G12 - MRGPRD complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 82.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic H8 L 292 8x59 G.H3 N 283 G.H3.15
Van-der-waals H8 L 292 8x59 G.H3 N 283 G.H3.15
Van-der-waals TM3 S 126 3x53 G.H5 I 378 G.H5.23
Hydrophobic H8 L 292 8x59 G.H3 K 284 G.H3.16
Van-der-waals H8 L 292 8x59 G.H3 K 284 G.H3.16
Hydrophobic ICL2 C 135 34x55 G.S3 I 221 G.S3.01
Hydrophobic TM6 L 219 6x33 G.H5 I 378 G.H5.23
Van-der-waals TM6 L 219 6x33 G.H5 I 378 G.H5.23
Hydrophobic ICL2 I 131 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 I 131 34x51 G.S3 I 221 G.S3.01
Hydrophobic TM3 V 127 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM3 V 127 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 127 3x54 G.H5 L 371 G.H5.16
Polar ICL2 H 136 34x56 G.hns1 R 56 G.hns1.03
Aromatic ICL2 H 136 34x56 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 H 136 34x56 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 H 136 34x56 G.hns1 R 56 G.hns1.03
Hydrophobic C-term L 296 - G.H3 N 283 G.H3.15
Van-der-waals C-term L 296 - G.H3 N 283 G.H3.15
Hydrophobic ICL2 P 130 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 130 34x50 G.H5 I 370 G.H5.15
Hydrophobic TM3 V 127 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 V 127 3x54 G.H5 L 375 G.H5.20
Polar ICL2 C 135 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 C 135 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 C 135 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic C-term L 300 - G.H2 F 239 G.H2.08
Van-der-waals C-term L 300 - G.H2 F 239 G.H2.08
Hydrophobic TM7 V 279 7x56 G.H5 M 379 G.H5.24
Hydrophobic TM6 V 222 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM6 V 222 6x36 G.H5 M 379 G.H5.24
Hydrophobic ICL2 C 135 34x55 G.S1 V 58 G.S1.02
Hydrophobic TM6 R 218 6x32 G.H5 M 379 G.H5.24
Hydrophobic H8 G 280 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 G 280 8x47 G.H5 M 379 G.H5.24
Hydrophobic H8 G 280 8x47 G.H5 L 380 G.H5.25
Hydrophobic ICL2 P 130 34x50 G.H5 K 367 G.H5.12
Polar ICL2 P 130 34x50 G.H5 N 374 G.H5.19
Van-der-waals ICL2 P 130 34x50 G.H5 N 374 G.H5.19
Van-der-waals TM2 P 60 2x38 G.hns1 R 55 G.hns1.02
Polar C-term L 300 - G.H2 Q 236 G.H2.05
Hydrophobic C-term L 300 - G.H2 Q 236 G.H2.05
Hydrophobic ICL2 P 130 34x50 G.H5 L 371 G.H5.16
Polar TM3 S 126 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 S 126 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 S 126 3x53 G.H5 N 374 G.H5.19
Polar ICL2 H 136 34x56 G.s2s3 K 220 G.s2s3.02
Hydrophobic ICL2 H 136 34x56 G.s2s3 K 220 G.s2s3.02
Van-der-waals ICL2 H 136 34x56 G.s2s3 K 220 G.s2s3.02
Hydrophobic TM2 C 62 2x40 G.H5 L 380 G.H5.25
Polar ICL3 R 213 - G.h4s6 R 342 G.h4s6.11
Hydrophobic ICL3 R 213 - G.h4s6 R 342 G.h4s6.11
Van-der-waals ICL3 R 213 - G.h4s6 R 342 G.h4s6.11
Hydrophobic ICL3 R 214 - G.h4s6 S 343 G.h4s6.12
Van-der-waals ICL3 R 214 - G.h4s6 S 343 G.h4s6.12
Ionic ICL2 K 134 34x54 G.H5 E 373 G.H5.18
Polar ICL2 K 134 34x54 G.H5 E 373 G.H5.18
Van-der-waals ICL2 K 134 34x54 G.H5 E 373 G.H5.18
Hydrophobic ICL2 I 131 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 I 131 34x51 G.H5 F 363 G.H5.08
Hydrophobic C-term L 296 - G.h2s4 F 242 G.h2s4.01
Hydrophobic C-term L 300 - G.H2 R 235 G.H2.04
Van-der-waals C-term L 300 - G.H2 R 235 G.H2.04
Hydrophobic ICL2 I 131 34x51 G.H5 I 370 G.H5.15
Hydrophobic TM6 L 219 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 L 219 6x33 G.H5 M 379 G.H5.24
Hydrophobic TM2 F 61 2x39 G.H5 I 378 G.H5.23
Van-der-waals TM2 F 61 2x39 G.H5 I 378 G.H5.23
Hydrophobic TM7 Y 276 7x53 G.H5 L 380 G.H5.25
Van-der-waals TM7 Y 276 7x53 G.H5 L 380 G.H5.25
Hydrophobic TM7 F 277 7x54 G.H5 L 380 G.H5.25
Van-der-waals TM7 F 277 7x54 G.H5 L 380 G.H5.25
Hydrophobic TM2 F 61 2x39 G.H5 D 377 G.H5.22
Hydrophobic ICL3 W 212 - G.h4s6 P 345 G.h4s6.20
Polar TM2 N 59 2x37 G.H5 D 377 G.H5.22
Hydrophobic TM2 N 59 2x37 G.H5 D 377 G.H5.22
Van-der-waals TM2 N 59 2x37 G.H5 D 377 G.H5.22
Hydrophobic ICL3 W 212 - G.H5 L 371 G.H5.16
Hydrophobic H8 L 292 8x59 G.H3 L 285 G.H3.17
Van-der-waals H8 L 292 8x59 G.H3 L 285 G.H3.17
Hydrophobic TM5 S 208 5x66 G.H5 L 371 G.H5.16
Hydrophobic ICL2 I 131 34x51 G.H5 K 367 G.H5.12
Hydrophobic TM6 L 219 6x33 G.H5 L 375 G.H5.20
Van-der-waals TM6 L 219 6x33 G.H5 L 375 G.H5.20
Hydrophobic C-term L 296 - G.H2 F 239 G.H2.08
Van-der-waals C-term L 296 - G.H2 F 239 G.H2.08
Hydrophobic ICL2 K 134 34x54 G.H5 I 370 G.H5.15
Van-der-waals ICL2 K 134 34x54 G.H5 I 370 G.H5.15
Hydrophobic TM2 I 65 2x43 G.H5 L 380 G.H5.25
Van-der-waals TM2 I 65 2x43 G.H5 L 380 G.H5.25
Hydrophobic ICL3 W 212 - G.H5 L 375 G.H5.20
Van-der-waals ICL3 W 212 - G.H5 L 375 G.H5.20
Polar H8 G 280 8x47 G.H5 Q 381 G.H5.26
Hydrophobic H8 G 280 8x47 G.H5 Q 381 G.H5.26
Van-der-waals H8 G 280 8x47 G.H5 Q 381 G.H5.26
Hydrophobic H8 T 289 8x56 G.H3 K 284 G.H3.16
Van-der-waals H8 T 289 8x56 G.H3 K 284 G.H3.16
Hydrophobic ICL2 F 133 34x53 G.H5 N 374 G.H5.19
Hydrophobic TM5 V 205 5x63 G.H5 L 375 G.H5.20
Polar TM3 R 123 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 123 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 123 3x50 G.H5 I 378 G.H5.23
Polar ICL3 W 212 - G.H5 D 368 G.H5.13
Hydrophobic ICL3 W 212 - G.H5 D 368 G.H5.13
Van-der-waals ICL3 W 212 - G.H5 D 368 G.H5.13
Van-der-waals TM6 R 218 6x32 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 H 136 34x56 G.S3 I 221 G.S3.01
Hydrophobic TM2 F 61 2x39 G.H5 L 380 G.H5.25
Hydrophobic ICL3 W 212 - G.H5 Q 372 G.H5.17
Van-der-waals ICL3 W 212 - G.H5 Q 372 G.H5.17
Polar H8 S 281 8x48 G.H5 L 380 G.H5.25