Gt1 - GPR88 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 79.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 19.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM4 R 156 4x40 G.HN K 20 G.HN.48
Aromatic ICL3 F 231 - G.S6 H 318 G.S6.04
Hydrophobic ICL3 F 231 - G.S6 H 318 G.S6.04
Van-der-waals ICL3 F 231 - G.S6 H 318 G.S6.04
Hydrophobic ICL3 Q 278 - G.H5 F 350 G.H5.26
Van-der-waals ICL3 Q 278 - G.H5 F 350 G.H5.26
Polar ICL3 L 233 - G.H5 K 341 G.H5.17
Hydrophobic ICL3 L 233 - G.H5 K 341 G.H5.17
Van-der-waals ICL3 L 233 - G.H5 K 341 G.H5.17
Polar ICL2 P 146 34x50 G.S3 N 191 G.S3.02
Hydrophobic ICL2 P 146 34x50 G.S3 N 191 G.S3.02
Van-der-waals ICL2 P 146 34x50 G.S3 N 191 G.S3.02
Hydrophobic ICL3 L 229 - G.H5 V 331 G.H5.07
Hydrophobic ICL3 L 229 - G.H5 F 330 G.H5.06
Van-der-waals ICL3 L 229 - G.H5 F 330 G.H5.06
Hydrophobic ICL3 L 234 - G.H5 F 350 G.H5.26
Van-der-waals ICL3 L 234 - G.H5 F 350 G.H5.26
Hydrophobic ICL4 R 339 - G.H5 F 350 G.H5.26
Van-der-waals ICL4 R 339 - G.H5 F 350 G.H5.26
Polar TM4 H 157 4x41 G.HN K 20 G.HN.48
Hydrophobic TM4 H 157 4x41 G.HN K 20 G.HN.48
Van-der-waals TM4 H 157 4x41 G.HN K 20 G.HN.48
Hydrophobic ICL2 A 147 34x51 G.S3 N 191 G.S3.02
Hydrophobic ICL2 P 146 34x50 G.S3 L 190 G.S3.01
Van-der-waals ICL2 P 146 34x50 G.S3 L 190 G.S3.01
Hydrophobic ICL2 A 145 - G.s2s3 D 189 G.s2s3.02
Van-der-waals ICL2 A 145 - G.s2s3 D 189 G.s2s3.02
Hydrophobic TM4 Q 154 4x38 G.HN E 24 G.HN.52
Polar H8 N 340 8x47 G.H5 D 346 G.H5.22
Hydrophobic TM6 V 286 6x37 G.H5 L 349 G.H5.25
Ionic TM5 R 225 5x71 G.H5 D 333 G.H5.09
Hydrophobic ICL2 A 147 34x51 G.HN E 24 G.HN.52
Van-der-waals ICL2 A 147 34x51 G.HN E 24 G.HN.52
Polar ICL2 A 145 - G.hns1 R 28 G.hns1.03
Hydrophobic ICL2 A 145 - G.hns1 R 28 G.hns1.03
Van-der-waals ICL2 A 145 - G.hns1 R 28 G.hns1.03
Hydrophobic TM5 I 215 5x61 G.H5 L 349 G.H5.25
Polar ICL2 P 146 34x50 G.hns1 R 28 G.hns1.03
Hydrophobic ICL2 P 146 34x50 G.hns1 R 28 G.hns1.03
Van-der-waals ICL2 P 146 34x50 G.hns1 R 28 G.hns1.03
Hydrophobic TM3 L 141 3x53 G.H5 C 347 G.H5.23
Van-der-waals TM3 L 141 3x53 G.H5 C 347 G.H5.23
Hydrophobic ICL2 P 146 34x50 G.S1 T 29 G.S1.01
Ionic TM4 R 156 4x40 G.HN E 16 G.HN.44
Polar TM4 R 156 4x40 G.HN E 16 G.HN.44
Van-der-waals TM4 R 156 4x40 G.HN E 16 G.HN.44
Hydrophobic H8 R 345 8x52 G.h4s6 V 312 G.h4s6.10
Hydrophobic TM3 R 138 3x50 G.H5 L 349 G.H5.25
Polar ICL2 P 146 34x50 G.s2s3 D 189 G.s2s3.02
Van-der-waals ICL2 P 146 34x50 G.s2s3 D 189 G.s2s3.02
Polar ICL2 A 147 34x51 G.HN K 25 G.HN.53
Hydrophobic ICL3 L 229 - G.H5 A 334 G.H5.10
Hydrophobic TM5 V 226 5x72 G.H5 D 337 G.H5.13
Van-der-waals TM5 V 226 5x72 G.H5 D 337 G.H5.13
Polar ICL2 A 147 34x51 G.hns1 R 28 G.hns1.03
Hydrophobic ICL2 A 147 34x51 G.hns1 R 28 G.hns1.03
Van-der-waals ICL2 A 147 34x51 G.hns1 R 28 G.hns1.03
Hydrophobic ICL3 L 234 - G.H5 K 341 G.H5.17
Hydrophobic TM5 R 218 5x64 G.H5 I 340 G.H5.16
Polar TM4 Q 154 4x38 G.HN K 20 G.HN.48
Hydrophobic TM4 Q 154 4x38 G.HN K 20 G.HN.48
Van-der-waals TM4 Q 154 4x38 G.HN K 20 G.HN.48
Polar TM5 S 222 5x68 G.H5 D 337 G.H5.13
Hydrophobic TM5 S 222 5x68 G.H5 D 337 G.H5.13
Van-der-waals TM5 S 222 5x68 G.H5 D 337 G.H5.13
Hydrophobic ICL2 P 146 34x50 G.S1 V 30 G.S1.02
Hydrophobic ICL3 F 231 - G.S6 S 317 G.S6.03
Van-der-waals ICL3 F 231 - G.S6 S 317 G.S6.03
Polar TM3 L 141 3x53 G.H5 N 343 G.H5.19
Hydrophobic TM3 L 141 3x53 G.H5 N 343 G.H5.19
Van-der-waals TM3 L 141 3x53 G.H5 N 343 G.H5.19
Hydrophobic ICL3 S 282 - G.H5 L 349 G.H5.25
Van-der-waals ICL3 S 282 - G.H5 L 349 G.H5.25
Polar TM3 R 138 3x50 G.H5 C 347 G.H5.23
Hydrophobic TM3 R 138 3x50 G.H5 C 347 G.H5.23
Van-der-waals TM3 R 138 3x50 G.H5 C 347 G.H5.23
Hydrophobic TM5 V 226 5x72 G.H5 A 334 G.H5.10
Hydrophobic TM3 I 142 3x54 G.H5 L 349 G.H5.25
Polar ICL2 Q 150 34x54 G.hns1 R 28 G.hns1.03
Hydrophobic ICL2 Q 150 34x54 G.hns1 R 28 G.hns1.03
Van-der-waals ICL2 Q 150 34x54 G.hns1 R 28 G.hns1.03
Polar ICL2 Q 150 34x54 G.hns1 A 27 G.hns1.02
Hydrophobic ICL2 Q 150 34x54 G.hns1 A 27 G.hns1.02
Van-der-waals ICL2 Q 150 34x54 G.hns1 A 27 G.hns1.02
Hydrophobic TM5 Y 212 5x58 G.H5 L 349 G.H5.25
Hydrophobic ICL3 L 233 - G.H5 I 338 G.H5.14
Hydrophobic TM5 V 228 5x74 G.H5 F 330 G.H5.06
Hydrophobic ICL2 A 151 34x55 G.HN E 24 G.HN.52
Van-der-waals ICL2 A 151 34x55 G.HN E 24 G.HN.52
Polar ICL2 T 148 34x52 G.hns1 R 28 G.hns1.03
Hydrophobic ICL2 T 148 34x52 G.hns1 R 28 G.hns1.03
Van-der-waals ICL2 T 148 34x52 G.hns1 R 28 G.hns1.03
Hydrophobic TM5 I 215 5x61 G.H5 L 344 G.H5.20
Hydrophobic ICL2 Q 150 34x54 G.HN E 24 G.HN.52
Hydrophobic ICL3 L 233 - G.H5 D 337 G.H5.13
Van-der-waals ICL3 L 233 - G.H5 D 337 G.H5.13
Hydrophobic H8 N 340 8x47 G.H5 G 348 G.H5.24
Hydrophobic TM3 I 142 3x54 G.H5 C 347 G.H5.23
Van-der-waals TM3 I 142 3x54 G.H5 C 347 G.H5.23
Hydrophobic TM3 I 142 3x54 G.H5 L 344 G.H5.20
Van-der-waals TM3 I 142 3x54 G.H5 L 344 G.H5.20
Hydrophobic ICL3 F 231 - G.H5 I 338 G.H5.14
Hydrophobic TM5 V 219 5x65 G.H5 L 344 G.H5.20
Van-der-waals TM5 V 219 5x65 G.H5 L 344 G.H5.20
Hydrophobic ICL3 L 229 - G.S6 H 318 G.S6.04
Polar H8 N 340 8x47 G.H5 K 345 G.H5.21
Hydrophobic ICL3 S 282 - G.H5 F 350 G.H5.26
Hydrophobic ICL2 Y 149 34x53 G.hns1 R 28 G.hns1.03
Van-der-waals ICL2 Y 149 34x53 G.hns1 R 28 G.hns1.03
Hydrophobic ICL4 R 339 - G.H5 G 348 G.H5.24
Van-der-waals ICL4 R 339 - G.H5 G 348 G.H5.24
Hydrophobic ICL3 F 231 - G.S6 Y 316 G.S6.02
Van-der-waals ICL3 F 231 - G.S6 Y 316 G.S6.02