G12 - GPR32 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 16.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 P 254 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 P 254 6x33 G.H5 M 379 G.H5.24
Hydrophobic ICL2 L 150 34x54 G.S1 V 58 G.S1.02
Aromatic ICL2 H 152 34x56 G.hns1 R 56 G.hns1.03
Polar H8 G 320 8x47 G.H5 M 379 G.H5.24
Hydrophobic H8 G 320 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 G 320 8x47 G.H5 M 379 G.H5.24
Hydrophobic ICL2 L 150 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 L 150 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 L 150 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 P 146 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 146 34x50 G.H5 K 367 G.H5.12
Hydrophobic ICL2 V 147 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 V 147 34x51 G.S3 I 221 G.S3.01
Ionic TM5 E 246 5x68 G.H5 K 367 G.H5.12
Hydrophobic ICL3 W 248 - G.H5 L 375 G.H5.20
Van-der-waals ICL3 W 248 - G.H5 L 375 G.H5.20
Polar ICL2 P 146 34x50 G.H5 N 374 G.H5.19
Van-der-waals ICL2 P 146 34x50 G.H5 N 374 G.H5.19
Polar H8 D 322 8x49 G.H5 L 380 G.H5.25
Hydrophobic H8 D 322 8x49 G.H5 L 380 G.H5.25
Van-der-waals H8 D 322 8x49 G.H5 L 380 G.H5.25
Hydrophobic ICL2 P 146 34x50 G.H5 L 371 G.H5.16
Polar TM3 S 142 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 S 142 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 S 142 3x53 G.H5 N 374 G.H5.19
Hydrophobic ICL2 P 146 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 146 34x50 G.H5 I 370 G.H5.15
Polar TM4 Q 156 4x40 G.HN R 52 G.HN.52
Hydrophobic TM4 Q 156 4x40 G.HN R 52 G.HN.52
Van-der-waals TM4 Q 156 4x40 G.HN R 52 G.HN.52
Hydrophobic TM2 F 81 2x43 G.H5 L 380 G.H5.25
Van-der-waals TM2 F 81 2x43 G.H5 L 380 G.H5.25
Hydrophobic ICL3 W 248 - G.H5 L 371 G.H5.16
Van-der-waals ICL3 W 248 - G.H5 L 371 G.H5.16
Hydrophobic ICL3 W 248 - G.H5 D 368 G.H5.13
Van-der-waals ICL3 W 248 - G.H5 D 368 G.H5.13
Hydrophobic TM6 R 253 6x32 G.H5 M 379 G.H5.24
Hydrophobic H8 D 322 8x49 G.H5 Q 381 G.H5.26
Polar TM3 R 139 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 139 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 139 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 V 143 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 143 3x54 G.H5 L 371 G.H5.16
Hydrophobic TM5 L 243 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 L 243 5x65 G.H5 L 375 G.H5.20
Hydrophobic TM5 E 246 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 E 246 5x68 G.H5 L 371 G.H5.16
Hydrophobic ICL2 V 147 34x51 G.H5 K 367 G.H5.12
Hydrophobic TM7 V 319 7x56 G.H5 M 379 G.H5.24
Hydrophobic TM3 V 143 3x54 G.H5 L 375 G.H5.20
Polar ICL2 N 151 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 N 151 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 N 151 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic TM3 S 142 3x53 G.H5 I 378 G.H5.23
Hydrophobic TM4 V 155 4x39 G.HN R 52 G.HN.52
Van-der-waals TM4 V 155 4x39 G.HN R 52 G.HN.52
Hydrophobic H8 R 321 8x48 G.H5 Q 381 G.H5.26
Hydrophobic ICL3 W 248 - G.H5 Q 372 G.H5.17
Van-der-waals ICL3 W 248 - G.H5 Q 372 G.H5.17
Ionic ICL2 R 153 34x57 G.H5 D 377 G.H5.22
Polar ICL2 R 153 34x57 G.H5 D 377 G.H5.22
Van-der-waals ICL2 R 153 34x57 G.H5 D 377 G.H5.22
Hydrophobic H8 G 320 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 G 320 8x47 G.H5 L 380 G.H5.25
Hydrophobic TM4 T 154 4x38 G.HN R 52 G.HN.52
Hydrophobic ICL2 V 147 34x51 G.H5 I 370 G.H5.15
Hydrophobic TM3 V 143 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 V 143 3x54 G.H5 I 378 G.H5.23
Polar TM2 S 77 2x39 G.H5 D 377 G.H5.22
Hydrophobic TM2 S 77 2x39 G.H5 D 377 G.H5.22
Van-der-waals TM2 S 77 2x39 G.H5 D 377 G.H5.22
Polar H8 R 321 8x48 G.H5 L 380 G.H5.25
Van-der-waals H8 R 321 8x48 G.H5 L 380 G.H5.25
Hydrophobic TM6 L 257 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM6 L 257 6x36 G.H5 M 379 G.H5.24
Hydrophobic ICL2 L 150 34x54 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 150 34x54 G.H5 I 370 G.H5.15
Hydrophobic TM7 V 317 7x54 G.H5 L 380 G.H5.25
Van-der-waals TM7 V 317 7x54 G.H5 L 380 G.H5.25
Hydrophobic TM7 Y 316 7x53 G.H5 L 380 G.H5.25
Van-der-waals TM7 Y 316 7x53 G.H5 L 380 G.H5.25