G13 - GPR78 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 82.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM2 T 38 2x36 G.hns1 K 46 G.hns1.02
Hydrophobic C-term V 333 - G.H2 K 231 G.H2.05
Hydrophobic C-term N 355 - H.HA V 98 H.HA.21
Polar H8 R 299 8x48 G.H5 Q 377 G.H5.26
Hydrophobic H8 R 299 8x48 G.H5 Q 377 G.H5.26
Van-der-waals H8 R 299 8x48 G.H5 Q 377 G.H5.26
Polar TM6 K 242 6x36 G.H5 L 376 G.H5.25
Hydrophobic TM6 K 242 6x36 G.H5 L 376 G.H5.25
Van-der-waals TM6 K 242 6x36 G.H5 L 376 G.H5.25
Hydrophobic TM5 M 206 5x72 G.H5 H 368 G.H5.17
Hydrophobic ICL2 P 111 34x50 G.H5 L 367 G.H5.16
Polar TM2 R 39 2x37 G.H5 Q 373 G.H5.22
Hydrophobic TM2 R 39 2x37 G.H5 Q 373 G.H5.22
Van-der-waals TM2 R 39 2x37 G.H5 Q 373 G.H5.22
Hydrophobic TM5 M 206 5x72 G.h4s6 P 341 G.h4s6.20
Van-der-waals TM5 M 206 5x72 G.h4s6 P 341 G.h4s6.20
Hydrophobic C-term T 353 - G.s4h3 R 260 G.s4h3.12
Van-der-waals C-term T 353 - G.s4h3 R 260 G.s4h3.12
Hydrophobic TM5 T 210 5x76 G.h4s6 P 341 G.h4s6.20
Hydrophobic TM3 Q 104 3x50 G.H5 L 374 G.H5.23
Van-der-waals TM3 Q 104 3x50 G.H5 L 374 G.H5.23
Polar C-term D 328 - G.H3 N 278 G.H3.15
Van-der-waals C-term D 328 - G.H3 N 278 G.H3.15
Hydrophobic C-term S 357 - H.hdhe F 168 H.hdhe.01
Van-der-waals C-term S 357 - H.hdhe F 168 H.hdhe.01
Polar C-term Q 360 - H.hdhe F 168 H.hdhe.01
Hydrophobic C-term Q 360 - H.hdhe F 168 H.hdhe.01
Van-der-waals C-term Q 360 - H.hdhe F 168 H.hdhe.01
Hydrophobic TM5 A 199 5x65 G.H5 L 371 G.H5.20
Van-der-waals TM5 A 199 5x65 G.H5 L 371 G.H5.20
Hydrophobic ICL2 L 112 34x51 G.H5 V 362 G.H5.11
Polar C-term N 355 - H.HB T 127 H.HB.14
Hydrophobic C-term N 355 - H.HB T 127 H.HB.14
Van-der-waals C-term N 355 - H.HB T 127 H.HB.14
Hydrophobic ICL2 L 112 34x51 G.H5 K 363 G.H5.12
Hydrophobic H8 R 298 8x47 G.H5 L 376 G.H5.25
Van-der-waals H8 R 298 8x47 G.H5 L 376 G.H5.25
Polar C-term R 339 - G.H3 N 270 G.H3.07
Hydrophobic C-term R 339 - G.H3 N 270 G.H3.07
Van-der-waals C-term R 339 - G.H3 N 270 G.H3.07
Hydrophobic C-term L 359 - H.HA L 106 H.HA.29
Van-der-waals C-term L 359 - H.HA L 106 H.HA.29
Hydrophobic ICL3 L 216 - G.H4 K 324 G.H4.09
Van-der-waals ICL3 L 216 - G.H4 K 324 G.H4.09
Hydrophobic C-term L 336 - G.H3 I 271 G.H3.08
Hydrophobic TM5 V 198 5x64 G.H5 L 367 G.H5.16
Hydrophobic TM5 H 202 5x68 G.H5 L 371 G.H5.20
Van-der-waals TM5 H 202 5x68 G.H5 L 371 G.H5.20
Van-der-waals C-term Q 360 - H.hdhe Q 169 H.hdhe.02
Ionic C-term R 339 - G.H3 E 273 G.H3.10
Polar C-term R 339 - G.H3 E 273 G.H3.10
Van-der-waals C-term R 339 - G.H3 E 273 G.H3.10
Hydrophobic TM5 H 202 5x68 G.H5 L 367 G.H5.16
Van-der-waals TM5 H 202 5x68 G.H5 L 367 G.H5.16
Polar ICL2 R 117 34x56 G.HN T 43 G.HN.52
Hydrophobic ICL2 R 117 34x56 G.HN T 43 G.HN.52
Van-der-waals ICL2 R 117 34x56 G.HN T 43 G.HN.52
Polar C-term Q 360 - H.HD E 167 H.HD.12
Hydrophobic C-term Q 360 - H.HD E 167 H.HD.12
Van-der-waals C-term Q 360 - H.HD E 167 H.HD.12
Polar ICL2 R 117 34x56 G.HN K 42 G.HN.51
Hydrophobic ICL2 R 117 34x56 G.HN K 42 G.HN.51
Van-der-waals ICL2 R 117 34x56 G.HN K 42 G.HN.51
Hydrophobic ICL2 L 112 34x51 G.H5 I 366 G.H5.15
Van-der-waals ICL2 L 112 34x51 G.H5 I 366 G.H5.15
Polar TM5 H 202 5x68 G.H5 H 368 G.H5.17
Hydrophobic TM5 H 202 5x68 G.H5 H 368 G.H5.17
Van-der-waals TM5 H 202 5x68 G.H5 H 368 G.H5.17
Hydrophobic C-term M 332 - G.H3 T 274 G.H3.11
Van-der-waals C-term M 332 - G.H3 T 274 G.H3.11
Hydrophobic C-term L 337 - G.H2 K 231 G.H2.05
Polar C-term R 339 - G.H2 R 227 G.H2.01
Hydrophobic TM3 V 108 3x54 G.H5 L 367 G.H5.16
Van-der-waals TM3 V 108 3x54 G.H5 L 367 G.H5.16
Hydrophobic C-term V 329 - G.H3 V 280 G.H3.17
Van-der-waals C-term V 329 - G.H3 V 280 G.H3.17
Hydrophobic C-term T 353 - G.s4h3 M 257 G.s4h3.09
Van-der-waals C-term T 353 - G.s4h3 M 257 G.s4h3.09
Polar C-term Q 335 - G.H3 T 274 G.H3.11
Hydrophobic C-term Q 335 - G.H3 T 274 G.H3.11
Polar ICL2 R 117 34x56 G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 R 117 34x56 G.hns1 R 47 G.hns1.03
Hydrophobic C-term C 358 - H.hdhe F 168 H.hdhe.01
Hydrophobic C-term L 336 - G.H3 I 275 G.H3.12
Polar C-term C 358 - G.s4h3 R 260 G.s4h3.12
Hydrophobic C-term C 358 - G.s4h3 R 260 G.s4h3.12
Van-der-waals C-term C 358 - G.s4h3 R 260 G.s4h3.12
Polar C-term S 357 - H.HA V 98 H.HA.21
Hydrophobic C-term S 357 - H.HA V 98 H.HA.21
Van-der-waals C-term S 357 - H.HA V 98 H.HA.21
Polar ICL3 A 213 - G.H4 R 331 G.H4.16
Hydrophobic ICL3 A 213 - G.H4 R 331 G.H4.16
Van-der-waals ICL3 A 213 - G.H4 R 331 G.H4.16
Polar C-term L 336 - G.H2 R 230 G.H2.04
Hydrophobic C-term L 336 - G.H2 R 230 G.H2.04
Hydrophobic ICL2 P 111 34x50 G.H5 I 366 G.H5.15
Van-der-waals ICL2 P 111 34x50 G.H5 I 366 G.H5.15
Hydrophobic ICL2 L 112 34x51 G.S3 V 216 G.S3.01
Hydrophobic C-term Q 360 - G.s4h3 Q 254 G.s4h3.06
Van-der-waals C-term Q 360 - G.s4h3 Q 254 G.s4h3.06
Polar TM6 K 242 6x36 G.H5 M 375 G.H5.24
Hydrophobic TM6 K 242 6x36 G.H5 M 375 G.H5.24
Van-der-waals TM6 K 242 6x36 G.H5 M 375 G.H5.24
Hydrophobic C-term M 332 - G.h2s4 F 237 G.h2s4.01
Van-der-waals C-term M 332 - G.h2s4 F 237 G.h2s4.01
Ionic C-term D 352 - H.hbhc R 128 H.hbhc.01
Polar C-term D 352 - H.hbhc R 128 H.hbhc.01
Van-der-waals C-term D 352 - H.hbhc R 128 H.hbhc.01
Hydrophobic TM6 A 239 6x33 G.H5 M 375 G.H5.24
Van-der-waals TM6 A 239 6x33 G.H5 M 375 G.H5.24
Hydrophobic C-term V 333 - G.H2 F 234 G.H2.08
Polar TM3 A 107 3x53 G.H5 N 370 G.H5.19
Hydrophobic TM3 A 107 3x53 G.H5 N 370 G.H5.19
Van-der-waals TM3 A 107 3x53 G.H5 N 370 G.H5.19
Hydrophobic C-term D 356 - H.HA V 98 H.HA.21
Van-der-waals ICL2 A 115 34x54 G.hns1 K 46 G.hns1.02
Hydrophobic C-term M 332 - G.H3 N 278 G.H3.15
Van-der-waals C-term M 332 - G.H3 N 278 G.H3.15
Polar C-term S 357 - H.HA A 102 H.HA.25
Hydrophobic C-term S 357 - H.HA A 102 H.HA.25
Van-der-waals C-term S 357 - H.HA A 102 H.HA.25
Ionic TM5 H 202 5x68 G.H5 D 364 G.H5.13
Polar TM5 H 202 5x68 G.H5 D 364 G.H5.13
Hydrophobic TM5 H 202 5x68 G.H5 D 364 G.H5.13
Van-der-waals TM5 H 202 5x68 G.H5 D 364 G.H5.13
Hydrophobic TM5 M 206 5x72 G.S6 Y 343 G.S6.02
Van-der-waals TM5 M 206 5x72 G.S6 Y 343 G.S6.02
Hydrophobic C-term L 359 - H.HA K 105 H.HA.28
Van-der-waals C-term L 359 - H.HA K 105 H.HA.28
Hydrophobic C-term M 332 - G.H3 F 281 G.H3.18
Ionic C-term E 354 - H.HA K 94 H.HA.17
Polar C-term E 354 - H.HA K 94 H.HA.17
Van-der-waals C-term E 354 - H.HA K 94 H.HA.17
Ionic TM5 R 205 5x71 G.H5 D 364 G.H5.13
Hydrophobic ICL2 L 112 34x51 G.S1 V 49 G.S1.02
Hydrophobic TM5 V 209 5x75 G.S6 Y 343 G.S6.02
Hydrophobic TM7 L 297 7x56 G.H5 L 376 G.H5.25
Van-der-waals TM7 L 297 7x56 G.H5 L 376 G.H5.25
Hydrophobic C-term T 340 - G.H2 R 227 G.H2.01
Van-der-waals C-term T 340 - G.H2 R 227 G.H2.01
Hydrophobic C-term E 354 - G.s4h3 M 257 G.s4h3.09
Van-der-waals C-term E 354 - G.s4h3 M 257 G.s4h3.09
Ionic C-term D 328 - G.H3 R 279 G.H3.16
Hydrophobic C-term D 328 - G.H3 R 279 G.H3.16
Van-der-waals C-term D 328 - G.H3 R 279 G.H3.16
Hydrophobic ICL2 A 115 34x54 G.H5 I 366 G.H5.15
Van-der-waals ICL2 A 115 34x54 G.H5 I 366 G.H5.15
Hydrophobic TM3 V 108 3x54 G.H5 L 374 G.H5.23
Van-der-waals TM3 V 108 3x54 G.H5 L 374 G.H5.23
Hydrophobic ICL2 R 113 34x52 G.S3 V 216 G.S3.01
Polar TM6 R 235 6x29 G.H5 H 368 G.H5.17
Polar C-term Q 360 - H.HD R 166 H.HD.11
Hydrophobic C-term Q 360 - H.HD R 166 H.HD.11
Van-der-waals C-term Q 360 - H.HD R 166 H.HD.11
Hydrophobic C-term L 336 - G.H3 T 274 G.H3.11
Polar ICL2 R 117 34x56 G.HN S 39 G.HN.48
Hydrophobic ICL2 L 112 34x51 G.S3 F 218 G.S3.03
Hydrophobic ICL2 G 116 34x55 G.hns1 K 46 G.hns1.02
Van-der-waals ICL2 G 116 34x55 G.hns1 K 46 G.hns1.02
Hydrophobic ICL2 L 112 34x51 G.H5 F 359 G.H5.08
Van-der-waals ICL2 L 112 34x51 G.H5 F 359 G.H5.08
Van-der-waals C-term L 359 - H.HD E 167 H.HD.12
Hydrophobic ICL2 G 116 34x55 G.hns1 R 47 G.hns1.03
Van-der-waals ICL2 G 116 34x55 G.hns1 R 47 G.hns1.03
Hydrophobic C-term L 336 - G.H2 W 233 G.H2.07
Hydrophobic TM3 V 108 3x54 G.H5 L 371 G.H5.20
Hydrophobic TM4 R 119 4x38 G.hns1 R 47 G.hns1.03
Van-der-waals TM4 R 119 4x38 G.hns1 R 47 G.hns1.03
Hydrophobic C-term M 332 - G.H3 I 275 G.H3.12
Polar TM6 R 235 6x29 G.H5 Q 377 G.H5.26
Hydrophobic TM6 R 235 6x29 G.H5 Q 377 G.H5.26
Van-der-waals TM6 R 235 6x29 G.H5 Q 377 G.H5.26
Hydrophobic C-term E 354 - G.hfs2 P 202 G.hfs2.04
Van-der-waals C-term E 354 - G.hfs2 P 202 G.hfs2.04
Hydrophobic C-term V 329 - G.H2 F 234 G.H2.08
Van-der-waals C-term V 329 - G.H2 F 234 G.H2.08
Polar C-term Q 360 - G.s4h3 V 255 G.s4h3.07
Hydrophobic C-term Q 360 - G.s4h3 V 255 G.s4h3.07
Van-der-waals C-term Q 360 - G.s4h3 V 255 G.s4h3.07
Hydrophobic TM5 A 199 5x65 G.H5 M 375 G.H5.24
Polar C-term N 355 - H.HA K 94 H.HA.17
Hydrophobic C-term N 355 - H.HA K 94 H.HA.17
Van-der-waals C-term N 355 - H.HA K 94 H.HA.17
Hydrophobic C-term L 337 - G.H2 R 227 G.H2.01
Van-der-waals C-term L 337 - G.H2 R 227 G.H2.01
Polar C-term S 357 - H.HA D 101 H.HA.24
Hydrophobic C-term S 357 - H.HA D 101 H.HA.24
Van-der-waals C-term S 357 - H.HA D 101 H.HA.24
Polar ICL2 R 117 34x56 G.hns1 K 46 G.hns1.02
Hydrophobic ICL2 R 117 34x56 G.hns1 K 46 G.hns1.02
Van-der-waals ICL2 R 117 34x56 G.hns1 K 46 G.hns1.02
Hydrophobic ICL2 P 111 34x50 G.H5 K 363 G.H5.12
Van-der-waals ICL2 P 111 34x50 G.H5 K 363 G.H5.12
Hydrophobic C-term L 359 - H.hdhe F 168 H.hdhe.01