G13 - HCA1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 79.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 I 127 34x57 G.hns1 K 46 G.hns1.02
Hydrophobic ICL2 H 121 34x51 G.S1 V 49 G.S1.02
Van-der-waals ICL2 H 121 34x51 G.S1 V 49 G.S1.02
Hydrophobic ICL3 L 209 - G.H5 D 364 G.H5.13
Van-der-waals ICL3 L 209 - G.H5 D 364 G.H5.13
Hydrophobic TM5 L 203 5x65 G.H5 L 367 G.H5.16
Polar H8 S 282 8x47 G.H5 L 376 G.H5.25
Hydrophobic H8 S 282 8x47 G.H5 L 376 G.H5.25
Van-der-waals H8 S 282 8x47 G.H5 L 376 G.H5.25
Polar H8 S 284 8x49 G.H5 Q 377 G.H5.26
Van-der-waals H8 S 284 8x49 G.H5 Q 377 G.H5.26
Hydrophobic ICL1 M 44 - G.H5 L 376 G.H5.25
Hydrophobic ICL2 H 121 34x51 G.H5 I 366 G.H5.15
Van-der-waals ICL2 H 121 34x51 G.H5 I 366 G.H5.15
Hydrophobic TM7 Y 279 7x54 G.H5 L 376 G.H5.25
Polar H8 S 282 8x47 G.H5 M 375 G.H5.24
Hydrophobic H8 S 282 8x47 G.H5 M 375 G.H5.24
Van-der-waals H8 S 282 8x47 G.H5 M 375 G.H5.24
Polar ICL2 T 126 34x56 G.hns1 K 46 G.hns1.02
Hydrophobic ICL2 T 126 34x56 G.hns1 K 46 G.hns1.02
Van-der-waals ICL2 T 126 34x56 G.hns1 K 46 G.hns1.02
Hydrophobic ICL2 P 120 34x50 G.H5 I 366 G.H5.15
Van-der-waals ICL2 P 120 34x50 G.H5 I 366 G.H5.15
Hydrophobic ICL3 L 209 - G.H5 L 367 G.H5.16
Hydrophobic TM6 R 214 6x29 G.H5 M 375 G.H5.24
Polar TM6 R 214 6x29 G.H5 H 368 G.H5.17
Hydrophobic TM6 R 214 6x29 G.H5 H 368 G.H5.17
Van-der-waals TM6 R 214 6x29 G.H5 H 368 G.H5.17
Ionic ICL3 R 206 - G.H5 D 364 G.H5.13
Polar ICL3 R 206 - G.H5 D 364 G.H5.13
Hydrophobic ICL3 R 206 - G.H5 D 364 G.H5.13
Van-der-waals ICL3 R 206 - G.H5 D 364 G.H5.13
Polar H8 S 284 8x49 G.H5 L 376 G.H5.25
Hydrophobic H8 S 284 8x49 G.H5 L 376 G.H5.25
Van-der-waals H8 S 284 8x49 G.H5 L 376 G.H5.25
Hydrophobic C-term W 345 - H.HA D 101 H.HA.24
Van-der-waals C-term W 345 - H.HA D 101 H.HA.24
Polar ICL3 R 206 - G.H5 K 363 G.H5.12
Hydrophobic ICL3 R 206 - G.H5 K 363 G.H5.12
Van-der-waals ICL3 R 206 - G.H5 K 363 G.H5.12
Hydrophobic TM3 V 117 3x54 G.H5 L 367 G.H5.16
Van-der-waals TM3 V 117 3x54 G.H5 L 367 G.H5.16
Polar TM3 R 113 3x50 G.H5 L 374 G.H5.23
Hydrophobic TM3 R 113 3x50 G.H5 L 374 G.H5.23
Van-der-waals TM3 R 113 3x50 G.H5 L 374 G.H5.23
Hydrophobic TM2 L 54 2x43 G.H5 L 376 G.H5.25
Hydrophobic H8 P 283 8x48 G.H5 Q 377 G.H5.26
Van-der-waals H8 P 283 8x48 G.H5 Q 377 G.H5.26
Hydrophobic ICL2 H 121 34x51 G.S3 V 216 G.S3.01
Van-der-waals ICL2 H 121 34x51 G.S3 V 216 G.S3.01
Hydrophobic ICL2 T 126 34x56 G.HN T 43 G.HN.52
Van-der-waals ICL2 T 126 34x56 G.HN T 43 G.HN.52
Hydrophobic TM3 V 117 3x54 G.H5 L 371 G.H5.20
Hydrophobic TM1 F 40 1x57 G.H5 L 376 G.H5.25
Hydrophobic ICL2 P 120 34x50 G.H5 K 363 G.H5.12
Van-der-waals ICL2 P 120 34x50 G.H5 K 363 G.H5.12
Hydrophobic TM3 V 117 3x54 G.H5 L 374 G.H5.23
Van-der-waals TM3 V 117 3x54 G.H5 L 374 G.H5.23
Hydrophobic TM6 M 215 6x30 G.H5 L 371 G.H5.20
Van-der-waals TM6 M 215 6x30 G.H5 L 371 G.H5.20
Hydrophobic TM6 K 217 6x32 G.H5 M 375 G.H5.24
Hydrophobic TM6 R 214 6x29 G.H5 K 372 G.H5.21
Van-der-waals TM6 R 214 6x29 G.H5 K 372 G.H5.21
Hydrophobic TM6 A 218 6x33 G.H5 L 371 G.H5.20
Van-der-waals TM6 A 218 6x33 G.H5 L 371 G.H5.20
Hydrophobic C-term W 345 - H.HA E 104 H.HA.27
Van-der-waals C-term W 345 - H.HA E 104 H.HA.27
Polar ICL2 T 126 34x56 G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 T 126 34x56 G.hns1 R 47 G.hns1.03
Van-der-waals ICL2 T 126 34x56 G.hns1 R 47 G.hns1.03
Polar TM3 V 118 3x55 G.H5 K 363 G.H5.12
Hydrophobic TM6 A 218 6x33 G.H5 M 375 G.H5.24
Hydrophobic ICL2 A 123 34x53 G.hns1 R 47 G.hns1.03
Van-der-waals ICL2 A 123 34x53 G.hns1 R 47 G.hns1.03
Polar TM2 K 48 2x37 G.H5 Q 373 G.H5.22
Hydrophobic TM2 K 48 2x37 G.H5 Q 373 G.H5.22
Van-der-waals TM2 K 48 2x37 G.H5 Q 373 G.H5.22
Hydrophobic TM7 Y 278 7x53 G.H5 L 376 G.H5.25
Van-der-waals TM7 Y 278 7x53 G.H5 L 376 G.H5.25
Polar TM3 K 116 3x53 G.H5 N 370 G.H5.19
Hydrophobic TM3 K 116 3x53 G.H5 N 370 G.H5.19
Van-der-waals TM3 K 116 3x53 G.H5 N 370 G.H5.19
Hydrophobic H8 F 285 8x50 G.H5 L 376 G.H5.25
Hydrophobic ICL2 H 121 34x51 G.H5 V 362 G.H5.11
Hydrophobic TM6 M 215 6x30 G.H5 L 367 G.H5.16
Hydrophobic C-term W 345 - H.HA K 105 H.HA.28
Van-der-waals C-term W 345 - H.HA K 105 H.HA.28
Hydrophobic ICL2 H 121 34x51 G.H5 K 363 G.H5.12
Polar TM6 Q 212 6x27 G.H5 H 368 G.H5.17
Hydrophobic TM6 Q 212 6x27 G.H5 H 368 G.H5.17
Van-der-waals TM6 Q 212 6x27 G.H5 H 368 G.H5.17
Hydrophobic TM3 K 116 3x53 G.H5 L 374 G.H5.23
Hydrophobic C-term V 343 - H.hahb H 107 H.hahb.01
Hydrophobic TM5 L 203 5x65 G.H5 L 371 G.H5.20
Polar TM6 R 214 6x29 G.H5 Q 377 G.H5.26
Hydrophobic TM6 R 214 6x29 G.H5 Q 377 G.H5.26
Van-der-waals TM6 R 214 6x29 G.H5 Q 377 G.H5.26
Hydrophobic ICL3 R 206 - G.H5 L 367 G.H5.16
Van-der-waals ICL3 R 206 - G.H5 L 367 G.H5.16