G12 - MCH2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 15.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 F 139 34x51 G.S1 V 58 G.S1.02
Van-der-waals ICL2 F 139 34x51 G.S1 V 58 G.S1.02
Polar H8 G 311 8x48 G.H5 M 379 G.H5.24
Hydrophobic TM2 L 89 2x60 G.HN S 2 G.HN.02
Polar TM3 T 107 3x26 G.HN S 2 G.HN.02
Hydrophobic TM3 T 107 3x26 G.HN S 2 G.HN.02
Van-der-waals TM3 T 107 3x26 G.HN S 2 G.HN.02
Hydrophobic TM5 T 224 5x65 G.H5 L 371 G.H5.16
Hydrophobic TM3 L 135 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 L 135 3x54 G.H5 L 371 G.H5.16
Polar TM6 R 245 6x29 G.H5 Q 372 G.H5.17
Van-der-waals TM6 R 245 6x29 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 R 143 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 R 143 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 F 139 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 F 139 34x51 G.S3 I 221 G.S3.01
Hydrophobic TM6 M 252 6x36 G.H5 M 379 G.H5.24
Hydrophobic TM2 D 69 2x40 G.H5 L 380 G.H5.25
Van-der-waals TM2 D 69 2x40 G.H5 L 380 G.H5.25
Hydrophobic TM2 P 68 2x39 G.H5 L 380 G.H5.25
Hydrophobic TM3 C 106 3x25 G.HN G 3 G.HN.03
Hydrophobic TM6 L 249 6x33 G.H5 I 378 G.H5.23
Polar TM3 P 104 3x23 G.HN V 4 G.HN.04
Hydrophobic TM3 P 104 3x23 G.HN V 4 G.HN.04
Van-der-waals TM3 P 104 3x23 G.HN V 4 G.HN.04
Hydrophobic TM3 L 105 3x24 G.HN V 4 G.HN.04
Van-der-waals TM3 L 105 3x24 G.HN V 4 G.HN.04
Hydrophobic ICL3 C 237 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 C 237 - G.h4s6 P 345 G.h4s6.20
Polar ICL2 R 140 34x52 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 R 140 34x52 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 P 138 34x50 G.H5 K 367 G.H5.12
Polar TM3 I 108 3x27 G.HN S 2 G.HN.02
Hydrophobic TM3 I 108 3x27 G.HN S 2 G.HN.02
Van-der-waals TM3 I 108 3x27 G.HN S 2 G.HN.02
Polar H8 S 310 8x47 G.H5 M 379 G.H5.24
Hydrophobic H8 S 310 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 S 310 8x47 G.H5 M 379 G.H5.24
Polar TM3 L 105 3x24 G.HN G 3 G.HN.03
Hydrophobic TM3 L 105 3x24 G.HN G 3 G.HN.03
Van-der-waals TM3 L 105 3x24 G.HN G 3 G.HN.03
Hydrophobic ICL2 P 138 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 138 34x50 G.H5 I 370 G.H5.15
Polar ICL3 C 237 - G.S6 F 347 G.S6.02
Hydrophobic ICL3 C 237 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 C 237 - G.S6 F 347 G.S6.02
Hydrophobic TM3 L 135 3x54 G.H5 N 374 G.H5.19
Hydrophobic TM2 L 89 2x60 G.HN M 1 G.HN.01
Van-der-waals TM2 L 89 2x60 G.HN M 1 G.HN.01
Polar TM3 A 134 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 134 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 134 3x53 G.H5 N 374 G.H5.19
Hydrophobic ICL2 F 139 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 F 139 34x51 G.H5 I 370 G.H5.15
Hydrophobic ECL1 W 99 23x50 G.HN S 2 G.HN.02
Van-der-waals ECL1 W 99 23x50 G.HN S 2 G.HN.02
Hydrophobic TM6 P 242 6x26 G.h4s6 P 345 G.h4s6.20
Polar TM3 R 131 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 131 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 T 107 3x26 G.HN G 3 G.HN.03
Hydrophobic TM5 M 227 5x68 G.H5 H 364 G.H5.09
Polar H8 S 310 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 S 310 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 S 310 8x47 G.H5 L 380 G.H5.25
Polar TM3 T 110 3x29 G.HN S 2 G.HN.02
Van-der-waals TM3 T 110 3x29 G.HN S 2 G.HN.02
Hydrophobic TM5 M 227 5x68 G.H5 K 367 G.H5.12
Polar ICL3 C 236 - G.S6 F 347 G.S6.02
Hydrophobic ICL3 C 236 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 C 236 - G.S6 F 347 G.S6.02
Polar ICL3 C 236 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 C 236 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 C 236 - G.S6 H 348 G.S6.03
Hydrophobic TM6 K 248 6x32 G.H5 M 379 G.H5.24
Hydrophobic TM6 L 249 6x33 G.H5 L 375 G.H5.20
Van-der-waals TM6 L 249 6x33 G.H5 L 375 G.H5.20
Hydrophobic TM2 I 72 2x43 G.H5 L 380 G.H5.25
Polar ICL2 T 142 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 T 142 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 T 142 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic TM3 L 135 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM3 I 109 3x28 G.HN G 3 G.HN.03
Van-der-waals TM3 I 109 3x28 G.HN G 3 G.HN.03
Polar ICL2 R 145 34x57 G.hns1 R 55 G.hns1.02
Hydrophobic TM6 R 245 6x29 G.H5 K 376 G.H5.21
Polar TM3 I 109 3x28 G.HN S 2 G.HN.02
Hydrophobic TM3 I 109 3x28 G.HN S 2 G.HN.02
Van-der-waals TM3 I 109 3x28 G.HN S 2 G.HN.02
Polar ICL3 R 235 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 R 235 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 R 235 - G.S6 H 348 G.S6.03
Hydrophobic TM2 F 88 2x59 G.HN S 2 G.HN.02
Van-der-waals TM2 F 88 2x59 G.HN S 2 G.HN.02
Polar ICL2 R 145 34x57 G.H5 N 374 G.H5.19
Van-der-waals ICL2 R 145 34x57 G.H5 N 374 G.H5.19
Van-der-waals TM5 N 231 5x72 G.S6 F 347 G.S6.02
Polar H8 F 313 8x50 G.H5 L 380 G.H5.25
Hydrophobic ICL3 C 236 - G.H5 F 361 G.H5.06
Van-der-waals ICL3 C 236 - G.H5 F 361 G.H5.06
Hydrophobic TM5 M 227 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 M 227 5x68 G.H5 D 368 G.H5.13
Polar ECL2 C 184 45x50 G.HN M 1 G.HN.01
Hydrophobic ECL2 C 184 45x50 G.HN M 1 G.HN.01
Van-der-waals ECL2 C 184 45x50 G.HN M 1 G.HN.01
Polar TM3 I 108 3x27 G.HN G 3 G.HN.03
Hydrophobic TM3 I 108 3x27 G.HN G 3 G.HN.03
Van-der-waals TM3 I 108 3x27 G.HN G 3 G.HN.03
Hydrophobic TM3 A 134 3x53 G.H5 I 378 G.H5.23
Hydrophobic TM6 V 241 6x25 G.h4s6 S 343 G.h4s6.12
Polar H8 N 312 8x49 G.H5 Q 381 G.H5.26
Hydrophobic H8 N 312 8x49 G.H5 Q 381 G.H5.26
Van-der-waals H8 N 312 8x49 G.H5 Q 381 G.H5.26
Hydrophobic TM6 M 252 6x36 G.H5 I 378 G.H5.23
Polar TM3 P 104 3x23 G.HN V 5 G.HN.05
Hydrophobic TM3 P 104 3x23 G.HN V 5 G.HN.05
Van-der-waals TM3 P 104 3x23 G.HN V 5 G.HN.05
Polar H8 N 312 8x49 G.H5 L 380 G.H5.25
Hydrophobic H8 N 312 8x49 G.H5 L 380 G.H5.25
Van-der-waals H8 N 312 8x49 G.H5 L 380 G.H5.25
Van-der-waals ICL3 C 236 - G.S6 L 346 G.S6.01
Hydrophobic TM6 L 249 6x33 G.H5 M 379 G.H5.24
Polar TM6 R 245 6x29 G.h4s6 S 343 G.h4s6.12
Van-der-waals TM6 R 245 6x29 G.h4s6 S 343 G.h4s6.12
Hydrophobic ECL2 C 184 45x50 G.HN S 2 G.HN.02
Hydrophobic TM6 R 245 6x29 G.H5 M 379 G.H5.24
Polar TM3 D 113 3x32 G.HN M 1 G.HN.01
Van-der-waals TM3 D 113 3x32 G.HN M 1 G.HN.01
Polar TM5 N 231 5x72 G.H5 D 368 G.H5.13
Hydrophobic TM5 N 231 5x72 G.H5 D 368 G.H5.13
Van-der-waals TM5 N 231 5x72 G.H5 D 368 G.H5.13
Polar TM3 I 109 3x28 G.HN M 1 G.HN.01
Hydrophobic TM3 I 109 3x28 G.HN M 1 G.HN.01
Van-der-waals TM3 I 109 3x28 G.HN M 1 G.HN.01
Hydrophobic ICL2 F 139 34x51 G.H5 V 366 G.H5.11
Hydrophobic TM3 L 135 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 L 135 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM3 I 108 3x27 G.HN V 5 G.HN.05
Hydrophobic TM3 P 104 3x23 G.HN G 3 G.HN.03
Van-der-waals TM3 P 104 3x23 G.HN G 3 G.HN.03
Polar TM3 L 105 3x24 G.HN S 2 G.HN.02
Hydrophobic TM3 L 105 3x24 G.HN S 2 G.HN.02
Van-der-waals TM3 L 105 3x24 G.HN S 2 G.HN.02
Hydrophobic TM2 P 68 2x39 G.H5 I 378 G.H5.23
Hydrophobic ICL2 F 139 34x51 G.H5 K 367 G.H5.12
Polar H8 G 311 8x48 G.H5 L 380 G.H5.25
Hydrophobic TM2 T 66 2x37 G.H5 D 377 G.H5.22
Hydrophobic TM3 I 108 3x27 G.HN V 4 G.HN.04
Van-der-waals TM3 I 108 3x27 G.HN V 4 G.HN.04
Hydrophobic H8 G 311 8x48 G.H5 Q 381 G.H5.26
Polar TM5 Q 230 5x71 G.H5 H 364 G.H5.09
Hydrophobic TM5 Q 230 5x71 G.H5 H 364 G.H5.09
Van-der-waals TM5 Q 230 5x71 G.H5 H 364 G.H5.09
Polar TM3 T 110 3x29 G.HN M 1 G.HN.01
Hydrophobic TM3 T 110 3x29 G.HN M 1 G.HN.01
Van-der-waals TM3 T 110 3x29 G.HN M 1 G.HN.01
Hydrophobic TM5 M 227 5x68 G.H5 L 371 G.H5.16
Polar ICL3 C 237 - G.S6 L 346 G.S6.01
Hydrophobic ICL3 C 237 - G.S6 L 346 G.S6.01
Hydrophobic TM2 P 68 2x39 G.H5 D 377 G.H5.22
Van-der-waals TM2 P 68 2x39 G.H5 D 377 G.H5.22
Polar TM5 Y 223 5x64 G.H5 K 367 G.H5.12
Hydrophobic TM5 Y 223 5x64 G.H5 K 367 G.H5.12
Van-der-waals TM5 Y 223 5x64 G.H5 K 367 G.H5.12
Polar ICL2 R 143 34x55 G.HN R 52 G.HN.52
Hydrophobic TM5 N 231 5x72 G.H5 H 364 G.H5.09
Van-der-waals TM5 N 231 5x72 G.H5 H 364 G.H5.09
Aromatic ICL2 F 139 34x51 G.H5 F 363 G.H5.08
Hydrophobic ICL2 F 139 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 F 139 34x51 G.H5 F 363 G.H5.08
Hydrophobic TM5 Y 223 5x64 G.H5 L 371 G.H5.16
Hydrophobic TM3 C 106 3x25 G.HN S 2 G.HN.02
Van-der-waals TM3 C 106 3x25 G.HN S 2 G.HN.02