G13 - MT2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 85.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 14.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 S 145 34x50 G.H5 N 370 G.H5.19
Van-der-waals ICL2 S 145 34x50 G.H5 N 370 G.H5.19
Hydrophobic ICL2 H 149 34x54 G.hns1 R 47 G.hns1.03
Hydrophobic TM4 R 153 4x38 G.HN T 43 G.HN.52
Hydrophobic TM5 L 226 5x64 G.H5 L 367 G.H5.16
Hydrophobic ICL2 M 146 34x51 G.H5 I 366 G.H5.15
Van-der-waals ICL2 M 146 34x51 G.H5 I 366 G.H5.15
Hydrophobic C-term A 336 - G.HN M 1 G.HN.01
Van-der-waals C-term A 336 - G.HN M 1 G.HN.01
Hydrophobic TM6 L 242 6x26 G.H5 M 375 G.H5.24
Van-der-waals TM6 L 242 6x26 G.H5 M 375 G.H5.24
Hydrophobic TM3 Y 141 3x53 G.H5 L 374 G.H5.23
Hydrophobic ICL2 S 145 34x50 G.H5 I 366 G.H5.15
Hydrophobic TM6 L 240 6x24 G.H5 H 368 G.H5.17
Van-der-waals TM6 L 240 6x24 G.H5 H 368 G.H5.17
Hydrophobic TM3 I 142 3x54 G.H5 L 374 G.H5.23
Van-der-waals TM3 I 142 3x54 G.H5 L 374 G.H5.23
Van-der-waals ICL3 K 235 - G.H4 R 331 G.H4.16
Hydrophobic TM3 I 142 3x54 G.H5 L 371 G.H5.20
Van-der-waals TM3 I 142 3x54 G.H5 L 371 G.H5.20
Polar TM3 Y 141 3x53 G.H5 N 370 G.H5.19
Hydrophobic TM3 Y 141 3x53 G.H5 N 370 G.H5.19
Van-der-waals TM3 Y 141 3x53 G.H5 N 370 G.H5.19
Ionic ICL1 R 69 12x48 G.HN D 3 G.HN.03
Polar ICL1 R 69 12x48 G.HN D 3 G.HN.03
Hydrophobic ICL1 R 69 12x48 G.HN D 3 G.HN.03
Van-der-waals ICL1 R 69 12x48 G.HN D 3 G.HN.03
Ionic TM5 K 233 5x71 G.H5 D 364 G.H5.13
Polar TM5 K 233 5x71 G.H5 D 364 G.H5.13
Hydrophobic TM5 K 233 5x71 G.H5 D 364 G.H5.13
Van-der-waals TM5 K 233 5x71 G.H5 D 364 G.H5.13
Polar ICL3 E 237 - G.h4s6 Q 337 G.h4s6.11
Hydrophobic ICL3 E 237 - G.h4s6 Q 337 G.h4s6.11
Van-der-waals ICL3 E 237 - G.h4s6 Q 337 G.h4s6.11
Hydrophobic TM3 I 142 3x54 G.H5 L 367 G.H5.16
Van-der-waals TM3 I 142 3x54 G.H5 L 367 G.H5.16
Hydrophobic TM6 D 246 6x30 G.H5 M 375 G.H5.24
Van-der-waals TM6 D 246 6x30 G.H5 M 375 G.H5.24
Polar ICL2 H 149 34x54 G.hns1 K 46 G.hns1.02
Hydrophobic ICL2 H 149 34x54 G.hns1 K 46 G.hns1.02
Van-der-waals ICL2 H 149 34x54 G.hns1 K 46 G.hns1.02
Hydrophobic ICL2 M 146 34x51 G.S1 V 49 G.S1.02
Polar TM2 N 73 2x37 G.H5 Q 377 G.H5.26
Hydrophobic TM2 N 73 2x37 G.H5 Q 377 G.H5.26
Van-der-waals TM2 N 73 2x37 G.H5 Q 377 G.H5.26
Polar TM3 Y 141 3x53 G.H5 Q 373 G.H5.22
Hydrophobic TM3 Y 141 3x53 G.H5 Q 373 G.H5.22
Van-der-waals TM3 Y 141 3x53 G.H5 Q 373 G.H5.22
Polar TM5 A 230 5x68 G.H5 H 368 G.H5.17
Hydrophobic TM5 A 230 5x68 G.H5 H 368 G.H5.17
Van-der-waals TM5 A 230 5x68 G.H5 H 368 G.H5.17
Hydrophobic ICL2 M 146 34x51 G.S3 V 216 G.S3.01
Van-der-waals ICL2 M 146 34x51 G.S3 V 216 G.S3.01
Hydrophobic TM3 R 138 3x50 G.H5 L 374 G.H5.23
Van-der-waals TM3 R 138 3x50 G.H5 L 374 G.H5.23
Hydrophobic TM6 S 249 6x33 G.H5 L 376 G.H5.25
Hydrophobic TM5 A 230 5x68 G.H5 L 371 G.H5.20
Hydrophobic TM6 S 249 6x33 G.H5 M 375 G.H5.24
Van-der-waals TM6 S 249 6x33 G.H5 M 375 G.H5.24
Hydrophobic TM5 V 227 5x65 G.H5 L 371 G.H5.20
Van-der-waals TM5 V 227 5x65 G.H5 L 371 G.H5.20
Hydrophobic TM6 F 250 6x34 G.H5 L 374 G.H5.23
Van-der-waals TM6 F 250 6x34 G.H5 L 374 G.H5.23
Hydrophobic TM6 L 247 6x31 G.H5 M 375 G.H5.24
Polar H8 N 314 8x49 G.H5 L 376 G.H5.25
Van-der-waals H8 N 314 8x49 G.H5 L 376 G.H5.25
Van-der-waals TM4 W 155 4x40 G.HN S 39 G.HN.48
Polar TM6 F 250 6x34 G.H5 M 375 G.H5.24
Hydrophobic TM6 F 250 6x34 G.H5 M 375 G.H5.24
Polar H8 N 312 8x47 G.H5 Q 377 G.H5.26
Hydrophobic H8 N 312 8x47 G.H5 Q 377 G.H5.26
Van-der-waals H8 N 312 8x47 G.H5 Q 377 G.H5.26
Hydrophobic TM6 D 246 6x30 G.H5 L 376 G.H5.25
Polar TM3 R 138 3x50 G.H5 Q 377 G.H5.26
Van-der-waals TM3 R 138 3x50 G.H5 Q 377 G.H5.26