Gs - GPER complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 80.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 12.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 D 154 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM3 D 154 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 D 154 3x49 G.H5 Y 391 G.H5.23
Polar TM3 L 159 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 159 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 159 3x54 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 A 162 34x50 G.H5 I 383 G.H5.15
Polar TM6 R 248 6x24 G.hgh4 D 323 G.hgh4.13
Hydrophobic TM6 R 248 6x24 G.hgh4 D 323 G.hgh4.13
Van-der-waals TM6 R 248 6x24 G.hgh4 D 323 G.hgh4.13
Polar ICL2 S 166 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 S 166 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 S 166 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic TM7 Y 324 7x53 G.H5 E 392 G.H5.24
Van-der-waals TM7 Y 324 7x53 G.H5 E 392 G.H5.24
Polar TM3 R 155 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 155 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 155 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 L 159 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 L 159 3x54 G.H5 L 388 G.H5.20
Hydrophobic ICL2 A 162 34x50 G.H5 R 380 G.H5.12
Polar ICL2 M 163 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 M 163 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 M 163 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 M 163 34x51 G.S3 F 219 G.S3.03
Van-der-waals ICL2 M 163 34x51 G.S3 F 219 G.S3.03
Polar TM6 A 257 6x33 G.H5 L 393 G.H5.25
Hydrophobic TM6 A 257 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 A 257 6x33 G.H5 L 393 G.H5.25
Polar H8 E 329 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 E 329 8x48 G.H5 E 392 G.H5.24
Hydrophobic ICL2 M 163 34x51 G.H5 C 379 G.H5.11
Van-der-waals ICL2 M 163 34x51 G.H5 C 379 G.H5.11
Hydrophobic TM2 F 98 2x43 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 C 165 34x53 G.H5 H 387 G.H5.19
Van-der-waals ICL2 C 165 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 M 163 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL2 M 163 34x51 G.H5 R 380 G.H5.12
Van-der-waals ICL2 M 163 34x51 G.H5 R 380 G.H5.12
Hydrophobic TM6 R 253 6x29 G.H5 L 394 G.H5.26
Van-der-waals TM6 R 253 6x29 G.H5 L 394 G.H5.26
Hydrophobic TM3 L 159 3x54 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 158 3x53 G.H5 Y 391 G.H5.23
Polar H8 T 330 8x49 G.H5 E 392 G.H5.24
Hydrophobic H8 T 330 8x49 G.H5 E 392 G.H5.24
Van-der-waals H8 T 330 8x49 G.H5 E 392 G.H5.24
Hydrophobic ICL2 M 163 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 M 163 34x51 G.H5 I 383 G.H5.15
Hydrophobic TM2 P 94 2x39 G.H5 Q 390 G.H5.22
Van-der-waals TM2 P 94 2x39 G.H5 Q 390 G.H5.22
Polar TM3 A 158 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 A 158 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 A 158 3x53 G.H5 H 387 G.H5.19
Ionic ICL3 H 245 - G.H5 D 381 G.H5.13
Polar ICL3 H 245 - G.H5 D 381 G.H5.13
Hydrophobic ICL3 H 245 - G.H5 D 381 G.H5.13
Van-der-waals ICL3 H 245 - G.H5 D 381 G.H5.13
Ionic H8 D 333 8x52 G.H5 R 389 G.H5.21
Polar H8 D 333 8x52 G.H5 R 389 G.H5.21
Van-der-waals H8 D 333 8x52 G.H5 R 389 G.H5.21
Polar ICL2 R 169 34x57 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 R 169 34x57 G.H5 Y 391 G.H5.23
Van-der-waals ICL2 R 169 34x57 G.H5 Y 391 G.H5.23
Hydrophobic TM5 V 240 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 V 240 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM7 S 325 7x54 G.H5 E 392 G.H5.24
Polar H8 F 331 8x50 G.H5 E 392 G.H5.24
Hydrophobic H8 F 331 8x50 G.H5 E 392 G.H5.24
Van-der-waals H8 F 331 8x50 G.H5 E 392 G.H5.24
Polar ICL2 R 169 34x57 G.H5 H 387 G.H5.19
Aromatic ICL2 R 169 34x57 G.H5 H 387 G.H5.19
Van-der-waals ICL2 R 169 34x57 G.H5 H 387 G.H5.19
Polar H8 G 328 8x47 G.H5 E 392 G.H5.24
Hydrophobic H8 G 328 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 G 328 8x47 G.H5 E 392 G.H5.24
Hydrophobic TM6 A 257 6x33 G.H5 L 388 G.H5.20
Polar H8 T 330 8x49 G.H5 R 389 G.H5.21
Hydrophobic H8 T 330 8x49 G.H5 R 389 G.H5.21
Van-der-waals H8 T 330 8x49 G.H5 R 389 G.H5.21
Ionic H8 D 333 8x52 G.h4s6 R 356 G.h4s6.12
Hydrophobic TM2 F 98 2x43 G.H5 E 392 G.H5.24
Hydrophobic TM6 L 250 6x26 G.H5 D 381 G.H5.13
Hydrophobic ICL2 A 162 34x50 G.H5 Q 384 G.H5.16
Van-der-waals ICL2 A 162 34x50 G.H5 Q 384 G.H5.16
Hydrophobic TM2 T 92 2x37 G.H5 Q 390 G.H5.22
Hydrophobic ICL2 M 163 34x51 G.S3 V 217 G.S3.01
Van-der-waals TM4 T 170 4x38 G.hns1 R 38 G.hns1.02
Hydrophobic TM2 P 94 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 P 94 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 155 3x50 G.H5 L 393 G.H5.25
Hydrophobic ICL2 R 164 34x52 G.S3 V 217 G.S3.01
Hydrophobic ICL2 L 167 34x55 G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 L 167 34x55 G.hns1 A 39 G.hns1.03
Polar TM6 R 253 6x29 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 R 253 6x29 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM6 R 253 6x29 G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 I 261 6x37 G.H5 L 393 G.H5.25
Polar H8 E 329 8x48 G.H5 L 394 G.H5.26
Hydrophobic H8 E 329 8x48 G.H5 L 394 G.H5.26
Van-der-waals H8 E 329 8x48 G.H5 L 394 G.H5.26
Hydrophobic TM6 L 250 6x26 G.H5 R 385 G.H5.17
Van-der-waals TM6 L 250 6x26 G.H5 R 385 G.H5.17
Polar ICL2 R 164 34x52 G.s2s3 D 215 G.s2s3.01
Hydrophobic ICL2 R 164 34x52 G.s2s3 D 215 G.s2s3.01
Van-der-waals ICL2 R 164 34x52 G.s2s3 D 215 G.s2s3.01
Van-der-waals H8 G 328 8x47 G.H5 L 394 G.H5.26
Hydrophobic TM6 M 260 6x36 G.H5 L 393 G.H5.25
Polar ICL2 R 164 34x52 G.s2s3 K 216 G.s2s3.02
Hydrophobic ICL2 R 164 34x52 G.s2s3 K 216 G.s2s3.02
Hydrophobic TM5 L 241 5x65 G.H5 L 388 G.H5.20
Polar TM6 K 256 6x32 G.H5 L 394 G.H5.26
Hydrophobic TM6 K 256 6x32 G.H5 L 394 G.H5.26
Van-der-waals TM6 K 256 6x32 G.H5 L 394 G.H5.26
Polar ICL2 S 166 34x54 G.hns1 A 39 G.hns1.03