Gi3 - GLP-1 receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 79.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 24.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 L 251 3x54 G.H5 L 353 G.H5.25
Van-der-waals TM3 L 251 3x54 G.H5 L 353 G.H5.25
Polar ICL2 S 258 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 S 258 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 S 258 - G.hns1 A 31 G.hns1.02
Hydrophobic TM6 L 359 6x48 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 359 6x48 G.H5 L 353 G.H5.25
Hydrophobic TM3 L 255 3x58 G.H5 I 344 G.H5.16
Van-der-waals TM3 L 255 3x58 G.H5 I 344 G.H5.16
Hydrophobic ICL2 L 260 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 S 258 - G.S3 L 194 G.S3.01
Hydrophobic TM4 S 261 4x38 G.HN R 24 G.HN.48
Hydrophobic ICL2 V 259 - G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 V 259 - G.hns1 K 32 G.hns1.03
Hydrophobic TM3 L 251 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 L 251 3x54 G.H5 L 348 G.H5.20
Polar TM3 Y 250 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 Y 250 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 Y 250 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM2 R 176 2x46 G.H5 G 352 G.H5.24
Van-der-waals TM2 R 176 2x46 G.H5 G 352 G.H5.24
Hydrophobic H8 L 411 8x52 G.h4s6 T 316 G.h4s6.10
Van-der-waals H8 L 411 8x52 G.h4s6 T 316 G.h4s6.10
Polar TM2 R 176 2x46 G.H5 K 349 G.H5.21
Van-der-waals TM2 R 176 2x46 G.H5 K 349 G.H5.21
Ionic TM5 K 334 5x64 G.H5 D 341 G.H5.13
Polar TM5 K 334 5x64 G.H5 D 341 G.H5.13
Hydrophobic TM5 K 334 5x64 G.H5 D 341 G.H5.13
Van-der-waals TM5 K 334 5x64 G.H5 D 341 G.H5.13
Hydrophobic TM3 L 254 3x57 G.H5 L 348 G.H5.20
Van-der-waals TM3 L 254 3x57 G.H5 L 348 G.H5.20
Hydrophobic TM6 L 356 6x45 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 356 6x45 G.H5 L 353 G.H5.25
Polar ICL2 L 260 - G.HN E 28 G.HN.52
Hydrophobic ICL2 L 260 - G.HN E 28 G.HN.52
Polar TM4 S 261 4x38 G.HN G 27 G.HN.51
Hydrophobic TM4 S 261 4x38 G.HN G 27 G.HN.51
Hydrophobic TM7 Y 402 7x57 G.H5 G 352 G.H5.24
Van-der-waals TM7 Y 402 7x57 G.H5 G 352 G.H5.24
Ionic H8 R 414 8x55 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM5 A 337 5x67 G.H5 A 338 G.H5.10
Hydrophobic TM3 F 257 3x60 G.hns1 K 32 G.hns1.03
Van-der-waals TM3 F 257 3x60 G.hns1 K 32 G.hns1.03
Hydrophobic TM2 R 176 2x46 G.H5 C 351 G.H5.23
Van-der-waals TM2 R 176 2x46 G.H5 C 351 G.H5.23
Hydrophobic TM7 Y 402 7x57 G.H5 L 353 G.H5.25
Aromatic TM4 W 264 4x41 G.HN R 24 G.HN.48
Hydrophobic TM4 W 264 4x41 G.HN R 24 G.HN.48
Van-der-waals TM4 W 264 4x41 G.HN R 24 G.HN.48
Polar TM2 R 176 2x46 G.H5 E 350 G.H5.22
Hydrophobic TM2 R 176 2x46 G.H5 E 350 G.H5.22
Van-der-waals TM2 R 176 2x46 G.H5 E 350 G.H5.22
Ionic ICL1 H 171 12x49 G.h3s5 E 261 G.h3s5.02
Van-der-waals ICL1 H 171 12x49 G.h3s5 E 261 G.h3s5.02
Hydrophobic TM5 A 337 5x67 G.H5 F 334 G.H5.06
Van-der-waals TM5 A 337 5x67 G.H5 F 334 G.H5.06
Hydrophobic ICL2 V 259 - G.HN K 29 G.HN.53
Van-der-waals ICL2 V 259 - G.HN K 29 G.HN.53
Polar ICL2 S 258 - G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 S 258 - G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 S 258 - G.hns1 K 32 G.hns1.03
Hydrophobic TM4 S 261 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 S 261 4x38 G.HN E 28 G.HN.52
Hydrophobic ICL2 V 259 - G.HN E 28 G.HN.52
Van-der-waals ICL2 V 259 - G.HN E 28 G.HN.52
Hydrophobic ICL2 V 259 - G.hns1 A 31 G.hns1.02
Hydrophobic TM3 L 255 3x58 G.H5 L 348 G.H5.20
Van-der-waals TM3 L 255 3x58 G.H5 L 348 G.H5.20
Hydrophobic TM3 L 254 3x57 G.H5 C 351 G.H5.23
Van-der-waals TM3 L 254 3x57 G.H5 C 351 G.H5.23