Ggust - GPR34 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM6 K 260 6x29 G.h4s6 E 315 G.h4s6.09
Van-der-waals TM6 K 260 6x29 G.h4s6 E 315 G.h4s6.09
Ionic ICL3 R 252 - G.H5 D 341 G.H5.13
Polar ICL3 R 252 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 R 252 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 R 252 - G.H5 D 341 G.H5.13
Polar TM3 R 152 3x50 G.H5 G 352 G.H5.24
Hydrophobic ICL2 K 164 34x55 G.HN E 28 G.HN.52
Van-der-waals ICL2 K 164 34x55 G.HN E 28 G.HN.52
Hydrophobic TM3 K 155 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 K 155 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM6 P 256 6x25 G.S6 Y 320 G.S6.02
Polar TM6 N 257 6x26 G.H5 D 341 G.H5.13
Hydrophobic TM6 N 257 6x26 G.H5 D 341 G.H5.13
Van-der-waals TM6 N 257 6x26 G.H5 D 341 G.H5.13
Hydrophobic ICL2 I 160 34x51 G.H5 T 340 G.H5.12
Van-der-waals ICL2 I 160 34x51 G.H5 T 340 G.H5.12
Polar ICL2 Q 161 34x52 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 Q 161 34x52 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 Q 161 34x52 G.hns1 R 32 G.hns1.03
Polar TM6 N 257 6x26 G.S6 Y 320 G.S6.02
Van-der-waals TM6 N 257 6x26 G.S6 Y 320 G.S6.02
Hydrophobic TM6 K 260 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 K 260 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 F 255 6x24 G.H5 A 338 G.H5.10
Polar TM3 R 152 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 152 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 152 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM6 F 255 6x24 G.H5 F 334 G.H5.06
Van-der-waals TM6 F 255 6x24 G.H5 F 334 G.H5.06
Aromatic TM6 F 255 6x24 G.S6 Y 320 G.S6.02
Hydrophobic TM6 F 255 6x24 G.S6 Y 320 G.S6.02
Van-der-waals TM6 F 255 6x24 G.S6 Y 320 G.S6.02
Hydrophobic TM6 N 257 6x26 G.H5 K 345 G.H5.17
Hydrophobic TM3 I 156 3x54 G.H5 C 351 G.H5.23
Hydrophobic TM6 Y 261 6x30 G.H5 L 348 G.H5.20
Van-der-waals TM6 Y 261 6x30 G.H5 L 348 G.H5.20
Polar TM7 M 330 7x56 G.H5 L 353 G.H5.25
Hydrophobic TM7 M 330 7x56 G.H5 L 353 G.H5.25
Van-der-waals TM7 M 330 7x56 G.H5 L 353 G.H5.25
Ionic H8 K 336 8x52 G.h4s6 D 316 G.h4s6.10
Hydrophobic TM6 P 256 6x25 G.S6 I 319 G.S6.01
Polar TM3 K 155 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 K 155 3x53 G.H5 N 347 G.H5.19
Polar TM6 Y 261 6x30 G.H5 D 341 G.H5.13
Hydrophobic TM6 Y 261 6x30 G.H5 D 341 G.H5.13
Van-der-waals TM6 Y 261 6x30 G.H5 D 341 G.H5.13
Hydrophobic ICL2 I 160 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 I 160 34x51 G.S3 L 194 G.S3.01
Polar TM7 M 330 7x56 G.H5 F 354 G.H5.26
Hydrophobic TM3 I 156 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 156 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM6 T 264 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM7 M 330 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 M 330 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM2 I 89 2x39 G.H5 D 350 G.H5.22
Polar TM7 S 332 7x58 G.H5 F 354 G.H5.26
Hydrophobic TM7 S 332 7x58 G.H5 F 354 G.H5.26
Van-der-waals TM7 S 332 7x58 G.H5 F 354 G.H5.26
Polar TM7 S 331 7x57 G.H5 F 354 G.H5.26
Polar TM6 N 257 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 N 257 6x26 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 N 257 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 I 248 5x68 G.H5 I 344 G.H5.16
Hydrophobic ICL2 R 163 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 R 163 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic TM5 L 245 5x65 G.H5 L 348 G.H5.20
Polar TM3 K 155 3x53 G.H5 D 350 G.H5.22
Hydrophobic TM6 Y 261 6x30 G.H5 I 344 G.H5.16
Van-der-waals TM6 Y 261 6x30 G.H5 I 344 G.H5.16
Hydrophobic TM6 S 268 6x37 G.H5 L 353 G.H5.25
Polar TM6 T 264 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 264 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 264 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 F 255 6x24 G.H5 D 337 G.H5.09
Van-der-waals TM6 F 255 6x24 G.H5 D 337 G.H5.09
Ionic TM6 K 260 6x29 G.h4s6 E 318 G.h4s6.12
Polar TM6 K 260 6x29 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 K 260 6x29 G.h4s6 E 318 G.h4s6.12
Polar TM7 S 331 7x57 G.H5 G 352 G.H5.24
Hydrophobic TM7 S 331 7x57 G.H5 G 352 G.H5.24
Hydrophobic ICL2 I 160 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 I 160 34x51 G.H5 I 343 G.H5.15
Ionic H8 K 336 8x52 G.h4s6 E 315 G.h4s6.09
Polar H8 K 336 8x52 G.h4s6 E 315 G.h4s6.09
Van-der-waals H8 K 336 8x52 G.h4s6 E 315 G.h4s6.09
Hydrophobic TM3 I 156 3x54 G.H5 L 353 G.H5.25
Van-der-waals TM3 I 156 3x54 G.H5 L 353 G.H5.25
Hydrophobic TM6 F 255 6x24 G.H5 D 341 G.H5.13
Polar TM2 N 87 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 N 87 2x37 G.H5 D 350 G.H5.22
Polar ICL2 Q 161 34x52 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 Q 161 34x52 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 Q 161 34x52 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM3 R 152 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM6 P 256 6x25 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 P 256 6x25 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM2 I 89 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 I 89 2x39 G.H5 C 351 G.H5.23
Ionic TM4 K 169 4x40 G.HN E 20 G.HN.44
Polar TM4 K 169 4x40 G.HN E 20 G.HN.44
Polar ICL3 R 252 - G.H5 T 340 G.H5.12
Hydrophobic ICL3 R 252 - G.H5 T 340 G.H5.12
Van-der-waals ICL3 R 252 - G.H5 T 340 G.H5.12
Ionic ICL3 R 252 - G.H5 D 337 G.H5.09
Polar ICL3 R 252 - G.H5 D 337 G.H5.09
Hydrophobic ICL3 R 252 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 R 252 - G.H5 D 337 G.H5.09
Polar TM6 Y 261 6x30 G.H5 K 345 G.H5.17