Golf - GPR157 complex model

GPCR CLASS (FAMILY)

Other

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 81.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 22.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 A 223 6x33 G.H5 L 381 G.H5.26
Hydrophobic TM3 A 111 3x57 G.H5 D 368 G.H5.13
Van-der-waals TM3 A 111 3x57 G.H5 D 368 G.H5.13
Ionic ICL1 D 41 12x49 G.HN R 36 G.HN.51
Polar ICL1 D 41 12x49 G.HN R 36 G.HN.51
Hydrophobic ICL1 D 41 12x49 G.HN R 36 G.HN.51
Van-der-waals ICL1 D 41 12x49 G.HN R 36 G.HN.51
Hydrophobic TM2 R 47 2x40 G.H5 L 380 G.H5.25
Van-der-waals TM2 R 47 2x40 G.H5 L 380 G.H5.25
Polar ICL1 P 40 12x48 G.hns1 K 40 G.hns1.02
Hydrophobic ICL1 P 40 12x48 G.hns1 K 40 G.hns1.02
Van-der-waals ICL1 P 40 12x48 G.hns1 K 40 G.hns1.02
Hydrophobic TM3 S 107 3x53 G.H5 L 375 G.H5.20
Hydrophobic TM6 M 222 6x32 G.H5 K 376 G.H5.21
Hydrophobic H8 T 283 8x47 G.H5 E 379 G.H5.24
Van-der-waals H8 T 283 8x47 G.H5 E 379 G.H5.24
Hydrophobic TM6 S 221 6x31 G.h4s6 Y 345 G.h4s6.20
Polar TM6 H 219 6x29 G.h4s6 Y 345 G.h4s6.20
Aromatic TM6 H 219 6x29 G.h4s6 Y 345 G.h4s6.20
Hydrophobic TM6 H 219 6x29 G.h4s6 Y 345 G.h4s6.20
Van-der-waals TM6 H 219 6x29 G.h4s6 Y 345 G.h4s6.20
Polar ICL1 D 41 12x49 G.hns1 K 40 G.hns1.02
Hydrophobic ICL1 D 41 12x49 G.hns1 K 40 G.hns1.02
Van-der-waals ICL1 D 41 12x49 G.hns1 K 40 G.hns1.02
Van-der-waals TM3 S 107 3x53 G.H5 Q 371 G.H5.16
Polar TM3 A 111 3x57 G.H5 R 367 G.H5.12
Polar H8 R 284 8x48 G.H5 E 379 G.H5.24
Hydrophobic H8 R 284 8x48 G.H5 E 379 G.H5.24
Van-der-waals H8 R 284 8x48 G.H5 E 379 G.H5.24
Hydrophobic TM6 S 221 6x31 G.H5 K 376 G.H5.21
Polar TM6 K 226 6x36 G.H5 L 381 G.H5.26
Hydrophobic TM6 K 226 6x36 G.H5 L 381 G.H5.26
Van-der-waals TM6 K 226 6x36 G.H5 L 381 G.H5.26
Polar TM6 S 220 6x30 G.h4s6 Y 345 G.h4s6.20
Hydrophobic TM6 S 220 6x30 G.h4s6 Y 345 G.h4s6.20
Van-der-waals TM6 S 220 6x30 G.h4s6 Y 345 G.h4s6.20
Polar H8 A 285 8x49 G.H5 E 379 G.H5.24
Hydrophobic H8 A 285 8x49 G.H5 E 379 G.H5.24
Van-der-waals H8 A 285 8x49 G.H5 E 379 G.H5.24
Hydrophobic TM3 A 111 3x57 G.H5 Q 371 G.H5.16
Van-der-waals TM6 R 215 6x25 G.H5 R 372 G.H5.17
Hydrophobic TM4 G 114 4x35 G.s2s3 K 203 G.s2s3.02
Polar ICL2 R 113 - G.H5 Q 371 G.H5.16
Hydrophobic ICL2 R 113 - G.H5 Q 371 G.H5.16
Van-der-waals ICL2 R 113 - G.H5 Q 371 G.H5.16
Hydrophobic TM2 A 46 2x39 G.H5 L 380 G.H5.25
Van-der-waals TM2 A 46 2x39 G.H5 L 380 G.H5.25
Van-der-waals TM4 G 114 4x35 G.s2s3 D 202 G.s2s3.01
Polar TM4 G 114 4x35 G.s2s3 D 202 G.s2s3.01
Hydrophobic TM4 G 114 4x35 G.s2s3 D 202 G.s2s3.01
Hydrophobic TM4 P 115 4x36 G.s2s3 K 203 G.s2s3.02
Van-der-waals TM4 P 115 4x36 G.s2s3 K 203 G.s2s3.02
Ionic TM2 R 47 2x40 G.H5 E 379 G.H5.24
Polar TM2 R 47 2x40 G.H5 E 379 G.H5.24
Hydrophobic TM2 R 47 2x40 G.H5 E 379 G.H5.24
Van-der-waals TM2 R 47 2x40 G.H5 E 379 G.H5.24
Hydrophobic ICL2 R 113 - G.S3 V 204 G.S3.01
Van-der-waals ICL2 R 113 - G.S3 V 204 G.S3.01
Polar ICL1 R 43 12x51 G.hns1 K 40 G.hns1.02
Van-der-waals ICL1 R 43 12x51 G.hns1 K 40 G.hns1.02
Hydrophobic TM3 I 108 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM6 I 230 6x40 G.H5 L 381 G.H5.26
Polar TM3 I 108 3x54 G.H5 R 372 G.H5.17
Hydrophobic TM3 I 108 3x54 G.H5 R 372 G.H5.17
Van-der-waals TM3 I 108 3x54 G.H5 R 372 G.H5.17
Polar ICL2 R 113 - G.S1 H 43 G.S1.02
Hydrophobic ICL2 R 113 - G.S1 H 43 G.S1.02
Van-der-waals ICL2 R 113 - G.S1 H 43 G.S1.02
Hydrophobic TM2 R 45 2x38 G.H5 L 380 G.H5.25
Polar H8 V 286 8x50 G.H5 E 379 G.H5.24
Van-der-waals H8 V 286 8x50 G.H5 E 379 G.H5.24
Hydrophobic TM2 S 44 2x37 G.H5 L 380 G.H5.25
Van-der-waals TM2 S 44 2x37 G.H5 L 380 G.H5.25
Hydrophobic TM3 L 104 3x50 G.H5 L 381 G.H5.26
Van-der-waals TM3 L 104 3x50 G.H5 L 381 G.H5.26
Hydrophobic TM7 F 279 7x53 G.H5 L 381 G.H5.26
Van-der-waals TM7 F 279 7x53 G.H5 L 381 G.H5.26
Polar TM2 S 44 2x37 G.H5 Y 378 G.H5.23
Hydrophobic TM3 I 108 3x54 G.H5 L 381 G.H5.26