Go - MRGPRE complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 77.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 23.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 F 58 2x39 G.H5 G 350 G.H5.22
Hydrophobic ICL2 A 129 34x51 G.s2s3 N 194 G.s2s3.02
Van-der-waals ICL2 A 129 34x51 G.s2s3 N 194 G.s2s3.02
Hydrophobic C-term R 288 - G.h3s5 I 261 G.h3s5.01
Van-der-waals C-term R 288 - G.h3s5 I 261 G.h3s5.01
Hydrophobic TM6 P 212 6x30 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 P 212 6x30 G.h4s6 E 318 G.h4s6.12
Ionic C-term R 300 - G.h2s4 E 217 G.h2s4.02
Polar C-term R 300 - G.h2s4 E 217 G.h2s4.02
Van-der-waals C-term R 300 - G.h2s4 E 217 G.h2s4.02
Polar TM4 H 138 4x40 G.HN K 24 G.HN.48
Hydrophobic TM4 H 138 4x40 G.HN K 24 G.HN.48
Van-der-waals TM4 H 138 4x40 G.HN K 24 G.HN.48
Ionic C-term R 288 - G.h3s5 D 262 G.h3s5.02
Polar C-term R 288 - G.h3s5 D 262 G.h3s5.02
Hydrophobic C-term R 288 - G.h3s5 D 262 G.h3s5.02
Van-der-waals C-term R 288 - G.h3s5 D 262 G.h3s5.02
Aromatic ICL3 R 209 - G.S6 H 322 G.S6.04
Hydrophobic ICL3 R 209 - G.S6 H 322 G.S6.04
Hydrophobic H8 Q 276 8x50 G.H5 R 349 G.H5.21
Van-der-waals H8 Q 276 8x50 G.H5 R 349 G.H5.21
Hydrophobic TM6 F 215 6x33 G.H5 L 348 G.H5.20
Van-der-waals TM6 F 215 6x33 G.H5 L 348 G.H5.20
Hydrophobic C-term A 289 - G.H5 R 349 G.H5.21
Van-der-waals C-term A 289 - G.H5 R 349 G.H5.21
Hydrophobic TM7 V 268 7x52 G.H5 L 353 G.H5.25
Hydrophobic C-term R 300 - G.H3 F 259 G.H3.17
Van-der-waals C-term R 300 - G.H3 F 259 G.H3.17
Polar TM2 A 59 2x40 G.H5 G 350 G.H5.22
Hydrophobic TM2 A 59 2x40 G.H5 G 350 G.H5.22
Van-der-waals TM2 A 59 2x40 G.H5 G 350 G.H5.22
Polar ICL2 C 133 34x55 G.s2s3 N 194 G.s2s3.02
Hydrophobic ICL2 C 133 34x55 G.s2s3 N 194 G.s2s3.02
Van-der-waals ICL2 C 133 34x55 G.s2s3 N 194 G.s2s3.02
Polar C-term E 293 - G.h2s4 D 218 G.h2s4.03
Van-der-waals C-term E 293 - G.h2s4 D 218 G.h2s4.03
Hydrophobic TM7 Y 269 7x53 G.H5 L 353 G.H5.25
Van-der-waals TM7 Y 269 7x53 G.H5 L 353 G.H5.25
Polar H8 Q 276 8x50 G.h4s6 P 315 G.h4s6.09
Hydrophobic H8 Q 276 8x50 G.h4s6 P 315 G.h4s6.09
Van-der-waals H8 Q 276 8x50 G.h4s6 P 315 G.h4s6.09
Polar H8 Q 276 8x50 G.h4s6 N 316 G.h4s6.10
Hydrophobic H8 Q 276 8x50 G.h4s6 N 316 G.h4s6.10
Van-der-waals H8 Q 276 8x50 G.h4s6 N 316 G.h4s6.10
Ionic ICL3 R 209 - G.H4 E 309 G.H4.16
Polar ICL3 R 209 - G.H4 E 309 G.H4.16
Hydrophobic TM6 F 215 6x33 G.H5 Y 354 G.H5.26
Polar ICL3 R 209 - G.H4 Q 305 G.H4.12
Hydrophobic ICL3 R 209 - G.H4 Q 305 G.H4.12
Van-der-waals ICL3 R 209 - G.H4 Q 305 G.H4.12
Polar ICL2 C 133 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 C 133 34x55 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 C 133 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic TM6 L 218 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 L 218 6x36 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 128 34x50 G.H5 F 336 G.H5.08
Van-der-waals ICL2 P 128 34x50 G.H5 F 336 G.H5.08
Hydrophobic TM2 N 56 2x37 G.H5 G 350 G.H5.22
Van-der-waals TM2 N 56 2x37 G.H5 G 350 G.H5.22
Hydrophobic TM5 P 207 5x67 G.H5 D 337 G.H5.09
Van-der-waals TM5 P 207 5x67 G.H5 D 337 G.H5.09
Hydrophobic TM4 R 137 4x39 G.HN I 28 G.HN.52
Van-der-waals TM4 R 137 4x39 G.HN I 28 G.HN.52
Hydrophobic TM3 Q 121 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 Q 121 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL2 P 128 34x50 G.S3 L 195 G.S3.01
Hydrophobic C-term E 293 - G.h2s4 E 217 G.h2s4.02
Van-der-waals C-term E 293 - G.h2s4 E 217 G.h2s4.02
Hydrophobic TM6 T 222 6x40 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 222 6x40 G.H5 L 353 G.H5.25
Polar C-term R 288 - G.H3 K 258 G.H3.16
Polar ICL2 A 129 34x51 G.s2s3 K 193 G.s2s3.01
Hydrophobic ICL2 A 129 34x51 G.s2s3 K 193 G.s2s3.01
Van-der-waals ICL2 A 129 34x51 G.s2s3 K 193 G.s2s3.01
Hydrophobic H8 A 275 8x49 G.h4s6 P 315 G.h4s6.09
Van-der-waals H8 A 275 8x49 G.h4s6 P 315 G.h4s6.09
Hydrophobic C-term L 290 - G.H5 G 350 G.H5.22
Polar TM2 N 56 2x37 G.H5 N 346 G.H5.18
Van-der-waals TM2 N 56 2x37 G.H5 N 346 G.H5.18
Polar TM4 R 137 4x39 G.HN K 24 G.HN.48
Polar TM4 R 137 4x39 G.HN L 23 G.HN.47
Hydrophobic TM2 F 58 2x39 G.H5 N 347 G.H5.19
Van-der-waals TM2 F 58 2x39 G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 128 34x50 G.H5 T 340 G.H5.12
Van-der-waals ICL2 P 128 34x50 G.H5 T 340 G.H5.12
Hydrophobic TM7 L 272 7x56 G.H5 L 353 G.H5.25
Van-der-waals TM7 L 272 7x56 G.H5 L 353 G.H5.25
Polar ICL2 C 133 34x55 G.S3 L 195 G.S3.01
Hydrophobic ICL2 C 133 34x55 G.S3 L 195 G.S3.01
Van-der-waals ICL2 C 133 34x55 G.S3 L 195 G.S3.01
Hydrophobic TM2 L 62 2x43 G.H5 C 351 G.H5.23
Van-der-waals TM2 L 62 2x43 G.H5 C 351 G.H5.23
Polar C-term A 289 - G.H5 G 350 G.H5.22
Hydrophobic C-term A 289 - G.H5 G 350 G.H5.22
Van-der-waals C-term A 289 - G.H5 G 350 G.H5.22
Hydrophobic TM3 A 125 3x54 G.H5 I 344 G.H5.16
Polar C-term R 300 - G.H2 H 214 G.H2.09
Hydrophobic C-term R 300 - G.H2 H 214 G.H2.09
Van-der-waals C-term R 300 - G.H2 H 214 G.H2.09
Polar TM2 N 56 2x37 G.H5 N 347 G.H5.19
Hydrophobic TM2 N 56 2x37 G.H5 N 347 G.H5.19
Polar ICL2 S 132 34x54 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 S 132 34x54 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 S 132 34x54 G.hns1 K 32 G.hns1.03
Hydrophobic H8 G 277 8x51 G.h4s6 P 315 G.h4s6.09
Van-der-waals H8 G 277 8x51 G.h4s6 P 315 G.h4s6.09
Hydrophobic TM2 L 62 2x43 G.H5 G 352 G.H5.24
Van-der-waals TM2 L 62 2x43 G.H5 G 352 G.H5.24
Polar H8 G 273 8x47 G.H5 Y 354 G.H5.26
Hydrophobic H8 G 273 8x47 G.H5 Y 354 G.H5.26
Van-der-waals H8 G 273 8x47 G.H5 Y 354 G.H5.26
Hydrophobic TM3 V 117 3x46 G.H5 L 353 G.H5.25
Hydrophobic TM7 L 272 7x56 G.H5 Y 354 G.H5.26
Van-der-waals TM7 L 272 7x56 G.H5 Y 354 G.H5.26
Hydrophobic ICL2 A 129 34x51 G.S3 L 195 G.S3.01
Hydrophobic TM6 F 215 6x33 G.H5 I 344 G.H5.16
Polar ICL2 R 134 34x56 G.s2s3 N 194 G.s2s3.02
Hydrophobic ICL2 R 134 34x56 G.s2s3 N 194 G.s2s3.02
Hydrophobic TM7 Y 269 7x53 G.H5 G 352 G.H5.24
Van-der-waals TM7 Y 269 7x53 G.H5 G 352 G.H5.24
Hydrophobic TM3 Q 121 3x50 G.H5 L 348 G.H5.20
Van-der-waals TM3 Q 121 3x50 G.H5 L 348 G.H5.20
Polar TM4 R 137 4x39 G.HN G 27 G.HN.51
Hydrophobic TM4 R 137 4x39 G.HN G 27 G.HN.51
Van-der-waals TM4 R 137 4x39 G.HN G 27 G.HN.51
Hydrophobic ICL2 Y 131 34x53 G.H5 N 347 G.H5.19
Van-der-waals ICL2 Y 131 34x53 G.H5 N 347 G.H5.19
Hydrophobic TM2 F 58 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 F 58 2x39 G.H5 C 351 G.H5.23
Polar ICL3 R 209 - G.S6 C 321 G.S6.03
Hydrophobic ICL3 R 209 - G.S6 C 321 G.S6.03
Van-der-waals ICL3 R 209 - G.S6 C 321 G.S6.03
Hydrophobic TM3 A 124 3x53 G.H5 I 344 G.H5.16
Hydrophobic ICL2 S 132 34x54 G.S3 L 195 G.S3.01
Van-der-waals ICL2 S 132 34x54 G.S3 L 195 G.S3.01