H5 L 371 G.H5.16
Hydrophobic ICL2 L 131 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 131 34x51 G.H5 F 363 G.H5.08
Hydrophobic TM6 A 227 6x26 G.H5 Q 372 G.H5.17
Hydrophobic TM6 K 233 6x32 G.H5 M 379 G.H5.24
Van-der-waals TM6 K 233 6x32 G.H5 M 379 G.H5.24
Hydrophobic ICL2 L 131 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 131 34x51 G.H5 I 370 G.H5.15
Hydrophobic TM6 V 234 6x33 G.H5 I 378 G.H5.23
Hydrophobic TM2 I 64 2x43 G.H5 L 380 G.H5.25
Polar ICL2 R 137 34x57 G.H5 N 374 G.H5.19
Van-der-waals ICL2 R 137 34x57 G.H5 N 374 G.H5.19
Hydrophobic ICL2 L 131 34x51 G.H5 K 367 G.H5.12
Hydrophobic ICL2 R 134 34x54 G.H5 I 370 G.H5.15
Hydrophobic ICL2 L 131 34x51 G.S1 V 58 G.S1.02
Van-der-waals ICL2 L 131 34x51 G.S1 V 58 G.S1.02
Hydrophobic ICL2 L 131 34x51 G.H5 V 366 G.H5.11
Hydrophobic TM4 P 139 4x39 G.hns1 R 55 G.hns1.02
Polar TM3 R 123 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 123 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL2 H 132 34x52 G.S3 I 221 G.S3.01
Van-der-waals ICL2 H 132 34x52 G.S3 I 221 G.S3.01
Hydrophobic TM7 V 295 7x56 G.H5 M 379 G.H5.24
Hydrophobic H8 H 298 8x49 G.H5 L 380 G.H5.25
Van-der-waals H8 H 298 8x49 G.H5 L 380 G.H5.25
Hydrophobic TM2 N 61 2x40 G.H5 L 380 G.H5.25
Van-der-waals TM2 N 61 2x40 G.H5 L 380 G.H5.25
Polar H8 S 296 8x47 G.H5 M 379 G.H5.24
Hydrophobic H8 S 296 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 S 296 8x47 G.H5 M 379 G.H5.24
Polar TM6 K 233 6x32 G.H5 Q 381 G.H5.26
Hydrophobic TM6 K 233 6x32 G.H5 Q 381 G.H5.26
Van-der-waals TM6 K 233 6x32 G.H5 Q 381 G.H5.26