G11 - GPR141 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 81.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.2
PAE mean: 24.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 R 113 3x50 G.H5 L 358 G.H5.25
Hydrophobic ICL3 H 218 - G.S3 I 199 G.S3.01
Hydrophobic TM2 T 51 2x39 G.H5 L 358 G.H5.25
Polar ICL2 K 121 34x51 G.hns1 R 37 G.hns1.02
Hydrophobic ICL2 K 121 34x51 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 K 121 34x51 G.hns1 R 37 G.hns1.02
Hydrophobic ICL2 C 120 34x50 G.HN K 33 G.HN.51
Van-der-waals ICL2 C 120 34x50 G.HN K 33 G.HN.51
Polar TM3 R 113 3x50 G.H5 N 357 G.H5.24
Van-der-waals TM3 R 113 3x50 G.H5 N 357 G.H5.24
Hydrophobic TM6 Q 219 6x29 G.S3 I 199 G.S3.01
Van-der-waals TM6 Q 219 6x29 G.S3 I 199 G.S3.01
Hydrophobic ICL2 K 121 34x51 G.HN K 33 G.HN.51
Polar ICL3 H 218 - G.hns1 R 38 G.hns1.03
Aromatic ICL3 H 218 - G.hns1 R 38 G.hns1.03
Hydrophobic ICL3 H 218 - G.hns1 R 38 G.hns1.03
Hydrophobic TM2 T 52 2x40 G.H5 V 359 G.H5.26
Van-der-waals TM2 T 52 2x40 G.H5 V 359 G.H5.26
Hydrophobic ICL1 M 45 12x48 G.H5 L 358 G.H5.25
Van-der-waals ICL1 M 45 12x48 G.H5 L 358 G.H5.25
Polar TM6 K 226 6x36 G.H5 N 357 G.H5.24
Hydrophobic TM6 K 226 6x36 G.H5 N 357 G.H5.24
Van-der-waals TM6 K 226 6x36 G.H5 N 357 G.H5.24
Polar TM3 L 115 3x52 G.hns1 R 37 G.hns1.02
Hydrophobic TM3 L 115 3x52 G.hns1 R 37 G.hns1.02
Van-der-waals TM3 L 115 3x52 G.hns1 R 37 G.hns1.02
Polar TM3 R 113 3x50 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 D 122 34x52 G.hns1 R 37 G.hns1.02
Ionic TM5 K 210 5x64 G.HN D 35 G.HN.53
Polar TM5 K 210 5x64 G.HN D 35 G.HN.53
Van-der-waals TM5 K 210 5x64 G.HN D 35 G.HN.53
Hydrophobic ICL1 M 45 12x48 G.H5 V 359 G.H5.26
Van-der-waals ICL1 M 45 12x48 G.H5 V 359 G.H5.26
Polar TM3 K 119 3x56 G.hns1 R 37 G.hns1.02
Hydrophobic TM3 K 119 3x56 G.hns1 R 37 G.hns1.02
Van-der-waals TM3 K 119 3x56 G.hns1 R 37 G.hns1.02
Hydrophobic TM1 L 41 1x57 G.H5 L 358 G.H5.25
Polar TM6 Q 219 6x29 G.H5 L 349 G.H5.16
Hydrophobic TM6 Q 219 6x29 G.H5 L 349 G.H5.16
Van-der-waals TM6 Q 219 6x29 G.H5 L 349 G.H5.16
Polar TM3 R 113 3x50 G.H5 V 359 G.H5.26
Hydrophobic TM3 R 113 3x50 G.H5 V 359 G.H5.26
Van-der-waals TM3 R 113 3x50 G.H5 V 359 G.H5.26
Hydrophobic TM5 M 207 5x61 G.hns1 R 38 G.hns1.03
Van-der-waals TM5 M 207 5x61 G.hns1 R 38 G.hns1.03
Polar TM3 I 116 3x53 G.hns1 R 37 G.hns1.02
Hydrophobic TM3 I 116 3x53 G.hns1 R 37 G.hns1.02
Van-der-waals TM3 I 116 3x53 G.hns1 R 37 G.hns1.02
Polar ICL3 S 217 - G.s2s3 N 198 G.s2s3.02
Hydrophobic ICL3 S 217 - G.s2s3 N 198 G.s2s3.02
Polar TM5 L 211 5x65 G.s2s3 N 198 G.s2s3.02
Hydrophobic TM5 L 211 5x65 G.s2s3 N 198 G.s2s3.02
Van-der-waals TM5 L 211 5x65 G.s2s3 N 198 G.s2s3.02
Polar ICL3 S 217 - G.s2s3 E 197 G.s2s3.01
Hydrophobic ICL3 S 217 - G.s2s3 E 197 G.s2s3.01
Van-der-waals ICL3 S 217 - G.s2s3 E 197 G.s2s3.01
Hydrophobic TM1 I 38 1x54 G.H5 L 358 G.H5.25
Van-der-waals TM1 I 38 1x54 G.H5 L 358 G.H5.25
Polar ICL2 C 120 34x50 G.HN R 30 G.HN.48
Hydrophobic ICL2 C 120 34x50 G.HN R 30 G.HN.48
Van-der-waals ICL2 C 120 34x50 G.HN R 30 G.HN.48
Polar H8 H 289 8x48 G.H5 Q 350 G.H5.17
Hydrophobic H8 H 289 8x48 G.H5 Q 350 G.H5.17
Van-der-waals H8 H 289 8x48 G.H5 Q 350 G.H5.17
Polar ICL2 C 120 34x50 G.HN R 34 G.HN.52
Hydrophobic ICL2 C 120 34x50 G.HN R 34 G.HN.52
Van-der-waals ICL2 C 120 34x50 G.HN R 34 G.HN.52
Polar ICL2 D 122 34x52 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 D 122 34x52 G.H5 Y 356 G.H5.23
Polar ICL3 S 214 - G.s2s3 N 198 G.s2s3.02
Hydrophobic ICL3 S 214 - G.s2s3 N 198 G.s2s3.02
Van-der-waals ICL3 S 214 - G.s2s3 N 198 G.s2s3.02
Ionic ICL2 K 123 34x53 G.H5 E 355 G.H5.22
Polar ICL2 K 123 34x53 G.H5 E 355 G.H5.22
Hydrophobic ICL2 K 123 34x53 G.H5 E 355 G.H5.22
Van-der-waals ICL2 K 123 34x53 G.H5 E 355 G.H5.22
Hydrophobic TM5 K 210 5x64 G.hns1 R 38 G.hns1.03
Van-der-waals TM5 K 210 5x64 G.hns1 R 38 G.hns1.03
Polar ICL3 H 218 - G.s2s3 E 197 G.s2s3.01
Van-der-waals ICL3 H 218 - G.s2s3 E 197 G.s2s3.01
Hydrophobic H8 K 292 8x51 G.H5 L 353 G.H5.20
Van-der-waals H8 K 292 8x51 G.H5 L 353 G.H5.20
Hydrophobic TM6 Q 219 6x29 G.H5 L 353 G.H5.20
Van-der-waals TM6 Q 219 6x29 G.H5 L 353 G.H5.20
Hydrophobic TM6 W 222 6x32 G.H5 N 357 G.H5.24
Polar TM3 F 118 3x55 G.HN R 34 G.HN.52
Hydrophobic TM3 F 118 3x55 G.HN R 34 G.HN.52
Van-der-waals TM3 F 118 3x55 G.HN R 34 G.HN.52
Hydrophobic TM5 L 211 5x65 G.hns1 R 38 G.hns1.03
Van-der-waals TM5 L 211 5x65 G.hns1 R 38 G.hns1.03
Ionic H8 H 289 8x48 G.H5 D 346 G.H5.13
Polar H8 H 289 8x48 G.H5 D 346 G.H5.13
Hydrophobic H8 H 289 8x48 G.H5 D 346 G.H5.13
Van-der-waals H8 H 289 8x48 G.H5 D 346 G.H5.13
Van-der-waals H8 K 292 8x51 G.H5 N 357 G.H5.24
Hydrophobic TM3 I 116 3x53 G.H5 Y 356 G.H5.23
Polar TM6 A 223 6x33 G.H5 N 357 G.H5.24
Hydrophobic TM6 A 223 6x33 G.H5 N 357 G.H5.24
Van-der-waals TM6 A 223 6x33 G.H5 N 357 G.H5.24
Polar TM3 F 117 3x54 G.hns1 R 37 G.hns1.02
Van-der-waals TM3 F 117 3x54 G.hns1 R 37 G.hns1.02
Polar TM3 F 117 3x54 G.HN R 34 G.HN.52
Aromatic TM3 F 117 3x54 G.HN R 34 G.HN.52
Van-der-waals TM3 F 117 3x54 G.HN R 34 G.HN.52
Hydrophobic TM2 S 49 2x37 G.H5 V 359 G.H5.26
Van-der-waals TM2 S 49 2x37 G.H5 V 359 G.H5.26
Van-der-waals ICL3 L 215 - G.s2s3 N 198 G.s2s3.02
Hydrophobic TM2 T 51 2x39 G.H5 V 359 G.H5.26
Van-der-waals TM2 T 51 2x39 G.H5 V 359 G.H5.26
Polar ICL3 H 218 - G.s2s3 N 198 G.s2s3.02
Hydrophobic ICL3 H 218 - G.s2s3 N 198 G.s2s3.02
Van-der-waals ICL3 H 218 - G.s2s3 N 198 G.s2s3.02
Hydrophobic TM7 F 283 7x53 G.H5 L 358 G.H5.25
Van-der-waals TM7 F 283 7x53 G.H5 L 358 G.H5.25
Ionic TM6 E 220 6x30 G.hns1 R 38 G.hns1.03
Polar TM6 E 220 6x30 G.hns1 R 38 G.hns1.03
Hydrophobic TM6 E 220 6x30 G.hns1 R 38 G.hns1.03
Van-der-waals TM6 E 220 6x30 G.hns1 R 38 G.hns1.03
Polar ICL2 C 120 34x50 G.hns1 R 37 G.hns1.02
Hydrophobic ICL2 C 120 34x50 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 C 120 34x50 G.hns1 R 37 G.hns1.02