Gi1 - GPR52 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 79.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 22.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 P 146 34x50 G.S3 L 194 G.S3.01
Polar TM3 R 139 3x50 G.H5 D 350 G.H5.22
Hydrophobic TM3 R 139 3x50 G.H5 D 350 G.H5.22
Van-der-waals TM3 R 139 3x50 G.H5 D 350 G.H5.22
Hydrophobic TM5 I 226 5x62 G.H5 L 353 G.H5.25
Van-der-waals TM5 I 226 5x62 G.H5 L 353 G.H5.25
Polar ICL2 S 148 34x52 G.hns1 A 30 G.hns1.01
Hydrophobic ICL2 S 148 34x52 G.hns1 A 30 G.hns1.01
Van-der-waals ICL2 S 148 34x52 G.hns1 A 30 G.hns1.01
Hydrophobic ICL2 L 147 34x51 G.S1 V 34 G.S1.02
Van-der-waals ICL2 L 147 34x51 G.S1 V 34 G.S1.02
Hydrophobic TM6 A 264 6x34 G.H5 C 351 G.H5.23
Van-der-waals TM6 A 264 6x34 G.H5 C 351 G.H5.23
Polar ICL2 P 146 34x50 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 P 146 34x50 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 P 146 34x50 G.hns1 A 31 G.hns1.02
Hydrophobic TM3 K 145 3x56 G.HN E 28 G.HN.52
Van-der-waals TM3 K 145 3x56 G.HN E 28 G.HN.52
Polar TM3 K 145 3x56 G.HN G 27 G.HN.51
Hydrophobic TM3 K 145 3x56 G.HN G 27 G.HN.51
Van-der-waals TM3 K 145 3x56 G.HN G 27 G.HN.51
Hydrophobic TM5 T 234 5x70 G.H5 F 354 G.H5.26
Van-der-waals TM5 T 234 5x70 G.H5 F 354 G.H5.26
Polar ICL2 S 148 34x52 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 S 148 34x52 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 S 148 34x52 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 P 146 34x50 G.H5 N 347 G.H5.19
Hydrophobic ICL2 L 147 34x51 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 L 147 34x51 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 D 260 6x30 G.H5 D 350 G.H5.22
Van-der-waals TM6 D 260 6x30 G.H5 D 350 G.H5.22
Hydrophobic TM6 R 261 6x31 G.H5 K 349 G.H5.21
Van-der-waals TM6 R 261 6x31 G.H5 K 349 G.H5.21
Polar TM3 K 145 3x56 G.hns1 A 31 G.hns1.02
Hydrophobic TM3 K 145 3x56 G.hns1 A 31 G.hns1.02
Van-der-waals TM3 K 145 3x56 G.hns1 A 31 G.hns1.02
Hydrophobic TM5 H 233 5x69 G.H5 L 348 G.H5.20
Hydrophobic TM6 D 260 6x30 G.H5 G 352 G.H5.24
Van-der-waals TM6 D 260 6x30 G.H5 G 352 G.H5.24
Hydrophobic TM6 H 257 6x27 G.H5 K 349 G.H5.21
Ionic TM5 R 240 5x76 G.H5 D 341 G.H5.13
Polar TM5 R 240 5x76 G.H5 D 341 G.H5.13
Hydrophobic TM5 R 240 5x76 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 240 5x76 G.H5 D 341 G.H5.13
Ionic TM5 E 236 5x72 G.s2s3 K 192 G.s2s3.01
Polar TM5 E 236 5x72 G.s2s3 K 192 G.s2s3.01
Van-der-waals TM5 E 236 5x72 G.s2s3 K 192 G.s2s3.01
Aromatic TM5 F 244 5x80 G.H5 F 334 G.H5.06
Hydrophobic TM5 F 244 5x80 G.H5 F 334 G.H5.06
Van-der-waals TM5 F 244 5x80 G.H5 F 334 G.H5.06
Hydrophobic TM5 I 229 5x65 G.H5 L 348 G.H5.20
Polar TM6 M 265 6x35 G.H5 G 352 G.H5.24
Van-der-waals TM6 M 265 6x35 G.H5 G 352 G.H5.24
Ionic TM5 R 240 5x76 G.H5 D 337 G.H5.09
Polar TM5 R 240 5x76 G.H5 D 337 G.H5.09
Hydrophobic TM5 R 240 5x76 G.H5 D 337 G.H5.09
Van-der-waals TM5 R 240 5x76 G.H5 D 337 G.H5.09
Hydrophobic TM3 I 143 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 143 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 L 147 34x51 G.S1 E 33 G.S1.01
Van-der-waals ICL2 L 147 34x51 G.S1 E 33 G.S1.01
Hydrophobic TM5 H 233 5x69 G.H5 I 344 G.H5.16
Van-der-waals TM5 H 233 5x69 G.H5 I 344 G.H5.16
Hydrophobic TM5 I 237 5x73 G.H5 D 341 G.H5.13
Van-der-waals TM5 I 237 5x73 G.H5 D 341 G.H5.13
Hydrophobic TM5 R 240 5x76 G.s2s3 K 192 G.s2s3.01
Van-der-waals TM5 R 240 5x76 G.s2s3 K 192 G.s2s3.01
Hydrophobic ICL2 L 147 34x51 G.hns1 A 30 G.hns1.01
Van-der-waals ICL2 L 147 34x51 G.hns1 A 30 G.hns1.01
Polar TM3 A 142 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 A 142 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 A 142 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM6 Y 263 6x33 G.H5 G 352 G.H5.24
Hydrophobic TM6 A 264 6x34 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 143 3x54 G.H5 L 353 G.H5.25
Van-der-waals TM3 I 143 3x54 G.H5 L 353 G.H5.25
Polar TM6 S 258 6x28 G.H5 K 349 G.H5.21
Hydrophobic TM6 S 258 6x28 G.H5 K 349 G.H5.21
Van-der-waals TM6 S 258 6x28 G.H5 K 349 G.H5.21
Hydrophobic ICL2 L 152 34x56 G.hns1 A 31 G.hns1.02
Polar TM6 R 261 6x31 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 261 6x31 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 261 6x31 G.H5 F 354 G.H5.26
Polar TM3 I 143 3x54 G.H5 C 351 G.H5.23
Hydrophobic TM3 I 143 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 I 143 3x54 G.H5 C 351 G.H5.23
Hydrophobic ICL2 L 147 34x51 G.h2s4 T 219 G.h2s4.05
Van-der-waals ICL2 L 147 34x51 G.h2s4 T 219 G.h2s4.05
Hydrophobic TM6 R 261 6x31 G.H5 G 352 G.H5.24
Van-der-waals TM6 R 261 6x31 G.H5 G 352 G.H5.24
Hydrophobic ICL2 L 147 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM6 D 260 6x30 G.H5 K 349 G.H5.21
Van-der-waals TM6 D 260 6x30 G.H5 K 349 G.H5.21
Hydrophobic TM5 C 230 5x66 G.H5 F 354 G.H5.26
Van-der-waals TM5 C 230 5x66 G.H5 F 354 G.H5.26
Polar TM6 A 264 6x34 G.H5 G 352 G.H5.24
Hydrophobic TM6 A 264 6x34 G.H5 G 352 G.H5.24
Van-der-waals TM6 A 264 6x34 G.H5 G 352 G.H5.24
Polar TM3 R 139 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 139 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 139 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM6 R 261 6x31 G.H5 L 353 G.H5.25
Polar TM3 T 144 3x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM3 T 144 3x55 G.hns1 R 32 G.hns1.03
Van-der-waals TM3 T 144 3x55 G.hns1 R 32 G.hns1.03
Polar ICL2 L 147 34x51 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 L 147 34x51 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 L 147 34x51 G.hns1 A 31 G.hns1.02