Gs - GPR3 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 11.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic TM5 H 223 5x68 G.H5 D 381 G.H5.13
Polar TM5 H 223 5x68 G.H5 D 381 G.H5.13
Hydrophobic TM5 H 223 5x68 G.H5 D 381 G.H5.13
Van-der-waals TM5 H 223 5x68 G.H5 D 381 G.H5.13
Polar ICL3 R 231 - G.h4s6 G 353 G.h4s6.09
Van-der-waals ICL3 R 231 - G.h4s6 G 353 G.h4s6.09
Hydrophobic C-term P 327 - G.h2s4 T 242 G.h2s4.05
Hydrophobic ICL2 A 141 34x50 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 L 142 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 L 142 34x51 G.S3 V 217 G.S3.01
Polar TM3 L 138 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 138 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 138 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM5 H 223 5x68 G.H5 L 394 G.H5.26
Hydrophobic TM6 L 249 6x37 G.H5 L 393 G.H5.25
Van-der-waals TM6 L 249 6x37 G.H5 L 393 G.H5.25
Hydrophobic TM5 I 227 5x72 G.h4s6 Y 358 G.h4s6.20
Van-der-waals TM5 I 227 5x72 G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL3 R 231 - G.h4s6 T 350 G.h4s6.03
Hydrophobic ICL2 T 143 34x52 G.s2s3 K 216 G.s2s3.02
Hydrophobic TM4 V 150 4x39 G.HN Q 35 G.HN.52
Van-der-waals TM4 V 150 4x39 G.HN Q 35 G.HN.52
Polar TM6 T 248 6x36 G.H5 E 392 G.H5.24
Polar ICL2 Y 145 34x54 G.H5 H 387 G.H5.19
Hydrophobic ICL2 Y 145 34x54 G.H5 H 387 G.H5.19
Van-der-waals ICL2 Y 145 34x54 G.H5 H 387 G.H5.19
Polar TM5 H 223 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 H 223 5x68 G.H5 Q 384 G.H5.16
Van-der-waals TM5 H 223 5x68 G.H5 Q 384 G.H5.16
Hydrophobic TM5 V 220 5x65 G.H5 L 388 G.H5.20
Van-der-waals TM5 V 220 5x65 G.H5 L 388 G.H5.20
Hydrophobic TM5 H 223 5x68 G.H5 L 388 G.H5.20
Van-der-waals TM5 H 223 5x68 G.H5 L 388 G.H5.20
Hydrophobic ICL2 Y 145 34x54 G.hns1 A 39 G.hns1.03
Hydrophobic C-term V 330 - G.H5 M 386 G.H5.18
Hydrophobic ICL3 R 231 - G.h4s6 G 355 G.h4s6.11
Van-der-waals ICL3 R 231 - G.h4s6 G 355 G.h4s6.11
Polar ICL2 S 146 34x55 G.HN Q 35 G.HN.52
Hydrophobic ICL2 E 147 34x56 G.HN Q 35 G.HN.52
Van-der-waals ICL2 E 147 34x56 G.HN Q 35 G.HN.52
Hydrophobic ICL2 S 146 34x55 G.hns1 A 39 G.hns1.03
Hydrophobic TM2 M 75 2x39 G.H5 Y 391 G.H5.23
Polar C-term P 327 - G.h3s5 T 284 G.h3s5.02
Hydrophobic C-term P 327 - G.h3s5 T 284 G.h3s5.02
Van-der-waals C-term P 327 - G.h3s5 T 284 G.h3s5.02
Hydrophobic TM5 V 220 5x65 G.H5 L 393 G.H5.25
Van-der-waals TM5 Q 226 5x71 G.H5 D 381 G.H5.13
Polar TM3 S 137 3x53 G.H5 H 387 G.H5.19
Hydrophobic TM3 S 137 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 S 137 3x53 G.H5 H 387 G.H5.19
Aromatic ICL2 Y 144 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 Y 144 34x53 G.H5 H 387 G.H5.19
Hydrophobic TM6 G 245 6x33 G.H5 L 393 G.H5.25
Van-der-waals TM6 G 245 6x33 G.H5 L 393 G.H5.25
Ionic TM7 R 300 7x56 G.H5 E 392 G.H5.24
Polar TM7 R 300 7x56 G.H5 E 392 G.H5.24
Hydrophobic TM7 R 300 7x56 G.H5 E 392 G.H5.24
Van-der-waals TM7 R 300 7x56 G.H5 E 392 G.H5.24
Hydrophobic TM5 H 223 5x68 G.H5 R 385 G.H5.17
Polar C-term V 330 - G.H5 R 389 G.H5.21
Hydrophobic C-term V 330 - G.H5 R 389 G.H5.21
Van-der-waals C-term V 330 - G.H5 R 389 G.H5.21
Hydrophobic C-term P 327 - G.H5 M 386 G.H5.18
Van-der-waals C-term P 327 - G.H5 M 386 G.H5.18
Polar C-term S 324 - G.hns1 R 38 G.hns1.02
Hydrophobic C-term S 324 - G.hns1 R 38 G.hns1.02
Van-der-waals C-term S 324 - G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 L 142 34x51 G.H5 C 379 G.H5.11
Hydrophobic ICL2 L 142 34x51 G.H5 I 383 G.H5.15
Van-der-waals ICL2 L 142 34x51 G.H5 I 383 G.H5.15
Hydrophobic C-term P 327 - G.h2s4 V 241 G.h2s4.04
Van-der-waals C-term P 327 - G.h2s4 V 241 G.h2s4.04
Hydrophobic TM5 I 227 5x72 G.H5 L 394 G.H5.26
Polar ICL1 R 72 12x51 G.HN Q 31 G.HN.48
Hydrophobic ICL1 R 72 12x51 G.HN Q 31 G.HN.48
Van-der-waals ICL1 R 72 12x51 G.HN Q 31 G.HN.48
Hydrophobic ICL2 L 142 34x51 G.H5 R 380 G.H5.12
Polar TM3 S 137 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 S 137 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM5 I 216 5x61 G.H5 L 393 G.H5.25
Hydrophobic C-term S 326 - G.H5 M 386 G.H5.18
Hydrophobic C-term V 330 - G.h3s5 T 284 G.h3s5.02
Van-der-waals C-term V 330 - G.h3s5 T 284 G.h3s5.02
Polar C-term S 328 - G.h3s5 T 284 G.h3s5.02
Hydrophobic C-term S 328 - G.h3s5 T 284 G.h3s5.02
Van-der-waals C-term S 328 - G.h3s5 T 284 G.h3s5.02
Hydrophobic TM5 I 219 5x64 G.H5 L 388 G.H5.20
Polar ICL3 Q 230 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 Q 230 - G.H5 R 385 G.H5.17
Hydrophobic C-term P 327 - G.h2s4 D 240 G.h2s4.03
Hydrophobic ICL2 L 142 34x51 G.H5 F 376 G.H5.08
Van-der-waals ICL2 L 142 34x51 G.H5 F 376 G.H5.08
Hydrophobic ICL2 Y 145 34x54 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 Y 145 34x54 G.hns1 R 38 G.hns1.02
Hydrophobic TM3 L 138 3x54 G.H5 H 387 G.H5.19
Polar TM5 Q 226 5x71 G.H5 R 385 G.H5.17
Hydrophobic ICL2 A 141 34x50 G.H5 I 383 G.H5.15
Polar ICL3 Q 230 - G.S6 C 359 G.S6.01
Van-der-waals ICL3 Q 230 - G.S6 C 359 G.S6.01
Hydrophobic TM6 T 248 6x36 G.H5 L 393 G.H5.25
Hydrophobic TM2 M 75 2x39 G.H5 Q 390 G.H5.22
Polar C-term S 324 - G.HN K 34 G.HN.51
Hydrophobic C-term S 324 - G.HN K 34 G.HN.51
Van-der-waals C-term S 324 - G.HN K 34 G.HN.51
Polar C-term R 323 - G.h2s4 N 239 G.h2s4.02
Hydrophobic C-term R 323 - G.h2s4 N 239 G.h2s4.02
Van-der-waals C-term R 323 - G.h2s4 N 239 G.h2s4.02
Hydrophobic ICL2 T 143 34x52 G.S3 V 217 G.S3.01
Van-der-waals ICL2 T 143 34x52 G.S3 V 217 G.S3.01
Polar C-term S 328 - G.h2s4 D 240 G.h2s4.03
Polar C-term S 326 - G.h2s4 D 240 G.h2s4.03
Hydrophobic C-term S 326 - G.h2s4 D 240 G.h2s4.03
Van-der-waals C-term S 326 - G.h2s4 D 240 G.h2s4.03
Ionic ICL1 R 72 12x51 G.HN E 27 G.HN.44
Polar ICL2 L 142 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 L 142 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 L 142 34x51 G.S1 H 41 G.S1.02
Hydrophobic ICL2 A 141 34x50 G.H5 R 380 G.H5.12
Hydrophobic TM5 A 224 5x69 G.H5 L 394 G.H5.26
Ionic ICL3 H 232 - G.hgh4 D 323 G.hgh4.13
Polar ICL3 H 232 - G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL3 H 232 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 H 232 - G.hgh4 D 323 G.hgh4.13
Hydrophobic C-term S 328 - G.h3s5 I 285 G.h3s5.03
Hydrophobic TM5 I 227 5x72 G.H5 R 385 G.H5.17
Van-der-waals TM5 I 227 5x72 G.H5 R 385 G.H5.17
Hydrophobic TM3 L 138 3x54 G.H5 L 388 G.H5.20
Van-der-waals TM3 L 138 3x54 G.H5 L 388 G.H5.20
Aromatic TM3 R 134 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 134 3x50 G.H5 Y 391 G.H5.23