G15 - GPR55 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 81.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 R 211 5x68 G.H5 L 364 G.H5.16
Van-der-waals TM5 R 211 5x68 G.H5 L 364 G.H5.16
Hydrophobic ICL2 L 127 34x51 G.S3 T 202 G.S3.01
Polar TM2 T 59 2x39 G.H5 E 370 G.H5.22
Hydrophobic TM2 T 59 2x39 G.H5 E 370 G.H5.22
Van-der-waals TM2 T 59 2x39 G.H5 E 370 G.H5.22
Hydrophobic TM3 I 123 3x54 G.H5 I 371 G.H5.23
Hydrophobic TM3 A 122 3x53 G.H5 Y 367 G.H5.19
Hydrophobic TM3 I 123 3x54 G.H5 L 364 G.H5.16
Hydrophobic TM2 T 59 2x39 G.H5 L 374 G.H5.26
Van-der-waals TM2 T 59 2x39 G.H5 L 374 G.H5.26
Polar ICL2 H 131 34x55 G.S1 L 43 G.S1.02
Hydrophobic ICL2 H 131 34x55 G.S1 L 43 G.S1.02
Van-der-waals ICL2 H 131 34x55 G.S1 L 43 G.S1.02
Hydrophobic ICL2 P 126 34x50 G.H5 Y 367 G.H5.19
Hydrophobic TM5 L 208 5x65 G.H5 L 368 G.H5.20
Aromatic ICL3 H 214 - G.H5 K 357 G.H5.09
Hydrophobic TM6 C 224 6x33 G.H5 I 371 G.H5.23
Van-der-waals TM6 C 224 6x33 G.H5 I 371 G.H5.23
Polar TM7 Y 288 7x53 G.H5 L 374 G.H5.26
Hydrophobic TM7 Y 288 7x53 G.H5 L 374 G.H5.26
Van-der-waals TM7 Y 288 7x53 G.H5 L 374 G.H5.26
Hydrophobic TM7 V 291 7x56 G.H5 N 372 G.H5.24
Van-der-waals TM7 V 291 7x56 G.H5 N 372 G.H5.24
Polar H8 N 298 8x53 G.h4s6 K 331 G.h4s6.13
Hydrophobic TM4 S 134 4x38 G.hns1 R 40 G.hns1.02
Ionic H8 E 294 8x49 G.h4s6 R 335 G.h4s6.17
Polar H8 E 294 8x49 G.h4s6 R 335 G.h4s6.17
Hydrophobic H8 E 294 8x49 G.h4s6 R 335 G.h4s6.17
Van-der-waals H8 E 294 8x49 G.h4s6 R 335 G.h4s6.17
Hydrophobic TM2 M 63 2x43 G.H5 L 374 G.H5.26
Van-der-waals TM2 M 63 2x43 G.H5 L 374 G.H5.26
Hydrophobic H8 A 301 8x56 G.h4s6 K 332 G.h4s6.14
Van-der-waals H8 A 301 8x56 G.h4s6 K 332 G.h4s6.14
Polar TM6 Q 220 6x29 G.H5 A 365 G.H5.17
Van-der-waals TM6 Q 220 6x29 G.H5 A 365 G.H5.17
Hydrophobic ICL2 L 127 34x51 G.H5 V 363 G.H5.15
Hydrophobic H8 F 295 8x50 G.H5 L 373 G.H5.25
Van-der-waals H8 F 295 8x50 G.H5 L 373 G.H5.25
Polar TM6 Q 220 6x29 G.h4s6 R 338 G.h4s6.20
Van-der-waals TM6 Q 220 6x29 G.h4s6 R 338 G.h4s6.20
Van-der-waals TM6 S 227 6x36 G.H5 L 374 G.H5.26
Polar TM6 C 224 6x33 G.H5 N 372 G.H5.24
Hydrophobic TM6 C 224 6x33 G.H5 N 372 G.H5.24
Van-der-waals TM6 C 224 6x33 G.H5 N 372 G.H5.24
Hydrophobic ICL2 P 126 34x50 G.H5 L 364 G.H5.16
Polar ICL2 S 130 34x54 G.H5 Y 367 G.H5.19
Hydrophobic ICL2 S 130 34x54 G.H5 Y 367 G.H5.19
Van-der-waals ICL2 S 130 34x54 G.H5 Y 367 G.H5.19
Polar TM6 Q 220 6x29 G.H5 N 372 G.H5.24
Van-der-waals TM6 Q 220 6x29 G.H5 N 372 G.H5.24
Hydrophobic ICL1 D 55 - G.H5 E 370 G.H5.22
Van-der-waals ICL1 D 55 - G.H5 E 370 G.H5.22
Polar TM6 Q 216 6x25 G.S6 L 339 G.S6.01
Van-der-waals TM6 Q 216 6x25 G.S6 L 339 G.S6.01
Hydrophobic TM6 D 217 6x26 G.h4s6 R 338 G.h4s6.20
Ionic ICL1 D 55 - G.H5 R 366 G.H5.18
Polar ICL1 D 55 - G.H5 R 366 G.H5.18
Hydrophobic ICL1 D 55 - G.H5 R 366 G.H5.18
Van-der-waals ICL1 D 55 - G.H5 R 366 G.H5.18
Hydrophobic TM7 C 287 7x52 G.H5 L 374 G.H5.26
Van-der-waals TM7 C 287 7x52 G.H5 L 374 G.H5.26
Hydrophobic ICL2 L 127 34x51 G.H5 R 360 G.H5.12
Hydrophobic TM6 C 224 6x33 G.H5 L 368 G.H5.20
Van-der-waals TM6 C 224 6x33 G.H5 L 368 G.H5.20
Hydrophobic H8 I 292 8x47 G.H5 L 373 G.H5.25
Van-der-waals H8 I 292 8x47 G.H5 L 373 G.H5.25
Hydrophobic ICL2 S 130 34x54 G.H5 V 363 G.H5.15
Polar H8 N 298 8x53 G.h4s6 K 332 G.h4s6.14
Hydrophobic H8 N 298 8x53 G.h4s6 K 332 G.h4s6.14
Van-der-waals H8 N 298 8x53 G.h4s6 K 332 G.h4s6.14
Hydrophobic ICL1 Y 56 - G.H5 L 373 G.H5.25
Van-der-waals ICL1 Y 56 - G.H5 L 373 G.H5.25
Hydrophobic ICL2 L 127 34x51 G.H5 F 356 G.H5.08
Van-der-waals ICL2 L 127 34x51 G.H5 F 356 G.H5.08
Polar ICL2 H 131 34x55 G.hns1 R 40 G.hns1.02
Hydrophobic ICL2 H 131 34x55 G.hns1 R 40 G.hns1.02
Van-der-waals ICL2 H 131 34x55 G.hns1 R 40 G.hns1.02
Hydrophobic TM6 Q 221 6x30 G.H5 L 368 G.H5.20
Polar H8 N 298 8x53 G.h4s6 G 333 G.h4s6.15
Hydrophobic TM6 Q 216 6x25 G.S6 F 340 G.S6.02
Hydrophobic TM6 Q 220 6x29 G.H5 L 368 G.H5.20
Polar TM3 R 119 3x50 G.H5 I 371 G.H5.23
Hydrophobic TM3 R 119 3x50 G.H5 I 371 G.H5.23
Hydrophobic ICL2 P 126 34x50 G.H5 R 360 G.H5.12
Van-der-waals ICL2 P 126 34x50 G.H5 R 360 G.H5.12
Hydrophobic ICL1 Y 56 - G.H5 E 370 G.H5.22
Van-der-waals ICL1 Y 56 - G.H5 E 370 G.H5.22
Hydrophobic TM3 R 119 3x50 G.H5 L 374 G.H5.26
Van-der-waals TM3 R 119 3x50 G.H5 L 374 G.H5.26
Hydrophobic ICL2 L 127 34x51 G.S1 L 43 G.S1.02
Van-der-waals ICL2 L 127 34x51 G.S1 L 43 G.S1.02
Hydrophobic ICL2 R 133 34x57 G.H5 Y 367 G.H5.19
Ionic TM5 R 211 5x68 G.H5 D 361 G.H5.13
Polar TM5 R 211 5x68 G.H5 D 361 G.H5.13
Van-der-waals TM5 R 211 5x68 G.H5 D 361 G.H5.13
Hydrophobic TM5 R 211 5x68 G.H5 R 360 G.H5.12
Van-der-waals TM5 R 211 5x68 G.H5 R 360 G.H5.12
Hydrophobic TM6 A 223 6x32 G.H5 N 372 G.H5.24
Van-der-waals TM6 A 223 6x32 G.H5 N 372 G.H5.24
Polar TM6 S 227 6x36 G.H5 I 371 G.H5.23
Van-der-waals TM7 Y 288 7x53 G.H5 L 373 G.H5.25
Polar ICL2 V 129 34x53 G.H5 Y 367 G.H5.19
Hydrophobic ICL2 V 129 34x53 G.H5 Y 367 G.H5.19
Van-der-waals ICL2 V 129 34x53 G.H5 Y 367 G.H5.19
Polar ICL2 H 131 34x55 G.hns1 G 41 G.hns1.03
Hydrophobic ICL2 H 131 34x55 G.hns1 G 41 G.hns1.03
Van-der-waals ICL2 H 131 34x55 G.hns1 G 41 G.hns1.03
Hydrophobic ICL2 L 127 34x51 G.H5 V 359 G.H5.11
Ionic ICL2 R 133 34x57 G.H5 E 370 G.H5.22
Polar ICL2 R 133 34x57 G.H5 E 370 G.H5.22
Hydrophobic ICL2 R 133 34x57 G.H5 E 370 G.H5.22
Van-der-waals ICL2 R 133 34x57 G.H5 E 370 G.H5.22
Polar TM6 Q 220 6x29 G.H5 D 369 G.H5.21
Van-der-waals TM6 Q 220 6x29 G.H5 D 369 G.H5.21
Polar ICL2 H 131 34x55 G.S1 E 42 G.S1.01
Hydrophobic ICL2 H 131 34x55 G.S1 E 42 G.S1.01
Van-der-waals ICL2 H 131 34x55 G.S1 E 42 G.S1.01
Hydrophobic ICL2 P 126 34x50 G.H5 V 363 G.H5.15
Van-der-waals ICL2 P 126 34x50 G.H5 V 363 G.H5.15
Hydrophobic TM3 I 123 3x54 G.H5 L 368 G.H5.20