Gi2 - GPR82 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 18.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 K 124 - G.S3 L 195 G.S3.01
Polar ICL2 K 124 - G.H5 T 341 G.H5.12
Hydrophobic ICL2 K 124 - G.H5 T 341 G.H5.12
Van-der-waals ICL2 K 124 - G.H5 T 341 G.H5.12
Hydrophobic ICL2 Q 128 - G.s2s3 K 193 G.s2s3.01
Hydrophobic TM6 T 243 6x29 G.H5 L 349 G.H5.20
Hydrophobic TM6 V 247 6x33 G.H5 L 354 G.H5.25
Polar TM4 Q 148 4x38 G.HN R 24 G.HN.48
Hydrophobic TM4 Q 148 4x38 G.HN R 24 G.HN.48
Van-der-waals TM4 Q 148 4x38 G.HN R 24 G.HN.48
Polar TM6 H 250 6x36 G.H5 L 354 G.H5.25
Hydrophobic TM6 H 250 6x36 G.H5 L 354 G.H5.25
Van-der-waals TM6 H 250 6x36 G.H5 L 354 G.H5.25
Hydrophobic TM2 T 50 2x39 G.H5 C 352 G.H5.23
Van-der-waals TM2 T 50 2x39 G.H5 C 352 G.H5.23
Hydrophobic TM5 I 231 5x68 G.H5 I 345 G.H5.16
Van-der-waals TM5 I 231 5x68 G.H5 I 345 G.H5.16
Hydrophobic H8 D 313 8x47 G.H5 G 353 G.H5.24
Hydrophobic TM3 L 121 3x54 G.H5 I 345 G.H5.16
Polar TM3 R 117 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM3 R 117 3x50 G.H5 C 352 G.H5.23
Van-der-waals TM3 R 117 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM6 Y 244 6x30 G.H5 L 349 G.H5.20
Polar TM3 T 120 3x53 G.H5 C 352 G.H5.23
Hydrophobic TM3 T 120 3x53 G.H5 C 352 G.H5.23
Van-der-waals TM3 T 120 3x53 G.H5 C 352 G.H5.23
Polar TM3 R 117 3x50 G.H5 G 353 G.H5.24
Van-der-waals TM3 R 117 3x50 G.H5 G 353 G.H5.24
Van-der-waals TM6 I 237 6x23 G.H5 D 342 G.H5.13
Polar ICL2 S 127 - G.s2s3 D 194 G.s2s3.02
Hydrophobic ICL2 S 127 - G.s2s3 D 194 G.s2s3.02
Van-der-waals ICL2 S 127 - G.s2s3 D 194 G.s2s3.02
Polar ICL3 S 236 - G.H5 D 338 G.H5.09
Van-der-waals ICL3 S 236 - G.H5 D 338 G.H5.09
Polar TM2 T 50 2x39 G.H5 D 351 G.H5.22
Van-der-waals TM2 T 50 2x39 G.H5 D 351 G.H5.22
Hydrophobic TM3 R 117 3x50 G.H5 L 354 G.H5.25
Van-der-waals TM3 R 117 3x50 G.H5 L 354 G.H5.25
Polar ICL2 R 147 34x57 G.H5 N 348 G.H5.19
Polar TM4 Q 148 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 Q 148 4x38 G.HN E 28 G.HN.52
Hydrophobic TM6 I 237 6x23 G.S6 H 323 G.S6.04
Polar TM6 K 240 6x26 G.S6 Y 321 G.S6.02
Hydrophobic TM6 K 240 6x26 G.S6 Y 321 G.S6.02
Van-der-waals TM6 K 240 6x26 G.S6 Y 321 G.S6.02
Polar TM2 T 48 2x37 G.H5 D 351 G.H5.22
Hydrophobic TM2 T 48 2x37 G.H5 D 351 G.H5.22
Hydrophobic TM6 I 237 6x23 G.H5 D 338 G.H5.09
Hydrophobic TM6 Y 244 6x30 G.H5 I 345 G.H5.16
Hydrophobic ICL3 T 235 - G.H5 D 342 G.H5.13
Hydrophobic TM6 V 247 6x33 G.H5 L 349 G.H5.20
Hydrophobic TM6 T 243 6x29 G.H5 F 355 G.H5.26
Van-der-waals TM6 T 243 6x29 G.H5 F 355 G.H5.26
Ionic ICL2 K 144 34x54 G.HN E 28 G.HN.52
Polar ICL2 K 144 34x54 G.HN E 28 G.HN.52
Hydrophobic ICL2 K 144 34x54 G.HN E 28 G.HN.52
Van-der-waals ICL2 K 144 34x54 G.HN E 28 G.HN.52
Hydrophobic TM5 F 224 5x61 G.H5 L 349 G.H5.20
Van-der-waals TM5 F 224 5x61 G.H5 L 349 G.H5.20
Hydrophobic TM5 F 224 5x61 G.H5 L 354 G.H5.25
Van-der-waals TM5 F 224 5x61 G.H5 L 354 G.H5.25
Polar TM6 Y 244 6x30 G.H5 D 342 G.H5.13
Van-der-waals TM6 Y 244 6x30 G.H5 D 342 G.H5.13
Hydrophobic ICL3 T 235 - G.H5 D 338 G.H5.09
Ionic TM6 K 240 6x26 G.H5 D 342 G.H5.13
Polar TM6 K 240 6x26 G.H5 D 342 G.H5.13
Hydrophobic TM6 K 240 6x26 G.H5 D 342 G.H5.13
Van-der-waals TM6 K 240 6x26 G.H5 D 342 G.H5.13
Van-der-waals ICL2 K 124 - G.H5 N 348 G.H5.19
Hydrophobic TM6 L 251 6x37 G.H5 L 354 G.H5.25
Van-der-waals TM6 L 251 6x37 G.H5 L 354 G.H5.25
Hydrophobic ICL2 K 124 - G.H5 I 344 G.H5.15
Van-der-waals ICL2 K 124 - G.H5 I 344 G.H5.15
Hydrophobic ICL2 K 145 34x55 G.HN R 24 G.HN.48
Van-der-waals ICL2 K 145 34x55 G.HN R 24 G.HN.48
Hydrophobic TM6 I 237 6x23 G.H5 A 339 G.H5.10
Van-der-waals TM6 I 237 6x23 G.H5 A 339 G.H5.10
Polar ICL2 S 127 - G.s2s3 K 193 G.s2s3.01
Hydrophobic ICL2 S 127 - G.s2s3 K 193 G.s2s3.01
Van-der-waals ICL2 S 127 - G.s2s3 K 193 G.s2s3.01
Hydrophobic TM3 L 121 3x54 G.H5 L 349 G.H5.20
Polar TM3 T 120 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 T 120 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 T 120 3x53 G.H5 N 348 G.H5.19
Polar H8 K 314 8x48 G.H5 F 355 G.H5.26
Aromatic H8 K 314 8x48 G.H5 F 355 G.H5.26
Hydrophobic H8 K 314 8x48 G.H5 F 355 G.H5.26
Van-der-waals H8 K 314 8x48 G.H5 F 355 G.H5.26
Hydrophobic ICL2 K 144 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 K 144 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 K 124 - G.H5 I 345 G.H5.16