G12 - GPR34 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 75.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 23.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Van-der-waals TM6 S 258 6x27 G.H5 K 376 G.H5.21
Hydrophobic ICL2 R 163 34x54 G.s2s3 K 220 G.s2s3.02
Polar TM6 Y 261 6x30 G.H5 T 369 G.H5.14
Hydrophobic TM2 N 87 2x37 G.hns1 R 55 G.hns1.02
Van-der-waals TM2 N 87 2x37 G.hns1 R 55 G.hns1.02
Hydrophobic TM6 N 267 6x36 G.H5 L 380 G.H5.25
Polar TM7 S 332 7x58 G.H5 L 380 G.H5.25
Van-der-waals TM7 S 332 7x58 G.H5 L 380 G.H5.25
Hydrophobic ICL2 I 160 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 I 160 34x51 G.S3 I 221 G.S3.01
Hydrophobic TM3 K 155 3x53 G.H5 M 379 G.H5.24
Polar TM2 Q 90 2x40 G.hns1 R 55 G.hns1.02
Van-der-waals TM2 Q 90 2x40 G.hns1 R 55 G.hns1.02
Polar TM6 Y 261 6x30 G.H5 E 373 G.H5.18
Hydrophobic TM6 Y 261 6x30 G.H5 E 373 G.H5.18
Van-der-waals TM6 Y 261 6x30 G.H5 E 373 G.H5.18
Polar TM7 N 333 7x59 G.H5 Q 381 G.H5.26
Hydrophobic TM7 N 333 7x59 G.H5 Q 381 G.H5.26
Van-der-waals TM7 N 333 7x59 G.H5 Q 381 G.H5.26
Hydrophobic TM7 M 330 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 M 330 7x56 G.H5 L 380 G.H5.25
Hydrophobic ICL1 R 84 - G.HN R 51 G.HN.51
Hydrophobic TM3 I 156 3x54 G.H5 M 379 G.H5.24
Van-der-waals TM3 I 156 3x54 G.H5 M 379 G.H5.24
Hydrophobic TM6 P 256 6x25 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 P 256 6x25 G.h4s6 P 345 G.h4s6.20
Ionic TM6 K 260 6x29 G.H5 E 373 G.H5.18
Polar TM6 K 260 6x29 G.H5 E 373 G.H5.18
Van-der-waals TM6 K 260 6x29 G.H5 E 373 G.H5.18
Hydrophobic TM6 T 264 6x33 G.H5 M 379 G.H5.24
Hydrophobic TM6 T 264 6x33 G.H5 L 380 G.H5.25
Van-der-waals TM6 T 264 6x33 G.H5 L 380 G.H5.25
Polar TM7 S 332 7x58 G.H5 Q 381 G.H5.26
Van-der-waals TM7 S 332 7x58 G.H5 Q 381 G.H5.26
Polar TM7 M 330 7x56 G.H5 Q 381 G.H5.26
Ionic TM6 K 260 6x29 G.H5 D 377 G.H5.22
Polar TM6 K 260 6x29 G.H5 D 377 G.H5.22
Hydrophobic TM6 K 260 6x29 G.H5 D 377 G.H5.22
Van-der-waals TM6 K 260 6x29 G.H5 D 377 G.H5.22
Polar TM6 N 257 6x26 G.h3s5 V 289 G.h3s5.03
Van-der-waals TM6 N 257 6x26 G.h3s5 V 289 G.h3s5.03
Hydrophobic TM6 K 254 6x23 G.S6 F 347 G.S6.02
Van-der-waals TM6 K 254 6x23 G.S6 F 347 G.S6.02
Polar ICL1 K 85 - G.HN A 48 G.HN.48
Hydrophobic ICL1 K 85 - G.HN A 48 G.HN.48
Van-der-waals ICL1 K 85 - G.HN A 48 G.HN.48
Hydrophobic TM2 I 89 2x39 G.H5 Q 381 G.H5.26
Van-der-waals TM2 I 89 2x39 G.H5 Q 381 G.H5.26
Polar TM3 R 152 3x50 G.H5 M 379 G.H5.24
Polar TM6 N 257 6x26 G.h4s6 K 344 G.h4s6.19
Hydrophobic TM6 N 257 6x26 G.h4s6 K 344 G.h4s6.19
Van-der-waals TM6 N 257 6x26 G.h4s6 K 344 G.h4s6.19
Van-der-waals TM6 N 257 6x26 G.S5 S 290 G.S5.01
Hydrophobic TM6 P 256 6x25 G.S6 F 347 G.S6.02
Van-der-waals TM6 P 256 6x25 G.S6 F 347 G.S6.02
Aromatic TM6 Y 261 6x30 G.H5 K 376 G.H5.21
Hydrophobic TM6 Y 261 6x30 G.H5 K 376 G.H5.21
Van-der-waals TM6 Y 261 6x30 G.H5 K 376 G.H5.21
Polar TM2 N 87 2x37 G.H5 Q 381 G.H5.26
Hydrophobic TM2 N 87 2x37 G.H5 Q 381 G.H5.26
Van-der-waals TM2 N 87 2x37 G.H5 Q 381 G.H5.26
Van-der-waals ICL1 K 85 - G.HN R 52 G.HN.52
Hydrophobic ICL2 I 160 34x51 G.H5 L 375 G.H5.20
Van-der-waals ICL2 I 160 34x51 G.H5 L 375 G.H5.20
Hydrophobic TM6 P 256 6x25 G.h4s6 K 344 G.h4s6.19
Van-der-waals TM6 P 256 6x25 G.h4s6 K 344 G.h4s6.19
Hydrophobic TM6 K 254 6x23 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 K 254 6x23 G.h4s6 P 345 G.h4s6.20
Polar TM6 Y 261 6x30 G.H5 Q 372 G.H5.17
Hydrophobic TM6 Y 261 6x30 G.H5 Q 372 G.H5.17
Van-der-waals TM6 Y 261 6x30 G.H5 Q 372 G.H5.17
Hydrophobic TM7 S 331 7x57 G.H5 L 380 G.H5.25
Van-der-waals TM7 S 331 7x57 G.H5 L 380 G.H5.25
Hydrophobic ICL2 I 160 34x51 G.H5 L 371 G.H5.16
Polar ICL1 K 85 - G.HN L 47 G.HN.47
Hydrophobic ICL1 K 85 - G.HN L 47 G.HN.47
Van-der-waals ICL1 K 85 - G.HN L 47 G.HN.47
Polar ICL3 R 252 - G.H5 Q 372 G.H5.17
Hydrophobic ICL3 R 252 - G.H5 Q 372 G.H5.17
Van-der-waals ICL3 R 252 - G.H5 Q 372 G.H5.17
Hydrophobic TM6 F 255 6x24 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM5 I 248 5x68 G.H5 Q 372 G.H5.17
Van-der-waals TM5 I 248 5x68 G.H5 Q 372 G.H5.17
Polar ICL3 R 252 - G.H5 T 369 G.H5.14
Hydrophobic ICL3 R 252 - G.H5 T 369 G.H5.14
Van-der-waals ICL3 R 252 - G.H5 T 369 G.H5.14
Hydrophobic ICL1 K 85 - G.HN R 51 G.HN.51
Van-der-waals ICL1 K 85 - G.HN R 51 G.HN.51
Polar ICL1 R 86 - G.hns1 R 55 G.hns1.02
Polar ICL2 R 163 34x54 G.hns1 R 56 G.hns1.03
Polar ICL1 K 85 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL1 K 85 - G.hns1 R 55 G.hns1.02
Polar TM4 T 168 4x39 G.HN R 52 G.HN.52
Van-der-waals TM4 T 168 4x39 G.HN R 52 G.HN.52
Hydrophobic TM5 I 248 5x68 G.H5 K 376 G.H5.21
Van-der-waals TM5 I 248 5x68 G.H5 K 376 G.H5.21
Aromatic TM6 F 255 6x24 G.S6 F 347 G.S6.02
Hydrophobic TM6 F 255 6x24 G.S6 F 347 G.S6.02
Van-der-waals TM6 F 255 6x24 G.S6 F 347 G.S6.02
Polar TM6 N 257 6x26 G.H5 E 373 G.H5.18
Hydrophobic TM6 N 257 6x26 G.H5 E 373 G.H5.18
Van-der-waals TM6 N 257 6x26 G.H5 E 373 G.H5.18
Polar TM6 K 260 6x29 G.h3s5 N 288 G.h3s5.02
Hydrophobic TM6 K 260 6x29 G.h3s5 N 288 G.h3s5.02
Van-der-waals TM6 K 260 6x29 G.h3s5 N 288 G.h3s5.02
Polar TM1 H 83 1x61 G.HN R 51 G.HN.51
Hydrophobic TM1 H 83 1x61 G.HN R 51 G.HN.51
Van-der-waals TM1 H 83 1x61 G.HN R 51 G.HN.51
Hydrophobic TM5 L 245 5x65 G.H5 M 379 G.H5.24
Hydrophobic TM6 K 260 6x29 G.H5 K 376 G.H5.21
Polar ICL3 R 252 - G.H5 D 368 G.H5.13
Hydrophobic ICL3 R 252 - G.H5 D 368 G.H5.13
Van-der-waals ICL3 R 252 - G.H5 D 368 G.H5.13
Hydrophobic TM6 F 255 6x24 G.H5 T 369 G.H5.14
Van-der-waals TM6 F 255 6x24 G.H5 T 369 G.H5.14
Hydrophobic TM7 S 331 7x57 G.H5 Q 381 G.H5.26
Van-der-waals TM7 S 331 7x57 G.H5 Q 381 G.H5.26