Gi3 - MT1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 86.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 17.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 133 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 133 34x51 G.S3 L 194 G.S3.01
Ionic TM6 D 233 6x30 G.H5 K 345 G.H5.17
Hydrophobic ICL2 L 133 34x51 G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 L 133 34x51 G.s2s3 K 192 G.s2s3.01
Hydrophobic TM6 M 240 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 M 240 6x37 G.H5 L 353 G.H5.25
Hydrophobic C-term V 350 - G.s4h3 E 236 G.s4h3.10
Van-der-waals C-term V 350 - G.s4h3 E 236 G.s4h3.10
Hydrophobic ICL2 L 133 34x51 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 L 133 34x51 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM5 V 221 5x72 G.H5 D 341 G.H5.13
Hydrophobic TM5 R 220 5x71 G.H5 A 338 G.H5.10
Van-der-waals TM5 R 220 5x71 G.H5 A 338 G.H5.10
Polar TM6 N 236 6x33 G.H5 Y 354 G.H5.26
Hydrophobic TM6 N 236 6x33 G.H5 Y 354 G.H5.26
Van-der-waals TM6 N 236 6x33 G.H5 Y 354 G.H5.26
Hydrophobic TM5 V 221 5x72 G.S6 Y 320 G.S6.02
Van-der-waals TM5 V 221 5x72 G.S6 Y 320 G.S6.02
Hydrophobic C-term V 347 - G.H3 K 248 G.H3.07
Van-der-waals TM5 R 220 5x71 G.s2s3 K 192 G.s2s3.01
Hydrophobic TM5 V 221 5x72 G.H5 A 338 G.H5.10
Van-der-waals TM5 V 221 5x72 G.H5 A 338 G.H5.10
Ionic ICL2 D 136 34x54 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 D 136 34x54 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 D 136 34x54 G.hns1 K 32 G.hns1.03
Polar TM3 Y 128 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 Y 128 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 Y 128 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM6 N 236 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 N 236 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM5 V 217 5x68 G.H5 K 345 G.H5.17
Van-der-waals TM5 V 217 5x68 G.H5 K 345 G.H5.17
Polar TM5 V 214 5x65 G.H5 Y 354 G.H5.26
Hydrophobic TM5 V 214 5x65 G.H5 Y 354 G.H5.26
Van-der-waals TM5 V 214 5x65 G.H5 Y 354 G.H5.26
Hydrophobic TM3 I 129 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 129 3x54 G.H5 L 348 G.H5.20
Polar TM3 R 125 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 125 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 125 3x50 G.H5 C 351 G.H5.23
Polar TM3 Y 128 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 Y 128 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 Y 128 3x53 G.H5 C 351 G.H5.23
Ionic ICL3 K 222 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 K 222 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 K 222 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 K 222 - G.h4s6 E 318 G.h4s6.12
Hydrophobic C-term V 350 - G.s4h3 D 237 G.s4h3.11
Ionic TM6 K 230 6x27 G.h4s6 E 318 G.h4s6.12
Polar TM6 K 230 6x27 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 K 230 6x27 G.h4s6 E 318 G.h4s6.12
Hydrophobic C-term S 349 - G.s4h3 M 240 G.s4h3.14
Van-der-waals C-term S 349 - G.s4h3 M 240 G.s4h3.14
Ionic TM5 R 220 5x71 G.H5 D 337 G.H5.09
Polar TM5 R 220 5x71 G.H5 D 337 G.H5.09
Van-der-waals TM5 R 220 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM6 D 233 6x30 G.H5 Y 354 G.H5.26
Van-der-waals TM6 D 233 6x30 G.H5 Y 354 G.H5.26
Hydrophobic TM6 M 240 6x37 G.H5 G 352 G.H5.24
Ionic TM5 R 220 5x71 G.H5 D 341 G.H5.13
Polar TM5 R 220 5x71 G.H5 D 341 G.H5.13
Hydrophobic TM5 R 220 5x71 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 220 5x71 G.H5 D 341 G.H5.13
Hydrophobic TM3 I 129 3x54 G.H5 L 353 G.H5.25
Van-der-waals TM3 I 129 3x54 G.H5 L 353 G.H5.25
Polar TM6 F 237 6x34 G.H5 L 353 G.H5.25
Hydrophobic TM5 V 217 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 V 217 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 V 221 5x72 G.H5 V 342 G.H5.14
Van-der-waals TM5 V 221 5x72 G.H5 V 342 G.H5.14
Hydrophobic TM5 I 210 5x61 G.H5 L 353 G.H5.25
Van-der-waals TM5 I 210 5x61 G.H5 L 353 G.H5.25
Hydrophobic TM5 V 214 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 V 214 5x65 G.H5 L 348 G.H5.20