G13 - GPR152 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 69.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.4
PAE mean: 19.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ECL2 D 187 - G.HN K 42 G.HN.51
Hydrophobic ECL2 D 187 - G.HN K 42 G.HN.51
Van-der-waals ECL2 D 187 - G.HN K 42 G.HN.51
Polar ECL2 Y 177 - G.s2s3 N 215 G.s2s3.02
Polar N-term H 14 - G.H4 R 320 G.H4.05
Aromatic N-term H 14 - G.H4 R 320 G.H4.05
Hydrophobic N-term H 14 - G.H4 R 320 G.H4.05
Hydrophobic TM1 Y 26 1x29 G.H5 L 371 G.H5.20
Van-der-waals TM1 Y 26 1x29 G.H5 L 371 G.H5.20
Polar TM7 Y 271 7x28 G.h4s6 Q 337 G.h4s6.11
Hydrophobic TM1 Y 26 1x29 G.H5 M 375 G.H5.24
Van-der-waals TM1 Y 26 1x29 G.H5 M 375 G.H5.24
Hydrophobic TM1 P 27 1x30 G.H5 K 372 G.H5.21
Van-der-waals TM1 P 27 1x30 G.H5 K 372 G.H5.21
Polar ECL2 Y 177 - G.s2s3 K 214 G.s2s3.01
Hydrophobic ECL2 Y 177 - G.s2s3 K 214 G.s2s3.01
Van-der-waals ECL2 Y 177 - G.s2s3 K 214 G.s2s3.01
Hydrophobic ECL2 L 179 - G.H5 L 371 G.H5.20
Hydrophobic ECL2 F 185 - G.hns1 K 46 G.hns1.02
Hydrophobic ECL2 W 175 - G.hns1 R 47 G.hns1.03
Van-der-waals ECL2 W 175 - G.hns1 R 47 G.hns1.03
Hydrophobic ECL2 W 176 - G.s2s3 K 214 G.s2s3.01
Van-der-waals ECL2 W 176 - G.s2s3 K 214 G.s2s3.01
Polar ECL2 D 184 45x52 G.hns1 K 46 G.hns1.02
Hydrophobic TM1 P 27 1x30 G.H5 M 375 G.H5.24
Polar ECL2 V 174 - G.hns1 R 47 G.hns1.03
Van-der-waals ECL2 V 174 - G.hns1 R 47 G.hns1.03
Hydrophobic TM1 P 27 1x30 G.H5 H 368 G.H5.17
Van-der-waals TM1 P 27 1x30 G.H5 H 368 G.H5.17
Hydrophobic ECL2 L 183 45x51 G.H5 L 374 G.H5.23
Van-der-waals ECL2 L 183 45x51 G.H5 L 374 G.H5.23
Polar TM7 Y 271 7x28 G.h4s6 Q 339 G.h4s6.13
Hydrophobic TM7 Y 271 7x28 G.h4s6 Q 339 G.h4s6.13
Van-der-waals TM7 Y 271 7x28 G.h4s6 Q 339 G.h4s6.13
Polar TM6 Y 260 6x58 G.H5 Q 377 G.H5.26
Van-der-waals TM6 Y 260 6x58 G.H5 Q 377 G.H5.26
Hydrophobic ECL2 A 173 - G.hns1 R 47 G.hns1.03
Van-der-waals ECL2 A 173 - G.hns1 R 47 G.hns1.03
Polar ECL2 W 186 - G.hns1 K 46 G.hns1.02
Van-der-waals ECL2 W 186 - G.hns1 K 46 G.hns1.02
Hydrophobic TM1 P 27 1x30 G.H5 L 371 G.H5.20
Hydrophobic ECL2 L 183 45x51 G.H5 M 375 G.H5.24
Hydrophobic ECL2 W 176 - G.H5 K 363 G.H5.12
Van-der-waals ECL2 W 176 - G.H5 K 363 G.H5.12
Hydrophobic ECL2 S 188 - G.HN K 42 G.HN.51
Hydrophobic TM7 W 274 7x31 G.H5 M 375 G.H5.24
Van-der-waals TM7 W 274 7x31 G.H5 M 375 G.H5.24
Polar TM1 S 25 1x28 G.H5 H 368 G.H5.17
Hydrophobic TM1 S 25 1x28 G.H5 H 368 G.H5.17
Van-der-waals TM1 S 25 1x28 G.H5 H 368 G.H5.17
Hydrophobic TM1 Y 26 1x29 G.H5 H 368 G.H5.17
Aromatic ECL2 F 185 - G.hns1 R 47 G.hns1.03
Hydrophobic ECL2 F 185 - G.hns1 R 47 G.hns1.03
Van-der-waals ECL2 F 185 - G.hns1 R 47 G.hns1.03
Polar ECL2 D 187 - G.HN T 43 G.HN.52
Van-der-waals ECL2 D 187 - G.HN T 43 G.HN.52
Polar ECL3 S 269 - G.h3s5 S 282 G.h3s5.01
Hydrophobic N-term L 20 - G.H5 D 361 G.H5.10
Hydrophobic TM7 L 273 7x30 G.H5 L 376 G.H5.25
Hydrophobic ECL2 W 176 - G.H5 L 367 G.H5.16
Van-der-waals ECL2 W 176 - G.H5 L 367 G.H5.16
Hydrophobic TM7 W 274 7x31 G.H5 K 372 G.H5.21
Van-der-waals TM7 W 274 7x31 G.H5 K 372 G.H5.21
Polar ECL2 D 187 - G.HN S 39 G.HN.48
Hydrophobic ECL2 D 187 - G.HN S 39 G.HN.48
Van-der-waals ECL2 D 187 - G.HN S 39 G.HN.48
Polar TM5 R 194 5x41 G.H5 Q 377 G.H5.26
Van-der-waals TM5 R 194 5x41 G.H5 Q 377 G.H5.26
Hydrophobic ECL2 W 176 - G.S3 V 216 G.S3.01
Van-der-waals ECL2 W 176 - G.S3 V 216 G.S3.01
Ionic TM5 E 190 5x37 G.hns1 K 46 G.hns1.02
Polar TM5 E 190 5x37 G.hns1 K 46 G.hns1.02
Hydrophobic TM5 E 190 5x37 G.hns1 K 46 G.hns1.02
Van-der-waals TM5 E 190 5x37 G.hns1 K 46 G.hns1.02
Hydrophobic ECL2 W 175 - G.H5 L 367 G.H5.16
Van-der-waals ECL2 W 175 - G.H5 L 367 G.H5.16
Hydrophobic ECL2 W 175 - G.S3 V 216 G.S3.01
Van-der-waals ECL2 W 175 - G.S3 V 216 G.S3.01
Ionic TM7 E 275 7x32 G.H5 K 372 G.H5.21
Polar TM7 E 275 7x32 G.H5 K 372 G.H5.21
Van-der-waals TM7 E 275 7x32 G.H5 K 372 G.H5.21
Hydrophobic ECL2 W 176 - G.S3 F 218 G.S3.03
Van-der-waals ECL2 W 176 - G.S3 F 218 G.S3.03
Hydrophobic TM6 F 263 6x61 G.H5 L 376 G.H5.25
Hydrophobic ECL2 W 175 - G.H5 L 371 G.H5.20
Hydrophobic ECL2 V 174 - G.s2s3 N 215 G.s2s3.02
Hydrophobic ECL2 Y 177 - G.H5 K 363 G.H5.12
Hydrophobic ECL2 W 175 - G.H5 L 374 G.H5.23
Van-der-waals ECL2 W 175 - G.H5 L 374 G.H5.23
Hydrophobic TM7 L 277 7x34 G.H5 L 376 G.H5.25
Van-der-waals TM7 L 277 7x34 G.H5 L 376 G.H5.25
Hydrophobic ECL2 F 185 - G.H5 L 374 G.H5.23
Polar ECL3 S 269 - G.h3s5 N 283 G.h3s5.02
Hydrophobic ECL3 S 269 - G.h3s5 N 283 G.h3s5.02
Van-der-waals ECL3 S 269 - G.h3s5 N 283 G.h3s5.02
Hydrophobic ECL2 W 175 - G.H5 N 370 G.H5.19
Hydrophobic ECL2 F 185 - G.HN T 43 G.HN.52
Hydrophobic TM7 W 274 7x31 G.H5 L 376 G.H5.25
Ionic TM5 E 190 5x37 G.HN K 42 G.HN.51
Polar TM5 E 190 5x37 G.HN K 42 G.HN.51
Van-der-waals TM5 E 190 5x37 G.HN K 42 G.HN.51
Polar TM6 Y 260 6x58 G.H5 L 376 G.H5.25
Hydrophobic TM6 Y 260 6x58 G.H5 L 376 G.H5.25
Van-der-waals TM6 Y 260 6x58 G.H5 L 376 G.H5.25
Hydrophobic ECL2 W 176 - G.S2 I 213 G.S2.08
Van-der-waals ECL2 W 176 - G.S2 I 213 G.S2.08
Hydrophobic ECL2 I 181 - G.H5 L 371 G.H5.20