Gt1 - GPR55 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 84.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 T 215 6x24 G.H5 D 337 G.H5.13
Van-der-waals TM6 T 215 6x24 G.H5 D 337 G.H5.13
Polar TM2 T 59 2x39 G.H5 D 346 G.H5.22
Hydrophobic TM2 T 59 2x39 G.H5 D 346 G.H5.22
Van-der-waals TM2 T 59 2x39 G.H5 D 346 G.H5.22
Hydrophobic TM6 Q 220 6x29 G.H5 F 350 G.H5.26
Van-der-waals TM6 Q 220 6x29 G.H5 F 350 G.H5.26
Polar ICL2 P 126 34x50 G.H5 N 343 G.H5.19
Van-der-waals ICL2 P 126 34x50 G.H5 N 343 G.H5.19
Hydrophobic TM5 R 211 5x68 G.H5 T 336 G.H5.12
Van-der-waals TM5 R 211 5x68 G.H5 T 336 G.H5.12
Polar ICL2 H 131 34x55 G.hns1 A 27 G.hns1.02
Hydrophobic ICL2 H 131 34x55 G.hns1 A 27 G.hns1.02
Van-der-waals ICL2 H 131 34x55 G.hns1 A 27 G.hns1.02
Van-der-waals ICL3 H 214 - G.S6 Y 316 G.S6.02
Hydrophobic ICL2 S 130 34x54 G.H5 I 339 G.H5.15
Polar ICL2 H 131 34x55 G.HN E 24 G.HN.52
Hydrophobic ICL2 H 131 34x55 G.HN E 24 G.HN.52
Van-der-waals ICL2 H 131 34x55 G.HN E 24 G.HN.52
Polar TM3 D 118 3x49 G.H5 C 347 G.H5.23
Hydrophobic TM3 D 118 3x49 G.H5 C 347 G.H5.23
Van-der-waals TM3 D 118 3x49 G.H5 C 347 G.H5.23
Hydrophobic ICL2 P 126 34x50 G.H5 I 339 G.H5.15
Hydrophobic TM6 C 224 6x33 G.H5 L 344 G.H5.20
Van-der-waals TM6 C 224 6x33 G.H5 L 344 G.H5.20
Polar H8 K 293 8x48 G.H5 F 350 G.H5.26
Hydrophobic H8 K 293 8x48 G.H5 F 350 G.H5.26
Van-der-waals H8 K 293 8x48 G.H5 F 350 G.H5.26
Polar TM6 Q 216 6x25 G.S6 I 315 G.S6.01
Hydrophobic TM6 Q 216 6x25 G.S6 I 315 G.S6.01
Van-der-waals TM6 Q 216 6x25 G.S6 I 315 G.S6.01
Ionic H8 E 294 8x49 G.H5 K 345 G.H5.21
Polar H8 E 294 8x49 G.H5 K 345 G.H5.21
Hydrophobic H8 E 294 8x49 G.H5 K 345 G.H5.21
Van-der-waals H8 E 294 8x49 G.H5 K 345 G.H5.21
Polar TM3 R 119 3x50 G.H5 G 348 G.H5.24
Hydrophobic TM7 V 291 7x56 G.H5 L 349 G.H5.25
Hydrophobic TM3 R 119 3x50 G.H5 L 349 G.H5.25
Van-der-waals TM3 R 119 3x50 G.H5 L 349 G.H5.25
Hydrophobic ICL2 P 126 34x50 G.H5 I 340 G.H5.16
Van-der-waals ICL2 P 126 34x50 G.H5 I 340 G.H5.16
Hydrophobic TM5 R 211 5x68 G.H5 I 340 G.H5.16
Van-der-waals TM5 R 211 5x68 G.H5 I 340 G.H5.16
Hydrophobic H8 I 292 8x47 G.H5 G 348 G.H5.24
Van-der-waals H8 I 292 8x47 G.H5 G 348 G.H5.24
Hydrophobic ICL2 P 126 34x50 G.H5 T 336 G.H5.12
Van-der-waals ICL2 P 126 34x50 G.H5 T 336 G.H5.12
Hydrophobic ICL2 L 127 34x51 G.H5 F 332 G.H5.08
Ionic ICL1 D 55 - G.H5 K 345 G.H5.21
Polar ICL1 D 55 - G.H5 K 345 G.H5.21
Van-der-waals ICL1 D 55 - G.H5 K 345 G.H5.21
Hydrophobic TM6 C 224 6x33 G.H5 L 349 G.H5.25
Polar TM2 T 59 2x39 G.H5 C 347 G.H5.23
Hydrophobic TM2 T 59 2x39 G.H5 C 347 G.H5.23
Van-der-waals TM2 T 59 2x39 G.H5 C 347 G.H5.23
Hydrophobic ICL1 Y 56 - G.H5 K 345 G.H5.21
Van-der-waals ICL1 Y 56 - G.H5 K 345 G.H5.21
Polar TM3 A 122 3x53 G.H5 N 343 G.H5.19
Hydrophobic TM3 A 122 3x53 G.H5 N 343 G.H5.19
Van-der-waals TM3 A 122 3x53 G.H5 N 343 G.H5.19
Polar ICL2 H 131 34x55 G.HN A 23 G.HN.51
Hydrophobic ICL2 H 131 34x55 G.HN A 23 G.HN.51
Van-der-waals ICL2 H 131 34x55 G.HN A 23 G.HN.51
Polar TM6 Q 216 6x25 G.h4s6 E 314 G.h4s6.12
Hydrophobic TM6 Q 216 6x25 G.h4s6 E 314 G.h4s6.12
Van-der-waals TM6 Q 216 6x25 G.h4s6 E 314 G.h4s6.12
Polar TM2 T 59 2x39 G.H5 G 348 G.H5.24
Hydrophobic TM2 T 59 2x39 G.H5 G 348 G.H5.24
Hydrophobic TM6 I 228 6x37 G.H5 L 349 G.H5.25
Polar ICL2 H 131 34x55 G.hns1 R 28 G.hns1.03
Hydrophobic ICL2 H 131 34x55 G.hns1 R 28 G.hns1.03
Van-der-waals ICL2 H 131 34x55 G.hns1 R 28 G.hns1.03
Polar ICL2 R 133 34x57 G.H5 C 347 G.H5.23
Hydrophobic ICL2 R 133 34x57 G.H5 C 347 G.H5.23
Van-der-waals ICL2 R 133 34x57 G.H5 C 347 G.H5.23
Polar TM3 R 119 3x50 G.H5 C 347 G.H5.23
Hydrophobic TM3 R 119 3x50 G.H5 C 347 G.H5.23
Hydrophobic TM3 I 123 3x54 G.H5 L 344 G.H5.20
Van-der-waals TM3 I 123 3x54 G.H5 L 344 G.H5.20
Ionic ICL2 R 133 34x57 G.H5 D 346 G.H5.22
Polar ICL2 R 133 34x57 G.H5 D 346 G.H5.22
Hydrophobic ICL2 R 133 34x57 G.H5 D 346 G.H5.22
Van-der-waals ICL2 R 133 34x57 G.H5 D 346 G.H5.22
Hydrophobic TM3 A 122 3x53 G.H5 C 347 G.H5.23
Van-der-waals TM3 A 122 3x53 G.H5 C 347 G.H5.23
Hydrophobic ICL2 L 127 34x51 G.S3 L 190 G.S3.01
Van-der-waals ICL2 L 127 34x51 G.S3 L 190 G.S3.01
Hydrophobic TM5 L 208 5x65 G.H5 L 344 G.H5.20
Hydrophobic TM6 S 227 6x36 G.H5 L 349 G.H5.25
Van-der-waals TM6 S 227 6x36 G.H5 L 349 G.H5.25
Hydrophobic ICL2 L 127 34x51 G.H5 I 339 G.H5.15
Van-der-waals ICL2 L 127 34x51 G.H5 I 339 G.H5.15
Ionic TM5 R 211 5x68 G.H5 D 337 G.H5.13
Polar TM5 R 211 5x68 G.H5 D 337 G.H5.13
Van-der-waals TM5 R 211 5x68 G.H5 D 337 G.H5.13
Hydrophobic ICL1 D 55 - G.H5 D 346 G.H5.22
Van-der-waals ICL1 D 55 - G.H5 D 346 G.H5.22