Gq - GPR171 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 83.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 25.1


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 L 116 3x54 G.H5 L 358 G.H5.25
Van-der-waals TM3 L 116 3x54 G.H5 L 358 G.H5.25
Polar TM3 R 112 3x50 G.H5 N 357 G.H5.24
Van-der-waals TM3 R 112 3x50 G.H5 N 357 G.H5.24
Hydrophobic ICL2 K 121 34x52 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 K 121 34x52 G.hns1 R 37 G.hns1.02
Polar ICL2 R 124 34x55 G.HN K 33 G.HN.51
Hydrophobic ICL2 R 124 34x55 G.HN K 33 G.HN.51
Van-der-waals ICL2 R 124 34x55 G.HN K 33 G.HN.51
Polar TM6 K 220 6x32 G.H5 V 359 G.H5.26
Hydrophobic TM6 K 220 6x32 G.H5 V 359 G.H5.26
Van-der-waals TM6 K 220 6x32 G.H5 V 359 G.H5.26
Polar TM4 E 127 4x38 G.h2s4 N 222 G.h2s4.03
Van-der-waals TM4 E 127 4x38 G.h2s4 N 222 G.h2s4.03
Polar ICL2 R 124 34x55 G.hns1 R 37 G.hns1.02
Hydrophobic ICL2 R 124 34x55 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 R 124 34x55 G.hns1 R 37 G.hns1.02
Ionic TM2 R 47 2x37 G.H5 E 355 G.H5.22
Polar TM2 R 47 2x37 G.H5 E 355 G.H5.22
Hydrophobic TM2 R 47 2x37 G.H5 E 355 G.H5.22
Van-der-waals TM2 R 47 2x37 G.H5 E 355 G.H5.22
Polar TM6 N 224 6x36 G.H5 L 358 G.H5.25
Van-der-waals TM6 N 224 6x36 G.H5 L 358 G.H5.25
Hydrophobic ICL2 I 122 34x53 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 I 122 34x53 G.hns1 R 37 G.hns1.02
Ionic TM1 K 42 1x60 G.h4s6 D 321 G.h4s6.12
Polar TM1 K 42 1x60 G.h4s6 D 321 G.h4s6.12
Polar ICL2 C 120 34x51 G.hns1 R 38 G.hns1.03
Hydrophobic ICL2 C 120 34x51 G.hns1 R 38 G.hns1.03
Van-der-waals ICL2 C 120 34x51 G.hns1 R 38 G.hns1.03
Polar TM6 N 217 6x29 G.H5 K 354 G.H5.21
Hydrophobic TM6 N 217 6x29 G.H5 K 354 G.H5.21
Van-der-waals TM6 N 217 6x29 G.H5 K 354 G.H5.21
Hydrophobic TM3 R 112 3x50 G.H5 L 358 G.H5.25
Van-der-waals TM3 R 112 3x50 G.H5 L 358 G.H5.25
Polar TM3 Q 115 3x53 G.H5 Y 356 G.H5.23
Hydrophobic TM3 Q 115 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 Q 115 3x53 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 C 120 34x51 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 C 120 34x51 G.hns1 R 37 G.hns1.02
Polar ICL2 Y 123 34x54 G.hns1 R 37 G.hns1.02
Hydrophobic ICL2 Y 123 34x54 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 Y 123 34x54 G.hns1 R 37 G.hns1.02
Hydrophobic TM3 H 118 3x56 G.H5 L 353 G.H5.20
Van-der-waals TM3 H 118 3x56 G.H5 L 353 G.H5.20
Hydrophobic TM6 Y 215 6x27 G.H5 L 353 G.H5.20
Van-der-waals TM6 Y 215 6x27 G.H5 L 353 G.H5.20
Polar TM7 L 288 7x56 G.H5 N 357 G.H5.24
Hydrophobic TM7 L 288 7x56 G.H5 N 357 G.H5.24
Van-der-waals TM7 L 288 7x56 G.H5 N 357 G.H5.24
Hydrophobic TM3 H 118 3x56 G.s2s3 S 198 G.s2s3.02
Van-der-waals TM3 H 118 3x56 G.s2s3 S 198 G.s2s3.02
Polar ICL2 C 120 34x51 G.s2s3 S 198 G.s2s3.02
Hydrophobic ICL2 C 120 34x51 G.s2s3 S 198 G.s2s3.02
Hydrophobic ICL2 Y 123 34x54 G.H5 Y 356 G.H5.23
Van-der-waals ICL2 Y 123 34x54 G.H5 Y 356 G.H5.23
Polar ICL2 R 124 34x55 G.hns1 A 36 G.hns1.01
Hydrophobic ICL2 R 124 34x55 G.hns1 A 36 G.hns1.01
Van-der-waals ICL2 R 124 34x55 G.hns1 A 36 G.hns1.01
Hydrophobic TM3 Q 115 3x53 G.H5 L 358 G.H5.25
Van-der-waals TM3 Q 115 3x53 G.H5 L 358 G.H5.25
Polar TM6 N 217 6x29 G.H5 Q 350 G.H5.17
Van-der-waals TM6 N 217 6x29 G.H5 Q 350 G.H5.17
Hydrophobic ICL2 K 121 34x52 G.HN R 34 G.HN.52
Van-der-waals ICL2 K 121 34x52 G.HN R 34 G.HN.52
Polar TM6 A 221 6x33 G.H5 L 358 G.H5.25
Hydrophobic TM6 A 221 6x33 G.H5 L 358 G.H5.25
Van-der-waals TM6 A 221 6x33 G.H5 L 358 G.H5.25
Hydrophobic ICL2 I 125 34x56 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 I 125 34x56 G.hns1 R 37 G.hns1.02
Polar ICL2 Q 126 34x57 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 Q 126 34x57 G.H5 Y 356 G.H5.23
Van-der-waals ICL2 Q 126 34x57 G.H5 Y 356 G.H5.23
Hydrophobic TM6 N 217 6x29 G.H5 V 359 G.H5.26
Van-der-waals TM6 N 217 6x29 G.H5 V 359 G.H5.26
Polar ICL2 Y 123 34x54 G.h2s4 T 224 G.h2s4.05
Van-der-waals ICL2 Y 123 34x54 G.h2s4 T 224 G.h2s4.05
Polar TM3 H 118 3x56 G.H5 L 349 G.H5.16
Hydrophobic TM3 H 118 3x56 G.H5 L 349 G.H5.16
Van-der-waals TM3 H 118 3x56 G.H5 L 349 G.H5.16
Polar ICL2 S 119 34x50 G.s2s3 S 198 G.s2s3.02
Polar H8 K 290 8x48 G.H5 N 357 G.H5.24
Van-der-waals H8 K 290 8x48 G.H5 N 357 G.H5.24
Hydrophobic ICL2 Y 123 34x54 G.S1 L 40 G.S1.02
Van-der-waals ICL2 Y 123 34x54 G.S1 L 40 G.S1.02
Hydrophobic TM2 V 49 2x39 G.H5 Y 356 G.H5.23
Van-der-waals TM2 V 49 2x39 G.H5 Y 356 G.H5.23
Polar TM6 N 214 6x26 G.H5 Q 350 G.H5.17
Van-der-waals TM6 N 214 6x26 G.H5 Q 350 G.H5.17
Hydrophobic TM3 Q 115 3x53 G.H5 L 353 G.H5.20
Van-der-waals TM3 Q 115 3x53 G.H5 L 353 G.H5.20
Hydrophobic TM6 Y 215 6x27 G.H5 Q 350 G.H5.17
Hydrophobic TM3 L 116 3x54 G.H5 L 353 G.H5.20
Van-der-waals TM3 L 116 3x54 G.H5 L 353 G.H5.20
Polar ICL2 S 119 34x50 G.hns1 R 38 G.hns1.03
Hydrophobic ICL2 S 119 34x50 G.hns1 R 38 G.hns1.03
Van-der-waals ICL2 S 119 34x50 G.hns1 R 38 G.hns1.03
Polar ICL3 N 212 - G.H5 D 346 G.H5.13
Van-der-waals ICL3 N 212 - G.H5 D 346 G.H5.13
Polar ICL1 N 45 - G.h3s5 N 266 G.h3s5.02
Hydrophobic ICL1 N 45 - G.h3s5 N 266 G.h3s5.02
Van-der-waals ICL1 N 45 - G.h3s5 N 266 G.h3s5.02
Aromatic TM4 F 130 4x41 G.hns1 R 37 G.hns1.02
Hydrophobic TM4 F 130 4x41 G.hns1 R 37 G.hns1.02
Van-der-waals TM4 F 130 4x41 G.hns1 R 37 G.hns1.02
Polar TM6 N 224 6x36 G.H5 N 357 G.H5.24
Ionic ICL2 K 121 34x52 G.HN D 35 G.HN.53
Polar ICL2 K 121 34x52 G.HN D 35 G.HN.53
Hydrophobic ICL2 K 121 34x52 G.HN D 35 G.HN.53
Van-der-waals ICL2 K 121 34x52 G.HN D 35 G.HN.53
Hydrophobic ICL2 C 120 34x51 G.S3 V 199 G.S3.01
Van-der-waals ICL2 C 120 34x51 G.S3 V 199 G.S3.01
Hydrophobic ICL2 K 121 34x52 G.hns1 R 38 G.hns1.03
Van-der-waals ICL2 K 121 34x52 G.hns1 R 38 G.hns1.03
Polar ICL2 C 120 34x51 G.S3 I 200 G.S3.02
Hydrophobic ICL2 C 120 34x51 G.S3 I 200 G.S3.02
Van-der-waals ICL2 C 120 34x51 G.S3 I 200 G.S3.02
Hydrophobic H8 S 289 8x47 G.H5 N 357 G.H5.24