G14 - GPR150 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 71.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 19.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL3 G 278 - G.H4 D 303 G.H4.09
Hydrophobic ICL3 G 278 - G.H4 D 303 G.H4.09
Van-der-waals ICL3 G 278 - G.H4 D 303 G.H4.09
Hydrophobic C-term W 398 - G.S2 P 189 G.S2.05
Hydrophobic TM6 A 289 6x29 G.H5 L 354 G.H5.25
Van-der-waals TM6 A 289 6x29 G.H5 L 354 G.H5.25
Aromatic C-term W 398 - G.S2 Y 188 G.S2.04
Hydrophobic C-term W 398 - G.S2 Y 188 G.S2.04
Van-der-waals C-term W 398 - G.S2 Y 188 G.S2.04
Hydrophobic TM6 A 289 6x29 G.H5 L 349 G.H5.20
Hydrophobic C-term L 416 - H.HA T 92 H.HA.28
Van-der-waals C-term L 416 - H.HA T 92 H.HA.28
Hydrophobic ICL2 H 155 - G.S3 I 195 G.S3.01
Van-der-waals ICL2 H 155 - G.S3 I 195 G.S3.01
Ionic TM4 R 157 4x38 G.HN D 31 G.HN.53
Polar TM4 R 157 4x38 G.HN D 31 G.HN.53
Hydrophobic TM4 R 157 4x38 G.HN D 31 G.HN.53
Van-der-waals TM4 R 157 4x38 G.HN D 31 G.HN.53
Hydrophobic C-term F 434 - G.h2s4 F 216 G.h2s4.01
Polar TM2 R 80 2x37 G.H5 N 353 G.H5.24
Hydrophobic TM2 R 80 2x37 G.H5 N 353 G.H5.24
Van-der-waals TM2 R 80 2x37 G.H5 N 353 G.H5.24
Polar TM5 S 274 5x80 G.H4 R 299 G.H4.05
Hydrophobic TM5 S 274 5x80 G.H4 R 299 G.H4.05
Van-der-waals TM5 S 274 5x80 G.H4 R 299 G.H4.05
Hydrophobic TM6 L 286 6x26 G.H5 L 349 G.H5.20
Hydrophobic TM6 Q 292 6x32 G.H5 V 355 G.H5.26
Van-der-waals TM6 Q 292 6x32 G.H5 V 355 G.H5.26
Polar C-term R 417 - H.HD R 145 H.HD.11
Ionic C-term R 407 - H.hbhc D 115 H.hbhc.01
Polar C-term R 407 - H.hbhc D 115 H.hbhc.01
Hydrophobic C-term R 407 - H.hbhc D 115 H.hbhc.01
Van-der-waals C-term R 407 - H.hbhc D 115 H.hbhc.01
Hydrophobic TM6 L 286 6x26 G.H5 D 342 G.H5.13
Van-der-waals TM6 L 286 6x26 G.H5 D 342 G.H5.13
Hydrophobic C-term F 434 - G.H3 I 254 G.H3.12
Polar ICL2 P 154 - G.H5 N 348 G.H5.19
Van-der-waals ICL2 P 154 - G.H5 N 348 G.H5.19
Ionic C-term R 408 - G.s1h1 E 45 G.s1h1.04
Polar C-term R 408 - G.s1h1 E 45 G.s1h1.04
Hydrophobic ICL3 A 282 - G.h4s6 V 319 G.h4s6.20
Polar TM4 R 157 4x38 G.HN K 30 G.HN.52
Hydrophobic TM4 R 157 4x38 G.HN K 30 G.HN.52
Van-der-waals TM4 R 157 4x38 G.HN K 30 G.HN.52
Hydrophobic H8 Q 356 8x47 G.H5 N 353 G.H5.24
Van-der-waals H8 Q 356 8x47 G.H5 N 353 G.H5.24
Hydrophobic TM6 L 286 6x26 G.H5 L 345 G.H5.16
Van-der-waals TM6 L 286 6x26 G.H5 L 345 G.H5.16
Hydrophobic ICL2 P 154 - G.H5 L 345 G.H5.16
Hydrophobic TM3 E 146 3x49 G.H5 F 352 G.H5.23
Aromatic C-term F 434 - G.H3 Y 257 G.H3.15
Hydrophobic C-term F 434 - G.H3 Y 257 G.H3.15
Van-der-waals C-term F 434 - G.H3 Y 257 G.H3.15
Polar TM3 A 150 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 A 150 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 A 150 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM2 K 81 2x38 G.H5 F 352 G.H5.23
Hydrophobic ICL2 P 154 - G.H5 K 341 G.H5.12
Polar TM2 R 80 2x37 G.H5 R 350 G.H5.21
Hydrophobic TM2 R 80 2x37 G.H5 R 350 G.H5.21
Van-der-waals TM2 R 80 2x37 G.H5 R 350 G.H5.21
Hydrophobic ICL2 H 155 - G.S1 L 36 G.S1.02
Van-der-waals ICL2 H 155 - G.S1 L 36 G.S1.02
Hydrophobic TM3 V 151 3x54 G.H5 L 345 G.H5.16
Van-der-waals TM3 V 151 3x54 G.H5 L 345 G.H5.16
Polar TM4 P 158 4x39 G.hns1 R 33 G.hns1.02
Hydrophobic TM4 P 158 4x39 G.hns1 R 33 G.hns1.02
Van-der-waals TM4 P 158 4x39 G.hns1 R 33 G.hns1.02
Hydrophobic ICL2 H 155 - G.H5 I 344 G.H5.15
Van-der-waals ICL2 H 155 - G.H5 I 344 G.H5.15
Polar C-term H 405 - H.HA Q 77 H.HA.13
Hydrophobic C-term H 405 - H.HA Q 77 H.HA.13
Van-der-waals C-term H 405 - H.HA Q 77 H.HA.13
Ionic C-term R 417 - G.s4h3 D 239 G.s4h3.12
Polar C-term R 417 - G.s4h3 D 239 G.s4h3.12
Hydrophobic C-term R 417 - G.s4h3 D 239 G.s4h3.12
Van-der-waals C-term R 417 - G.s4h3 D 239 G.s4h3.12
Hydrophobic TM2 R 80 2x37 G.H5 E 351 G.H5.22
Van-der-waals TM2 R 80 2x37 G.H5 E 351 G.H5.22
Polar C-term W 398 - G.S2 E 187 G.S2.03
Hydrophobic C-term W 398 - G.S2 E 187 G.S2.03
Van-der-waals C-term W 398 - G.S2 E 187 G.S2.03
Hydrophobic ICL2 P 154 - G.H5 I 344 G.H5.15
Van-der-waals ICL2 P 154 - G.H5 I 344 G.H5.15
Polar C-term R 417 - G.s4h3 L 235 G.s4h3.08
Hydrophobic C-term L 393 - G.H2 H 214 G.H2.09
Van-der-waals C-term L 393 - G.H2 H 214 G.H2.09
Polar TM6 S 293 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM6 S 293 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 S 293 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM6 L 286 6x26 G.H5 Q 346 G.H5.17
Van-der-waals TM6 L 286 6x26 G.H5 Q 346 G.H5.17
Polar TM2 D 83 2x40 G.H5 N 353 G.H5.24
Van-der-waals TM2 D 83 2x40 G.H5 N 353 G.H5.24
Hydrophobic TM3 R 147 3x50 G.H5 L 354 G.H5.25
Van-der-waals TM3 R 147 3x50 G.H5 L 354 G.H5.25
Van-der-waals C-term R 417 - H.hdhe Q 148 H.hdhe.02
Hydrophobic TM3 A 150 3x53 G.H5 L 345 G.H5.16
Hydrophobic ICL2 H 155 - G.H5 K 341 G.H5.12
Van-der-waals ICL2 H 155 - G.H5 K 341 G.H5.12
Ionic C-term R 407 - H.HB E 113 H.HB.13
Hydrophobic TM3 A 150 3x53 G.H5 F 352 G.H5.23
Van-der-waals TM3 A 150 3x53 G.H5 F 352 G.H5.23
Hydrophobic TM6 A 289 6x29 G.H5 V 355 G.H5.26
Van-der-waals TM6 A 289 6x29 G.H5 V 355 G.H5.26
Hydrophobic TM4 R 157 4x38 G.hns1 R 34 G.hns1.03
Van-der-waals TM4 R 157 4x38 G.hns1 R 34 G.hns1.03
Polar ICL3 S 276 - G.H4 R 302 G.H4.08
Van-der-waals ICL3 S 276 - G.H4 R 302 G.H4.08
Polar C-term R 417 - H.HD E 146 H.HD.12
Hydrophobic C-term R 417 - H.HD E 146 H.HD.12
Van-der-waals C-term R 417 - H.HD E 146 H.HD.12
Polar TM3 R 147 3x50 G.H5 N 353 G.H5.24
Polar ICL3 P 277 - G.H4 D 303 G.H4.09
Hydrophobic ICL3 P 277 - G.H4 D 303 G.H4.09
Van-der-waals ICL3 P 277 - G.H4 D 303 G.H4.09
Polar TM2 M 82 2x39 G.H5 E 351 G.H5.22
Hydrophobic TM2 M 82 2x39 G.H5 E 351 G.H5.22
Van-der-waals TM2 M 82 2x39 G.H5 E 351 G.H5.22
Hydrophobic C-term Y 403 - G.hfs2 V 180 G.hfs2.03
Van-der-waals C-term Y 403 - G.hfs2 V 180 G.hfs2.03
Hydrophobic C-term A 406 - G.hfs2 T 183 G.hfs2.06
Hydrophobic C-term R 417 - H.hdhe Y 147 H.hdhe.01
Polar ICL3 S 276 - G.H4 R 299 G.H4.05
Hydrophobic ICL3 S 276 - G.H4 R 299 G.H4.05
Van-der-waals ICL3 S 276 - G.H4 R 299 G.H4.05
Polar TM2 K 81 2x38 G.H5 E 351 G.H5.22
Hydrophobic TM2 K 81 2x38 G.H5 E 351 G.H5.22
Van-der-waals TM2 K 81 2x38 G.H5 E 351 G.H5.22
Hydrophobic C-term H 405 - H.HA L 74 H.HA.10
Van-der-waals C-term H 405 - H.HA L 74 H.HA.10
Hydrophobic ICL3 S 276 - G.H4 D 303 G.H4.09
Van-der-waals ICL3 S 276 - G.H4 D 303 G.H4.09
Hydrophobic TM6 K 290 6x30 G.H5 L 345 G.H5.16
Van-der-waals TM6 K 290 6x30 G.H5 L 345 G.H5.16
Hydrophobic TM3 V 151 3x54 G.H5 L 349 G.H5.20
Hydrophobic H8 D 359 8x50 G.H5 V 355 G.H5.26
Hydrophobic C-term R 408 - G.s4h3 A 236 G.s4h3.09
Van-der-waals C-term R 408 - G.s4h3 A 236 G.s4h3.09
Polar TM3 R 147 3x50 G.H5 F 352 G.H5.23
Hydrophobic TM3 R 147 3x50 G.H5 F 352 G.H5.23
Van-der-waals TM3 R 147 3x50 G.H5 F 352 G.H5.23
Hydrophobic TM2 M 82 2x39 G.H5 F 352 G.H5.23
Van-der-waals TM2 M 82 2x39 G.H5 F 352 G.H5.23
Hydrophobic C-term F 434 - G.H3 T 253 G.H3.11
Van-der-waals C-term F 434 - G.H3 T 253 G.H3.11
Hydrophobic C-term R 417 - G.s4h3 V 234 G.s4h3.07
Van-der-waals C-term R 417 - G.s4h3 V 234 G.s4h3.07
Hydrophobic TM6 K 290 6x30 G.H5 L 349 G.H5.20
Van-der-waals TM6 K 290 6x30 G.H5 L 349 G.H5.20