Golf - MT2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 17.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 R 231 5x69 G.H5 L 381 G.H5.26
Hydrophobic ICL2 M 146 34x51 G.S3 V 204 G.S3.01
Van-der-waals ICL2 M 146 34x51 G.S3 V 204 G.S3.01
Hydrophobic ICL2 S 145 34x50 G.H5 I 370 G.H5.15
Hydrophobic TM6 L 247 6x31 G.H5 L 380 G.H5.25
Hydrophobic TM3 I 142 3x54 G.H5 L 380 G.H5.25
Hydrophobic ICL2 S 145 34x50 G.H5 H 374 G.H5.19
Van-der-waals ICL2 S 145 34x50 G.H5 H 374 G.H5.19
Hydrophobic ICL2 M 146 34x51 G.H5 C 366 G.H5.11
Hydrophobic TM5 L 226 5x64 G.H5 Q 371 G.H5.16
Polar TM6 F 250 6x34 G.H5 Y 378 G.H5.23
Van-der-waals TM6 F 250 6x34 G.H5 Y 378 G.H5.23
Polar H8 Q 313 8x48 G.H5 E 379 G.H5.24
Hydrophobic H8 Q 313 8x48 G.H5 E 379 G.H5.24
Hydrophobic ICL2 M 146 34x51 G.H5 R 367 G.H5.12
Polar TM3 Y 141 3x53 G.H5 Q 377 G.H5.22
Van-der-waals TM3 Y 141 3x53 G.H5 Q 377 G.H5.22
Polar TM3 Y 141 3x53 G.H5 H 374 G.H5.19
Aromatic TM3 Y 141 3x53 G.H5 H 374 G.H5.19
Hydrophobic TM3 Y 141 3x53 G.H5 H 374 G.H5.19
Van-der-waals TM3 Y 141 3x53 G.H5 H 374 G.H5.19
Hydrophobic TM3 I 142 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 I 142 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM4 R 153 4x38 G.HN L 37 G.HN.52
Hydrophobic TM6 L 242 6x26 G.H5 L 381 G.H5.26
Van-der-waals TM6 L 242 6x26 G.H5 L 381 G.H5.26
Polar TM3 R 138 3x50 G.H5 Y 378 G.H5.23
Aromatic TM3 R 138 3x50 G.H5 Y 378 G.H5.23
Hydrophobic TM3 R 138 3x50 G.H5 Y 378 G.H5.23
Van-der-waals TM3 R 138 3x50 G.H5 Y 378 G.H5.23
Hydrophobic ICL2 M 146 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 M 146 34x51 G.H5 I 370 G.H5.15
Ionic TM5 K 233 5x71 G.H5 D 368 G.H5.13
Polar TM5 K 233 5x71 G.H5 D 368 G.H5.13
Hydrophobic TM5 K 233 5x71 G.H5 D 368 G.H5.13
Van-der-waals TM5 K 233 5x71 G.H5 D 368 G.H5.13
Polar TM3 I 142 3x54 G.H5 Q 371 G.H5.16
Van-der-waals TM3 I 142 3x54 G.H5 Q 371 G.H5.16
Polar ICL2 H 149 34x54 G.hns1 K 40 G.hns1.02
Hydrophobic ICL2 H 149 34x54 G.hns1 K 40 G.hns1.02
Van-der-waals ICL2 H 149 34x54 G.hns1 K 40 G.hns1.02
Ionic ICL3 E 237 - G.H4 R 329 G.H4.12
Polar ICL3 E 237 - G.H4 R 329 G.H4.12
Hydrophobic ICL2 M 146 34x51 G.H5 F 363 G.H5.08
Hydrophobic ICL2 H 149 34x54 G.hns1 A 41 G.hns1.03
Polar TM5 R 231 5x69 G.H5 L 380 G.H5.25
Hydrophobic ICL3 E 237 - G.h4s6 T 337 G.h4s6.03
Hydrophobic TM6 L 240 6x24 G.h4s6 G 340 G.h4s6.09
Van-der-waals TM6 L 240 6x24 G.h4s6 G 340 G.h4s6.09
Hydrophobic TM6 D 246 6x30 G.H5 E 379 G.H5.24
Van-der-waals TM6 D 246 6x30 G.H5 E 379 G.H5.24
Polar TM3 C 143 3x55 G.H5 Q 371 G.H5.16
Van-der-waals TM3 C 143 3x55 G.H5 Q 371 G.H5.16
Polar TM6 L 247 6x31 G.H5 E 379 G.H5.24
Hydrophobic TM6 L 247 6x31 G.H5 E 379 G.H5.24
Van-der-waals TM6 L 247 6x31 G.H5 E 379 G.H5.24
Hydrophobic TM6 F 250 6x34 G.H5 L 380 G.H5.25
Van-der-waals TM6 F 250 6x34 G.H5 L 380 G.H5.25
Hydrophobic TM5 I 223 5x61 G.H5 L 380 G.H5.25
Hydrophobic TM6 L 240 6x24 G.h4s6 Y 345 G.h4s6.20
Hydrophobic ICL3 S 238 - G.h4s6 T 337 G.h4s6.03
Hydrophobic TM5 A 234 5x72 G.H5 R 372 G.H5.17
Van-der-waals TM5 A 234 5x72 G.H5 R 372 G.H5.17
Hydrophobic TM5 A 230 5x68 G.H5 L 375 G.H5.20
Hydrophobic ICL2 S 145 34x50 G.H5 Q 371 G.H5.16
Polar TM6 R 248 6x32 G.H5 E 379 G.H5.24
Van-der-waals TM6 R 248 6x32 G.H5 E 379 G.H5.24
Polar TM6 S 249 6x33 G.H5 Y 378 G.H5.23
Hydrophobic TM6 S 249 6x33 G.H5 Y 378 G.H5.23
Van-der-waals TM6 S 249 6x33 G.H5 Y 378 G.H5.23
Polar ICL2 R 150 34x55 G.s2s3 K 203 G.s2s3.02
Hydrophobic TM3 I 142 3x54 G.H5 Y 378 G.H5.23
Hydrophobic TM4 W 155 4x40 G.HN L 37 G.HN.52
Van-der-waals TM4 W 155 4x40 G.HN L 37 G.HN.52
Hydrophobic TM5 V 227 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 V 227 5x65 G.H5 L 375 G.H5.20
Hydrophobic TM6 L 240 6x24 G.h4s6 G 342 G.h4s6.11
Van-der-waals TM6 L 240 6x24 G.h4s6 G 342 G.h4s6.11
Hydrophobic TM4 W 155 4x40 G.HN Q 33 G.HN.48
Van-der-waals TM4 W 155 4x40 G.HN Q 33 G.HN.48
Hydrophobic TM5 A 230 5x68 G.H5 L 381 G.H5.26
Hydrophobic ICL3 E 237 - G.H4 L 333 G.H4.16
Van-der-waals ICL3 E 237 - G.H4 L 333 G.H4.16
Aromatic TM3 Y 141 3x53 G.H5 Y 378 G.H5.23
Hydrophobic TM3 Y 141 3x53 G.H5 Y 378 G.H5.23
Van-der-waals TM3 Y 141 3x53 G.H5 Y 378 G.H5.23
Hydrophobic TM5 V 227 5x65 G.H5 L 380 G.H5.25
Polar TM6 S 249 6x33 G.H5 E 379 G.H5.24
Hydrophobic TM6 S 249 6x33 G.H5 E 379 G.H5.24
Van-der-waals TM6 S 249 6x33 G.H5 E 379 G.H5.24
Hydrophobic TM6 D 246 6x30 G.H5 L 381 G.H5.26
Polar TM5 A 230 5x68 G.H5 R 372 G.H5.17
Hydrophobic ICL2 M 146 34x51 G.S3 F 206 G.S3.03
Van-der-waals ICL2 M 146 34x51 G.S3 F 206 G.S3.03
Hydrophobic ICL2 M 146 34x51 G.S1 H 43 G.S1.02
Van-der-waals ICL2 M 146 34x51 G.S1 H 43 G.S1.02
Hydrophobic TM6 D 246 6x30 G.H5 L 380 G.H5.25