G12 - MAS1L complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 73.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 15.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 K 258 - G.H5 K 376 G.H5.21
Van-der-waals ICL3 K 258 - G.H5 K 376 G.H5.21
Hydrophobic TM6 R 261 6x32 G.H5 Q 381 G.H5.26
Van-der-waals TM6 R 261 6x32 G.H5 Q 381 G.H5.26
Polar ICL2 P 178 34x50 G.H5 N 374 G.H5.19
Van-der-waals ICL2 P 178 34x50 G.H5 N 374 G.H5.19
Polar TM3 C 174 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 C 174 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 C 174 3x53 G.H5 N 374 G.H5.19
Hydrophobic ICL2 P 178 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 178 34x50 G.H5 I 370 G.H5.15
Hydrophobic TM6 V 262 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 V 262 6x33 G.H5 M 379 G.H5.24
Hydrophobic C-term V 376 - G.S2 I 211 G.S2.01
Hydrophobic ICL2 I 179 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 I 179 34x51 G.H5 F 363 G.H5.08
Hydrophobic C-term E 371 - G.S2 V 212 G.S2.02
Hydrophobic C-term L 368 - G.h1ha R 83 G.h1ha.02
Van-der-waals C-term L 368 - G.h1ha R 83 G.h1ha.02
Hydrophobic TM3 R 171 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 171 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL2 H 184 34x56 G.S3 I 221 G.S3.01
Hydrophobic TM2 M 109 2x40 G.H5 L 380 G.H5.25
Van-der-waals TM2 M 109 2x40 G.H5 L 380 G.H5.25
Polar C-term V 374 - G.S2 I 211 G.S2.01
Hydrophobic TM2 Y 108 2x39 G.H5 L 380 G.H5.25
Polar ICL2 H 184 34x56 G.s2s3 K 220 G.s2s3.02
Hydrophobic ICL2 H 184 34x56 G.s2s3 K 220 G.s2s3.02
Van-der-waals ICL2 H 184 34x56 G.s2s3 K 220 G.s2s3.02
Hydrophobic TM6 V 265 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM6 V 265 6x36 G.H5 M 379 G.H5.24
Polar ICL2 C 183 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 C 183 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 C 183 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic TM3 C 174 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 C 174 3x53 G.H5 I 378 G.H5.23
Van-der-waals ICL3 Q 256 - G.S6 F 347 G.S6.02
Hydrophobic C-term V 376 - G.H2 Q 240 G.H2.09
Van-der-waals C-term V 376 - G.H2 Q 240 G.H2.09
Hydrophobic C-term R 373 - G.S2 V 212 G.S2.02
Polar TM2 Y 108 2x39 G.H5 I 378 G.H5.23
Hydrophobic TM2 Y 108 2x39 G.H5 I 378 G.H5.23
Van-der-waals TM2 Y 108 2x39 G.H5 I 378 G.H5.23
Polar H8 K 322 8x51 G.H5 Q 381 G.H5.26
Hydrophobic H8 K 322 8x51 G.H5 Q 381 G.H5.26
Van-der-waals H8 K 322 8x51 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 I 179 34x51 G.H5 I 370 G.H5.15
Hydrophobic ICL2 P 178 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 178 34x50 G.H5 K 367 G.H5.12
Hydrophobic ICL2 I 179 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 I 179 34x51 G.S3 I 221 G.S3.01
Hydrophobic TM6 R 261 6x32 G.H5 M 379 G.H5.24
Van-der-waals TM6 R 261 6x32 G.H5 M 379 G.H5.24
Polar C-term L 367 - G.h1ha R 83 G.h1ha.02
Hydrophobic H8 G 318 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 G 318 8x47 G.H5 M 379 G.H5.24
Polar C-term H 372 - G.S2 E 213 G.S2.03
Van-der-waals C-term H 372 - G.S2 E 213 G.S2.03
Polar H8 S 319 8x48 G.H5 M 379 G.H5.24
Hydrophobic ICL2 P 178 34x50 G.H5 L 371 G.H5.16
Polar ICL3 Q 256 - G.H5 Q 372 G.H5.17
Hydrophobic ICL3 Q 256 - G.H5 Q 372 G.H5.17
Van-der-waals ICL3 Q 256 - G.H5 Q 372 G.H5.17
Hydrophobic C-term P 369 - G.h1ha R 83 G.h1ha.02
Van-der-waals C-term P 369 - G.h1ha R 83 G.h1ha.02
Hydrophobic ICL2 R 182 34x54 G.H5 I 370 G.H5.15
Van-der-waals ICL2 R 182 34x54 G.H5 I 370 G.H5.15
Polar TM4 Y 188 4x40 G.HN R 52 G.HN.52
Hydrophobic TM4 Y 188 4x40 G.HN R 52 G.HN.52
Van-der-waals TM4 Y 188 4x40 G.HN R 52 G.HN.52
Hydrophobic ICL3 K 258 - G.H5 Q 372 G.H5.17
Van-der-waals ICL3 K 258 - G.H5 Q 372 G.H5.17
Polar H8 S 319 8x48 G.H5 L 380 G.H5.25
Polar TM2 N 106 2x37 G.H5 D 377 G.H5.22
Hydrophobic TM2 N 106 2x37 G.H5 D 377 G.H5.22
Van-der-waals TM2 N 106 2x37 G.H5 D 377 G.H5.22
Ionic ICL2 R 182 34x54 G.H5 E 373 G.H5.18
Polar ICL2 R 182 34x54 G.H5 E 373 G.H5.18
Hydrophobic ICL2 R 182 34x54 G.H5 E 373 G.H5.18
Van-der-waals ICL2 R 182 34x54 G.H5 E 373 G.H5.18
Ionic C-term E 371 - G.H1 R 78 G.H1.09
Polar C-term E 371 - G.H1 R 78 G.H1.09
Van-der-waals C-term E 371 - G.H1 R 78 G.H1.09
Hydrophobic TM3 V 175 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 175 3x54 G.H5 L 371 G.H5.16
Polar ICL2 H 184 34x56 G.hns1 R 56 G.hns1.03
Aromatic ICL2 H 184 34x56 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 I 179 34x51 G.H5 K 367 G.H5.12
Hydrophobic TM6 V 262 6x33 G.H5 L 375 G.H5.20
Van-der-waals TM6 V 262 6x33 G.H5 L 375 G.H5.20
Hydrophobic TM3 V 175 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM4 K 187 4x39 G.HN R 52 G.HN.52
Van-der-waals TM4 K 187 4x39 G.HN R 52 G.HN.52
Ionic C-term D 339 - G.HN R 51 G.HN.51
Polar C-term D 339 - G.HN R 51 G.HN.51
Hydrophobic C-term D 339 - G.HN R 51 G.HN.51
Van-der-waals C-term D 339 - G.HN R 51 G.HN.51
Ionic C-term E 371 - G.S2 H 214 G.S2.04
Polar C-term E 371 - G.S2 H 214 G.S2.04
Hydrophobic C-term E 371 - G.S2 H 214 G.S2.04
Van-der-waals C-term E 371 - G.S2 H 214 G.S2.04
Hydrophobic TM6 A 259 6x30 G.H5 L 375 G.H5.20
Polar H8 G 318 8x47 G.H5 Q 381 G.H5.26
Hydrophobic H8 G 318 8x47 G.H5 Q 381 G.H5.26
Van-der-waals H8 G 318 8x47 G.H5 Q 381 G.H5.26
Hydrophobic TM7 F 315 7x54 G.H5 L 380 G.H5.25
Van-der-waals TM7 F 315 7x54 G.H5 L 380 G.H5.25
Hydrophobic TM7 V 317 7x56 G.H5 M 379 G.H5.24
Hydrophobic ICL2 Y 181 34x53 G.H5 N 374 G.H5.19