G12 - H1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 88.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL3 S 398 - G.h4s6 R 342 G.h4s6.11
Van-der-waals ICL3 S 398 - G.h4s6 R 342 G.h4s6.11
Hydrophobic TM3 V 129 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 V 129 3x54 G.H5 I 378 G.H5.23
Polar TM3 S 128 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 S 128 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 S 128 3x53 G.H5 N 374 G.H5.19
Hydrophobic ICL2 L 133 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 133 34x51 G.S3 I 221 G.S3.01
Hydrophobic ICL3 P 232 - G.H4 V 332 G.H4.12
Polar TM5 H 220 5x68 G.H5 Q 372 G.H5.17
Hydrophobic TM5 H 220 5x68 G.H5 Q 372 G.H5.17
Van-der-waals TM5 H 220 5x68 G.H5 Q 372 G.H5.17
Hydrophobic TM6 Q 416 6x36 G.H5 L 380 G.H5.25
Hydrophobic ICL3 P 232 - G.H4 R 329 G.H4.09
Van-der-waals ICL3 P 232 - G.H4 R 329 G.H4.09
Hydrophobic ICL3 L 231 - G.H4 D 336 G.H4.16
Hydrophobic TM3 V 129 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 129 3x54 G.H5 L 371 G.H5.16
Ionic ICL2 R 139 34x57 G.H5 D 377 G.H5.22
Polar ICL2 R 139 34x57 G.H5 D 377 G.H5.22
Van-der-waals ICL2 R 139 34x57 G.H5 D 377 G.H5.22
Hydrophobic ICL2 L 136 34x54 G.H5 I 370 G.H5.15
Hydrophobic ICL2 P 132 34x50 G.H5 K 367 G.H5.12
Hydrophobic TM5 H 220 5x68 G.H5 L 375 G.H5.20
Van-der-waals TM5 H 220 5x68 G.H5 L 375 G.H5.20
Hydrophobic TM5 I 227 5x75 G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL2 P 132 34x50 G.H5 L 371 G.H5.16
Hydrophobic ICL2 P 132 34x50 G.H5 I 370 G.H5.15
Hydrophobic TM5 V 217 5x65 G.H5 L 380 G.H5.25
Polar TM5 H 223 5x71 G.H5 H 364 G.H5.09
Aromatic TM5 H 223 5x71 G.H5 H 364 G.H5.09
Hydrophobic TM5 H 223 5x71 G.H5 H 364 G.H5.09
Van-der-waals TM5 H 223 5x71 G.H5 H 364 G.H5.09
Hydrophobic TM3 V 129 3x54 G.H5 L 375 G.H5.20
Hydrophobic ICL2 L 133 34x51 G.H5 V 366 G.H5.11
Polar TM6 K 412 6x32 G.H5 Q 381 G.H5.26
Hydrophobic TM6 K 412 6x32 G.H5 Q 381 G.H5.26
Van-der-waals TM6 K 412 6x32 G.H5 Q 381 G.H5.26
Hydrophobic H8 N 472 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 N 472 8x47 G.H5 M 379 G.H5.24
Hydrophobic ICL2 L 136 34x54 G.S1 V 58 G.S1.02
Hydrophobic ICL2 L 133 34x51 G.S1 V 58 G.S1.02
Hydrophobic TM5 I 213 5x61 G.H5 L 380 G.H5.25
Van-der-waals TM5 I 213 5x61 G.H5 L 380 G.H5.25
Hydrophobic TM5 H 220 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 H 220 5x68 G.H5 L 371 G.H5.16
Hydrophobic TM3 R 125 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM7 Y 468 7x53 G.H5 M 379 G.H5.24
Van-der-waals TM7 Y 468 7x53 G.H5 M 379 G.H5.24
Hydrophobic ICL2 L 136 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic ICL3 L 231 - G.S6 H 348 G.S6.03
Polar TM5 C 221 5x69 G.H5 Q 381 G.H5.26
Van-der-waals TM5 C 221 5x69 G.H5 Q 381 G.H5.26
Polar TM5 R 224 5x72 G.H5 Q 372 G.H5.17
Hydrophobic TM5 R 224 5x72 G.H5 Q 372 G.H5.17
Van-der-waals TM5 R 224 5x72 G.H5 Q 372 G.H5.17
Hydrophobic TM5 I 227 5x75 G.S6 F 347 G.S6.02
Van-der-waals TM5 I 227 5x75 G.S6 F 347 G.S6.02
Hydrophobic TM5 R 224 5x72 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM3 R 125 3x50 G.H5 M 379 G.H5.24
Van-der-waals TM3 R 125 3x50 G.H5 M 379 G.H5.24
Ionic TM5 R 224 5x72 G.H5 D 368 G.H5.13
Polar TM5 R 224 5x72 G.H5 D 368 G.H5.13
Hydrophobic TM5 R 224 5x72 G.H5 D 368 G.H5.13
Van-der-waals TM5 R 224 5x72 G.H5 D 368 G.H5.13
Hydrophobic TM6 L 417 6x37 G.H5 L 380 G.H5.25
Van-der-waals TM6 L 417 6x37 G.H5 L 380 G.H5.25
Hydrophobic ICL3 L 231 - G.H4 V 332 G.H4.12
Van-der-waals ICL3 L 231 - G.H4 V 332 G.H4.12
Ionic TM5 H 220 5x68 G.H5 D 368 G.H5.13
Polar TM5 H 220 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 H 220 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 H 220 5x68 G.H5 D 368 G.H5.13
Polar TM6 A 413 6x33 G.H5 L 380 G.H5.25
Hydrophobic TM6 A 413 6x33 G.H5 L 380 G.H5.25
Van-der-waals TM6 A 413 6x33 G.H5 L 380 G.H5.25
Hydrophobic TM7 C 471 7x56 G.H5 M 379 G.H5.24
Van-der-waals TM7 C 471 7x56 G.H5 M 379 G.H5.24
Hydrophobic ICL3 L 231 - G.S6 L 346 G.S6.01
Hydrophobic ICL3 F 234 - G.H4 R 337 G.H4.17
Hydrophobic ICL2 L 133 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 133 34x51 G.H5 I 370 G.H5.15
Polar H8 N 472 8x47 G.H5 D 377 G.H5.22
Polar TM6 R 409 6x29 G.h4s6 S 343 G.h4s6.12
Van-der-waals TM6 R 409 6x29 G.h4s6 S 343 G.h4s6.12
Hydrophobic TM5 I 227 5x75 G.S6 L 346 G.S6.01
Van-der-waals TM5 I 227 5x75 G.S6 L 346 G.S6.01
Hydrophobic ICL2 L 133 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 133 34x51 G.H5 F 363 G.H5.08
Hydrophobic TM5 V 217 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 V 217 5x65 G.H5 L 375 G.H5.20
Polar ICL3 S 230 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 S 230 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 S 230 - G.S6 H 348 G.S6.03
Hydrophobic ICL2 L 133 34x51 G.H5 K 367 G.H5.12
Polar ICL3 P 232 - G.H4 Q 333 G.H4.13
Hydrophobic ICL3 P 232 - G.H4 Q 333 G.H4.13
Van-der-waals ICL3 P 232 - G.H4 Q 333 G.H4.13
Hydrophobic TM6 R 409 6x29 G.H5 Q 381 G.H5.26