Gi2 - MRGPRF complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 75.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 16.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 W 152 34x54 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 W 152 34x54 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 P 148 34x50 G.H5 I 344 G.H5.15
Hydrophobic TM6 I 241 6x37 G.H5 I 345 G.H5.16
Polar ICL2 W 152 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 W 152 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 W 152 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic TM6 L 237 6x33 G.H5 I 345 G.H5.16
Hydrophobic C-term D 316 - G.h3s5 D 262 G.h3s5.02
Van-der-waals C-term D 316 - G.h3s5 D 262 G.h3s5.02
Hydrophobic ICL3 R 233 - G.H5 I 345 G.H5.16
Van-der-waals ICL3 R 233 - G.H5 I 345 G.H5.16
Hydrophobic TM2 F 78 2x39 G.H5 D 351 G.H5.22
Ionic ICL3 R 233 - G.H5 D 342 G.H5.13
Polar ICL3 R 233 - G.H5 D 342 G.H5.13
Hydrophobic ICL3 R 233 - G.H5 D 342 G.H5.13
Van-der-waals ICL3 R 233 - G.H5 D 342 G.H5.13
Hydrophobic TM5 R 227 5x66 G.H5 T 341 G.H5.12
Van-der-waals TM5 R 227 5x66 G.H5 T 341 G.H5.12
Hydrophobic H8 G 295 8x47 G.H5 F 355 G.H5.26
Hydrophobic TM6 M 244 6x40 G.H5 L 349 G.H5.20
Hydrophobic TM6 L 237 6x33 G.H5 D 342 G.H5.13
Hydrophobic ICL2 W 152 34x54 G.S1 V 34 G.S1.02
Ionic TM4 K 157 4x39 G.HN E 28 G.HN.52
Polar TM4 K 157 4x39 G.HN E 28 G.HN.52
Hydrophobic TM4 K 157 4x39 G.HN E 28 G.HN.52
Van-der-waals TM4 K 157 4x39 G.HN E 28 G.HN.52
Hydrophobic TM6 L 237 6x33 G.H5 F 355 G.H5.26
Van-der-waals TM6 L 237 6x33 G.H5 F 355 G.H5.26
Hydrophobic TM2 F 82 2x43 G.H5 L 354 G.H5.25
Polar TM6 S 234 6x30 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 S 234 6x30 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 S 234 6x30 G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL3 R 231 - G.H5 F 335 G.H5.06
Polar ICL2 R 153 34x55 G.s2s3 D 194 G.s2s3.02
Van-der-waals ICL2 R 153 34x55 G.s2s3 D 194 G.s2s3.02
Polar TM3 S 144 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 S 144 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 S 144 3x53 G.H5 N 348 G.H5.19
Hydrophobic ICL2 A 149 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 A 149 34x51 G.S3 L 195 G.S3.01
Hydrophobic ICL2 Y 151 34x53 G.H5 N 348 G.H5.19
Polar ICL2 R 153 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 R 153 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 153 34x55 G.hns1 R 32 G.hns1.03
Polar ICL2 R 153 34x55 G.S3 H 196 G.S3.02
Aromatic ICL2 R 153 34x55 G.S3 H 196 G.S3.02
Hydrophobic ICL2 R 153 34x55 G.S3 H 196 G.S3.02
Van-der-waals ICL2 R 153 34x55 G.S3 H 196 G.S3.02
Hydrophobic C-term A 313 - G.H5 K 350 G.H5.21
Van-der-waals C-term A 313 - G.H5 K 350 G.H5.21
Hydrophobic ICL2 W 152 34x54 G.S3 L 195 G.S3.01
Polar ICL3 R 231 - G.H5 Q 334 G.H5.05
Van-der-waals ICL3 R 231 - G.H5 Q 334 G.H5.05
Hydrophobic TM6 V 240 6x36 G.H5 F 355 G.H5.26
Van-der-waals TM6 V 240 6x36 G.H5 F 355 G.H5.26
Hydrophobic TM3 R 141 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM7 Y 291 7x53 G.H5 L 354 G.H5.25
Hydrophobic TM6 L 237 6x33 G.H5 L 349 G.H5.20
Van-der-waals TM6 L 237 6x33 G.H5 L 349 G.H5.20
Polar TM2 N 76 2x37 G.H5 D 351 G.H5.22
Hydrophobic TM2 N 76 2x37 G.H5 D 351 G.H5.22
Van-der-waals TM2 N 76 2x37 G.H5 D 351 G.H5.22
Hydrophobic TM6 I 241 6x37 G.H5 L 349 G.H5.20
Van-der-waals TM6 I 241 6x37 G.H5 L 349 G.H5.20
Hydrophobic ICL2 P 148 34x50 G.H5 T 341 G.H5.12
Van-der-waals ICL2 P 148 34x50 G.H5 T 341 G.H5.12
Hydrophobic ICL2 W 152 34x54 G.H5 I 344 G.H5.15
Ionic C-term D 316 - G.H5 K 350 G.H5.21
Polar C-term D 316 - G.H5 K 350 G.H5.21
Hydrophobic C-term D 316 - G.H5 K 350 G.H5.21
Van-der-waals C-term D 316 - G.H5 K 350 G.H5.21
Hydrophobic H8 D 297 8x49 G.h4s6 T 317 G.h4s6.10
Van-der-waals H8 D 297 8x49 G.h4s6 T 317 G.h4s6.10
Ionic TM5 R 227 5x66 G.H5 D 342 G.H5.13
Polar TM5 R 227 5x66 G.H5 D 342 G.H5.13
Van-der-waals TM5 R 227 5x66 G.H5 D 342 G.H5.13
Hydrophobic TM3 V 145 3x54 G.H5 L 349 G.H5.20
Ionic ICL2 R 154 34x56 G.s2s3 D 194 G.s2s3.02
Hydrophobic ICL2 P 148 34x50 G.H5 I 345 G.H5.16
Van-der-waals ICL2 P 148 34x50 G.H5 I 345 G.H5.16
Hydrophobic ICL2 W 152 34x54 G.S1 E 33 G.S1.01
Van-der-waals ICL2 W 152 34x54 G.S1 E 33 G.S1.01
Hydrophobic TM3 V 145 3x54 G.H5 I 345 G.H5.16
Hydrophobic TM7 A 294 7x56 G.H5 L 354 G.H5.25
Ionic ICL3 R 231 - G.H5 D 338 G.H5.09
Polar ICL3 R 231 - G.H5 D 338 G.H5.09
Hydrophobic ICL3 R 231 - G.H5 D 338 G.H5.09
Van-der-waals ICL3 R 231 - G.H5 D 338 G.H5.09
Hydrophobic TM6 V 240 6x36 G.H5 L 354 G.H5.25
Van-der-waals TM6 V 240 6x36 G.H5 L 354 G.H5.25
Polar C-term R 312 - G.H5 K 350 G.H5.21
Hydrophobic C-term R 312 - G.H5 K 350 G.H5.21
Van-der-waals C-term R 312 - G.H5 K 350 G.H5.21
Hydrophobic TM3 R 141 3x50 G.H5 L 354 G.H5.25
Van-der-waals TM3 R 141 3x50 G.H5 L 354 G.H5.25
Ionic TM5 R 227 5x66 G.H5 D 338 G.H5.09
Polar TM5 R 227 5x66 G.H5 D 338 G.H5.09
Hydrophobic TM5 R 227 5x66 G.H5 D 338 G.H5.09
Van-der-waals TM5 R 227 5x66 G.H5 D 338 G.H5.09
Hydrophobic TM6 L 237 6x33 G.H5 K 346 G.H5.17
Hydrophobic TM2 F 78 2x39 G.H5 C 352 G.H5.23
Van-der-waals TM2 F 78 2x39 G.H5 C 352 G.H5.23
Polar TM6 K 236 6x32 G.h4s6 K 315 G.h4s6.08
Van-der-waals TM6 K 236 6x32 G.h4s6 K 315 G.h4s6.08
Hydrophobic TM2 F 82 2x43 G.H5 C 352 G.H5.23
Van-der-waals TM2 F 82 2x43 G.H5 C 352 G.H5.23
Hydrophobic TM6 M 244 6x40 G.H5 L 354 G.H5.25
Van-der-waals TM6 M 244 6x40 G.H5 L 354 G.H5.25
Ionic TM6 K 236 6x32 G.h4s6 D 316 G.h4s6.09
Polar TM6 K 236 6x32 G.h4s6 D 316 G.h4s6.09
Van-der-waals TM6 K 236 6x32 G.h4s6 D 316 G.h4s6.09