Gs - GPR157 complex model

GPCR CLASS (FAMILY)

Other

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 80.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 22.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM2 R 47 2x40 G.H5 Y 391 G.H5.23
Hydrophobic TM2 A 46 2x39 G.H5 L 393 G.H5.25
Van-der-waals TM2 A 46 2x39 G.H5 L 393 G.H5.25
Polar TM6 K 226 6x36 G.H5 L 394 G.H5.26
Hydrophobic TM6 K 226 6x36 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 226 6x36 G.H5 L 394 G.H5.26
Polar ICL2 R 113 - G.H5 Q 384 G.H5.16
Hydrophobic ICL2 R 113 - G.H5 Q 384 G.H5.16
Van-der-waals ICL2 R 113 - G.H5 Q 384 G.H5.16
Polar TM2 R 47 2x40 G.H5 E 392 G.H5.24
Hydrophobic TM2 R 47 2x40 G.H5 E 392 G.H5.24
Van-der-waals TM2 R 47 2x40 G.H5 E 392 G.H5.24
Polar ICL1 R 43 12x51 G.hns1 R 38 G.hns1.02
Van-der-waals ICL1 R 43 12x51 G.hns1 R 38 G.hns1.02
Hydrophobic TM3 S 107 3x53 G.H5 L 388 G.H5.20
Hydrophobic TM3 A 111 3x57 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 104 3x50 G.H5 L 394 G.H5.26
Van-der-waals TM3 L 104 3x50 G.H5 L 394 G.H5.26
Polar TM3 I 108 3x54 G.H5 R 385 G.H5.17
Hydrophobic TM3 I 108 3x54 G.H5 R 385 G.H5.17
Hydrophobic ICL1 R 43 12x51 G.H5 L 393 G.H5.25
Van-der-waals ICL1 R 43 12x51 G.H5 L 393 G.H5.25
Hydrophobic H8 T 283 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 T 283 8x47 G.H5 E 392 G.H5.24
Polar TM3 S 107 3x53 G.H5 Q 384 G.H5.16
Hydrophobic TM3 S 107 3x53 G.H5 Q 384 G.H5.16
Van-der-waals TM3 S 107 3x53 G.H5 Q 384 G.H5.16
Aromatic ICL2 R 113 - G.H5 H 387 G.H5.19
Hydrophobic TM2 A 46 2x39 G.H5 L 394 G.H5.26
Hydrophobic ICL1 L 42 12x50 G.H5 L 393 G.H5.25
Van-der-waals ICL1 L 42 12x50 G.H5 L 393 G.H5.25
Hydrophobic TM7 F 279 7x53 G.H5 L 394 G.H5.26
Van-der-waals TM7 F 279 7x53 G.H5 L 394 G.H5.26
Polar H8 A 285 8x49 G.H5 E 392 G.H5.24
Hydrophobic H8 A 285 8x49 G.H5 E 392 G.H5.24
Van-der-waals H8 A 285 8x49 G.H5 E 392 G.H5.24
Hydrophobic TM4 P 115 4x36 G.s2s3 K 216 G.s2s3.02
Van-der-waals TM4 P 115 4x36 G.s2s3 K 216 G.s2s3.02
Hydrophobic TM4 G 114 4x35 G.s2s3 K 216 G.s2s3.02
Polar TM4 G 114 4x35 G.s2s3 D 215 G.s2s3.01
Hydrophobic TM4 G 114 4x35 G.s2s3 D 215 G.s2s3.01
Van-der-waals TM4 G 114 4x35 G.s2s3 D 215 G.s2s3.01
Aromatic TM6 H 219 6x29 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 H 219 6x29 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM6 H 219 6x29 G.h4s6 Y 358 G.h4s6.20
Polar TM2 S 44 2x37 G.H5 L 393 G.H5.25
Hydrophobic TM2 S 44 2x37 G.H5 L 393 G.H5.25
Van-der-waals TM2 S 44 2x37 G.H5 L 393 G.H5.25
Polar ICL2 R 113 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 R 113 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 R 113 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 R 113 - G.s2s3 D 215 G.s2s3.01
Hydrophobic TM3 A 111 3x57 G.H5 R 380 G.H5.12
Van-der-waals TM3 A 111 3x57 G.H5 R 380 G.H5.12
Hydrophobic TM6 L 217 6x27 G.S6 Y 360 G.S6.02
Hydrophobic TM6 S 221 6x31 G.H5 R 389 G.H5.21
Van-der-waals TM6 S 221 6x31 G.H5 R 389 G.H5.21
Hydrophobic TM3 A 111 3x57 G.H5 D 381 G.H5.13
Van-der-waals TM3 A 111 3x57 G.H5 D 381 G.H5.13
Polar ICL1 P 40 12x48 G.hns1 R 38 G.hns1.02
Hydrophobic ICL1 P 40 12x48 G.hns1 R 38 G.hns1.02
Van-der-waals ICL1 P 40 12x48 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 R 113 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 R 113 - G.S3 V 217 G.S3.01
Hydrophobic TM3 I 108 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 108 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL1 D 41 12x49 G.HN K 34 G.HN.51
Polar ICL1 D 41 12x49 G.hns1 R 38 G.hns1.02
Hydrophobic ICL1 D 41 12x49 G.hns1 R 38 G.hns1.02
Van-der-waals ICL1 D 41 12x49 G.hns1 R 38 G.hns1.02
Polar H8 R 284 8x48 G.H5 E 392 G.H5.24
Hydrophobic H8 R 284 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 R 284 8x48 G.H5 E 392 G.H5.24
Hydrophobic TM3 I 100 3x46 G.H5 L 394 G.H5.26
Polar TM2 R 47 2x40 G.H5 L 393 G.H5.25
Hydrophobic TM2 R 47 2x40 G.H5 L 393 G.H5.25
Van-der-waals TM2 R 47 2x40 G.H5 L 393 G.H5.25
Polar TM6 H 214 6x24 G.H5 R 385 G.H5.17
Aromatic TM6 H 214 6x24 G.H5 R 385 G.H5.17
Hydrophobic TM6 H 214 6x24 G.H5 R 385 G.H5.17
Van-der-waals TM6 H 214 6x24 G.H5 R 385 G.H5.17