Gs - MRGPRX1 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 78.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 21.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic N-term E 19 - G.H5 L 393 G.H5.25
Van-der-waals N-term E 19 - G.H5 L 393 G.H5.25
Hydrophobic N-term L 22 - G.H5 E 392 G.H5.24
Van-der-waals N-term L 22 - G.H5 E 392 G.H5.24
Ionic ECL3 D 245 - G.H5 R 389 G.H5.21
Polar ECL1 H 92 - G.h2s4 F 238 G.h2s4.01
Hydrophobic ECL1 H 92 - G.h2s4 F 238 G.h2s4.01
Van-der-waals ECL1 H 92 - G.h2s4 F 238 G.h2s4.01
Hydrophobic TM6 F 236 6x55 G.H3 W 281 G.H3.17
Polar ECL1 H 92 - G.h2s4 N 239 G.h2s4.02
Hydrophobic ECL1 H 92 - G.h2s4 N 239 G.h2s4.02
Van-der-waals ECL1 H 92 - G.h2s4 N 239 G.h2s4.02
Hydrophobic ECL2 L 164 - G.H3 N 279 G.H3.15
Van-der-waals ECL2 L 164 - G.H3 N 279 G.H3.15
Ionic TM4 E 157 4x60 G.H3 R 280 G.H3.16
Polar TM4 E 157 4x60 G.H3 R 280 G.H3.16
Hydrophobic TM4 E 157 4x60 G.H3 R 280 G.H3.16
Van-der-waals TM4 E 157 4x60 G.H3 R 280 G.H3.16
Polar ECL1 T 93 - G.H2 Q 236 G.H2.09
Hydrophobic ECL1 T 93 - G.H2 Q 236 G.H2.09
Van-der-waals ECL1 T 93 - G.H2 Q 236 G.H2.09
Hydrophobic ECL2 L 164 - G.H2 W 234 G.H2.07
Polar ECL3 R 246 - G.h3s5 R 283 G.h3s5.01
Hydrophobic ECL3 R 246 - G.h3s5 R 283 G.h3s5.01
Van-der-waals ECL3 R 246 - G.h3s5 R 283 G.h3s5.01
Hydrophobic TM2 F 87 2x65 G.HN K 34 G.HN.51
Van-der-waals TM2 F 87 2x65 G.HN K 34 G.HN.51
Polar TM6 L 240 6x59 G.h3s5 R 283 G.h3s5.01
Van-der-waals TM6 L 240 6x59 G.h3s5 R 283 G.h3s5.01
Hydrophobic TM7 F 250 7x30 G.h3s5 T 284 G.h3s5.02
Van-der-waals TM7 F 250 7x30 G.h3s5 T 284 G.h3s5.02
Polar ECL3 V 244 - G.h4s6 R 356 G.h4s6.12
Hydrophobic ECL3 V 244 - G.h4s6 R 356 G.h4s6.12
Van-der-waals ECL3 V 244 - G.h4s6 R 356 G.h4s6.12
Hydrophobic TM5 C 173 5x36 G.H3 R 280 G.H3.16
Ionic TM6 H 243 6x62 G.h4s6 D 354 G.h4s6.10
Polar TM6 H 243 6x62 G.h4s6 D 354 G.h4s6.10
Hydrophobic TM6 H 243 6x62 G.h4s6 D 354 G.h4s6.10
Van-der-waals TM6 H 243 6x62 G.h4s6 D 354 G.h4s6.10
Polar TM7 C 251 7x31 G.H5 Q 390 G.H5.22
Ionic TM5 D 177 5x40 G.H3 R 280 G.H3.16
Polar TM5 D 177 5x40 G.H3 R 280 G.H3.16
Hydrophobic TM5 S 170 5x33 G.H3 N 278 G.H3.14
Hydrophobic ECL3 R 246 - G.h3s5 T 284 G.h3s5.02
Van-der-waals ECL3 R 246 - G.h3s5 T 284 G.h3s5.02
Polar N-term T 21 - G.H5 L 393 G.H5.25
Hydrophobic N-term T 21 - G.H5 L 393 G.H5.25
Van-der-waals N-term T 21 - G.H5 L 393 G.H5.25
Polar ECL3 R 246 - G.h4s6 H 357 G.h4s6.13
Aromatic ECL3 R 246 - G.h4s6 H 357 G.h4s6.13
Hydrophobic ECL3 R 246 - G.h4s6 H 357 G.h4s6.13
Van-der-waals ECL3 R 246 - G.h4s6 H 357 G.h4s6.13
Hydrophobic TM1 L 28 1x33 G.hns1 R 38 G.hns1.02
Polar ECL1 H 92 - G.H2 Q 236 G.H2.09
Hydrophobic ECL1 H 92 - G.H2 Q 236 G.H2.09
Van-der-waals ECL1 H 92 - G.H2 Q 236 G.H2.09
Polar TM6 L 240 6x59 G.h4s6 R 356 G.h4s6.12
Hydrophobic TM6 L 240 6x59 G.h4s6 R 356 G.h4s6.12
Van-der-waals TM6 L 240 6x59 G.h4s6 R 356 G.h4s6.12
Ionic N-term E 20 - G.hns1 R 38 G.hns1.02
Polar N-term E 20 - G.hns1 R 38 G.hns1.02
Hydrophobic ECL2 F 165 - G.H3 L 272 G.H3.08
Polar TM3 K 96 3x26 G.H2 I 235 G.H2.08
Hydrophobic TM3 K 96 3x26 G.H2 I 235 G.H2.08
Van-der-waals TM3 K 96 3x26 G.H2 I 235 G.H2.08
Ionic TM5 D 169 5x32 G.H3 K 274 G.H3.10
Polar TM5 D 169 5x32 G.H3 K 274 G.H3.10
Polar TM6 H 243 6x62 G.h4s6 S 352 G.h4s6.08
Hydrophobic TM6 H 243 6x62 G.h4s6 S 352 G.h4s6.08
Van-der-waals TM6 H 243 6x62 G.h4s6 S 352 G.h4s6.08
Polar TM4 C 161 4x64 G.H3 R 280 G.H3.16
Hydrophobic TM4 C 161 4x64 G.H3 R 280 G.H3.16
Van-der-waals TM4 C 161 4x64 G.H3 R 280 G.H3.16
Hydrophobic ECL2 L 164 - G.H2 I 235 G.H2.08
Van-der-waals ECL2 L 164 - G.H2 I 235 G.H2.08
Aromatic ECL2 F 165 - G.H2 W 234 G.H2.07
Hydrophobic ECL2 F 165 - G.H2 W 234 G.H2.07
Van-der-waals ECL2 F 165 - G.H2 W 234 G.H2.07
Hydrophobic N-term E 20 - G.H5 L 393 G.H5.25
Hydrophobic ECL2 G 162 - G.H2 I 235 G.H2.08
Van-der-waals ECL2 G 162 - G.H2 I 235 G.H2.08
Polar ECL3 R 246 - G.h4s6 R 356 G.h4s6.12
Hydrophobic ECL3 R 246 - G.h4s6 R 356 G.h4s6.12
Van-der-waals ECL3 R 246 - G.h4s6 R 356 G.h4s6.12
Polar TM6 F 239 6x58 G.h4s6 R 356 G.h4s6.12
Van-der-waals TM6 F 239 6x58 G.h4s6 R 356 G.h4s6.12
Ionic ECL3 E 247 - G.H5 R 389 G.H5.21
Polar ECL3 E 247 - G.H5 R 389 G.H5.21
Hydrophobic ECL3 E 247 - G.H5 R 389 G.H5.21
Van-der-waals ECL3 E 247 - G.H5 R 389 G.H5.21
Polar N-term C 23 - G.H5 E 392 G.H5.24
Hydrophobic N-term C 23 - G.H5 E 392 G.H5.24
Van-der-waals N-term C 23 - G.H5 E 392 G.H5.24
Hydrophobic ECL2 L 164 - G.H3 I 276 G.H3.12
Polar TM6 I 242 6x61 G.h4s6 R 356 G.h4s6.12
Hydrophobic TM6 I 242 6x61 G.h4s6 R 356 G.h4s6.12
Van-der-waals TM6 I 242 6x61 G.h4s6 R 356 G.h4s6.12
Aromatic TM3 Y 99 3x29 G.H3 W 281 G.H3.17
Hydrophobic TM3 Y 99 3x29 G.H3 W 281 G.H3.17
Van-der-waals TM3 Y 99 3x29 G.H3 W 281 G.H3.17
Hydrophobic TM6 H 243 6x62 G.h4s6 G 353 G.h4s6.09
Polar TM3 Y 99 3x29 G.H3 R 280 G.H3.16
Van-der-waals TM3 Y 99 3x29 G.H3 R 280 G.H3.16
Hydrophobic ECL2 F 165 - G.H2 R 231 G.H2.04
Van-der-waals ECL2 F 165 - G.H2 R 231 G.H2.04
Ionic TM7 H 252 7x32 G.H5 E 392 G.H5.24
Polar TM7 H 252 7x32 G.H5 E 392 G.H5.24
Hydrophobic TM7 H 252 7x32 G.H5 E 392 G.H5.24
Van-der-waals TM7 H 252 7x32 G.H5 E 392 G.H5.24
Polar N-term T 21 - G.H5 E 392 G.H5.24
Hydrophobic N-term T 21 - G.H5 E 392 G.H5.24
Van-der-waals N-term T 21 - G.H5 E 392 G.H5.24
Hydrophobic TM7 L 249 7x29 G.h4s6 R 356 G.h4s6.12
Van-der-waals TM7 L 249 7x29 G.h4s6 R 356 G.h4s6.12
Hydrophobic TM6 H 243 6x62 G.h4s6 R 356 G.h4s6.12
Hydrophobic TM6 F 236 6x55 G.H3 R 280 G.H3.16
Van-der-waals TM6 F 236 6x55 G.H3 R 280 G.H3.16
Hydrophobic TM1 L 28 1x33 G.HN K 34 G.HN.51
Van-der-waals TM1 L 28 1x33 G.HN K 34 G.HN.51
Polar TM7 C 251 7x31 G.H5 E 392 G.H5.24
Hydrophobic TM7 C 251 7x31 G.H5 E 392 G.H5.24
Van-der-waals TM7 C 251 7x31 G.H5 E 392 G.H5.24
Polar N-term Y 24 - G.hns1 R 38 G.hns1.02
Hydrophobic N-term Y 24 - G.hns1 R 38 G.hns1.02
Van-der-waals N-term Y 24 - G.hns1 R 38 G.hns1.02
Hydrophobic ECL2 F 165 - G.H2 R 232 G.H2.05
Van-der-waals ECL2 F 165 - G.H2 R 232 G.H2.05
Hydrophobic TM3 K 96 3x26 G.H2 Q 236 G.H2.09
Van-der-waals TM3 K 96 3x26 G.H2 Q 236 G.H2.09
Polar N-term T 21 - G.H5 Y 391 G.H5.23
Van-der-waals N-term T 21 - G.H5 Y 391 G.H5.23
Polar N-term Y 24 - G.H5 Y 391 G.H5.23
Aromatic N-term Y 24 - G.H5 Y 391 G.H5.23
Hydrophobic N-term Y 24 - G.H5 Y 391 G.H5.23
Van-der-waals N-term Y 24 - G.H5 Y 391 G.H5.23
Polar ECL1 S 89 - G.hns1 Y 37 G.hns1.01
Hydrophobic ECL1 S 89 - G.hns1 Y 37 G.hns1.01
Van-der-waals ECL1 S 89 - G.hns1 Y 37 G.hns1.01
Hydrophobic ECL2 L 164 - G.h2s4 F 238 G.h2s4.01
Van-der-waals ECL2 L 164 - G.h2s4 F 238 G.h2s4.01
Aromatic TM6 W 241 6x60 G.h3s5 R 283 G.h3s5.01
Hydrophobic TM6 W 241 6x60 G.h3s5 R 283 G.h3s5.01
Van-der-waals TM6 W 241 6x60 G.h3s5 R 283 G.h3s5.01
Hydrophobic N-term C 23 - G.H5 Y 391 G.H5.23