G14 - GPR160 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.2
PAE mean: 25.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic C-term P 320 - G.H3 T 256 G.H3.14
Van-der-waals C-term P 320 - G.H3 T 256 G.H3.14
Hydrophobic H8 K 302 8x53 G.h3s5 L 261 G.h3s5.01
Hydrophobic C-term P 320 - G.H3 P 258 G.H3.16
Van-der-waals C-term P 320 - G.H3 P 258 G.H3.16
Hydrophobic ICL2 F 132 - G.H5 V 355 G.H5.26
Van-der-waals ICL2 F 132 - G.H5 V 355 G.H5.26
Hydrophobic ICL3 I 221 - G.H2 I 213 G.H2.08
Hydrophobic C-term I 323 - G.H3 Y 257 G.H3.15
Van-der-waals C-term I 323 - G.H3 Y 257 G.H3.15
Polar H8 G 305 8x56 G.h3s5 N 262 G.h3s5.02
Hydrophobic H8 I 304 8x55 G.h3s5 L 261 G.h3s5.01
Van-der-waals H8 I 304 8x55 G.h3s5 L 261 G.h3s5.01
Hydrophobic C-term E 330 - G.H2 R 210 G.H2.05
Van-der-waals C-term E 330 - G.H2 R 210 G.H2.05
Polar TM5 Y 216 5x70 G.H2 C 215 G.H2.10
Hydrophobic TM5 Y 216 5x70 G.H2 C 215 G.H2.10
Van-der-waals TM5 Y 216 5x70 G.H2 C 215 G.H2.10
Ionic H8 K 302 8x53 G.h4s6 E 317 G.h4s6.12
Polar H8 K 302 8x53 G.h4s6 E 317 G.h4s6.12
Hydrophobic H8 K 302 8x53 G.h4s6 E 317 G.h4s6.12
Van-der-waals H8 K 302 8x53 G.h4s6 E 317 G.h4s6.12
Polar TM5 Y 216 5x70 G.h2s4 F 216 G.h2s4.01
Hydrophobic TM5 Y 216 5x70 G.h2s4 F 216 G.h2s4.01
Van-der-waals TM5 Y 216 5x70 G.h2s4 F 216 G.h2s4.01
Hydrophobic C-term I 319 - G.H3 P 258 G.H3.16
Van-der-waals C-term I 319 - G.H3 P 258 G.H3.16
Hydrophobic C-term I 333 - G.H2 S 207 G.H2.02
Van-der-waals C-term I 333 - G.H2 S 207 G.H2.02
Polar TM5 Y 216 5x70 G.h2s4 E 217 G.h2s4.02
Hydrophobic TM5 Y 216 5x70 G.h2s4 E 217 G.h2s4.02
Van-der-waals TM5 Y 216 5x70 G.h2s4 E 217 G.h2s4.02
Hydrophobic TM5 M 217 5x71 G.h2s4 E 217 G.h2s4.02
Van-der-waals TM5 M 217 5x71 G.h2s4 E 217 G.h2s4.02
Hydrophobic C-term K 315 - G.H3 P 258 G.H3.16
Van-der-waals C-term K 315 - G.H3 P 258 G.H3.16
Polar C-term T 322 - G.H3 T 253 G.H3.11
Hydrophobic C-term T 322 - G.H3 T 253 G.H3.11
Van-der-waals H8 K 302 8x53 G.h3s5 N 262 G.h3s5.02
Hydrophobic C-term I 319 - G.H3 W 259 G.H3.17
Van-der-waals C-term I 319 - G.H3 W 259 G.H3.17
Hydrophobic ICL3 Y 223 - G.H2 I 213 G.H2.08
Van-der-waals ICL3 Y 223 - G.H2 I 213 G.H2.08
Polar H8 I 304 8x55 G.h3s5 N 262 G.h3s5.02
Hydrophobic H8 I 304 8x55 G.h3s5 N 262 G.h3s5.02
Van-der-waals H8 I 304 8x55 G.h3s5 N 262 G.h3s5.02
Hydrophobic H8 L 301 8x52 G.H3 P 258 G.H3.16
Polar TM5 Y 216 5x70 G.H2 I 213 G.H2.08
Hydrophobic TM5 Y 216 5x70 G.H2 I 213 G.H2.08
Van-der-waals TM5 Y 216 5x70 G.H2 I 213 G.H2.08
Hydrophobic H8 K 302 8x53 G.h4s6 K 318 G.h4s6.13
Van-der-waals H8 K 302 8x53 G.h4s6 K 318 G.h4s6.13
Hydrophobic TM5 T 214 5x68 G.H2 I 213 G.H2.08
Hydrophobic H8 L 301 8x52 G.h3s5 L 261 G.h3s5.01
Van-der-waals H8 L 301 8x52 G.h3s5 L 261 G.h3s5.01
Ionic H8 K 302 8x53 G.h4s6 D 315 G.h4s6.10
Polar H8 K 302 8x53 G.h4s6 D 315 G.h4s6.10
Hydrophobic H8 K 302 8x53 G.h4s6 D 315 G.h4s6.10
Van-der-waals H8 K 302 8x53 G.h4s6 D 315 G.h4s6.10
Hydrophobic ICL3 I 221 - G.H3 W 259 G.H3.17
Van-der-waals ICL3 I 221 - G.H3 W 259 G.H3.17
Hydrophobic C-term I 329 - G.H2 R 206 G.H2.01
Aromatic ICL3 Y 223 - G.H3 W 259 G.H3.17
Hydrophobic ICL3 Y 223 - G.H3 W 259 G.H3.17
Van-der-waals ICL3 Y 223 - G.H3 W 259 G.H3.17
Hydrophobic H8 I 304 8x55 G.H3 P 258 G.H3.16
Van-der-waals H8 I 304 8x55 G.H3 P 258 G.H3.16
Polar C-term I 329 - G.H2 R 210 G.H2.05
Van-der-waals C-term I 329 - G.H2 R 210 G.H2.05
Hydrophobic C-term F 318 - G.H3 P 258 G.H3.16
Van-der-waals C-term F 318 - G.H3 P 258 G.H3.16
Hydrophobic C-term I 319 - G.H3 Y 257 G.H3.15
Polar TM5 Y 216 5x70 G.H2 H 214 G.H2.09
Hydrophobic TM5 Y 216 5x70 G.H2 H 214 G.H2.09
Van-der-waals TM5 Y 216 5x70 G.H2 H 214 G.H2.09
Polar C-term T 322 - G.H3 T 256 G.H3.14
Polar H8 N 300 8x51 G.h4s6 E 317 G.h4s6.12