Go - MRGPRD complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 83.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 R 123 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 123 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL2 I 131 34x51 G.s2s3 N 194 G.s2s3.02
Polar ICL3 R 214 - G.h4s6 E 318 G.h4s6.12
Polar H8 G 280 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 G 280 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 G 280 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM2 F 61 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 F 61 2x39 G.H5 C 351 G.H5.23
Hydrophobic ICL3 W 212 - G.H5 I 344 G.H5.16
Hydrophobic ICL3 W 212 - G.H5 Y 354 G.H5.26
Hydrophobic TM3 V 127 3x54 G.H5 I 344 G.H5.16
Polar ICL2 C 135 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 C 135 34x55 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 C 135 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 K 134 34x54 G.S1 V 34 G.S1.02
Polar H8 R 283 8x50 G.h4s6 N 316 G.h4s6.10
Hydrophobic H8 R 283 8x50 G.h4s6 N 316 G.h4s6.10
Van-der-waals H8 R 283 8x50 G.h4s6 N 316 G.h4s6.10
Hydrophobic C-term L 296 - G.H3 N 257 G.H3.15
Polar ICL2 K 134 34x54 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 K 134 34x54 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 K 134 34x54 G.hns1 K 32 G.hns1.03
Polar ICL3 R 214 - G.h4s6 P 315 G.h4s6.09
Van-der-waals ICL3 R 214 - G.h4s6 P 315 G.h4s6.09
Polar TM3 R 123 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 123 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 123 3x50 G.H5 C 351 G.H5.23
Polar TM6 R 218 6x32 G.H5 Y 354 G.H5.26
Hydrophobic TM6 R 218 6x32 G.H5 Y 354 G.H5.26
Van-der-waals TM6 R 218 6x32 G.H5 Y 354 G.H5.26
Hydrophobic TM5 V 205 5x63 G.H5 L 348 G.H5.20
Polar TM3 S 126 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 S 126 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 S 126 3x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 130 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM4 R 139 4x39 G.HN I 28 G.HN.52
Van-der-waals TM4 R 139 4x39 G.HN I 28 G.HN.52
Polar ICL3 W 212 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 W 212 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 W 212 - G.H5 D 341 G.H5.13
Hydrophobic TM6 P 216 6x30 G.H5 Y 354 G.H5.26
Hydrophobic TM6 R 218 6x32 G.H5 L 353 G.H5.25
Hydrophobic ICL2 I 131 34x51 G.S3 L 195 G.S3.01
Polar C-term E 302 - G.H2 K 210 G.H2.05
Hydrophobic ICL3 W 212 - G.H5 L 348 G.H5.20
Hydrophobic H8 V 295 8x62 G.H3 K 258 G.H3.16
Hydrophobic ICL2 P 130 34x50 G.H5 T 340 G.H5.12
Hydrophobic TM2 F 61 2x39 G.H5 G 350 G.H5.22
Van-der-waals ICL3 R 213 - G.H4 Q 305 G.H4.12
Polar H8 R 283 8x50 G.H5 Y 354 G.H5.26
Hydrophobic H8 R 283 8x50 G.H5 Y 354 G.H5.26
Van-der-waals H8 R 283 8x50 G.H5 Y 354 G.H5.26
Hydrophobic TM6 L 219 6x33 G.H5 L 348 G.H5.20
Van-der-waals TM6 L 219 6x33 G.H5 L 348 G.H5.20
Hydrophobic C-term L 296 - G.H2 I 213 G.H2.08
Ionic ICL3 R 213 - G.H4 E 309 G.H4.16
Polar ICL3 R 213 - G.H4 E 309 G.H4.16
Hydrophobic ICL3 R 213 - G.H4 E 309 G.H4.16
Van-der-waals ICL3 R 213 - G.H4 E 309 G.H4.16
Polar ICL2 K 134 34x54 G.S1 D 33 G.S1.01
Hydrophobic ICL2 K 134 34x54 G.S1 D 33 G.S1.01
Van-der-waals ICL2 K 134 34x54 G.S1 D 33 G.S1.01
Polar ICL2 K 134 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 K 134 34x54 G.hns1 A 31 G.hns1.02
Polar ICL3 R 214 - G.h4s6 S 314 G.h4s6.08
Hydrophobic TM5 L 201 5x59 G.H5 L 348 G.H5.20
Hydrophobic ICL2 K 134 34x54 G.H5 I 343 G.H5.15
Hydrophobic TM5 W 204 5x62 G.H5 I 344 G.H5.16
Van-der-waals TM5 W 204 5x62 G.H5 I 344 G.H5.16
Polar ICL3 R 214 - G.h4s6 K 317 G.h4s6.11
Hydrophobic C-term L 300 - G.H2 I 213 G.H2.08
Hydrophobic ICL3 W 212 - G.H5 A 345 G.H5.17
Hydrophobic H8 L 292 8x59 G.H3 F 259 G.H3.17
Van-der-waals H8 L 292 8x59 G.H3 F 259 G.H3.17
Polar H8 L 292 8x59 G.H3 K 258 G.H3.16
Hydrophobic H8 L 292 8x59 G.H3 K 258 G.H3.16
Van-der-waals H8 L 292 8x59 G.H3 K 258 G.H3.16
Hydrophobic ICL2 C 135 34x55 G.S3 L 195 G.S3.01
Van-der-waals ICL2 C 135 34x55 G.S3 L 195 G.S3.01
Polar TM6 L 219 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 L 219 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 219 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 130 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 130 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM5 L 201 5x59 G.H5 L 353 G.H5.25
Hydrophobic ICL2 F 133 34x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 I 131 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 I 131 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM6 V 223 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM6 V 222 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 222 6x36 G.H5 L 353 G.H5.25
Polar C-term L 300 - G.H2 K 210 G.H2.05
Hydrophobic C-term L 300 - G.H2 K 210 G.H2.05
Van-der-waals C-term L 300 - G.H2 K 210 G.H2.05
Hydrophobic C-term L 296 - G.H3 F 259 G.H3.17
Van-der-waals C-term L 296 - G.H3 F 259 G.H3.17
Hydrophobic TM3 V 127 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 127 3x54 G.H5 L 348 G.H5.20
Polar TM3 S 126 3x53 G.H5 C 351 G.H5.23