G11 - GPR50 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 66.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 14.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 N 61 2x37 G.H5 Y 356 G.H5.23
Polar TM3 R 126 3x50 G.H5 N 357 G.H5.24
Hydrophobic TM3 R 126 3x50 G.H5 N 357 G.H5.24
Van-der-waals TM3 R 126 3x50 G.H5 N 357 G.H5.24
Polar H8 N 300 8x49 G.H5 N 357 G.H5.24
Van-der-waals H8 N 300 8x49 G.H5 N 357 G.H5.24
Hydrophobic TM5 Y 208 5x58 G.H5 L 358 G.H5.25
Van-der-waals TM5 Y 208 5x58 G.H5 L 358 G.H5.25
Polar ICL3 Q 224 - G.H5 D 346 G.H5.13
Van-der-waals ICL3 Q 224 - G.H5 D 346 G.H5.13
Hydrophobic TM2 G 63 2x39 G.H5 Y 356 G.H5.23
Polar TM3 Y 129 3x53 G.H5 E 355 G.H5.22
Hydrophobic TM3 Y 129 3x53 G.H5 E 355 G.H5.22
Van-der-waals TM3 Y 129 3x53 G.H5 E 355 G.H5.22
Polar H8 N 298 8x47 G.H5 N 357 G.H5.24
Hydrophobic H8 N 298 8x47 G.H5 N 357 G.H5.24
Van-der-waals H8 N 298 8x47 G.H5 N 357 G.H5.24
Polar H8 N 300 8x49 G.H5 E 355 G.H5.22
Van-der-waals H8 N 300 8x49 G.H5 E 355 G.H5.22
Hydrophobic C-term V 365 - G.S2 I 190 G.S2.02
Van-der-waals C-term V 365 - G.S2 I 190 G.S2.02
Hydrophobic TM5 A 218 5x68 G.H5 L 349 G.H5.16
Van-der-waals TM5 A 218 5x68 G.H5 L 349 G.H5.16
Polar ICL3 Q 224 - G.S6 Y 325 G.S6.02
Hydrophobic ICL3 Q 224 - G.S6 Y 325 G.S6.02
Van-der-waals ICL3 Q 224 - G.S6 Y 325 G.S6.02
Polar ICL2 Y 136 34x53 G.H5 Y 356 G.H5.23
Hydrophobic ICL2 Y 136 34x53 G.H5 Y 356 G.H5.23
Van-der-waals ICL2 Y 136 34x53 G.H5 Y 356 G.H5.23
Hydrophobic TM5 V 215 5x65 G.H5 L 349 G.H5.16
Van-der-waals TM5 V 215 5x65 G.H5 L 349 G.H5.16
Hydrophobic TM3 I 130 3x54 G.H5 N 352 G.H5.19
Hydrophobic TM6 T 238 6x36 G.H5 V 359 G.H5.26
Polar TM6 M 239 6x37 G.H5 L 358 G.H5.25
Hydrophobic TM6 M 239 6x37 G.H5 L 358 G.H5.25
Van-der-waals TM6 M 239 6x37 G.H5 L 358 G.H5.25
Polar TM3 Y 129 3x53 G.hns1 R 37 G.hns1.02
Hydrophobic TM3 Y 129 3x53 G.hns1 R 37 G.hns1.02
Van-der-waals TM3 Y 129 3x53 G.hns1 R 37 G.hns1.02
Hydrophobic TM6 T 238 6x36 G.H5 L 358 G.H5.25
Van-der-waals TM6 T 238 6x36 G.H5 L 358 G.H5.25
Hydrophobic C-term V 458 - G.H3 A 253 G.H3.07
Hydrophobic TM3 I 130 3x54 G.H5 L 353 G.H5.20
Van-der-waals TM3 I 130 3x54 G.H5 L 353 G.H5.20
Hydrophobic C-term M 363 - G.H1 R 60 G.H1.09
Van-der-waals C-term M 363 - G.H1 R 60 G.H1.09
Hydrophobic TM3 R 126 3x50 G.H5 L 358 G.H5.25
Van-der-waals TM3 R 126 3x50 G.H5 L 358 G.H5.25
Hydrophobic TM5 K 214 5x64 G.H5 L 349 G.H5.16
Van-der-waals TM5 K 214 5x64 G.H5 L 349 G.H5.16
Ionic TM5 R 219 5x69 G.H5 D 346 G.H5.13
Hydrophobic TM5 R 219 5x69 G.H5 D 346 G.H5.13
Hydrophobic TM5 V 215 5x65 G.H5 L 353 G.H5.20
Hydrophobic TM5 A 222 5x72 G.H5 A 343 G.H5.10
Hydrophobic C-term F 460 - G.H3 T 257 G.H3.11
Hydrophobic C-term L 370 - G.H2 K 215 G.H2.06
Hydrophobic TM6 M 239 6x37 G.H5 L 353 G.H5.20
Hydrophobic ICL3 Q 224 - G.h4s6 I 323 G.h4s6.20
Van-der-waals ICL3 Q 224 - G.h4s6 I 323 G.h4s6.20
Hydrophobic TM6 N 235 6x33 G.H5 V 359 G.H5.26
Van-der-waals TM6 N 235 6x33 G.H5 V 359 G.H5.26
Hydrophobic C-term V 458 - G.H3 L 254 G.H3.08
Hydrophobic TM5 A 222 5x72 G.H5 A 342 G.H5.09
Van-der-waals TM3 N 125 3x49 G.H5 Y 356 G.H5.23
Hydrophobic TM5 A 222 5x72 G.S6 Y 325 G.S6.02
Van-der-waals TM5 A 222 5x72 G.S6 Y 325 G.S6.02
Hydrophobic TM5 A 222 5x72 G.H5 F 339 G.H5.06
Van-der-waals TM5 A 222 5x72 G.H5 F 339 G.H5.06
Hydrophobic C-term V 458 - G.H3 T 257 G.H3.11
Van-der-waals C-term V 458 - G.H3 T 257 G.H3.11
Polar C-term F 460 - G.H3 Y 261 G.H3.15
Aromatic C-term F 460 - G.H3 Y 261 G.H3.15
Hydrophobic C-term F 460 - G.H3 Y 261 G.H3.15
Van-der-waals C-term F 460 - G.H3 Y 261 G.H3.15
Hydrophobic TM5 I 211 5x61 G.H5 L 353 G.H5.20
Hydrophobic C-term L 370 - G.H2 H 218 G.H2.09
Polar TM3 R 126 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 R 126 3x50 G.H5 Y 356 G.H5.23
Van-der-waals TM3 R 126 3x50 G.H5 Y 356 G.H5.23
Hydrophobic TM3 I 130 3x54 G.H5 L 358 G.H5.25
Van-der-waals TM3 I 130 3x54 G.H5 L 358 G.H5.25
Hydrophobic C-term M 363 - G.h1ha A 65 G.h1ha.02
Hydrophobic C-term F 460 - G.H2 W 216 G.H2.07
Ionic ICL2 E 137 34x54 G.hns1 R 37 G.hns1.02
Polar ICL2 E 137 34x54 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 E 137 34x54 G.hns1 R 37 G.hns1.02
Hydrophobic TM3 I 130 3x54 G.H5 L 349 G.H5.16
Van-der-waals TM3 I 130 3x54 G.H5 L 349 G.H5.16
Polar C-term S 457 - G.H3 E 250 G.H3.04
Van-der-waals C-term S 457 - G.H3 E 250 G.H3.04
Hydrophobic TM5 A 218 5x68 G.H5 D 346 G.H5.13
Hydrophobic TM6 M 239 6x37 G.H5 V 359 G.H5.26
Polar H8 N 300 8x49 G.H5 K 354 G.H5.21
Polar H8 E 299 8x48 G.H5 N 357 G.H5.24
Van-der-waals H8 E 299 8x48 G.H5 N 357 G.H5.24
Ionic C-term R 339 - G.h2s4 E 221 G.h2s4.02
Polar C-term R 339 - G.h2s4 E 221 G.h2s4.02
Van-der-waals C-term R 339 - G.h2s4 E 221 G.h2s4.02
Polar C-term S 457 - G.H2 R 210 G.H2.01
Hydrophobic C-term S 457 - G.H2 R 210 G.H2.01
Van-der-waals C-term S 457 - G.H2 R 210 G.H2.01
Hydrophobic ICL2 L 134 34x51 G.hns1 R 38 G.hns1.03
Hydrophobic C-term F 460 - G.H3 I 258 G.H3.12
Hydrophobic C-term F 460 - G.h2s4 F 220 G.h2s4.01
Van-der-waals C-term F 460 - G.h2s4 F 220 G.h2s4.01
Aromatic TM3 Y 129 3x53 G.H5 Y 356 G.H5.23
Hydrophobic TM3 Y 129 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 Y 129 3x53 G.H5 Y 356 G.H5.23
Hydrophobic TM5 P 221 5x71 G.H5 A 342 G.H5.09
Polar TM3 Y 129 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 Y 129 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 Y 129 3x53 G.H5 N 352 G.H5.19