Gi2 - GPR32 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 12.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 146 34x50 G.H5 I 345 G.H5.16
Van-der-waals ICL2 P 146 34x50 G.H5 I 345 G.H5.16
Hydrophobic TM5 L 243 5x65 G.H5 L 349 G.H5.20
Polar ICL3 H 250 - G.h4s6 D 316 G.h4s6.09
Hydrophobic ICL3 H 250 - G.h4s6 D 316 G.h4s6.09
Van-der-waals ICL3 H 250 - G.h4s6 D 316 G.h4s6.09
Hydrophobic TM3 R 139 3x50 G.H5 L 354 G.H5.25
Hydrophobic TM3 V 143 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 V 143 3x54 G.H5 L 349 G.H5.20
Hydrophobic TM4 T 154 4x38 G.hns1 R 32 G.hns1.03
Van-der-waals TM4 T 154 4x38 G.hns1 R 32 G.hns1.03
Polar ICL3 W 248 - G.H5 D 342 G.H5.13
Hydrophobic ICL3 W 248 - G.H5 D 342 G.H5.13
Van-der-waals ICL3 W 248 - G.H5 D 342 G.H5.13
Hydrophobic ICL3 W 248 - G.H5 I 345 G.H5.16
Van-der-waals ICL3 W 248 - G.H5 I 345 G.H5.16
Polar ICL3 H 250 - G.h4s6 T 317 G.h4s6.10
Hydrophobic ICL2 L 150 34x54 G.S3 L 195 G.S3.01
Van-der-waals ICL2 L 150 34x54 G.S3 L 195 G.S3.01
Polar ICL2 N 151 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 N 151 34x55 G.hns1 R 32 G.hns1.03
Polar TM3 R 139 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM3 R 139 3x50 G.H5 C 352 G.H5.23
Van-der-waals TM3 R 139 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM5 K 242 5x64 G.H5 I 345 G.H5.16
Hydrophobic TM3 V 143 3x54 G.H5 I 345 G.H5.16
Van-der-waals ICL2 V 147 34x51 G.s2s3 K 193 G.s2s3.01
Hydrophobic ICL2 L 150 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 L 150 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic TM5 L 243 5x65 G.H5 I 345 G.H5.16
Hydrophobic TM6 L 258 6x37 G.H5 L 354 G.H5.25
Hydrophobic TM6 P 254 6x33 G.H5 F 355 G.H5.26
Ionic ICL2 R 153 34x57 G.H5 D 351 G.H5.22
Polar ICL2 R 153 34x57 G.H5 D 351 G.H5.22
Van-der-waals ICL2 R 153 34x57 G.H5 D 351 G.H5.22
Ionic H8 D 322 8x49 G.H5 K 350 G.H5.21
Polar H8 D 322 8x49 G.H5 K 350 G.H5.21
Hydrophobic H8 D 322 8x49 G.H5 K 350 G.H5.21
Van-der-waals H8 D 322 8x49 G.H5 K 350 G.H5.21
Polar TM2 T 75 2x37 G.H5 D 351 G.H5.22
Hydrophobic TM2 T 75 2x37 G.H5 D 351 G.H5.22
Van-der-waals TM2 T 75 2x37 G.H5 D 351 G.H5.22
Hydrophobic ICL3 H 250 - G.H5 F 355 G.H5.26
Hydrophobic ICL2 V 147 34x51 G.H5 F 337 G.H5.08
Hydrophobic ICL2 V 147 34x51 G.S3 L 195 G.S3.01
Hydrophobic ICL2 L 150 34x54 G.S1 V 34 G.S1.02
Polar ICL2 N 151 34x55 G.s2s3 D 194 G.s2s3.02
Van-der-waals ICL2 N 151 34x55 G.s2s3 D 194 G.s2s3.02
Hydrophobic TM2 F 81 2x43 G.H5 C 352 G.H5.23
Polar TM6 P 254 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM6 P 254 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 P 254 6x33 G.H5 L 354 G.H5.25
Polar ICL3 H 250 - G.h4s6 K 315 G.h4s6.08
Hydrophobic ICL3 H 250 - G.h4s6 K 315 G.h4s6.08
Van-der-waals ICL3 H 250 - G.h4s6 K 315 G.h4s6.08
Polar ICL2 R 153 34x57 G.H5 C 352 G.H5.23
Hydrophobic ICL2 P 146 34x50 G.H5 I 344 G.H5.15
Hydrophobic ICL3 W 248 - G.H5 K 346 G.H5.17
Van-der-waals ICL3 W 248 - G.H5 K 346 G.H5.17
Hydrophobic ICL2 L 150 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 L 150 34x54 G.hns1 A 31 G.hns1.02
Polar TM2 S 77 2x39 G.H5 D 351 G.H5.22
Hydrophobic TM2 S 77 2x39 G.H5 D 351 G.H5.22
Van-der-waals TM2 S 77 2x39 G.H5 D 351 G.H5.22
Hydrophobic TM6 P 254 6x33 G.H5 L 349 G.H5.20
Hydrophobic TM6 L 261 6x40 G.H5 L 354 G.H5.25
Polar TM6 R 253 6x32 G.H5 F 355 G.H5.26
Hydrophobic TM6 R 253 6x32 G.H5 F 355 G.H5.26
Van-der-waals TM6 R 253 6x32 G.H5 F 355 G.H5.26
Polar H8 G 320 8x47 G.H5 G 353 G.H5.24
Hydrophobic H8 G 320 8x47 G.H5 G 353 G.H5.24
Hydrophobic ICL3 W 248 - G.H5 L 349 G.H5.20
Hydrophobic TM6 L 257 6x36 G.H5 L 354 G.H5.25
Van-der-waals TM6 L 257 6x36 G.H5 L 354 G.H5.25
Hydrophobic ICL2 V 147 34x51 G.s2s3 D 194 G.s2s3.02
Polar TM3 S 142 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 S 142 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 S 142 3x53 G.H5 N 348 G.H5.19
Polar TM2 S 77 2x39 G.H5 C 352 G.H5.23
Hydrophobic TM2 S 77 2x39 G.H5 C 352 G.H5.23
Hydrophobic ICL2 P 146 34x50 G.H5 T 341 G.H5.12
Van-der-waals ICL2 P 146 34x50 G.H5 T 341 G.H5.12
Hydrophobic ICL2 L 150 34x54 G.H5 I 344 G.H5.15
Hydrophobic TM5 E 246 5x68 G.H5 I 345 G.H5.16