Gt2 - MRGPRX3 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 81.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 I 128 34x51 G.H5 I 343 G.H5.15
Hydrophobic ICL2 P 127 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL2 I 128 34x51 G.s2s3 D 193 G.s2s3.02
Ionic ICL3 R 207 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 R 207 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 R 207 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM2 V 61 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 V 61 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM6 L 214 6x33 G.H5 L 348 G.H5.20
Van-der-waals TM6 L 214 6x33 G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 127 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 127 34x50 G.H5 I 344 G.H5.16
Hydrophobic ICL2 I 128 34x51 G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 I 128 34x51 G.s2s3 K 192 G.s2s3.01
Polar TM3 S 123 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 S 123 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 S 123 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM6 L 211 6x30 G.H5 F 354 G.H5.26
Hydrophobic TM6 L 214 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 I 128 34x51 G.S3 L 194 G.S3.01
Hydrophobic ICL2 Y 130 34x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 H 131 34x54 G.H5 I 343 G.H5.15
Ionic ICL2 R 133 34x56 G.s2s3 D 193 G.s2s3.02
Polar ICL2 R 133 34x56 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 R 133 34x56 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 R 133 34x56 G.s2s3 D 193 G.s2s3.02
Polar ICL3 R 207 - G.S6 H 322 G.S6.04
Polar ICL2 C 132 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 C 132 34x55 G.s2s3 D 193 G.s2s3.02
Ionic C-term D 297 - G.H3 K 257 G.H3.16
Polar TM3 S 123 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 S 123 3x53 G.H5 C 351 G.H5.23
Hydrophobic C-term V 290 - G.H3 K 257 G.H3.16
Van-der-waals C-term V 290 - G.H3 K 257 G.H3.16
Hydrophobic ICL3 R 207 - G.H5 A 338 G.H5.10
Van-der-waals ICL3 R 207 - G.H5 A 338 G.H5.10
Hydrophobic TM6 T 217 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 217 6x36 G.H5 L 353 G.H5.25
Polar ICL3 R 207 - G.S6 Y 320 G.S6.02
Hydrophobic ICL3 R 207 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 R 207 - G.S6 Y 320 G.S6.02
Polar ICL1 R 57 - G.HN Q 24 G.HN.48
Hydrophobic ICL2 I 128 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 I 128 34x51 G.H5 F 336 G.H5.08
Polar TM4 R 136 4x39 G.HN Q 24 G.HN.48
Hydrophobic TM4 R 136 4x39 G.HN Q 24 G.HN.48
Van-der-waals TM4 R 136 4x39 G.HN Q 24 G.HN.48
Hydrophobic ICL3 M 209 - G.H5 D 341 G.H5.13
Polar TM3 R 120 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 120 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 120 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM7 G 276 7x57 G.H5 G 352 G.H5.24
Hydrophobic TM5 L 198 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM3 R 120 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 120 3x50 G.H5 L 353 G.H5.25
Polar ICL3 R 207 - G.H5 D 337 G.H5.09
Hydrophobic ICL3 R 207 - G.H5 D 337 G.H5.09
Polar TM6 R 213 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 213 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 213 6x32 G.H5 F 354 G.H5.26
Ionic ICL3 R 207 - G.H5 D 341 G.H5.13
Polar ICL3 R 207 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 R 207 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 R 207 - G.H5 D 341 G.H5.13
Hydrophobic TM3 I 124 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 124 3x54 G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 127 34x50 G.H5 T 340 G.H5.12
Van-der-waals ICL2 P 127 34x50 G.H5 T 340 G.H5.12
Hydrophobic TM3 I 124 3x54 G.H5 I 344 G.H5.16
Hydrophobic C-term L 291 - G.H3 F 258 G.H3.17
Van-der-waals C-term L 291 - G.H3 F 258 G.H3.17
Polar ICL2 P 127 34x50 G.H5 N 347 G.H5.19
Polar ICL2 H 131 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 H 131 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 H 131 34x54 G.hns1 A 31 G.hns1.02
Polar ICL2 C 132 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 C 132 34x55 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 C 132 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic ICL3 M 209 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 M 209 - G.H5 K 345 G.H5.17
Hydrophobic TM6 L 211 6x30 G.H5 L 348 G.H5.20
Polar TM2 N 59 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 N 59 2x37 G.H5 D 350 G.H5.22
Hydrophobic ICL2 C 132 34x55 G.S3 L 194 G.S3.01
Van-der-waals ICL2 C 132 34x55 G.S3 L 194 G.S3.01