Gz - LPA3 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 87.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 R 127 3x50 G.H5 G 353 G.H5.24
Polar ICL3 H 223 - G.S6 S 322 G.S6.03
Van-der-waals ICL3 H 223 - G.S6 S 322 G.S6.03
Polar TM6 S 229 6x25 G.h4s6 E 316 G.h4s6.09
Hydrophobic TM6 S 229 6x25 G.h4s6 E 316 G.h4s6.09
Van-der-waals TM6 S 229 6x25 G.h4s6 E 316 G.h4s6.09
Hydrophobic TM6 T 233 6x29 G.H5 C 355 G.H5.26
Van-der-waals TM6 T 233 6x29 G.H5 C 355 G.H5.26
Hydrophobic TM6 S 227 6x23 G.h4s6 E 319 G.h4s6.12
Hydrophobic C-term I 323 - G.H3 W 259 G.H3.17
Hydrophobic TM5 K 216 5x68 G.H5 I 345 G.H5.16
Hydrophobic ICL2 M 134 34x50 G.H5 F 337 G.H5.08
Hydrophobic TM2 F 65 2x39 G.H5 I 352 G.H5.23
Van-der-waals TM2 F 65 2x39 G.H5 I 352 G.H5.23
Polar ICL3 S 225 - G.H4 E 309 G.H4.16
Hydrophobic ICL3 S 225 - G.H4 E 309 G.H4.16
Van-der-waals ICL3 S 225 - G.H4 E 309 G.H4.16
Hydrophobic TM2 F 63 2x37 G.H5 Y 351 G.H5.22
Van-der-waals TM2 F 63 2x37 G.H5 Y 351 G.H5.22
Polar TM7 K 296 7x56 G.H5 L 354 G.H5.25
Van-der-waals TM7 K 296 7x56 G.H5 L 354 G.H5.25
Hydrophobic TM5 L 220 5x72 G.S6 Y 321 G.S6.02
Aromatic ICL3 H 223 - G.H5 F 335 G.H5.06
Hydrophobic ICL3 H 223 - G.H5 F 335 G.H5.06
Van-der-waals ICL3 H 223 - G.H5 F 335 G.H5.06
Hydrophobic TM3 S 130 3x53 G.H5 I 352 G.H5.23
Hydrophobic ICL3 T 224 - G.S6 Y 321 G.S6.02
Van-der-waals ICL3 T 224 - G.S6 Y 321 G.S6.02
Hydrophobic ICL2 M 134 34x50 G.H5 T 341 G.H5.12
Van-der-waals ICL2 M 134 34x50 G.H5 T 341 G.H5.12
Hydrophobic ICL2 S 138 34x54 G.H5 Y 351 G.H5.22
Hydrophobic TM5 V 213 5x65 G.H5 L 349 G.H5.20
Polar TM3 R 127 3x50 G.H5 I 352 G.H5.23
Hydrophobic TM3 R 127 3x50 G.H5 I 352 G.H5.23
Van-der-waals TM3 R 127 3x50 G.H5 I 352 G.H5.23
Polar TM3 S 130 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM6 L 237 6x33 G.H5 C 355 G.H5.26
Hydrophobic TM3 I 131 3x54 G.H5 I 352 G.H5.23
Polar TM5 T 217 5x69 G.H5 D 342 G.H5.13
Hydrophobic TM6 L 237 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM5 L 220 5x72 G.H5 A 339 G.H5.10
Hydrophobic TM5 Y 206 5x58 G.H5 L 354 G.H5.25
Hydrophobic ICL2 R 135 34x51 G.H5 I 344 G.H5.15
Van-der-waals ICL2 R 135 34x51 G.H5 I 344 G.H5.15
Polar ICL3 T 224 - G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL3 T 224 - G.h4s6 E 319 G.h4s6.12
Van-der-waals ICL3 T 224 - G.h4s6 E 319 G.h4s6.12
Hydrophobic TM3 I 131 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 I 131 3x54 G.H5 L 349 G.H5.20
Hydrophobic TM2 F 65 2x39 G.H5 Y 351 G.H5.22
Polar TM6 I 228 6x24 G.h4s6 K 315 G.h4s6.08
Hydrophobic TM5 L 220 5x72 G.H5 D 338 G.H5.09
Van-der-waals TM5 L 220 5x72 G.H5 D 338 G.H5.09
Polar TM6 S 227 6x23 G.h4s6 E 316 G.h4s6.09
Ionic TM6 R 230 6x26 G.H5 D 342 G.H5.13
Polar TM6 R 230 6x26 G.H5 D 342 G.H5.13
Hydrophobic TM6 R 230 6x26 G.H5 D 342 G.H5.13
Van-der-waals TM6 R 230 6x26 G.H5 D 342 G.H5.13
Hydrophobic ICL2 V 136 34x52 G.S1 I 34 G.S1.02
Hydrophobic ICL2 V 136 34x52 G.h2s4 T 220 G.h2s4.05
Ionic TM6 R 230 6x26 G.h4s6 E 319 G.h4s6.12
Polar TM6 R 230 6x26 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 R 230 6x26 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 R 230 6x26 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 L 237 6x33 G.H5 L 349 G.H5.20
Hydrophobic TM5 Y 212 5x64 G.H5 I 345 G.H5.16
Van-der-waals TM5 Y 212 5x64 G.H5 I 345 G.H5.16
Polar TM6 T 233 6x29 G.H5 Q 346 G.H5.17
Hydrophobic TM6 T 233 6x29 G.H5 Q 346 G.H5.17
Van-der-waals TM6 T 233 6x29 G.H5 Q 346 G.H5.17
Polar ICL2 H 137 34x53 G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 H 137 34x53 G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 H 137 34x53 G.hns1 R 31 G.hns1.02
Polar ICL2 S 138 34x54 G.hns1 R 31 G.hns1.02
Hydrophobic TM5 L 220 5x72 G.H5 D 342 G.H5.13
Van-der-waals TM5 L 220 5x72 G.H5 D 342 G.H5.13
Hydrophobic ICL2 V 136 34x52 G.H5 I 344 G.H5.15
Polar TM6 R 230 6x26 G.S6 Y 321 G.S6.02
Hydrophobic TM6 R 230 6x26 G.S6 Y 321 G.S6.02
Van-der-waals TM6 R 230 6x26 G.S6 Y 321 G.S6.02
Hydrophobic ICL2 M 134 34x50 G.H5 I 344 G.H5.15
Hydrophobic TM5 L 220 5x72 G.H5 F 335 G.H5.06
Polar TM6 S 227 6x23 G.h4s6 K 315 G.h4s6.08
Van-der-waals TM6 S 227 6x23 G.h4s6 K 315 G.h4s6.08
Hydrophobic TM6 T 233 6x29 G.H5 L 349 G.H5.20
Van-der-waals TM6 T 233 6x29 G.H5 L 349 G.H5.20
Hydrophobic C-term S 321 - G.H3 W 259 G.H3.17
Polar TM6 T 240 6x36 G.H5 L 354 G.H5.25
Hydrophobic TM6 T 240 6x36 G.H5 L 354 G.H5.25
Van-der-waals TM6 T 240 6x36 G.H5 L 354 G.H5.25
Hydrophobic TM3 R 127 3x50 G.H5 L 354 G.H5.25
Van-der-waals TM3 R 127 3x50 G.H5 L 354 G.H5.25
Hydrophobic TM5 V 213 5x65 G.H5 I 345 G.H5.16
Hydrophobic TM5 K 216 5x68 G.H5 T 341 G.H5.12
Hydrophobic TM6 K 236 6x32 G.H5 C 355 G.H5.26
Ionic TM5 K 216 5x68 G.H5 D 338 G.H5.09
Polar TM5 K 216 5x68 G.H5 D 338 G.H5.09
Hydrophobic TM5 I 209 5x61 G.H5 L 354 G.H5.25
Hydrophobic TM3 I 131 3x54 G.H5 L 354 G.H5.25
Hydrophobic TM6 R 230 6x26 G.H5 Q 346 G.H5.17
Polar ICL2 R 135 34x51 G.H5 N 348 G.H5.19
Van-der-waals ICL2 R 135 34x51 G.H5 N 348 G.H5.19