Gz - kisspeptin receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 M 227 5x61 G.H5 L 354 G.H5.25
Van-der-waals TM5 M 227 5x61 G.H5 L 354 G.H5.25
Hydrophobic TM3 R 140 3x50 G.H5 L 354 G.H5.25
Polar TM5 Q 246 5x80 G.S6 S 322 G.S6.03
Hydrophobic TM5 Q 246 5x80 G.S6 S 322 G.S6.03
Van-der-waals TM5 Q 246 5x80 G.S6 S 322 G.S6.03
Ionic ICL2 R 153 34x56 G.s2s3 E 194 G.s2s3.02
Hydrophobic ICL2 L 148 34x51 G.S1 I 34 G.S1.02
Ionic TM5 D 242 5x76 G.HG K 272 G.HG.01
Polar TM5 D 242 5x76 G.HG K 272 G.HG.01
Van-der-waals TM5 D 242 5x76 G.HG K 272 G.HG.01
Hydrophobic TM5 S 243 5x77 G.S6 F 324 G.S6.05
Polar ICL2 H 152 34x55 G.s2s3 E 194 G.s2s3.02
Hydrophobic ICL2 P 147 34x50 G.H5 I 345 G.H5.16
Van-der-waals ICL2 P 147 34x50 G.H5 I 345 G.H5.16
Hydrophobic TM5 L 231 5x65 G.H5 I 345 G.H5.16
Polar TM5 Q 246 5x80 G.S6 F 324 G.S6.05
Hydrophobic TM5 Q 246 5x80 G.S6 F 324 G.S6.05
Van-der-waals TM5 Q 246 5x80 G.S6 F 324 G.S6.05
Hydrophobic TM3 V 143 3x53 G.H5 I 352 G.H5.23
Hydrophobic TM5 V 234 5x68 G.H5 D 342 G.H5.13
Van-der-waals TM5 V 234 5x68 G.H5 D 342 G.H5.13
Hydrophobic TM6 V 257 6x29 G.H5 C 355 G.H5.26
Ionic ICL1 K 71 12x48 G.HN D 20 G.HN.44
Hydrophobic ICL3 L 250 - G.S6 H 323 G.S6.04
Hydrophobic TM6 K 260 6x32 G.H5 C 355 G.H5.26
Van-der-waals TM6 K 260 6x32 G.H5 C 355 G.H5.26
Ionic TM6 R 253 6x25 G.H4 E 309 G.H4.16
Polar TM6 R 253 6x25 G.H4 E 309 G.H4.16
Hydrophobic TM6 R 253 6x25 G.H4 E 309 G.H4.16
Van-der-waals TM6 R 253 6x25 G.H4 E 309 G.H4.16
Hydrophobic TM6 V 261 6x33 G.H5 C 355 G.H5.26
Hydrophobic ICL2 L 151 34x54 G.S1 I 34 G.S1.02
Hydrophobic ICL2 H 152 34x55 G.S3 L 195 G.S3.01
Van-der-waals ICL2 H 152 34x55 G.S3 L 195 G.S3.01
Ionic TM5 R 237 5x71 G.H5 D 342 G.H5.13
Hydrophobic TM5 P 240 5x74 G.H5 F 335 G.H5.06
Van-der-waals TM5 P 240 5x74 G.H5 F 335 G.H5.06
Hydrophobic TM6 V 261 6x33 G.H5 L 349 G.H5.20
Hydrophobic TM3 T 144 3x54 G.H5 I 345 G.H5.16
Hydrophobic ICL2 P 147 34x50 G.H5 T 341 G.H5.12
Hydrophobic ICL2 L 151 34x54 G.S3 L 195 G.S3.01
Hydrophobic ICL2 L 148 34x51 G.s2s3 K 193 G.s2s3.01
Van-der-waals ICL2 L 148 34x51 G.s2s3 K 193 G.s2s3.01
Polar ICL2 P 147 34x50 G.H5 N 348 G.H5.19
Polar H8 S 328 8x48 G.H5 C 355 G.H5.26
Hydrophobic TM6 V 257 6x29 G.H5 L 349 G.H5.20
Ionic TM5 R 237 5x71 G.H5 D 338 G.H5.09
Polar TM5 R 237 5x71 G.H5 D 338 G.H5.09
Hydrophobic TM5 R 237 5x71 G.H5 D 338 G.H5.09
Van-der-waals TM5 R 237 5x71 G.H5 D 338 G.H5.09
Polar ICL2 H 152 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 H 152 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 H 152 34x55 G.hns1 R 32 G.hns1.03
Polar TM6 R 253 6x25 G.S6 I 320 G.S6.01
Van-der-waals TM6 R 253 6x25 G.S6 I 320 G.S6.01
Polar TM3 V 143 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 V 143 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 V 143 3x53 G.H5 N 348 G.H5.19
Hydrophobic ICL2 L 148 34x51 G.H5 I 344 G.H5.15
Hydrophobic ICL2 L 148 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 L 148 34x51 G.S3 L 195 G.S3.01
Hydrophobic TM6 V 257 6x29 G.H5 Q 346 G.H5.17
Van-der-waals TM6 V 257 6x29 G.H5 Q 346 G.H5.17
Hydrophobic ICL2 P 147 34x50 G.H5 I 344 G.H5.15
Polar TM2 T 77 2x39 G.H5 Y 351 G.H5.22
Van-der-waals TM2 T 77 2x39 G.H5 Y 351 G.H5.22
Hydrophobic TM6 V 261 6x33 G.H5 L 354 G.H5.25
Hydrophobic H8 G 327 8x47 G.H5 G 353 G.H5.24
Polar TM5 Q 246 5x80 G.H4 Q 305 G.H4.12
Aromatic H8 H 329 8x49 G.H5 Y 351 G.H5.22
Hydrophobic H8 H 329 8x49 G.H5 Y 351 G.H5.22
Hydrophobic TM5 L 245 5x79 G.H4 V 302 G.H4.08
Van-der-waals TM5 L 245 5x79 G.H4 V 302 G.H4.08
Hydrophobic TM5 L 231 5x65 G.H5 L 349 G.H5.20
Hydrophobic ICL2 L 148 34x51 G.H5 T 341 G.H5.12
Ionic ICL2 R 149 34x52 G.s2s3 E 194 G.s2s3.02
Polar ICL2 R 149 34x52 G.s2s3 E 194 G.s2s3.02
Van-der-waals ICL2 R 149 34x52 G.s2s3 E 194 G.s2s3.02
Hydrophobic ICL2 L 151 34x54 G.H5 I 344 G.H5.15
Hydrophobic TM2 T 77 2x39 G.H5 I 352 G.H5.23
Hydrophobic H8 H 329 8x49 G.H5 K 350 G.H5.21
Polar TM3 R 140 3x50 G.H5 I 352 G.H5.23
Hydrophobic TM3 R 140 3x50 G.H5 I 352 G.H5.23
Van-der-waals TM3 R 140 3x50 G.H5 I 352 G.H5.23
Hydrophobic TM5 V 234 5x68 G.H5 I 345 G.H5.16
Hydrophobic TM5 Q 246 5x80 G.S6 H 323 G.S6.04
Van-der-waals TM5 Q 246 5x80 G.S6 H 323 G.S6.04
Hydrophobic TM6 L 264 6x36 G.H5 L 354 G.H5.25
Van-der-waals TM6 L 264 6x36 G.H5 L 354 G.H5.25
Hydrophobic TM3 T 144 3x54 G.H5 L 349 G.H5.20