Gt1 - GPR12 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 80.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 16.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 T 246 6x30 G.H5 F 350 G.H5.26
Hydrophobic TM2 M 79 2x39 G.H5 D 346 G.H5.22
Van-der-waals TM2 M 79 2x39 G.H5 D 346 G.H5.22
Hydrophobic TM3 Y 144 3x56 G.hns1 A 27 G.hns1.02
Van-der-waals TM3 Y 144 3x56 G.hns1 A 27 G.hns1.02
Hydrophobic TM3 L 142 3x54 G.H5 N 343 G.H5.19
Polar TM3 Y 143 3x55 G.hns1 R 28 G.hns1.03
Hydrophobic TM3 Y 143 3x55 G.hns1 R 28 G.hns1.03
Van-der-waals TM6 K 248 6x32 G.H5 F 350 G.H5.26
Hydrophobic TM5 I 220 5x61 G.H5 L 349 G.H5.25
Van-der-waals TM5 I 220 5x61 G.H5 L 349 G.H5.25
Hydrophobic C-term V 334 - G.H3 H 244 G.H3.07
Hydrophobic ICL2 A 145 34x50 G.H5 I 340 G.H5.16
Hydrophobic ICL2 L 146 34x51 G.H5 I 339 G.H5.15
Van-der-waals ICL2 L 146 34x51 G.H5 I 339 G.H5.15
Hydrophobic TM5 Q 230 5x71 G.H5 D 337 G.H5.13
Van-der-waals TM5 Q 230 5x71 G.H5 D 337 G.H5.13
Polar TM5 Q 234 5x75 G.H5 D 333 G.H5.09
Hydrophobic TM5 Q 234 5x75 G.H5 D 333 G.H5.09
Van-der-waals TM5 Q 234 5x75 G.H5 D 333 G.H5.09
Hydrophobic ICL3 L 238 - G.S6 H 318 G.S6.04
Hydrophobic ICL2 T 147 34x52 G.hns1 D 26 G.hns1.01
Van-der-waals ICL2 T 147 34x52 G.hns1 D 26 G.hns1.01
Ionic C-term R 327 - G.h4s6 D 311 G.h4s6.09
Polar C-term R 327 - G.h4s6 D 311 G.h4s6.09
Van-der-waals C-term R 327 - G.h4s6 D 311 G.h4s6.09
Polar ICL2 L 146 34x51 G.h2s4 T 215 G.h2s4.05
Hydrophobic ICL2 L 146 34x51 G.h2s4 T 215 G.h2s4.05
Van-der-waals ICL2 L 146 34x51 G.h2s4 T 215 G.h2s4.05
Hydrophobic TM6 H 242 6x26 G.S6 Y 316 G.S6.02
Hydrophobic C-term V 334 - G.H3 S 248 G.H3.11
Van-der-waals C-term V 334 - G.H3 S 248 G.H3.11
Polar ICL2 A 145 34x50 G.H5 N 343 G.H5.19
Hydrophobic ICL2 A 145 34x50 G.H5 N 343 G.H5.19
Van-der-waals ICL2 A 145 34x50 G.H5 N 343 G.H5.19
Hydrophobic TM5 V 224 5x65 G.H5 L 344 G.H5.20
Van-der-waals TM5 V 224 5x65 G.H5 L 344 G.H5.20
Hydrophobic ICL3 L 238 - G.H5 F 330 G.H5.06
Ionic TM5 H 227 5x68 G.H5 D 337 G.H5.13
Polar TM5 H 227 5x68 G.H5 D 337 G.H5.13
Van-der-waals TM5 H 227 5x68 G.H5 D 337 G.H5.13
Hydrophobic ICL2 R 152 - G.HN A 23 G.HN.51
Van-der-waals ICL2 R 152 - G.HN A 23 G.HN.51
Polar ICL2 T 147 34x52 G.hns1 A 27 G.hns1.02
Hydrophobic ICL2 T 147 34x52 G.hns1 A 27 G.hns1.02
Van-der-waals ICL2 T 147 34x52 G.hns1 A 27 G.hns1.02
Polar TM3 S 141 3x53 G.H5 C 347 G.H5.23
Hydrophobic TM3 S 141 3x53 G.H5 C 347 G.H5.23
Van-der-waals TM3 S 141 3x53 G.H5 C 347 G.H5.23
Hydrophobic TM5 H 227 5x68 G.H5 I 340 G.H5.16
Van-der-waals TM5 H 227 5x68 G.H5 I 340 G.H5.16
Polar TM5 Q 234 5x75 G.H5 A 334 G.H5.10
Hydrophobic TM5 Q 234 5x75 G.H5 A 334 G.H5.10
Van-der-waals TM5 Q 234 5x75 G.H5 A 334 G.H5.10
Hydrophobic TM5 I 231 5x72 G.H5 D 337 G.H5.13
Van-der-waals TM5 I 231 5x72 G.H5 D 337 G.H5.13
Polar ICL2 R 152 - G.HN L 19 G.HN.47
Van-der-waals ICL2 R 152 - G.HN L 19 G.HN.47
Ionic ICL2 R 152 - G.hns1 D 26 G.hns1.01
Polar ICL2 R 152 - G.hns1 D 26 G.hns1.01
Van-der-waals ICL2 R 152 - G.hns1 D 26 G.hns1.01
Hydrophobic TM6 T 245 6x29 G.H5 F 350 G.H5.26
Van-der-waals TM6 T 245 6x29 G.H5 F 350 G.H5.26
Hydrophobic TM3 L 142 3x54 G.H5 C 347 G.H5.23
Ionic ICL2 H 149 - G.H5 D 346 G.H5.22
Hydrophobic TM3 L 142 3x54 G.H5 L 344 G.H5.20
Van-der-waals TM3 L 142 3x54 G.H5 L 344 G.H5.20
Ionic H8 K 310 8x52 G.h4s6 D 311 G.h4s6.09
Polar H8 K 310 8x52 G.h4s6 D 311 G.h4s6.09
Van-der-waals H8 K 310 8x52 G.h4s6 D 311 G.h4s6.09
Hydrophobic C-term R 327 - G.h4s6 R 309 G.h4s6.04
Hydrophobic C-term P 331 - G.H3 N 251 G.H3.14
Hydrophobic ICL2 L 146 34x51 G.S1 V 30 G.S1.02
Van-der-waals ICL2 L 146 34x51 G.S1 V 30 G.S1.02
Hydrophobic TM3 R 138 3x50 G.H5 L 349 G.H5.25
Van-der-waals TM3 R 138 3x50 G.H5 L 349 G.H5.25
Polar TM3 Y 144 3x56 G.hns1 R 28 G.hns1.03
Hydrophobic TM3 Y 144 3x56 G.hns1 R 28 G.hns1.03
Van-der-waals TM3 Y 144 3x56 G.hns1 R 28 G.hns1.03
Polar TM3 S 141 3x53 G.H5 N 343 G.H5.19
Polar TM6 H 242 6x26 G.H5 K 341 G.H5.17
Hydrophobic TM6 H 242 6x26 G.H5 K 341 G.H5.17
Van-der-waals TM6 H 242 6x26 G.H5 K 341 G.H5.17
Hydrophobic TM5 Q 234 5x75 G.H5 F 330 G.H5.06
Van-der-waals TM5 Q 234 5x75 G.H5 F 330 G.H5.06
Hydrophobic TM6 L 253 6x37 G.H5 L 349 G.H5.25
Van-der-waals TM6 L 253 6x37 G.H5 L 349 G.H5.25
Hydrophobic ICL2 L 146 34x51 G.S3 L 190 G.S3.01
Van-der-waals ICL2 L 146 34x51 G.S3 L 190 G.S3.01
Hydrophobic ICL2 T 147 34x52 G.S1 T 29 G.S1.01
Van-der-waals ICL2 T 147 34x52 G.S1 T 29 G.S1.01
Polar C-term R 327 - G.h4s6 M 308 G.h4s6.03
Hydrophobic C-term R 327 - G.h4s6 M 308 G.h4s6.03
Van-der-waals C-term R 327 - G.h4s6 M 308 G.h4s6.03
Ionic TM6 H 242 6x26 G.h4s6 E 314 G.h4s6.12
Hydrophobic TM3 L 142 3x54 G.H5 L 349 G.H5.25
Polar TM5 Q 230 5x71 G.s2s3 K 188 G.s2s3.01
Hydrophobic TM5 Q 230 5x71 G.s2s3 K 188 G.s2s3.01
Van-der-waals TM5 Q 230 5x71 G.s2s3 K 188 G.s2s3.01
Hydrophobic TM6 G 249 6x33 G.H5 L 349 G.H5.25
Van-der-waals TM6 G 249 6x33 G.H5 L 349 G.H5.25
Hydrophobic TM6 I 256 6x40 G.H5 L 349 G.H5.25
Polar TM5 Q 234 5x75 G.H5 D 337 G.H5.13
Van-der-waals TM5 Q 234 5x75 G.H5 D 337 G.H5.13
Hydrophobic ICL2 R 152 - G.HN D 22 G.HN.50
Hydrophobic ICL2 T 147 34x52 G.hns1 R 28 G.hns1.03
Hydrophobic ICL3 F 237 - G.H5 F 330 G.H5.06
Van-der-waals ICL3 F 237 - G.H5 F 330 G.H5.06
Polar TM3 R 138 3x50 G.H5 C 347 G.H5.23
Hydrophobic TM3 R 138 3x50 G.H5 C 347 G.H5.23
Van-der-waals TM3 R 138 3x50 G.H5 C 347 G.H5.23