Gs - GPR151 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 73.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 25.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic H8 E 315 8x52 G.h4s6 R 356 G.h4s6.12
Hydrophobic TM2 M 72 2x38 G.H5 Y 391 G.H5.23
Van-der-waals TM2 M 72 2x38 G.H5 Y 391 G.H5.23
Polar TM6 N 241 6x26 G.H5 Q 384 G.H5.16
Hydrophobic TM1 L 61 1x57 G.H5 E 392 G.H5.24
Van-der-waals TM1 L 61 1x57 G.H5 E 392 G.H5.24
Hydrophobic ICL2 Q 146 34x53 G.S1 H 41 G.S1.02
Van-der-waals ICL2 Q 146 34x53 G.S1 H 41 G.S1.02
Polar ICL3 Q 237 - G.S6 H 362 G.S6.04
Hydrophobic ICL3 Q 237 - G.S6 H 362 G.S6.04
Van-der-waals ICL3 Q 237 - G.S6 H 362 G.S6.04
Hydrophobic TM2 I 73 2x39 G.H5 L 393 G.H5.25
Van-der-waals TM2 I 73 2x39 G.H5 L 393 G.H5.25
Polar ICL2 Q 146 34x53 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 A 144 34x51 G.H5 R 380 G.H5.12
Van-der-waals ICL2 A 144 34x51 G.H5 R 380 G.H5.12
Polar TM6 N 238 6x23 G.H5 D 381 G.H5.13
Hydrophobic TM6 N 238 6x23 G.H5 D 381 G.H5.13
Van-der-waals TM6 N 238 6x23 G.H5 D 381 G.H5.13
Hydrophobic TM6 R 240 6x25 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM6 R 240 6x25 G.h4s6 Y 358 G.h4s6.20
Polar ICL2 P 143 34x50 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 P 143 34x50 G.H5 Q 384 G.H5.16
Van-der-waals ICL2 P 143 34x50 G.H5 Q 384 G.H5.16
Polar C-term V 386 - G.h2s4 N 239 G.h2s4.02
Hydrophobic C-term V 386 - G.h2s4 N 239 G.h2s4.02
Van-der-waals C-term V 386 - G.h2s4 N 239 G.h2s4.02
Hydrophobic TM3 Y 139 3x53 G.H5 L 393 G.H5.25
Hydrophobic C-term F 389 - G.h2s4 D 240 G.h2s4.03
Van-der-waals C-term F 389 - G.h2s4 D 240 G.h2s4.03
Polar TM3 Y 139 3x53 G.H5 Y 391 G.H5.23
Aromatic TM3 Y 139 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 Y 139 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 Y 139 3x53 G.H5 Y 391 G.H5.23
Polar TM6 R 244 6x29 G.h4s6 G 355 G.h4s6.11
Van-der-waals TM6 R 244 6x29 G.h4s6 G 355 G.h4s6.11
Hydrophobic TM6 N 238 6x23 G.S6 Y 360 G.S6.02
Van-der-waals TM6 N 238 6x23 G.S6 Y 360 G.S6.02
Ionic H8 E 315 8x52 G.H5 R 389 G.H5.21
Hydrophobic C-term V 396 - G.h4s6 R 356 G.h4s6.12
Van-der-waals C-term V 396 - G.h4s6 R 356 G.h4s6.12
Polar TM6 R 244 6x29 G.H5 L 394 G.H5.26
Hydrophobic TM6 R 244 6x29 G.H5 L 394 G.H5.26
Van-der-waals TM6 R 244 6x29 G.H5 L 394 G.H5.26
Polar TM2 H 74 2x40 G.H5 Q 390 G.H5.22
Hydrophobic TM2 H 74 2x40 G.H5 Q 390 G.H5.22
Van-der-waals TM2 H 74 2x40 G.H5 Q 390 G.H5.22
Hydrophobic ICL2 Q 146 34x53 G.H5 I 383 G.H5.15
Van-der-waals ICL2 Q 146 34x53 G.H5 I 383 G.H5.15
Polar C-term S 398 - G.h3s5 R 283 G.h3s5.01
Hydrophobic C-term S 398 - G.h3s5 R 283 G.h3s5.01
Van-der-waals C-term S 398 - G.h3s5 R 283 G.h3s5.01
Hydrophobic C-term R 393 - G.h3s5 I 285 G.h3s5.03
Van-der-waals C-term R 393 - G.h3s5 I 285 G.h3s5.03
Polar TM6 R 244 6x29 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM6 R 244 6x29 G.h4s6 Y 358 G.h4s6.20
Aromatic C-term W 390 - G.H3 W 281 G.H3.17
Hydrophobic C-term W 390 - G.H3 W 281 G.H3.17
Van-der-waals C-term W 390 - G.H3 W 281 G.H3.17
Ionic C-term D 403 - G.H3 R 280 G.H3.16
Polar C-term D 403 - G.H3 R 280 G.H3.16
Hydrophobic C-term D 403 - G.H3 R 280 G.H3.16
Van-der-waals C-term D 403 - G.H3 R 280 G.H3.16
Polar C-term R 393 - G.H3 W 281 G.H3.17
Hydrophobic TM3 Y 139 3x53 G.H5 L 388 G.H5.20
Hydrophobic C-term W 407 - G.H2 R 228 G.H2.01
Van-der-waals C-term W 407 - G.H2 R 228 G.H2.01
Polar C-term R 393 - G.h3s5 T 284 G.h3s5.02
Hydrophobic C-term R 393 - G.h3s5 T 284 G.h3s5.02
Van-der-waals C-term R 393 - G.h3s5 T 284 G.h3s5.02
Polar C-term W 390 - G.h2s4 N 239 G.h2s4.02
Hydrophobic C-term W 390 - G.h2s4 N 239 G.h2s4.02
Van-der-waals C-term W 390 - G.h2s4 N 239 G.h2s4.02
Hydrophobic ICL1 K 69 - G.hns1 R 38 G.hns1.02
Van-der-waals ICL1 K 69 - G.hns1 R 38 G.hns1.02
Hydrophobic TM6 L 252 6x37 G.H5 L 393 G.H5.25
Polar ICL2 V 147 34x54 G.H5 Y 391 G.H5.23
Van-der-waals ICL2 V 147 34x54 G.H5 Y 391 G.H5.23
Polar H8 E 312 8x49 G.H5 E 392 G.H5.24
Hydrophobic H8 E 312 8x49 G.H5 E 392 G.H5.24
Van-der-waals H8 E 312 8x49 G.H5 E 392 G.H5.24
Polar TM6 R 240 6x25 G.h4s6 G 353 G.h4s6.09
Polar TM6 N 238 6x23 G.H5 N 377 G.H5.09
Polar TM2 S 71 2x37 G.H5 Q 390 G.H5.22
Hydrophobic TM2 S 71 2x37 G.H5 Q 390 G.H5.22
Van-der-waals TM2 S 71 2x37 G.H5 Q 390 G.H5.22
Ionic TM2 H 74 2x40 G.H5 E 392 G.H5.24
Polar TM2 H 74 2x40 G.H5 E 392 G.H5.24
Hydrophobic TM2 H 74 2x40 G.H5 E 392 G.H5.24
Van-der-waals TM2 H 74 2x40 G.H5 E 392 G.H5.24
Hydrophobic TM6 R 240 6x25 G.h4s6 G 355 G.h4s6.11
Van-der-waals TM6 R 240 6x25 G.h4s6 G 355 G.h4s6.11
Ionic C-term D 385 - G.HN K 34 G.HN.51
Polar C-term D 385 - G.HN K 34 G.HN.51
Van-der-waals C-term D 385 - G.HN K 34 G.HN.51
Polar TM2 H 74 2x40 G.H5 Y 391 G.H5.23
Hydrophobic TM2 H 74 2x40 G.H5 Y 391 G.H5.23
Van-der-waals TM2 H 74 2x40 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 Q 146 34x53 G.H5 H 387 G.H5.19
Van-der-waals ICL2 Q 146 34x53 G.H5 H 387 G.H5.19
Polar TM1 N 64 1x60 G.H5 E 392 G.H5.24
Hydrophobic TM1 N 64 1x60 G.H5 E 392 G.H5.24
Van-der-waals TM1 N 64 1x60 G.H5 E 392 G.H5.24
Polar ICL2 I 149 34x56 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 I 149 34x56 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 P 143 34x50 G.H5 R 380 G.H5.12
Polar TM2 S 71 2x37 G.H5 Y 391 G.H5.23
Hydrophobic TM2 S 71 2x37 G.H5 Y 391 G.H5.23
Van-der-waals TM2 S 71 2x37 G.H5 Y 391 G.H5.23
Hydrophobic TM6 R 240 6x25 G.H5 R 385 G.H5.17
Van-der-waals TM6 R 240 6x25 G.H5 R 385 G.H5.17
Polar TM6 N 241 6x26 G.H5 R 385 G.H5.17
Hydrophobic TM6 N 241 6x26 G.H5 R 385 G.H5.17
Van-der-waals TM6 N 241 6x26 G.H5 R 385 G.H5.17
Hydrophobic C-term W 407 - G.H2 D 229 G.H2.02
Hydrophobic TM6 V 248 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 V 248 6x33 G.H5 L 393 G.H5.25
Polar ICL3 Q 237 - G.H5 N 377 G.H5.09
Hydrophobic C-term D 394 - G.H3 W 281 G.H3.17
Van-der-waals C-term D 394 - G.H3 W 281 G.H3.17
Hydrophobic H8 E 312 8x49 G.H5 R 389 G.H5.21
Van-der-waals H8 E 312 8x49 G.H5 R 389 G.H5.21
Hydrophobic C-term W 407 - G.H2 R 232 G.H2.05
Van-der-waals C-term W 407 - G.H2 R 232 G.H2.05
Ionic C-term D 403 - G.h3s5 R 283 G.h3s5.01
Polar C-term D 403 - G.h3s5 R 283 G.h3s5.01
Van-der-waals C-term D 403 - G.h3s5 R 283 G.h3s5.01
Hydrophobic C-term F 389 - G.H5 M 386 G.H5.18
Polar TM6 N 241 6x26 G.H5 D 381 G.H5.13
Hydrophobic TM6 N 241 6x26 G.H5 D 381 G.H5.13
Van-der-waals TM6 N 241 6x26 G.H5 D 381 G.H5.13
Polar H8 E 312 8x49 G.H5 L 394 G.H5.26
Hydrophobic H8 E 312 8x49 G.H5 L 394 G.H5.26
Van-der-waals H8 E 312 8x49 G.H5 L 394 G.H5.26
Hydrophobic C-term V 386 - G.h2s4 D 240 G.h2s4.03
Van-der-waals C-term V 386 - G.h2s4 D 240 G.h2s4.03
Polar C-term W 407 - G.H2 R 231 G.H2.04
Aromatic C-term W 407 - G.H2 R 231 G.H2.04
Hydrophobic C-term W 407 - G.H2 R 231 G.H2.04
Van-der-waals C-term W 407 - G.H2 R 231 G.H2.04
Polar TM6 N 238 6x23 G.H5 R 385 G.H5.17
Hydrophobic C-term W 390 - G.h2s4 F 238 G.h2s4.01
Van-der-waals C-term W 390 - G.h2s4 F 238 G.h2s4.01
Hydrophobic C-term P 404 - G.H3 S 275 G.H3.11