Ggust - GPR87 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 79.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 I 254 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 I 254 6x37 G.H5 L 353 G.H5.25
Ionic C-term R 350 - G.H5 D 341 G.H5.13
Polar C-term R 350 - G.H5 D 341 G.H5.13
Hydrophobic C-term R 350 - G.H5 D 341 G.H5.13
Van-der-waals C-term R 350 - G.H5 D 341 G.H5.13
Hydrophobic C-term I 351 - G.H4 K 304 G.H4.12
Van-der-waals C-term I 351 - G.H4 K 304 G.H4.12
Hydrophobic ICL2 P 146 34x50 G.H5 I 343 G.H5.15
Hydrophobic C-term Q 342 - G.h4s6 E 315 G.h4s6.09
Van-der-waals C-term Q 342 - G.h4s6 E 315 G.h4s6.09
Polar C-term Y 352 - G.S6 S 321 G.S6.03
Van-der-waals C-term Y 352 - G.S6 S 321 G.S6.03
Polar TM7 M 317 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM7 M 317 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 M 317 7x56 G.H5 G 352 G.H5.24
Hydrophobic ICL2 F 147 34x51 G.s2s3 D 193 G.s2s3.02
Hydrophobic C-term R 345 - G.h4s6 K 314 G.h4s6.08
Van-der-waals C-term R 345 - G.h4s6 K 314 G.h4s6.08
Polar C-term E 348 - G.S6 I 319 G.S6.01
Polar TM6 S 253 6x36 G.H5 C 351 G.H5.23
Hydrophobic C-term R 350 - G.S6 Y 320 G.S6.02
Van-der-waals C-term R 350 - G.S6 Y 320 G.S6.02
Hydrophobic TM3 V 143 3x54 G.H5 L 353 G.H5.25
Hydrophobic C-term R 350 - G.H5 K 345 G.H5.17
Van-der-waals C-term R 350 - G.H5 K 345 G.H5.17
Van-der-waals TM7 F 316 7x55 G.H5 G 352 G.H5.24
Hydrophobic C-term V 349 - G.H4 L 308 G.H4.16
Van-der-waals C-term V 349 - G.H4 L 308 G.H4.16
Hydrophobic ICL3 F 240 - G.H5 F 334 G.H5.06
Van-der-waals ICL3 F 240 - G.H5 F 334 G.H5.06
Hydrophobic C-term E 348 - G.h4s6 E 318 G.h4s6.12
Aromatic C-term Y 352 - G.S6 H 322 G.S6.04
Hydrophobic C-term Y 352 - G.S6 H 322 G.S6.04
Polar TM6 S 253 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM6 S 253 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 S 253 6x36 G.H5 L 353 G.H5.25
Ionic H8 R 319 8x48 G.h4s6 D 316 G.h4s6.10
Polar ICL2 F 147 34x51 G.hns1 R 32 G.hns1.03
Ionic C-term R 350 - G.h4s6 E 318 G.h4s6.12
Polar C-term R 350 - G.h4s6 E 318 G.h4s6.12
Hydrophobic C-term R 350 - G.h4s6 E 318 G.h4s6.12
Van-der-waals C-term R 350 - G.h4s6 E 318 G.h4s6.12
Polar C-term R 350 - G.S6 S 321 G.S6.03
Van-der-waals C-term R 350 - G.S6 S 321 G.S6.03
Hydrophobic TM3 R 139 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 139 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM6 H 250 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 H 250 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM5 Y 232 5x64 G.H5 I 344 G.H5.16
Van-der-waals TM5 Y 232 5x64 G.H5 I 344 G.H5.16
Polar ICL3 Q 239 - G.H5 D 337 G.H5.09
Hydrophobic ICL3 Q 239 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 Q 239 - G.H5 D 337 G.H5.09
Hydrophobic C-term R 346 - G.h4s6 K 314 G.h4s6.08
Van-der-waals C-term R 346 - G.h4s6 K 314 G.h4s6.08
Hydrophobic ICL2 F 147 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 F 147 34x51 G.H5 I 343 G.H5.15
Aromatic TM6 H 250 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM6 H 250 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 H 250 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM7 M 317 7x56 G.H5 C 351 G.H5.23
Van-der-waals TM7 M 317 7x56 G.H5 C 351 G.H5.23
Polar TM5 S 236 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 S 236 5x68 G.H5 D 341 G.H5.13
Polar C-term S 347 - G.H4 L 308 G.H4.16
Van-der-waals C-term S 347 - G.H4 L 308 G.H4.16
Hydrophobic TM6 H 250 6x33 G.H5 L 348 G.H5.20
Polar C-term S 343 - G.h4s6 E 315 G.h4s6.09
Hydrophobic C-term S 343 - G.h4s6 E 315 G.h4s6.09
Van-der-waals C-term S 343 - G.h4s6 E 315 G.h4s6.09
Polar C-term E 348 - G.h4s6 K 314 G.h4s6.08
Van-der-waals C-term E 348 - G.h4s6 K 314 G.h4s6.08
Hydrophobic TM5 I 233 5x65 G.H5 L 348 G.H5.20
Ionic C-term R 345 - G.h4s6 E 315 G.h4s6.09
Polar C-term R 345 - G.h4s6 E 315 G.h4s6.09
Hydrophobic C-term R 345 - G.h4s6 E 315 G.h4s6.09
Van-der-waals C-term R 345 - G.h4s6 E 315 G.h4s6.09
Hydrophobic ICL3 F 240 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 F 240 - G.H5 D 337 G.H5.09
Hydrophobic TM3 V 143 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 143 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM3 K 142 3x53 G.H5 C 351 G.H5.23
Polar TM6 S 253 6x36 G.H5 G 352 G.H5.24
Hydrophobic TM6 S 253 6x36 G.H5 G 352 G.H5.24
Van-der-waals TM6 S 253 6x36 G.H5 G 352 G.H5.24
Hydrophobic TM5 S 236 5x68 G.H5 I 344 G.H5.16
Hydrophobic ICL2 F 147 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 F 147 34x51 G.S3 L 194 G.S3.01
Aromatic ICL3 F 240 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 F 240 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 F 240 - G.S6 Y 320 G.S6.02
Polar C-term R 350 - G.S6 I 319 G.S6.01
Van-der-waals C-term R 350 - G.S6 I 319 G.S6.01
Polar ICL2 G 148 34x52 G.hns1 R 32 G.hns1.03
Aromatic C-term Y 352 - G.H5 F 334 G.H5.06
Hydrophobic C-term Y 352 - G.H5 F 334 G.H5.06
Van-der-waals C-term Y 352 - G.H5 F 334 G.H5.06
Ionic TM6 R 248 6x31 G.h4s6 E 315 G.h4s6.09
Polar TM6 R 248 6x31 G.h4s6 E 315 G.h4s6.09
Hydrophobic TM6 R 248 6x31 G.h4s6 E 315 G.h4s6.09
Van-der-waals TM6 R 248 6x31 G.h4s6 E 315 G.h4s6.09
Van-der-waals ICL2 P 146 34x50 G.H5 N 347 G.H5.19
Hydrophobic ICL3 F 240 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 F 240 - G.H5 D 341 G.H5.13
Hydrophobic TM3 V 143 3x54 G.H5 I 344 G.H5.16
Polar TM3 K 142 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 K 142 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 K 142 3x53 G.H5 N 347 G.H5.19
Ionic ICL2 D 149 34x53 G.hns1 R 32 G.hns1.03
Polar ICL2 D 149 34x53 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 D 149 34x53 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 D 149 34x53 G.hns1 R 32 G.hns1.03
Hydrophobic TM4 I 155 4x39 G.HN Q 24 G.HN.48
Van-der-waals TM4 I 155 4x39 G.HN Q 24 G.HN.48
Polar C-term S 347 - G.h4s6 K 314 G.h4s6.08
Hydrophobic C-term S 347 - G.h4s6 K 314 G.h4s6.08
Van-der-waals C-term S 347 - G.h4s6 K 314 G.h4s6.08
Polar C-term Y 352 - G.H5 D 337 G.H5.09
Hydrophobic C-term Y 352 - G.H5 D 337 G.H5.09
Van-der-waals C-term Y 352 - G.H5 D 337 G.H5.09
Ionic C-term D 354 - G.S6 H 322 G.S6.04
Hydrophobic C-term D 354 - G.S6 H 322 G.S6.04
Van-der-waals C-term D 354 - G.S6 H 322 G.S6.04
Polar TM3 R 139 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 139 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 139 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL3 F 240 - G.H5 A 338 G.H5.10
Van-der-waals ICL3 F 240 - G.H5 A 338 G.H5.10